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Conserved domains on  [gi|767935250|ref|XP_011541427|]
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A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 230-340 6.41e-39

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.87  E-value: 6.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  230 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTID-WPRKFDVAGTAFHYKRPTDEPE 308
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767935250  309 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 340
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 355-410 1.13e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767935250  355 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPEnQRACNTEPC 410
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 1.33e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.43  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  129 DFREKQCADFDNMPFR-----GKYYNWK---PYTGGGVKpCALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDIC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWGaavPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767935250  195 INGECKHVGCDNILGSDAREDRCRVCGGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 414-470 1.64e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.17  E-value: 1.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767935250  414 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEetlDYSGC-LTHRPVEKEPCNNQSC 470
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIV---PDSECsAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 474-528 3.02e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 3.02e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767935250  474 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 528
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-582 6.81e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.81e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767935250  533 WVTGDWGQCSAQCGLGQQMRTVQCLSYTG---QASSDCLETVRPPSMQQCESK 582
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 594-626 3.64e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 46.37  E-value: 3.64e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767935250  594 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 626
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 230-340 6.41e-39

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.87  E-value: 6.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  230 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTID-WPRKFDVAGTAFHYKRPTDEPE 308
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767935250  309 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 340
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 355-410 1.13e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767935250  355 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPEnQRACNTEPC 410
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 1.33e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.43  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  129 DFREKQCADFDNMPFR-----GKYYNWK---PYTGGGVKpCALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDIC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWGaavPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767935250  195 INGECKHVGCDNILGSDAREDRCRVCGGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 414-470 1.64e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.17  E-value: 1.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767935250  414 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEetlDYSGC-LTHRPVEKEPCNNQSC 470
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIV---PDSECsAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 474-528 3.02e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 3.02e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767935250  474 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 528
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-582 6.81e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.81e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767935250  533 WVTGDWGQCSAQCGLGQQMRTVQCLSYTG---QASSDCLETVRPPSMQQCESK 582
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 594-626 3.64e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 46.37  E-value: 3.64e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767935250  594 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 626
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 417-471 1.91e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 1.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767935250   417 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETldysgcLTHRPVEKEPCNNQSCP 471
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP------CTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 359-411 3.52e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.52e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767935250   359 PWSECSATCAGGVQRQEVVCKrlDDNSIVQNNYCDPDSKppeNQRACNTEPCP 411
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCC--SPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 533-580 6.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 6.61e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767935250   533 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS-SDCLET---VRPPSMQQCE 580
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEdveTRACNEQPCP 53
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 230-340 6.41e-39

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.87  E-value: 6.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  230 IEGFFNDSlPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTID-WPRKFDVAGTAFHYKRPTDEPE 308
Cdd:pfam05986   2 VSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPALE 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767935250  309 SLEALGPTSENLIVMVLLQ---EQNLGIRYKFNVP 340
Cdd:pfam05986  81 ELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 355-410 1.13e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767935250  355 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPEnQRACNTEPC 410
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 1.33e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.43  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935250  129 DFREKQCADFDNMPFR-----GKYYNWK---PYTGGGVKpCALNCLAEGYNFYTERAPAVIDGTQCNAD------SLDIC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWGaavPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767935250  195 INGECKHVGCDNILGSDAREDRCRVCGGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 414-470 1.64e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.17  E-value: 1.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767935250  414 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEetlDYSGC-LTHRPVEKEPCNNQSC 470
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIV---PDSECsAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 474-528 3.02e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.62  E-value: 3.02e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767935250  474 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 528
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 533-582 6.81e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.81e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767935250  533 WVTGDWGQCSAQCGLGQQMRTVQCLSYTG---QASSDCLETVRPPSMQQCESK 582
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLK 53
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 594-626 3.64e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 46.37  E-value: 3.64e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767935250  594 CKDvnKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 626
Cdd:pfam08686   1 CKD--KFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 417-471 1.91e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 1.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767935250   417 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETldysgcLTHRPVEKEPCNNQSCP 471
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP------CTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 359-411 3.52e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.52e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767935250   359 PWSECSATCAGGVQRQEVVCKrlDDNSIVQNNYCDPDSKppeNQRACNTEPCP 411
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCC--SPPPQNGGGPCTGEDV---ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 533-580 6.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 6.61e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767935250   533 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS-SDCLET---VRPPSMQQCE 580
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEdveTRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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