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Conserved domains on  [gi|1039732535|ref|XP_017169348|]
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proto-oncogene tyrosine-protein kinase ROS isoform X6 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
100-296 8.89e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.19  E-value: 8.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  100 SYEEEVLESTELPTAP---FASSIGSHGVTLRWNPANISGVK-YIIQWKYAQlPGSWTFTETVSKLSYTVEPLHPFTEYI 175
Cdd:COG3401    221 SNEVSVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYY 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  176 FRVVWIFTAqlHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPhfPGGPILGYNL----RLISKNQKLDS 251
Cdd:COG3401    300 YRVTAVDAA--GNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAE 375

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1039732535  252 GTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSV 296
Cdd:COG3401    376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASA 420
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 568-664 5.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 5.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  568 PGHPQEVSVLF-GSREALIQWTPPalaigaSPSAWQNWTYEVKVYSQDILEITQV-FSNISGTMLNVPELQSSTKYTVSV 645
Cdd:cd00063      1 PSPPTNLRVTDvTSTSVTLSWTPP------EDDGGPITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*....
gi 1039732535  646 RASSPKGPGPWSAPSVGTT 664
Cdd:cd00063     75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1143 4.34e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535 1037 PSAPENPRIFILSSgrytkkNEVVVefRWNKPKHENGVLTKFEIFYhiskqsgTNRSTEDWMSASV-IPPVMSFQLEAVS 1115
Cdd:cd00063      1 PSPPTNLRVTDVTS------TSVTL--SWTPPEDDGGPITGYVVEY-------REKGSGDWKEVEVtPGSETSYTLTGLK 65

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039732535 1116 P--EYTvaFQVRVFTSKGPGPFSDIVMSKT 1143
Cdd:cd00063     66 PgtEYE--FRVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
100-296 8.89e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.19  E-value: 8.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  100 SYEEEVLESTELPTAP---FASSIGSHGVTLRWNPANISGVK-YIIQWKYAQlPGSWTFTETVSKLSYTVEPLHPFTEYI 175
Cdd:COG3401    221 SNEVSVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYY 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  176 FRVVWIFTAqlHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPhfPGGPILGYNL----RLISKNQKLDS 251
Cdd:COG3401    300 YRVTAVDAA--GNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAE 375

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1039732535  252 GTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSV 296
Cdd:COG3401    376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASA 420
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 207-291 2.35e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  207 APLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQK-----LDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGE 281
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1039732535  282 GPEAESTVTT 291
Cdd:cd00063     83 SPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
207-284 6.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 6.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  207 APLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKN------QKLDSGTQrTSFQFYSTLPNTTYRFSIAAVNEVG 280
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwnEITVPGTT-TSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039732535  281 EGPE 284
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 207-282 5.37e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 5.37e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535   207 APLILNMESWSPDTVEVSWAPPHFPG--GPILGYNLRLISKN---QKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGE 281
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1039732535   282 G 282
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 568-664 5.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 5.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  568 PGHPQEVSVLF-GSREALIQWTPPalaigaSPSAWQNWTYEVKVYSQDILEITQV-FSNISGTMLNVPELQSSTKYTVSV 645
Cdd:cd00063      1 PSPPTNLRVTDvTSTSVTLSWTPP------EDDGGPITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*....
gi 1039732535  646 RASSPKGPGPWSAPSVGTT 664
Cdd:cd00063     75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1143 4.34e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535 1037 PSAPENPRIFILSSgrytkkNEVVVefRWNKPKHENGVLTKFEIFYhiskqsgTNRSTEDWMSASV-IPPVMSFQLEAVS 1115
Cdd:cd00063      1 PSPPTNLRVTDVTS------TSVTL--SWTPPEDDGGPITGYVVEY-------REKGSGDWKEVEVtPGSETSYTLTGLK 65

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039732535 1116 P--EYTvaFQVRVFTSKGPGPFSDIVMSKT 1143
Cdd:cd00063     66 PgtEYE--FRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 568-654 8.81e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 8.81e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535   568 PGHPQEVSVLF-GSREALIQWTPPALAIGASPSAwqnwTYEVKvYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVR 646
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV----GYRVE-YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 1039732535   647 ASSPKGPG 654
Cdd:smart00060   76 AVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
571-657 1.62e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  571 PQEVSVLF-GSREALIQWTPPAlaigASPSAWQNwtYEVKVYSQDILEITQVFsNISGT--MLNVPELQSSTKYTVSVRA 647
Cdd:pfam00041    3 PSNLTVTDvTSTSLTVSWTPPP----DGNGPITG--YEVEYRPKNSGEPWNEI-TVPGTttSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 1039732535  648 SSPKGPGPWS 657
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1037-1133 2.48e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.48e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  1037 PSAPENPRIFILSSGRytkknevvVEFRWNKPKHENGvlTKFEIFYHISKQSgtnrSTEDWMSASVIPPVMSFQLEAVSP 1116
Cdd:smart00060    1 PSPPSNLRVTDVTSTS--------VTLSWEPPPDDGI--TGYIVGYRVEYRE----EGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 1039732535  1117 EYTVAFQVRVFTSKGPG 1133
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1038-1136 6.30e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 6.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535 1038 SAPENPRIfilssgryTKKNEVVVEFRWNKPKHENGVLTKFEIFYhisKQSGTNrstEDWMSASVIPPVMSFQLEAVSP- 1116
Cdd:pfam00041    1 SAPSNLTV--------TDVTSTSLTVSWTPPPDGNGPITGYEVEY---RPKNSG---EPWNEITVPGTTTSVTLTGLKPg 66

                           90       100
                   ....*....|....*....|.
gi 1039732535 1117 -EYTvaFQVRVFTSKGPGPFS 1136
Cdd:pfam00041   67 tEYE--VRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
100-296 8.89e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.19  E-value: 8.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  100 SYEEEVLESTELPTAP---FASSIGSHGVTLRWNPANISGVK-YIIQWKYAQlPGSWTFTETVSKLSYTVEPLHPFTEYI 175
Cdd:COG3401    221 SNEVSVTTPTTPPSAPtglTATADTPGSVTLSWDPVTESDATgYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYY 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  176 FRVVWIFTAqlHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPhfPGGPILGYNL----RLISKNQKLDS 251
Cdd:COG3401    300 YRVTAVDAA--GNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVyrstSGGGTYTKIAE 375

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1039732535  252 GTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSV 296
Cdd:COG3401    376 TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASA 420
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 207-291 2.35e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  207 APLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQK-----LDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGE 281
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1039732535  282 GPEAESTVTT 291
Cdd:cd00063     83 SPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
207-284 6.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 6.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  207 APLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKN------QKLDSGTQrTSFQFYSTLPNTTYRFSIAAVNEVG 280
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwnEITVPGTT-TSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039732535  281 EGPE 284
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 207-282 5.37e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 5.37e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535   207 APLILNMESWSPDTVEVSWAPPHFPG--GPILGYNLRLISKN---QKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGE 281
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1039732535   282 G 282
Cdd:smart00060   83 G 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 112-179 4.40e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 4.40e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039732535   112 PTAPFASSIGSHGVTLRWN-PANISGVKYIIQWK--YAQLPGSW-TFTETVSKLSYTVEPLHPFTEYIFRVV 179
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRveYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 568-664 5.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 5.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  568 PGHPQEVSVLF-GSREALIQWTPPalaigaSPSAWQNWTYEVKVYSQDILEITQV-FSNISGTMLNVPELQSSTKYTVSV 645
Cdd:cd00063      1 PSPPTNLRVTDvTSTSVTLSWTPP------EDDGGPITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*....
gi 1039732535  646 RASSPKGPGPWSAPSVGTT 664
Cdd:cd00063     75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 112-195 5.87e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 5.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  112 PTAPFASSIGSHGVTLRWNPANISG---VKYIIQWKYAQLPGSWTF-TETVSKLSYTVEPLHPFTEYIFRVVWIFTAQlh 187
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG-- 81


                   ....*...
gi 1039732535  188 lYSPPSPS 195
Cdd:cd00063     82 -ESPPSES 88
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
151-291 1.64e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  151 SWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQlhlYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPhf 230
Cdd:COG3401    182 TTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGG---ESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV-- 256

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039732535  231 PGGPILGYNL-RLISKNQKLD--SGTQRTSFQFYSTLPNTTYRFSIAAVNEVGE--GPEAESTVTT 291
Cdd:COG3401    257 TESDATGYRVyRSNSGDGPFTkvATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTT 322
fn3 pfam00041
Fibronectin type III domain;
112-179 1.69e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.69e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039732535  112 PTAPFASSIGSHGVTLRWNPANISG---VKYIIQWKYAQLPGSW-TFTETVSKLSYTVEPLHPFTEYIFRVV 179
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1143 4.34e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535 1037 PSAPENPRIFILSSgrytkkNEVVVefRWNKPKHENGVLTKFEIFYhiskqsgTNRSTEDWMSASV-IPPVMSFQLEAVS 1115
Cdd:cd00063      1 PSPPTNLRVTDVTS------TSVTL--SWTPPEDDGGPITGYVVEY-------REKGSGDWKEVEVtPGSETSYTLTGLK 65

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039732535 1116 P--EYTvaFQVRVFTSKGPGPFSDIVMSKT 1143
Cdd:cd00063     66 PgtEYE--FRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 568-654 8.81e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 8.81e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535   568 PGHPQEVSVLF-GSREALIQWTPPALAIGASPSAwqnwTYEVKvYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVR 646
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV----GYRVE-YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 1039732535   647 ASSPKGPG 654
Cdd:smart00060   76 AVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
571-657 1.62e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  571 PQEVSVLF-GSREALIQWTPPAlaigASPSAWQNwtYEVKVYSQDILEITQVFsNISGT--MLNVPELQSSTKYTVSVRA 647
Cdd:pfam00041    3 PSNLTVTDvTSTSLTVSWTPPP----DGNGPITG--YEVEYRPKNSGEPWNEI-TVPGTttSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 1039732535  648 SSPKGPGPWS 657
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1037-1133 2.48e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.48e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535  1037 PSAPENPRIFILSSGRytkknevvVEFRWNKPKHENGvlTKFEIFYHISKQSgtnrSTEDWMSASVIPPVMSFQLEAVSP 1116
Cdd:smart00060    1 PSPPSNLRVTDVTSTS--------VTLSWEPPPDDGI--TGYIVGYRVEYRE----EGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 1039732535  1117 EYTVAFQVRVFTSKGPG 1133
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1038-1136 6.30e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 6.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732535 1038 SAPENPRIfilssgryTKKNEVVVEFRWNKPKHENGVLTKFEIFYhisKQSGTNrstEDWMSASVIPPVMSFQLEAVSP- 1116
Cdd:pfam00041    1 SAPSNLTV--------TDVTSTSLTVSWTPPPDGNGPITGYEVEY---RPKNSG---EPWNEITVPGTTTSVTLTGLKPg 66

                           90       100
                   ....*....|....*....|.
gi 1039732535 1117 -EYTvaFQVRVFTSKGPGPFS 1136
Cdd:pfam00041   67 tEYE--VRVQAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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