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Conserved domains on  [gi|1370487735|ref|XP_016864218|]
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homeodomain-only protein isoform X2 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 48-100 3.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 3.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370487735  48 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 100
Cdd:cd00086     8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 48-100 3.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 3.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370487735  48 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 100
Cdd:cd00086     8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
47-98 3.96e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 3.96e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370487735  47 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 98
Cdd:pfam00046   7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 48-97 4.93e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.39  E-value: 4.93e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1370487735   48 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 97
Cdd:smart00389   9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
48-99 7.33e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.65  E-value: 7.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370487735  48 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 99
Cdd:COG5576    59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 48-100 3.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 3.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370487735  48 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 100
Cdd:cd00086     8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
47-98 3.96e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 3.96e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370487735  47 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 98
Cdd:pfam00046   7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 48-97 4.93e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.39  E-value: 4.93e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1370487735   48 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 97
Cdd:smart00389   9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
48-99 7.33e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.65  E-value: 7.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370487735  48 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 99
Cdd:COG5576    59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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