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Conserved domains on  [gi|1039736144|ref|XP_017169840|]
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integrin beta-4 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 38-455 0e+00

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member smart00187:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 423  Bit Score: 561.17  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144    38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 1039736144   428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 992-1086 2.91e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


:

Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.91e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   992 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1071
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 1039736144  1072 LLRGrqVRRFQVQLS 1086
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-711 1.11e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 99.27  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELKKAEE-VVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 705
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 1039736144  706 KDCPPG 711
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1688-1773 1.13e-21

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 1.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1688 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1039736144 1768 EGFGPE 1773
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1574-1655 1.17e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.54  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1574 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                   ...
gi 1039736144 1653 GWG 1655
Cdd:cd00063     81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1127-1207 6.40e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1127 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1039736144 1203 EGPYS 1207
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1219-1312 3.56e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1219 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1298
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 1039736144 1299 ARNGAGWGPEREAI 1312
Cdd:cd00063     76 AVNGGGESPPSESV 89
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.00e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 55.19  E-value: 1.00e-09
                           10        20
                   ....*....|....*....|....*....
gi 1039736144  459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-455 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 561.17  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144    38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 1039736144   428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 126-371 1.23e-146

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 452.34  E-value: 1.23e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  126 PLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 201
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  202 FSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAnvLAGI 281
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  282 MNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLE 361
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 1039736144  362 EAFYRIRSNL 371
Cdd:pfam00362  239 EAYEKIRSKV 248
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 992-1086 2.91e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.91e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   992 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1071
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 1039736144  1072 LLRGrqVRRFQVQLS 1086
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-711 1.11e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 99.27  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELKKAEE-VVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 705
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 1039736144  706 KDCPPG 711
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1688-1773 1.13e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 1.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1688 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1039736144 1768 EGFGPE 1773
Cdd:pfam00041   79 GGEGPP 84
Calx-beta pfam03160
Calx-beta domain;
992-1086 4.57e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 89.23  E-value: 4.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  992 GVVSFEQPEYSVSRGDQVARIPVIRHILD-NGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLElqevD 1070
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 1039736144 1071 SLLRGRqvRRFQVQLS 1086
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1574-1655 1.17e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.54  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1574 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                   ...
gi 1039736144 1653 GWG 1655
Cdd:cd00063     81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1575-1657 3.17e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 3.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1575 DTPTRLVFSALGPTSLKVSWQEP-QCDRMLLGYSVEYQLLNGGEM-HRLNIPNPgQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPwNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1039736144 1653 GWGRE 1657
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1687-1772 2.82e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.61  E-value: 2.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1687 PSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQART 1766
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 1039736144 1767 TEGFGP 1772
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1127-1207 6.40e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1127 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1039736144 1203 EGPYS 1207
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1574-1655 4.45e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.88  E-value: 4.45e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1574 PDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRLN--IPNPGQTSVVVEDLLPNHSYVFRVRAQSQ 1651
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039736144  1652 EGWG 1655
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1687-1771 6.13e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 6.13e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1687 PSAPGPLVFTALSPDSLQLSWERPRRPNGDilGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQART 1766
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039736144  1767 TEGFG 1771
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1219-1312 3.56e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1219 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1298
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 1039736144 1299 ARNGAGWGPEREAI 1312
Cdd:cd00063     76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1220-1308 4.02e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1220 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1299
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 1039736144 1300 RNGAGWGPE 1308
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1127-1214 1.63e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 1.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1127 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1039736144 1203 EGPYSSLVSCRT 1214
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1573-1792 2.75e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.96  E-value: 2.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1573 VPDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRlnIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1653 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDILGYLVTcemaQGGA 1731
Cdd:COG3401    309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039736144 1732 PARTFR-VDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLG 1792
Cdd:COG3401    366 GGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.00e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 55.19  E-value: 1.00e-09
                           10        20
                   ....*....|....*....|....*....
gi 1039736144  459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1127-1204 1.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.28e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1127 GAPQNPNAKAAGSRKIHFNWLPPPGK-PMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039736144  1203 EG 1204
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1219-1306 2.86e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.86e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1219 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1298
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 1039736144  1299 ARNGAGWG 1306
Cdd:smart00060   76 AVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 994-1106 2.06e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 59.42  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  994 VSFEQPEYSVSRGDQVARIPVIRHILDNGKS-QVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLL--ELQEVD 1070
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736144 1071 sllrgrqvRRFQVQLSNPKFG--------------ARLGQPSTTTV-ILDE 1106
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVtILDD 524
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1625-1769 1.92e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1625 NPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1703
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039736144 1704 QLSWERPrrPNGDILGYLVtcemAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEG 1769
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 38-455 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 561.17  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144    38 SCTECIRVDKSCAYCTDELFKER---RCNTQAELLAAGCRGESILVMESSLEITENTQID---TSLHRSQVSPQGLQVRL 111
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   112 RPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 191
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   192 KEPWPN----SDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESA 267
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   268 FHYEADGAnvLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLG 347
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   348 VLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSdTLQKTETGSFHikRGEVGTYNVHLRAVEDIDGTHVCQl 427
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*....
gi 1039736144   428 aKEDQGGNIHLKP-SFSDGLRMDASVICD 455
Cdd:smart00187  395 -PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 126-371 1.23e-146

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 452.34  E-value: 1.23e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  126 PLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 201
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  202 FSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAnvLAGI 281
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  282 MNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLE 361
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 1039736144  362 EAFYRIRSNL 371
Cdd:pfam00362  239 EAYEKIRSKV 248
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 992-1086 2.91e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 106.96  E-value: 2.91e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144   992 GVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLelqeVDS 1071
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDD 77

                            90
                    ....*....|....*
gi 1039736144  1072 LLRGrqVRRFQVQLS 1086
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-711 1.11e-24

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 99.27  E-value: 1.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  628 CEDLRSCVQCQAWGTGEKKGRACD-DCPFKVKMVDELKKAEE-VVEYCSFRDEdDDCTYSYNVEGDgsPGPNSTVLVHKK 705
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCSrNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 1039736144  706 KDCPPG 711
Cdd:pfam07965   78 RECPPG 83
fn3 pfam00041
Fibronectin type III domain;
1688-1773 1.13e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 90.94  E-value: 1.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1688 SAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQARTT 1767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1039736144 1768 EGFGPE 1773
Cdd:pfam00041   79 GGEGPP 84
Calx-beta pfam03160
Calx-beta domain;
992-1086 4.57e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 89.23  E-value: 4.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  992 GVVSFEQPEYSVSRGDQVARIPVIRHILD-NGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLElqevD 1070
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 1039736144 1071 SLLRGRqvRRFQVQLS 1086
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1574-1655 1.17e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 82.54  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1574 PDTPTRLVFSALGPTSLKVSWQEPQCD-RMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                   ...
gi 1039736144 1653 GWG 1655
Cdd:cd00063     81 GES 83
fn3 pfam00041
Fibronectin type III domain;
1575-1657 3.17e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 3.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1575 DTPTRLVFSALGPTSLKVSWQEP-QCDRMLLGYSVEYQLLNGGEM-HRLNIPNPgQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPwNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1039736144 1653 GWGRE 1657
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1687-1772 2.82e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.61  E-value: 2.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1687 PSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDnpESRLTVPGLSENVPYKFKVQART 1766
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 1039736144 1767 TEGFGP 1772
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1127-1207 6.40e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1127 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1039736144 1203 EGPYS 1207
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1574-1655 4.45e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.88  E-value: 4.45e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1574 PDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRLN--IPNPGQTSVVVEDLLPNHSYVFRVRAQSQ 1651
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039736144  1652 EGWG 1655
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1687-1771 6.13e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 6.13e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1687 PSAPGPLVFTALSPDSLQLSWERPRRPNGDilGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQART 1766
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039736144  1767 TEGFG 1771
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1219-1312 3.56e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1219 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1298
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 1039736144 1299 ARNGAGWGPEREAI 1312
Cdd:cd00063     76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1220-1308 4.02e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1220 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1299
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 1039736144 1300 RNGAGWGPE 1308
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1127-1214 1.63e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 1.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1127 GAPQNPNAKAAGSRKIHFNWLPPP---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1039736144 1203 EGPYSSLVSCRT 1214
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1573-1792 2.75e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.96  E-value: 2.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1573 VPDTPTRLVFSALGPTSLKVSWQEPQCDRmLLGYSVEYQLLNGGEMHRlnIPNPGQTSVVVEDLLPNHSYVFRVRAQSQE 1652
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWDPVTESD-ATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1653 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDILGYLVTcemaQGGA 1731
Cdd:COG3401    309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039736144 1732 PARTFR-VDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLG 1792
Cdd:COG3401    366 GGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 29-74 3.86e-11

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 59.49  E-value: 3.86e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039736144   29 NRCKKAQvKSCTECIRVDKSCAYCTDELF--KERRCNTQAELLAAGCR 74
Cdd:pfam17205    1 NRCTSAS-TSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1128-1304 1.10e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1128 APQNPNAKAAGSRKIHFNWLPPPGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1198
Cdd:COG3401    235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1199 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVcYglvnEDNRPIGPMKKVlVDNP 1277
Cdd:COG3401    306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-Y----RSTSGGGTYTKI-AETV 377

                          170       180
                   ....*....|....*....|....*..
gi 1039736144 1278 KNRMLLIENLRESQPYRYTVKARNGAG 1304
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 459-487 1.00e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 55.19  E-value: 1.00e-09
                           10        20
                   ....*....|....*....|....*....
gi 1039736144  459 CELQKEVRSARCHFRGDFMCGHCVCNEGW 487
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1127-1204 1.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.28e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1127 GAPQNPNAKAAGSRKIHFNWLPPPGK-PMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1202
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039736144  1203 EG 1204
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1219-1306 2.86e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.86e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  1219 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1298
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 1039736144  1299 ARNGAGWG 1306
Cdd:smart00060   76 AVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 994-1106 2.06e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 59.42  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  994 VSFEQPEYSVSRGDQVARIPVIRHILDNGKS-QVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLL--ELQEVD 1070
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039736144 1071 sllrgrqvRRFQVQLSNPKFG--------------ARLGQPSTTTV-ILDE 1106
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVtILDD 524
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1625-1769 1.92e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1625 NPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1703
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039736144 1704 QLSWERPrrPNGDILGYLVtcemAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEG 1769
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 980-1093 1.91e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 53.26  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144  980 LVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTA-HGHRDYVPVEGELLFHPGETWKE 1058
Cdd:TIGR00845  516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFENDETEKT 595

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1039736144 1059 LQVKLLELQEVDsllrgRQVrRFQVQLSNPKFGAR 1093
Cdd:TIGR00845  596 IRVKIVDDEEYE-----KND-TFFIELGEPRWAKR 624
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1091-1304 2.68e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 2.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1091 GARLGQPSTTTVILDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKI--HFNWLPPPGKPMGYRVKYWIQGDSES 1168
Cdd:COG3401    103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANasGTTASSVAGAGVVVSPDTSATAAVAT 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1169 EAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNge 1248
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD-- 260

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039736144 1249 ITAYEVCYGlvnedNRPIGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1304
Cdd:COG3401    261 ATGYRVYRS-----NSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1687-1769 1.53e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.84  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039736144 1687 PSAPGPLVFTALSPDSLQLSWErPRRPNGDILGYLVTcemaQGGAPARTfrVDGDNpesRLTVPGLSENVPYKFKVQART 1766
Cdd:COG3979      3 PTAPTGLTASNVTSSSVSLSWD-ASTDNVGVTGYDVY----RGGDQVAT--VTGLT---AWTVTGLTPGTEYTFTVGACD 72


                   ...
gi 1039736144 1767 TEG 1769
Cdd:COG3979     73 AAG 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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