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Conserved domains on  [gi|966953970|ref|XP_014998755|]
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protein ABHD4 isoform X1 [Macaca mulatta]

Protein Classification

alpha/beta hydrolase domain-containing protein( domain architecture ID 1005082)

alpha/beta hydrolase (abhydrolase) domain-containing protein

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02894 super family cl30398
hydrolase, alpha/beta fold family protein
 32-314 7.75e-66

hydrolase, alpha/beta fold family protein


The actual alignment was detected with superfamily member PLN02894:

Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 212.08  E-value: 7.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  32 IWTVTVsPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFP-RDPEGAEDEFVTSIETWRET 110
Cdd:PLN02894  94 INTVTF-DSKEDAPTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKA 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 111 MGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVA 186
Cdd:PLN02894 173 KNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 187 GPWGPGLVQRFRpdfKRKFADFF--------EDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVP 258
Cdd:PLN02894 253 GPWGPNLVRRYT---TARFGAHStgdilseeESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VP 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966953970 259 ITMIYGSNTWIDTSTGKKV--KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 314
Cdd:PLN02894 328 TTFIYGRHDWMNYEGAVEArkRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 32-314 7.75e-66

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 212.08  E-value: 7.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  32 IWTVTVsPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFP-RDPEGAEDEFVTSIETWRET 110
Cdd:PLN02894  94 INTVTF-DSKEDAPTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKA 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 111 MGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVA 186
Cdd:PLN02894 173 KNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 187 GPWGPGLVQRFRpdfKRKFADFF--------EDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVP 258
Cdd:PLN02894 253 GPWGPNLVRRYT---TARFGAHStgdilseeESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VP 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966953970 259 ITMIYGSNTWIDTSTGKKV--KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 314
Cdd:PLN02894 328 TTFIYGRHDWMNYEGAVEArkRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 43-317 6.41e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.78  E-value: 6.41e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  43 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEG-AEDefvtsIETWRETMGIPSMILLGH 121
Cdd:COG0596   22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDlADD-----LAALLDALGLERVVLVGH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 122 SLGGFLATSYSIKYPDRVKHLILVDpwgfplrptnpseirapptwvkavasvlgrsnplavlrvagpwgpglvqrfrpDF 201
Cdd:COG0596   97 SMGGMVALELAARHPERVAGLVLVD-----------------------------------------------------EV 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 202 KRKFADFFEDDtiseyiyhcnaqnPSGETAFKAMMESF-GWARRPMLERIhlirkDVPITMIYGSN-TWIDTSTGKKVKM 279
Cdd:COG0596  124 LAALAEPLRRP-------------GLAPEALAALLRALaRTDLRERLARI-----TVPTLVIWGEKdPIVPPALARRLAE 185

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966953970 280 QRPDSYVRdmEIEGASHHVYADQPHIFNAVVEEICDSV 317
Cdd:COG0596  186 LLPNAELV--VLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-303 6.74e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 97.96  E-value: 6.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970   45 TPLVMVHGFGGGVGLWILNMDSLS-ARRTLHTFDLLGFGRSSRPafPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSL 123
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRP--KAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  124 GGFLATSYSIKYPDRVKHLILVDP--WGFPLRPTNPSEIRAPPTWVKAVASVLGR--SNPLAVLRVAGPWGPGLVQRFRP 199
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPnpLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  200 DFKRKFADFFEDDTISEYIYHCNAQNpsgetafkammesfGWARRPMLERIHliRKDVPITMIYGSNTWIDTSTGkKVKM 279
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIE--------------TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPPQA-LEKL 221

                         250       260
                  ....*....|....*....|....
gi 966953970  280 QRPDSYVRDMEIEGASHHVYADQP 303
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 117-187 6.61e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 40.69  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 117 ILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAP------------PTWVKAVASVlgrSNPLAVLR 184
Cdd:cd12808  191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPLADVPhllvwgdyidadPRWPRYRATV---DAYAAALR 267


                 ...
gi 966953970 185 VAG 187
Cdd:cd12808  268 AAG 270
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 32-314 7.75e-66

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 212.08  E-value: 7.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  32 IWTVTVsPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFP-RDPEGAEDEFVTSIETWRET 110
Cdd:PLN02894  94 INTVTF-DSKEDAPTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKA 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 111 MGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVA 186
Cdd:PLN02894 173 KNLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 187 GPWGPGLVQRFRpdfKRKFADFF--------EDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVP 258
Cdd:PLN02894 253 GPWGPNLVRRYT---TARFGAHStgdilseeESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VP 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966953970 259 ITMIYGSNTWIDTSTGKKV--KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 314
Cdd:PLN02894 328 TTFIYGRHDWMNYEGAVEArkRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 43-317 6.41e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.78  E-value: 6.41e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  43 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEG-AEDefvtsIETWRETMGIPSMILLGH 121
Cdd:COG0596   22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDlADD-----LAALLDALGLERVVLVGH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 122 SLGGFLATSYSIKYPDRVKHLILVDpwgfplrptnpseirapptwvkavasvlgrsnplavlrvagpwgpglvqrfrpDF 201
Cdd:COG0596   97 SMGGMVALELAARHPERVAGLVLVD-----------------------------------------------------EV 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 202 KRKFADFFEDDtiseyiyhcnaqnPSGETAFKAMMESF-GWARRPMLERIhlirkDVPITMIYGSN-TWIDTSTGKKVKM 279
Cdd:COG0596  124 LAALAEPLRRP-------------GLAPEALAALLRALaRTDLRERLARI-----TVPTLVIWGEKdPIVPPALARRLAE 185

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966953970 280 QRPDSYVRdmEIEGASHHVYADQPHIFNAVVEEICDSV 317
Cdd:COG0596  186 LLPNAELV--VLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-303 6.74e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 97.96  E-value: 6.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970   45 TPLVMVHGFGGGVGLWILNMDSLS-ARRTLHTFDLLGFGRSSRPafPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSL 123
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRP--KAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  124 GGFLATSYSIKYPDRVKHLILVDP--WGFPLRPTNPSEIRAPPTWVKAVASVLGR--SNPLAVLRVAGPWGPGLVQRFRP 199
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPnpLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  200 DFKRKFADFFEDDTISEYIYHCNAQNpsgetafkammesfGWARRPMLERIHliRKDVPITMIYGSNTWIDTSTGkKVKM 279
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIE--------------TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPPQA-LEKL 221

                         250       260
                  ....*....|....*....|....
gi 966953970  280 QRPDSYVRDMEIEGASHHVYADQP 303
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 43-150 1.85e-18

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 84.61  E-value: 1.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  43 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSrpafPRDPEGAEDEFVTSIETWRETMGIPSMILLGHS 122
Cdd:PRK14875 130 DGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASS----KAVGAGSLDELAAAVLAFLDALGIERAHLVGHS 205

                         90       100
                 ....*....|....*....|....*...
gi 966953970 123 LGGFLATSYSIKYPDRVKHLILVDPWGF 150
Cdd:PRK14875 206 MGGAVALRLAARAPQRVASLTLIAPAGL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
39-148 5.07e-17

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 78.51  E-value: 5.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  39 PEQKDRTPLVMVHGFGGGVGLWILNMDSLSARR-TLHTFDLLGFGRSSRP-AFPRDPEGAEDEFVTSIETWRETMGIPsM 116
Cdd:COG2267   23 PAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGyAVLAFDLRGHGRSDGPrGHVDSFDDYVDDLRAALDALRARPGLP-V 101

                         90       100       110
                 ....*....|....*....|....*....|..
gi 966953970 117 ILLGHSLGGFLATSYSIKYPDRVKHLILVDPW 148
Cdd:COG2267  102 VLLGHSMGGLIALLYAARYPDRVAGLVLLAPA 133
PLN02578 PLN02578
hydrolase
 40-149 1.03e-12

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 67.94  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  40 EQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIetwRETMGIPSmILL 119
Cdd:PLN02578  82 VQGEGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQVADFV---KEVVKEPA-VLV 157

                         90       100       110
                 ....*....|....*....|....*....|
gi 966953970 120 GHSLGGFLATSYSIKYPDRVKHLILVDPWG 149
Cdd:PLN02578 158 GNSLGGFTALSTAVGYPELVAGVALLNSAG 187
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 47-309 1.03e-11

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 63.26  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970   47 LVMVHGFGGGVGLWIlnmDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETmgipsmILLGHSLGGF 126
Cdd:pfam12697   1 VVLVHGAGLSAAPLA---ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARPV------VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  127 LATSYsikYPDRVKHLILVDPWGFPLRPTNPseirapptwvkavasvlgrsnplAVLRVAGPWGPGLVQRFRPDFKRkfA 206
Cdd:pfam12697  72 VALAA---AAAALVVGVLVAPLAAPPGLLAA-----------------------LLALLARLGAALAAPAWLAAESL--A 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  207 DFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPmlerihlirkdVPITMIYGSNTWIDTSTGKKVKMQRPDSYV 286
Cdd:pfam12697 124 RGFLDDLPADAEWAAALARLAALLAALALLPLAAWRDLP-----------VPVLVLAEEDRLVPELAQRLLAALAGARLV 192

                         250       260
                  ....*....|....*....|...
gi 966953970  287 rdmEIEGASHHVYaDQPHIFNAV 309
Cdd:pfam12697 193 ---VLPGAGHLPL-DDPEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 47-206 1.18e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 63.39  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970   47 LVMVHGFGGGVGLWILNMDSLSAR-RTLHTFDLLGFGRSS-RPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLG 124
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADALAAQgFAVYAYDHRGHGRSDgKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLGHSMG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  125 GFLATSYSIKYPDRVKHLILVDPWgfpLRPTNPSeiraPPTWVKAVASVLGRSNPLavLRVAGPWGPGLVQRfRPDFKRK 204
Cdd:pfam12146  87 GLIAALYALRYPDKVDGLILSAPA---LKIKPYL----APPILKLLAKLLGKLFPR--LRVPNNLLPDSLSR-DPEVVAA 156


                  ..
gi 966953970  205 FA 206
Cdd:pfam12146 157 YA 158
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 33-146 2.46e-10

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 60.62  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  33 WTVTVSPEQKDRTP-LVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAfprdpegaedEFVTSIETW---- 107
Cdd:PLN02679  76 YLVKGSPEVTSSGPpVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKPP----------GFSYTMETWaeli 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966953970 108 ----RETMGIPSmILLGHSLGGF---LATSYSikYPDRVKHLILVD 146
Cdd:PLN02679 146 ldflEEVVQKPT-VLIGNSVGSLacvIAASES--TRDLVRGLVLLN 188
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 39-171 2.54e-10

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 60.98  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  39 PEQKDRTPLVMVHGFGGGVGLWILNM-----DSLSARRTLHTFDLLGFGRSSRPAfprDPEGAEDEFVTSIE-TWRETMG 112
Cdd:PLN03087 196 KDNKAKEDVLFIHGFISSSAFWTETLfpnfsDAAKSTYRLFAVDLLGFGRSPKPA---DSLYTLREHLEMIErSVLERYK 272

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966953970 113 IPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLrptnPSEIRAPPTWVKAVA 171
Cdd:PLN03087 273 VKSFHIVAHSLGCILALALAVKHPGAVKSLTLLAPPYYPV----PKGVQATQYVMRKVA 327
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 41-147 4.99e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 55.99  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  41 QKDRTPLVMVHGFGGGVGLWILNMDSLSAR-RTLHTFDLlgfgrssrPAFPRDPEGAEDEFVTSIETWRETMGIPSMILL 119
Cdd:COG1075    2 AATRYPVVLVHGLGGSAASWAPLAPRLRAAgYPVYALNY--------PSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLV 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 966953970 120 GHSLGGFLATSY--SIKYPDRVKHLILVDP 147
Cdd:COG1075   74 GHSMGGLVARYYlkRLGGAAKVARVVTLGT 103
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 45-147 1.12e-09

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 58.21  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  45 TPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPafprDPEGAEDEFVTSIETW--------RETMGIPSM 116
Cdd:PLN02824  30 PALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKP----NPRSAPPNSFYTFETWgeqlndfcSDVVGDPAF 105

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966953970 117 ILLgHSLGGFLATSYSIKYPDRVKHLILVDP 147
Cdd:PLN02824 106 VIC-NSVGGVVGLQAAVDAPELVRGVMLINI 135
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
30-145 1.03e-07

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 52.33  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  30 NKIWTVTVSpeqKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSrpAFprdpeGAedefvTSIETWRE 109
Cdd:PRK10349   2 NNIWWQTKG---QGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSR--GF-----GA-----LSLADMAE 66

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966953970 110 TM---GIPSMILLGHSLGGFLATSYSIKYPDRVKHLILV 145
Cdd:PRK10349  67 AVlqqAPDKAIWLGWSLGGLVASQIALTHPERVQALVTV 105
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
48-311 8.15e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 46.47  E-value: 8.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  48 VMVHGFGGG---VGLWilnmdslsARR------TLHTFDLLGFGRSSRPAFPRDPE----GAEDEFVTSIETWRETmgip 114
Cdd:COG1647   19 LLLHGFTGSpaeMRPL--------AEAlakagyTVYAPRLPGHGTSPEDLLKTTWEdwleDVEEAYEILKAGYDKV---- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 115 smILLGHSLGGFLATSYSIKYPDrVKHLILVDPwgfPLRPTNPSEIRAPptwvkavasvlgrsnplaVLRVAGPWgpglv 194
Cdd:COG1647   87 --IVIGLSMGGLLALLLAARYPD-VAGLVLLSP---ALKIDDPSAPLLP------------------LLKYLARS----- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 195 qrfrpdfKRKFADFFEDDTISEYIYHCNAQNpsgetAFKAMMESFGWARRPmLERIHlirkdVPITMIYGSN-TWIDTST 273
Cdd:COG1647  138 -------LRGIGSDIEDPEVAEYAYDRTPLR-----ALAELQRLIREVRRD-LPKIT-----APTLIIQSRKdEVVPPES 199

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966953970 274 GKKVKMQRPDSYVRDMEIEGASH--HVYADQPHIFNAVVE 311
Cdd:COG1647  200 ARYIYERLGSPDKELVWLEDSGHviTLDKDREEVAEEILD 239
PRK10673 PRK10673
esterase;
38-146 2.26e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 45.11  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  38 SPEQ-KDRTPLVMVHG-FGGGVGLWILNMDsLSARRTLHTFDLLGFGRSsrpafPRDPEGAEDEFVTSIETWRETMGIPS 115
Cdd:PRK10673   9 TAQNpHNNSPIVLVHGlFGSLDNLGVLARD-LVNDHDIIQVDMRNHGLS-----PRDPVMNYPAMAQDLLDTLDALQIEK 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966953970 116 MILLGHSLGGFLATSYSIKYPDRVKHLILVD 146
Cdd:PRK10673  83 ATFIGHSMGGKAVMALTALAPDRIDKLVAID 113
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 40-140 6.32e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 43.83  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  40 EQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPafprDPEGAEDEFVTSIETWRETMGIPSMILL 119
Cdd:PRK03592  23 ETGEGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKP----DIDYTFADHARYLDAWFDALGLDDVVLV 98

                         90       100
                 ....*....|....*....|.
gi 966953970 120 GHSLGGFLATSYSIKYPDRVK 140
Cdd:PRK03592  99 GHDWGSALGFDWAARHPDRVR 119
YpfH COG0400
Predicted esterase [General function prediction only];
40-164 5.71e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 40.28  E-value: 5.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  40 EQKDRTPLVMVHGFGG----GVGLWilnmDSLSARRTLH-----TFDLLGFGRS----SRPAFPRDPEGAE---DEFVTS 103
Cdd:COG0400    1 GGPAAPLVVLLHGYGGdeedLLPLA----PELALPGAAVlapraPVPEGPGGRAwfdlSFLEGREDEEGLAaaaEALAAF 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966953970 104 IETWRETMGIPS--MILLGHSLGGFLATSYSIKYPDRVKHLILvdpwgfpLRPTNPSEIRAPP 164
Cdd:COG0400   77 IDELEARYGIDPerIVLAGFSQGAAMALSLALRRPELLAGVVA-------LSGYLPGEEALPA 132
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 117-187 6.61e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 40.69  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970 117 ILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAP------------PTWVKAVASVlgrSNPLAVLR 184
Cdd:cd12808  191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPLADVPhllvwgdyidadPRWPRYRATV---DAYAAALR 267


                 ...
gi 966953970 185 VAG 187
Cdd:cd12808  268 AAG 270
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 43-147 1.09e-03

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 40.25  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  43 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETW--RETMGIPSMILLG 120
Cdd:PLN03084 126 NNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLidELKSDKVSLVVQG 205

                         90       100
                 ....*....|....*....|....*....
gi 966953970 121 HslggF--LATSYSIKYPDRVKHLILVDP 147
Cdd:PLN03084 206 Y----FspPVVKYASAHPDKIKKLILLNP 230
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
31-147 1.47e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 39.23  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  31 KIWTVTVSPEQKDRTPLVM-VHGFGGGVGL-WILNMDSLSAR--RTLhTFDLLGFGRSSRPAfprdPEGAEDEFVTSIET 106
Cdd:COG1506    9 TLPGWLYLPADGKKYPVVVyVHGGPGSRDDsFLPLAQALASRgyAVL-APDYRGYGESAGDW----GGDEVDDVLAAIDY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966953970 107 WRETMGIPS--MILLGHSLGGFLATSYSIKYPDRVKHLILVDP 147
Cdd:COG1506   84 LAARPYVDPdrIGIYGHSYGGYMALLAAARHPDRFKAAVALAG 126
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 47-148 1.94e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.13  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966953970  47 LVMVHGFGGGVGLWILNMDSLsARRTLHT--FDLLGFGRSS-RPAFPRDPEgAEDeFVTSIETWRETMGIPS--MILLGH 121
Cdd:COG1073   40 VVVAHGNGGVKEQRALYAQRL-AELGFNVlaFDYRGYGESEgEPREEGSPE-RRD-ARAAVDYLRTLPGVDPerIGLLGI 116

                         90       100
                 ....*....|....*....|....*..
gi 966953970 122 SLGGFLATSYSIKYPdRVKHLILVDPW 148
Cdd:COG1073  117 SLGGGYALNAAATDP-RVKAVILDSPF 142
PAF-AH_p_II pfam03403
Platelet-activating factor acetylhydrolase, isoform II; Platelet-activating factor ...
 115-163 4.94e-03

Platelet-activating factor acetylhydrolase, isoform II; Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.


Pssm-ID: 397462 [Multi-domain]  Cd Length: 372  Bit Score: 38.19  E-value: 4.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 966953970  115 SMILLGHSLGGflATSY-SIKYPDRVKHLILVDPWGFPLRPTNPSEIRAP 163
Cdd:pfam03403 222 KIAVIGHSFGG--ATVIqSLSEDTRFRCGIALDAWMFPVGDDVYSKARQP 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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