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Conserved domains on  [gi|767904906|ref|XP_011539989|]
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pre-mRNA-splicing factor 38B isoform X2 [Homo sapiens]

Protein Classification

pre-mRNA-splicing factor 38( domain architecture ID 10505891)

pre-mRNA-splicing factor 38 is involved in pre-mRNA splicing as a component of the spliceosome

Gene Ontology:  GO:0003723|GO:0000398
SCOP:  4007353

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 47-186 2.36e-58

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


:

Pssm-ID: 460901  Cd Length: 165  Bit Score: 180.72  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906   47 LPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTyHEVVDEIYFKVTHVEPWEKGSRKTAgqtgmcggvrgvgtggivS 126
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKP------------------S 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906  127 TAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEE 186
Cdd:pfam03371  62 PFLCLLLKLLQLQPTKEQILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYR 121
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 47-186 2.36e-58

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 180.72  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906   47 LPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTyHEVVDEIYFKVTHVEPWEKGSRKTAgqtgmcggvrgvgtggivS 126
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKP------------------S 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906  127 TAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEE 186
Cdd:pfam03371  62 PFLCLLLKLLQLQPTKEQILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYR 121
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 47-186 2.36e-58

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 180.72  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906   47 LPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTyHEVVDEIYFKVTHVEPWEKGSRKTAgqtgmcggvrgvgtggivS 126
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKENLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKP------------------S 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904906  127 TAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEE 186
Cdd:pfam03371  62 PFLCLLLKLLQLQPTKEQILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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