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Conserved domains on  [gi|1370454110|ref|XP_011540191|]
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blood group Rh(CE) polypeptide isoform X2 [Homo sapiens]

Protein Classification

ammonium transporter family protein( domain architecture ID 518)

ammonium transporter family protein similar to Dictyostelium discoideum ammonium transporter 3 that mediates the import of ammonium in prespore cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ammonium_transp super family cl03012
Ammonium Transporter Family;
62-412 1.96e-52

Ammonium Transporter Family;


The actual alignment was detected with superfamily member pfam00909:

Pssm-ID: 445985  Cd Length: 399  Bit Score: 181.34  E-value: 1.96e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110  62 DAGPATLHASYSLSADFMPGTVLVGQDL--TVMAALGLGFLTSNFRRHSWSSVAFNLFMLALGVQWAILLDG--FLSQFP 137
Cdd:pfam00909  14 QPGFALLESGLVRSKNVLNILYKNFQDVaiGVLAYWLFGYSLAFGKRYGFSGFIGNLGVSAAGIQWGTLPDGlfFLFQMM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 138 PGKVVITLFSIRLATMSAMSVLISAGAVLGKVNLAQLVVMVLVEVTALGTLRMVISNIFNTDYHMnlrhfyvFAAYFGLT 217
Cdd:pfam00909  94 FAATAITIVSGAVAERIKFSAYLLFSALLGTLVYPPVAHWVWGEGGWLAKLGVLVDFAGSTVVHI-------FGGYAGLA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 218 VAWCLPKPLPKGTEDNDQRATIPSLSAMLGALFLWMFWPSVN--SALLRSPIQRKNAMFNTYYALAVSVVTAISGSSLAH 295
Cdd:pfam00909 167 AALVLGPRIGRFTGKNEAITPHNLPFAVLGTFLLWFGWFGFNagSALTANGRARAIAAVNTNLAAAGGGLTALLISRLKT 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 296 pqRKISMTYVHSAVLAGGVAVGTSCHLIpSPWLAMVLGLVAGLISIGGAKCLpvccNRVLGIHHISVMHSIFSLLGLLGE 375
Cdd:pfam00909 247 --GKPNMLGLANGALAGLVAITPACGVV-TPWGALIIGLIAGVLSVLGYKFL----KEKLGIDDPLDVFPVHGVGGIWGG 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1370454110 376 ITYIVLLVL-------HTVWNGNGM--IGFQVLLSIGELSLAIVIA 412
Cdd:pfam00909 320 IAVGIFAAPyvntsgiYGGLLYGNGkqLGVQLIGIAVILAYAFGVT 365
 
Name Accession Description Interval E-value
Ammonium_transp pfam00909
Ammonium Transporter Family;
62-412 1.96e-52

Ammonium Transporter Family;


Pssm-ID: 395729  Cd Length: 399  Bit Score: 181.34  E-value: 1.96e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110  62 DAGPATLHASYSLSADFMPGTVLVGQDL--TVMAALGLGFLTSNFRRHSWSSVAFNLFMLALGVQWAILLDG--FLSQFP 137
Cdd:pfam00909  14 QPGFALLESGLVRSKNVLNILYKNFQDVaiGVLAYWLFGYSLAFGKRYGFSGFIGNLGVSAAGIQWGTLPDGlfFLFQMM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 138 PGKVVITLFSIRLATMSAMSVLISAGAVLGKVNLAQLVVMVLVEVTALGTLRMVISNIFNTDYHMnlrhfyvFAAYFGLT 217
Cdd:pfam00909  94 FAATAITIVSGAVAERIKFSAYLLFSALLGTLVYPPVAHWVWGEGGWLAKLGVLVDFAGSTVVHI-------FGGYAGLA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 218 VAWCLPKPLPKGTEDNDQRATIPSLSAMLGALFLWMFWPSVN--SALLRSPIQRKNAMFNTYYALAVSVVTAISGSSLAH 295
Cdd:pfam00909 167 AALVLGPRIGRFTGKNEAITPHNLPFAVLGTFLLWFGWFGFNagSALTANGRARAIAAVNTNLAAAGGGLTALLISRLKT 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 296 pqRKISMTYVHSAVLAGGVAVGTSCHLIpSPWLAMVLGLVAGLISIGGAKCLpvccNRVLGIHHISVMHSIFSLLGLLGE 375
Cdd:pfam00909 247 --GKPNMLGLANGALAGLVAITPACGVV-TPWGALIIGLIAGVLSVLGYKFL----KEKLGIDDPLDVFPVHGVGGIWGG 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1370454110 376 ITYIVLLVL-------HTVWNGNGM--IGFQVLLSIGELSLAIVIA 412
Cdd:pfam00909 320 IAVGIFAAPyvntsgiYGGLLYGNGkqLGVQLIGIAVILAYAFGVT 365
AmtB COG0004
Ammonia channel protein AmtB [Inorganic ion transport and metabolism];
244-343 7.68e-09

Ammonia channel protein AmtB [Inorganic ion transport and metabolism];


Pssm-ID: 439775  Cd Length: 413  Bit Score: 57.43  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 244 AMLGALFLWMFWPSVN--SALLRSPIQrKNAMFNTYYALAVSVVTAISGSSLAHpqRKISMTYVHSAVLAGGVAVGTSCH 321
Cdd:COG0004   206 AALGAFLLWFGWFGFNagSALAANGLA-GLAFVNTNLAAAAGALAWLLVEWLRK--GKPDLLGAANGALAGLVAITPAAG 282

                          90       100
                  ....*....|....*....|..
gi 1370454110 322 LIpSPWLAMVLGLVAGLISIGG 343
Cdd:COG0004   283 FV-SPLGALVIGLIAGVICVFA 303
 
Name Accession Description Interval E-value
Ammonium_transp pfam00909
Ammonium Transporter Family;
62-412 1.96e-52

Ammonium Transporter Family;


Pssm-ID: 395729  Cd Length: 399  Bit Score: 181.34  E-value: 1.96e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110  62 DAGPATLHASYSLSADFMPGTVLVGQDL--TVMAALGLGFLTSNFRRHSWSSVAFNLFMLALGVQWAILLDG--FLSQFP 137
Cdd:pfam00909  14 QPGFALLESGLVRSKNVLNILYKNFQDVaiGVLAYWLFGYSLAFGKRYGFSGFIGNLGVSAAGIQWGTLPDGlfFLFQMM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 138 PGKVVITLFSIRLATMSAMSVLISAGAVLGKVNLAQLVVMVLVEVTALGTLRMVISNIFNTDYHMnlrhfyvFAAYFGLT 217
Cdd:pfam00909  94 FAATAITIVSGAVAERIKFSAYLLFSALLGTLVYPPVAHWVWGEGGWLAKLGVLVDFAGSTVVHI-------FGGYAGLA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 218 VAWCLPKPLPKGTEDNDQRATIPSLSAMLGALFLWMFWPSVN--SALLRSPIQRKNAMFNTYYALAVSVVTAISGSSLAH 295
Cdd:pfam00909 167 AALVLGPRIGRFTGKNEAITPHNLPFAVLGTFLLWFGWFGFNagSALTANGRARAIAAVNTNLAAAGGGLTALLISRLKT 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 296 pqRKISMTYVHSAVLAGGVAVGTSCHLIpSPWLAMVLGLVAGLISIGGAKCLpvccNRVLGIHHISVMHSIFSLLGLLGE 375
Cdd:pfam00909 247 --GKPNMLGLANGALAGLVAITPACGVV-TPWGALIIGLIAGVLSVLGYKFL----KEKLGIDDPLDVFPVHGVGGIWGG 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1370454110 376 ITYIVLLVL-------HTVWNGNGM--IGFQVLLSIGELSLAIVIA 412
Cdd:pfam00909 320 IAVGIFAAPyvntsgiYGGLLYGNGkqLGVQLIGIAVILAYAFGVT 365
AmtB COG0004
Ammonia channel protein AmtB [Inorganic ion transport and metabolism];
244-343 7.68e-09

Ammonia channel protein AmtB [Inorganic ion transport and metabolism];


Pssm-ID: 439775  Cd Length: 413  Bit Score: 57.43  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454110 244 AMLGALFLWMFWPSVN--SALLRSPIQrKNAMFNTYYALAVSVVTAISGSSLAHpqRKISMTYVHSAVLAGGVAVGTSCH 321
Cdd:COG0004   206 AALGAFLLWFGWFGFNagSALAANGLA-GLAFVNTNLAAAAGALAWLLVEWLRK--GKPDLLGAANGALAGLVAITPAAG 282

                          90       100
                  ....*....|....*....|..
gi 1370454110 322 LIpSPWLAMVLGLVAGLISIGG 343
Cdd:COG0004   283 FV-SPLGALVIGLIAGVICVFA 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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