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Conserved domains on  [gi|1039743073|ref|XP_017170862|]
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methylglutaconyl-CoA hydratase, mitochondrial isoform X2 [Mus musculus]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 61-114 2.42e-10

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 57.12  E-value: 2.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  61 NRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 114
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCA 55
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 61-114 2.42e-10

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 57.12  E-value: 2.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  61 NRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 114
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCA 55
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 59-114 9.55e-09

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 51.79  E-value: 9.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA 114
Cdd:cd06558     4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCA 58
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 59-114 1.27e-06

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 46.31  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA 114
Cdd:COG1024     4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCA 58
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 59-114 6.48e-04

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 38.50  E-value: 6.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCA 114
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCA 55
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 61-114 2.42e-10

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 57.12  E-value: 2.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  61 NRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 114
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCA 55
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 59-114 9.55e-09

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 51.79  E-value: 9.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA 114
Cdd:cd06558     4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCA 58
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 57-114 7.71e-07

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 47.24  E-value: 7.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743073  57 LEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCA 114
Cdd:PRK08139   14 LREDRDGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCA 70
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 59-114 1.27e-06

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 46.31  E-value: 1.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA 114
Cdd:COG1024     4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCA 58
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 48-114 3.35e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 42.16  E-value: 3.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743073  48 TEDELRVrHLEEenrGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCA 114
Cdd:PRK06688    3 MVTDLLV-ELED---GVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTG-AGRAFSA 64
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
53-114 6.53e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 41.40  E-value: 6.53e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743073  53 RVRhLEEENrGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA 114
Cdd:PRK07509    4 RVS-VTIED-GIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGE-GGAFCA 62
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 63-124 1.08e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 40.77  E-value: 1.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743073  63 GIVVLGINRAYGkNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEvpGIFcavsFQLKADIQ 124
Cdd:PRK07658   11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE--GRF----FSAGADIK 65
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 48-114 1.14e-04

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 40.96  E-value: 1.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743073  48 TEDELRVrhlEEENR-GIVVLgiNRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 114
Cdd:PRK05617    1 TEDEVLA---EVEGGvGVITL--NRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCA 63
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 49-104 1.42e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 40.42  E-value: 1.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  49 EDELRVRHLEEenrGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIII 104
Cdd:PRK08138    6 TDVVLLERPAD---GVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVL 58
PLN02888 PLN02888
enoyl-CoA hydratase
 57-114 1.60e-04

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 40.51  E-value: 1.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743073  57 LEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA 114
Cdd:PLN02888   13 VPKSRNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRA-FCS 69
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
56-121 1.70e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 40.47  E-value: 1.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743073  56 HLEEENRG-IVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAvSFQLKA 121
Cdd:PRK07799    6 HALVEQRGhTLIVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCA-GMDLKA 70
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
56-114 1.74e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 40.43  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039743073  56 HLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA 114
Cdd:PRK07468    7 RIAVDARGVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKS-FCA 64
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 61-114 2.71e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 39.72  E-value: 2.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  61 NRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 114
Cdd:PRK07657   11 TPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCA 64
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 59-114 6.48e-04

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 38.50  E-value: 6.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCA 114
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCA 55
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
48-121 1.83e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 37.28  E-value: 1.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  48 TEDELRVrhleEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAvSFQLKA 121
Cdd:PRK08252    1 MSDEVLV----ERRGRVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGIL-TGAGGTFCA-GMDLKA 68
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 48-114 3.38e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 36.49  E-value: 3.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743073  48 TEDELRVRHLEeenrGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPgIFCA 114
Cdd:PRK06190    2 TEPILLVETHD----RVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGADP-AFCA 63
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
59-104 6.29e-03

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 35.88  E-value: 6.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1039743073  59 EENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIII 104
Cdd:PRK05809    9 EKEGHIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVIL 54
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 51-114 7.17e-03

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 35.71  E-value: 7.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039743073  51 ELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSeVPGIFCA 114
Cdd:PRK07110    2 MMKVVELREVEEGIAQVTMQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILTG-YPNYFAT 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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