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Conserved domains on  [gi|1034558229|ref|XP_016856674|]
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potassium channel subfamily T member 2 isoform X8 [Homo sapiens]

Protein Classification

potassium channel subfamily T member( domain architecture ID 10545829)

potassium channel subfamily T member is a calcium-activated potassium channel similar to Gallus gallus potassium channel subfamily T member 1 that generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BK_channel_a pfam03493
Calcium-activated BK potassium channel alpha subunit;
407-501 2.14e-41

Calcium-activated BK potassium channel alpha subunit;


:

Pssm-ID: 460947  Cd Length: 90  Bit Score: 146.54  E-value: 2.14e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558229  407 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEEstffaEYEGKSFTYA 486
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGEEGQKSSEQWQKEYLRGSGNEIYTIKLSD-----AFVGKTFTEA 75

                           90
                   ....*....|....*
gi 1034558229  487 SFHAHKKFGVCLIGV 501
Cdd:pfam03493   76 ARLAYKKLGVILIGI 90
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-247 4.08e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.08e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034558229  181 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 247
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
 
Name Accession Description Interval E-value
BK_channel_a pfam03493
Calcium-activated BK potassium channel alpha subunit;
407-501 2.14e-41

Calcium-activated BK potassium channel alpha subunit;


Pssm-ID: 460947  Cd Length: 90  Bit Score: 146.54  E-value: 2.14e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558229  407 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEEstffaEYEGKSFTYA 486
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGEEGQKSSEQWQKEYLRGSGNEIYTIKLSD-----AFVGKTFTEA 75

                           90
                   ....*....|....*
gi 1034558229  487 SFHAHKKFGVCLIGV 501
Cdd:pfam03493   76 ARLAYKKLGVILIGI 90
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-247 4.08e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.08e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034558229  181 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 247
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
PRK10537 PRK10537
voltage-gated potassium channel protein;
202-244 2.62e-06

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 50.79  E-value: 2.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034558229  202 LNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVV 244
Cdd:PRK10537   167 ESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITV 209
 
Name Accession Description Interval E-value
BK_channel_a pfam03493
Calcium-activated BK potassium channel alpha subunit;
407-501 2.14e-41

Calcium-activated BK potassium channel alpha subunit;


Pssm-ID: 460947  Cd Length: 90  Bit Score: 146.54  E-value: 2.14e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558229  407 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEEstffaEYEGKSFTYA 486
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGEEGQKSSEQWQKEYLRGSGNEIYTIKLSD-----AFVGKTFTEA 75

                           90
                   ....*....|....*
gi 1034558229  487 SFHAHKKFGVCLIGV 501
Cdd:pfam03493   76 ARLAYKKLGVILIGI 90
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-247 4.08e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.08e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034558229  181 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 247
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
PRK10537 PRK10537
voltage-gated potassium channel protein;
202-244 2.62e-06

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 50.79  E-value: 2.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034558229  202 LNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVV 244
Cdd:PRK10537   167 ESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITV 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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