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Conserved domains on  [gi|767912428|ref|XP_011542490|]
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galectin-8 isoform X2 [Homo sapiens]

Protein Classification

GLECT domain-containing protein( domain architecture ID 10448431)

GLECT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-149 6.18e-50

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


:

Pssm-ID: 459768  Cd Length: 124  Bit Score: 162.42  E-value: 6.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428   24 PDQLDPGTLIVIRGHVPSDADRFQVDLQNGssMKPRADVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFKREKSF 103
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDE-NVIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767912428  104 EIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 236-310 3.42e-26

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 100.36  E-value: 3.42e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912428   236 PMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNiTSFPFSPGMYFE 310
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFE 76
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-149 6.18e-50

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 162.42  E-value: 6.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428   24 PDQLDPGTLIVIRGHVPSDADRFQVDLQNGssMKPRADVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFKREKSF 103
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDE-NVIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767912428  104 EIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-149 6.98e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 161.99  E-value: 6.98e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428    24 PDQLDPGTLIVIRGHVPSDADRFQVDLQNGssmkPRADVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFKREKSF 103
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCG----PNADIALHFNPRFDE-GTIVRNSKQNGKWGKEERSGGFPFQPGQPF 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767912428   104 EIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:smart00908  76 ELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 18-149 3.37e-48

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 158.18  E-value: 3.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428  18 PFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSmkpraDVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPF 97
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-----DIALHFNPRFDE-NVIVRNSFLNGNWGPEERSGGFPF 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767912428  98 KREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:cd00070   75 QPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 236-310 3.42e-26

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 100.36  E-value: 3.42e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912428   236 PMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNiTSFPFSPGMYFE 310
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFE 76
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 228-310 2.12e-25

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 98.48  E-value: 2.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428 228 PFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSkDIALHLNPRLNIKAFVRNSFLQESWGEEERnITSFPFSPGM 307
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEER-SGGFPFQPGQ 78


                 ...
gi 767912428 308 YFE 310
Cdd:cd00070   79 PFE 81
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 234-310 6.17e-24

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 94.63  E-value: 6.17e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767912428  234 NTPMGPGRTVVVKGEVNANAKSFNVDLLAG--KSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNiTSFPFSPGMYFE 310
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEERE-GGFPFQPGQPFE 78
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-149 6.18e-50

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 162.42  E-value: 6.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428   24 PDQLDPGTLIVIRGHVPSDADRFQVDLQNGssMKPRADVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFKREKSF 103
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDE-NVIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767912428  104 EIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-149 6.98e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 161.99  E-value: 6.98e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428    24 PDQLDPGTLIVIRGHVPSDADRFQVDLQNGssmkPRADVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFKREKSF 103
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCG----PNADIALHFNPRFDE-GTIVRNSKQNGKWGKEERSGGFPFQPGQPF 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767912428   104 EIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:smart00908  76 ELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 18-149 3.37e-48

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 158.18  E-value: 3.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428  18 PFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSmkpraDVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPF 97
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-----DIALHFNPRFDE-NVIVRNSFLNGNWGPEERSGGFPF 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767912428  98 KREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSI 149
Cdd:cd00070   75 QPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 19-152 7.63e-44

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 146.99  E-value: 7.63e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428    19 FVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSmkpraDVAFHFNPRFKRaGCIVCNTLINEKWGREEITYDTPFK 98
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGD-----DIALHFNPRFNE-NKIVCNSKLNGSWGSEEREGGFPFQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767912428    99 REKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFS 152
Cdd:smart00276  75 PGQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSFE 128
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 236-310 3.42e-26

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 100.36  E-value: 3.42e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912428   236 PMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNiTSFPFSPGMYFE 310
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFE 76
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 228-310 2.12e-25

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 98.48  E-value: 2.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428 228 PFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSkDIALHLNPRLNIKAFVRNSFLQESWGEEERnITSFPFSPGM 307
Cdd:cd00070    1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEER-SGGFPFQPGQ 78


                 ...
gi 767912428 308 YFE 310
Cdd:cd00070   79 PFE 81
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 229-310 3.85e-25

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 98.07  E-value: 3.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912428   229 FAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSkDIALHLNPRLNIKAFVRNSFLQESWGEEERnITSFPFSPGMY 308
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGD-DIALHFNPRFNENKIVCNSKLNGSWGSEER-EGGFPFQPGQP 78


                   ..
gi 767912428   309 FE 310
Cdd:smart00276  79 FD 80
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 234-310 6.17e-24

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 94.63  E-value: 6.17e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767912428  234 NTPMGPGRTVVVKGEVNANAKSFNVDLLAG--KSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNiTSFPFSPGMYFE 310
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEERE-GGFPFQPGQPFE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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