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Conserved domains on  [gi|1191878359|ref|XP_013852916|]
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ataxin-10 isoform X1 [Sus scrofa]

Protein Classification

Ataxin-10 homo-association domain-containing protein( domain architecture ID 10561049)

Ataxin-10 homo-association domain-containing protein, similar to Candida albicans copper transport protein 86

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Atx10homo_assoc pfam09759
Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues ...
 370-467 3.58e-44

Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localization, specifically to the olivocerebellar region.


:

Pssm-ID: 462885 [Multi-domain]  Cd Length: 99  Bit Score: 150.31  E-value: 3.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191878359 370 FKSHLIRLIGNLCYKNKENQDKVSELDGIPLILDSCGIDDSNPFLTQWVVYAIRNLTEDNSRNQDLIAKMEEQGLADPSL 449
Cdd:pfam09759   1 FKRDLIRLIGNLCYKNKEVQDEVRELGGLPLILSNCNIDDNNPFIREWAIFCIRNLLEGNEENQELIAELEPQGVVDSEE 80

                          90
                  ....*....|....*....
gi 1191878359 450 LKKMGFEVEKRGD-KLILK 467
Cdd:pfam09759  81 LEEMGLEVEIDSDgKLKLK 99
 
Name Accession Description Interval E-value
Atx10homo_assoc pfam09759
Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues ...
 370-467 3.58e-44

Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localization, specifically to the olivocerebellar region.


Pssm-ID: 462885 [Multi-domain]  Cd Length: 99  Bit Score: 150.31  E-value: 3.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191878359 370 FKSHLIRLIGNLCYKNKENQDKVSELDGIPLILDSCGIDDSNPFLTQWVVYAIRNLTEDNSRNQDLIAKMEEQGLADPSL 449
Cdd:pfam09759   1 FKRDLIRLIGNLCYKNKEVQDEVRELGGLPLILSNCNIDDNNPFIREWAIFCIRNLLEGNEENQELIAELEPQGVVDSEE 80

                          90
                  ....*....|....*....
gi 1191878359 450 LKKMGFEVEKRGD-KLILK 467
Cdd:pfam09759  81 LEEMGLEVEIDSDgKLKLK 99
 
Name Accession Description Interval E-value
Atx10homo_assoc pfam09759
Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues ...
 370-467 3.58e-44

Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localization, specifically to the olivocerebellar region.


Pssm-ID: 462885 [Multi-domain]  Cd Length: 99  Bit Score: 150.31  E-value: 3.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191878359 370 FKSHLIRLIGNLCYKNKENQDKVSELDGIPLILDSCGIDDSNPFLTQWVVYAIRNLTEDNSRNQDLIAKMEEQGLADPSL 449
Cdd:pfam09759   1 FKRDLIRLIGNLCYKNKEVQDEVRELGGLPLILSNCNIDDNNPFIREWAIFCIRNLLEGNEENQELIAELEPQGVVDSEE 80

                          90
                  ....*....|....*....
gi 1191878359 450 LKKMGFEVEKRGD-KLILK 467
Cdd:pfam09759  81 LEEMGLEVEIDSDgKLKLK 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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