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Conserved domains on  [gi|1039788056|ref|XP_017168139|]
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transportin-2 isoform X3 [Mus musculus]

Protein Classification

ATP-binding protein; HEAT repeat domain-containing protein; tetratricopeptide repeat protein; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein; importin beta family protein; importin beta family protein( domain architecture ID 12145881)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to Saccharomyces cerevisiae checkpoint protein RAD24 and Arabidopsis thaliana disease resistance protein RPS5; ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Caenorhabditis elegans serine/threonine-protein phosphatase PP2A regulatory subunit that acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (probable); HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulatory subunit A and BRCA1-associated ATM activator 1; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Homo sapiens HEAT repeat-containing protein 9 (HEATR9) and Penaeus monodon serine/threonine-protein phosphatase 2A (PP2A); HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; tetratricopeptide repeat (TPR) protein similar to Arabidopsis thaliana protein high chlorophyll fluorescent 107 (HCF107) and ER membrane protein complex subunit 2 (EMC2) from Xenopus; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulatory subunit A and BRCA1-associated ATM activator 1; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulatory subunit A and BRCA1-associated ATM activator 1; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein; HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates; HEAT repeat domain-containing protein similar to human protein phosphatase 2A regulartory subunit A and bilin biosynthesis protein RpcF; importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Gene Ontology:  GO:0061608|GO:0008139|GO:0006606
PubMed:  15525506

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
103-634 5.13e-15

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 79.21  E-value: 5.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 103 DDPEVRKNVCRALVMLLEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILV 181
Cdd:COG5215   233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNH 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 182 NGMKYSEIDII--LLKGDVEEDeavPDSEQDIkprfhksrtvtltheaerpdssedaeddddddalsdWNLRKCSAAALD 259
Cdd:COG5215   313 GFARAAVADVLpeLLSLLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQ 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 260 VLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLS 338
Cdd:COG5215   354 LFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFG 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 339 RYA-HWVVSQPPDMHLKPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQ 409
Cdd:COG5215   434 AIAdHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELAL 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 410 HKNLL--ILYDAIGTL----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYC 480
Cdd:COG5215   512 NESNLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDI 591

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 481 EPVYQRCVTLVQKTLAQAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQ 560
Cdd:COG5215   592 EDVEDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLN 657

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 561 SSFALLGDLTKACFIHVKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVE 631
Cdd:COG5215   658 SAVGLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQ 730


                  ...
gi 1039788056 632 IIN 634
Cdd:COG5215   731 ASE 733
HEAT COG1413
HEAT repeat [General function prediction only];
3-154 3.33e-05

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056   3 PELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSelldsdalnrplnimIPKFLQFFKHCSPKIRSHAIACVNQFIMDRA 82
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGRIGDPEA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039788056  83 qalmdnidtfIEHLFALAVDDDPEVRKNVCRALVMLLEVRidrliphmhsIIQYMLQRTQDHDENVALEACE 154
Cdd:COG1413    80 ----------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
103-634 5.13e-15

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 79.21  E-value: 5.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 103 DDPEVRKNVCRALVMLLEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILV 181
Cdd:COG5215   233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNH 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 182 NGMKYSEIDII--LLKGDVEEDeavPDSEQDIkprfhksrtvtltheaerpdssedaeddddddalsdWNLRKCSAAALD 259
Cdd:COG5215   313 GFARAAVADVLpeLLSLLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQ 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 260 VLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLS 338
Cdd:COG5215   354 LFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFG 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 339 RYA-HWVVSQPPDMHLKPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQ 409
Cdd:COG5215   434 AIAdHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELAL 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 410 HKNLL--ILYDAIGTL----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYC 480
Cdd:COG5215   512 NESNLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDI 591

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 481 EPVYQRCVTLVQKTLAQAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQ 560
Cdd:COG5215   592 EDVEDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLN 657

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 561 SSFALLGDLTKACFIHVKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVE 631
Cdd:COG5215   658 SAVGLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQ 730


                  ...
gi 1039788056 632 IIN 634
Cdd:COG5215   731 ASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 286-340 2.21e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.78  E-value: 2.21e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039788056 286 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 340
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
3-154 3.33e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056   3 PELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSelldsdalnrplnimIPKFLQFFKHCSPKIRSHAIACVNQFIMDRA 82
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGRIGDPEA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039788056  83 qalmdnidtfIEHLFALAVDDDPEVRKNVCRALVMLLEVRidrliphmhsIIQYMLQRTQDHDENVALEACE 154
Cdd:COG1413    80 ----------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 64-115 4.92e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 4.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039788056  64 PKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRAL 115
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
103-634 5.13e-15

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 79.21  E-value: 5.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 103 DDPEVRKNVCRALVMLLEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILV 181
Cdd:COG5215   233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNH 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 182 NGMKYSEIDII--LLKGDVEEDeavPDSEQDIkprfhksrtvtltheaerpdssedaeddddddalsdWNLRKCSAAALD 259
Cdd:COG5215   313 GFARAAVADVLpeLLSLLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQ 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 260 VLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLS 338
Cdd:COG5215   354 LFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFG 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 339 RYA-HWVVSQPPDMHLKPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQ 409
Cdd:COG5215   434 AIAdHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELAL 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 410 HKNLL--ILYDAIGTL----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYC 480
Cdd:COG5215   512 NESNLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDI 591

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 481 EPVYQRCVTLVQKTLAQAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQ 560
Cdd:COG5215   592 EDVEDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLN 657

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 561 SSFALLGDLTKACFIHVKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVE 631
Cdd:COG5215   658 SAVGLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQ 730


                  ...
gi 1039788056 632 IIN 634
Cdd:COG5215   731 ASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 286-340 2.21e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.78  E-value: 2.21e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039788056 286 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 340
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
3-154 3.33e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056   3 PELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSelldsdalnrplnimIPKFLQFFKHCSPKIRSHAIACVNQFIMDRA 82
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGRIGDPEA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039788056  83 qalmdnidtfIEHLFALAVDDDPEVRKNVCRALVMLLEVRidrliphmhsIIQYMLQRTQDHDENVALEACE 154
Cdd:COG1413    80 ----------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
288-458 5.37e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 288 VKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIACWTLSRyahwvvsqppdMHLKPLMTELLKRILDG 367
Cdd:COG1413     1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGR-----------LGDPRAVPALLEALKDP 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 368 NKRVQEAACSAFATL-EEEACTELVPYLsyildtlvfafgkyQHKNLLILYDAIGTLAdsvghHLNQPEYIqklmPPLIQ 446
Cdd:COG1413    60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                         170
                  ....*....|..
gi 1039788056 447 KwneLKDEDKDL 458
Cdd:COG1413   117 A---LKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
255-395 3.27e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.46  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039788056 255 AAALDVLANVFREELLPHLLPLLKgllfHPEWVVKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIAC 334
Cdd:COG1413     3 RAAARALGRLGDPAAVPALIAALA----DEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039788056 335 WTLSRYAhwvvsqppDMHLKPLMTELLKrilDGNKRVQEAACSAFATL-EEEACTELVPYLS 395
Cdd:COG1413    69 EALGRIG--------DPEAVPALIAALK---DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 64-115 4.92e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 4.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039788056  64 PKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRAL 115
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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