|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1583-1718 |
5.59e-90 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 287.92 E-value: 5.59e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1583 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1662
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767904870 1663 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1718
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1226-1312 |
5.84e-36 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 131.46 E-value: 5.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1226 RAVVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1305
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75
|
....*..
gi 767904870 1306 LTSLRVI 1312
Cdd:pfam00030 76 IGSLRPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1321-1401 |
2.46e-29 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 112.59 E-value: 2.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1321 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1400
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904870 1401 V 1401
Cdd:pfam00030 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1226-1312 |
3.36e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.44 E-value: 3.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1226 RAVVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1305
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75
|
....*..
gi 767904870 1306 LTSLRVI 1312
Cdd:smart00247 76 ISSIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1501-1581 |
5.49e-25 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 99.88 E-value: 5.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1501 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1579
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 767904870 1580 PI 1581
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1132-1212 |
9.83e-22 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 90.63 E-value: 9.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1132 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1211
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904870 1212 M 1212
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1414-1493 |
5.66e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.93 E-value: 5.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1414 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1490
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 767904870 1491 QKV 1493
Cdd:pfam00030 80 RPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1502-1581 |
2.65e-17 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 78.32 E-value: 2.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1502 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1580
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 767904870 1581 I 1581
Cdd:smart00247 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1044-1123 |
2.39e-15 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 72.53 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1044 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1118
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77
|
....*
gi 767904870 1119 SLRRV 1123
Cdd:pfam00030 78 SLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1414-1490 |
5.26e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.77 E-value: 5.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1414 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1490
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1321-1401 |
6.65e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1321 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1400
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904870 1401 V 1401
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
305-767 |
1.11e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 70.35 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 305 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 384
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 385 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 458
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 459 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 533
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 534 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 610
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 611 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 684
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 685 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 762
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018
|
....*
gi 767904870 763 PAPSS 767
Cdd:PHA03247 3019 PPPVS 3023
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1044-1123 |
7.98e-11 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 59.83 E-value: 7.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1044 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1118
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77
|
....*
gi 767904870 1119 SLRRV 1123
Cdd:smart00247 78 SIRRI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1132-1212 |
7.18e-10 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 57.13 E-value: 7.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1132 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1211
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904870 1212 M 1212
Cdd:smart00247 82 I 82
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
350-799 |
8.40e-08 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 57.23 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 350 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 426
Cdd:pfam05109 445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 427 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 506
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 507 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 582
Cdd:pfam05109 568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 583 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 662
Cdd:pfam05109 648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 663 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 739
Cdd:pfam05109 715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 740 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 799
Cdd:pfam05109 785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1626-1713 |
6.19e-06 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 47.14 E-value: 6.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1626 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1703
Cdd:pfam00652 40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
|
90
....*....|
gi 767904870 1704 PDEDRASQIW 1713
Cdd:pfam00652 117 CDSGNPNQQW 126
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1583-1718 |
5.59e-90 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 287.92 E-value: 5.59e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1583 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1662
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767904870 1663 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1718
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
|
|
| beta-trefoil_Ricin_CRYBG |
cd23430 |
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ... |
1586-1717 |
5.49e-75 |
|
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467308 [Multi-domain] Cd Length: 133 Bit Score: 244.81 E-value: 5.49e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1586 VYFRLWNAALGGFLAVPDHVEDmKAGRVVVADPQAG-GSCIWYYEDGLLKNQMAPTMSLQVIGPPS-PGSKVVLWAESRL 1663
Cdd:cd23430 1 VYFRLRNKATGLFLSVNGNLED-LKLLRVQVMPDVGaDDQIWYYQEGLIKCRIAEDCCLTVIGSLVtPGSKVGLWLEQNA 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 767904870 1664 PRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHV 1717
Cdd:cd23430 80 DRQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVWEIMV 133
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1226-1312 |
5.84e-36 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 131.46 E-value: 5.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1226 RAVVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1305
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75
|
....*..
gi 767904870 1306 LTSLRVI 1312
Cdd:pfam00030 76 IGSLRPI 82
|
|
| beta-trefoil_Ricin_vlAKAP |
cd23463 |
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ... |
1583-1718 |
2.65e-33 |
|
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467341 Cd Length: 136 Bit Score: 126.01 E-value: 2.65e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1583 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVAdpQAGGSC--IWYYEDGLLKNQMAPTmSLQVIG-PPSPGSKVVLWA 1659
Cdd:cd23463 1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVS--QYNGKDtqIWYYCRGLLKSKANDA-CLDVIGgKDNPGSKVALWT 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 767904870 1660 ESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1718
Cdd:cd23463 78 EHGKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKWDIELL 136
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1321-1401 |
2.46e-29 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 112.59 E-value: 2.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1321 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1400
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904870 1401 V 1401
Cdd:pfam00030 82 I 82
|
|
| beta-trefoil_Ricin_CRYBG1 |
cd23464 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1583-1718 |
3.12e-27 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467342 Cd Length: 137 Bit Score: 108.35 E-value: 3.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1583 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGP-PSPGSKVVLWAES 1661
Cdd:cd23464 1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNlVTAGSKLGLSLEQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767904870 1662 RLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1718
Cdd:cd23464 81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1226-1312 |
3.36e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.44 E-value: 3.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1226 RAVVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1305
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75
|
....*..
gi 767904870 1306 LTSLRVI 1312
Cdd:smart00247 76 ISSIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1501-1581 |
5.49e-25 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 99.88 E-value: 5.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1501 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1579
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 767904870 1580 PI 1581
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1132-1212 |
9.83e-22 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 90.63 E-value: 9.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1132 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1211
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904870 1212 M 1212
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1414-1493 |
5.66e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.93 E-value: 5.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1414 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1490
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 767904870 1491 QKV 1493
Cdd:pfam00030 80 RPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1502-1581 |
2.65e-17 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 78.32 E-value: 2.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1502 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1580
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 767904870 1581 I 1581
Cdd:smart00247 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1044-1123 |
2.39e-15 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 72.53 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1044 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1118
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77
|
....*
gi 767904870 1119 SLRRV 1123
Cdd:pfam00030 78 SLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1414-1490 |
5.26e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.77 E-value: 5.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1414 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1490
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1321-1401 |
6.65e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1321 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1400
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904870 1401 V 1401
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
305-767 |
1.11e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 70.35 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 305 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 384
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 385 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 458
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 459 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 533
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 534 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 610
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 611 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 684
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 685 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 762
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018
|
....*
gi 767904870 763 PAPSS 767
Cdd:PHA03247 3019 PPPVS 3023
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1044-1123 |
7.98e-11 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 59.83 E-value: 7.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1044 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1118
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77
|
....*
gi 767904870 1119 SLRRV 1123
Cdd:smart00247 78 SIRRI 82
|
|
| beta-trefoil_Ricin_SCDase |
cd23456 |
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ... |
1587-1713 |
2.22e-10 |
|
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467334 [Multi-domain] Cd Length: 122 Bit Score: 59.68 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1587 YFRLWNAALGGFLAVPDHVedMKAGRVVVADPQAGGSCIWYYE-DGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPR 1665
Cdd:cd23456 2 YFQLKSQASGLCLDVSGGA--TNGANVVVYDCNNSNSQKWYYDaTGRLHSKANPGKCLDAGGENSNGANVVLWACNDSAN 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767904870 1666 QTWSIsESGHICSQMFEGQILDVKGGRGydrDHVVLWEPDEDrASQIW 1713
Cdd:cd23456 80 QRWDF-DGNFIRSRNNTNLALDAYGSQG---SNVGLWQFHGG-ANQQW 122
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
407-923 |
3.01e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 3.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 407 SVPSsPRLETHVPSPGLTHPAKQPVVPTHPGARLTPL-----------VLPPKKKDGPVDPPAATvlPMVRSEHVTVPGQ 475
Cdd:PHA03247 2567 SVPP-PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpapPSPLPPDTHAPDPPPPS--PSPAANEPDPHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 476 PPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVlpftqrevvKGPGAPAASSPTRKEVVQGSSASAASSPtwkEVV 555
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP---------QRPRRRAARPTVGSLTSLADPPPPPPTP---EPA 2711
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 556 KGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDAsfPTWKEVVKGPGAPAASSPTQKEVvqgsGAPAALSTT 635
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG--PARPARPPTTAGPPAPAPPAAPA----AGPPRRLTR 2785
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 636 PKEVVKGPGAPAASSPtqkevvKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAP- 714
Cdd:PHA03247 2786 PAVASLSESRESLPSP------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPg 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 715 -PLTKEETVQGPIAPATSLPKqdkgvqdsegSPISSLTQKEVVQDPDALPAPSSSVDRvSPSPGGTPAPVPTGAEASTES 793
Cdd:PHA03247 2860 gDVRRRPPSRSPAAKPAAPAR----------PPVRRLARPAVSRSTESFALPPDQPER-PPQPQAPPPPQPQPQPPPPPQ 2928
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 794 QLVSDPTEGKtctetsreedevalaadleifldtlrsmePPEilrthrlPRAPRSSYLSMYATLPAIEEDQLGPWVlgPG 873
Cdd:PHA03247 2929 PQPPPPPPPR-----------------------------PQP-------PLAPTTDPAGAGEPSGAVPQPWLGALV--PG 2970
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 767904870 874 PQEVPsleekeeeeeeepenpylsddeklqrRQEKAGPSPSRDLhPARPT 923
Cdd:PHA03247 2971 RVAVP--------------------------RFRVPQPAPSREA-PASST 2993
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1132-1212 |
7.18e-10 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 57.13 E-value: 7.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1132 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1211
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904870 1212 M 1212
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
160-799 |
3.62e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.26 E-value: 3.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 160 PPPKekrPEGRLKEAVDQS-DGSRQAPRTEPPCVGAMARTELLVPLPG-PREPsphpgvgltsgssrsleeyrvtrtvrt 237
Cdd:PHA03247 2552 PPPL---PPAAPPAAPDRSvPPPRPAPRPSEPAVTSRARRPDAPPQSArPRAP--------------------------- 2601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 238 ttvvgghVDRRMSSSVTVRPVSsgealprgrqvsrmvppvvvgsppgspsrsqavkvlsnlvpaghSPPASHLPRPTAGG 317
Cdd:PHA03247 2602 -------VDDRGDPRGPAPPSP--------------------------------------------LPPDTHAPDPPPPS 2630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 318 PRSTGlgstvgaalRQLPETGTAELKDSSALASTGIPASAHLPKNQdapaacpdRDQGRAPDARA-CELWQVLGAPSSTe 396
Cdd:PHA03247 2631 PSPAA---------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--------RRLGRAAQASSpPQRPRRRAARPTV- 2692
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 397 lplqtsqgqASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTPLVLPPKKKD-GPVDPPAATVLPMVrsehVTVPGQ 475
Cdd:PHA03247 2693 ---------GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGG----PARPAR 2759
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 476 PPAPSTTRRKDVPS-PGGLSAPSSPRNKFVQNSENVPVLPFTqrevvKGPGAPAASSPTRKEVVQGSSASAASSPTWKEV 554
Cdd:PHA03247 2760 PPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 555 VKGPGAPAASSPTQKEVVQGSSAPAALF---PTWKEVVKGPGAP----------------DASFPTWKEVVKGPGAPAAS 615
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPAAParppvrrlarpavsrsTESFALPPDQPERPPQPQAP 2914
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 616 SPTQKevvQGSGAPAALSTTPKEVVKGPGAPAAssPTQKEVVKGPCAPAASSPTQKEVVQGS-GAPAALSPKSTEVVQGP 694
Cdd:PHA03247 2915 PPPQP---QPQPPPPPQPQPPPPPPPRPQPPLA--PTTDPAGAGEPSGAVPQPWLGALVPGRvAVPRFRVPQPAPSREAP 2989
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 695 KGSSSIQKE----AVQGIAGSLApplTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEVVQDPDALPAPSSSVD 770
Cdd:PHA03247 2990 ASSTPPLTGhslsRVSSWASSLA---LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPF 3066
|
650 660
....*....|....*....|....*....
gi 767904870 771 RVSPSPgGTPApvpTGAEASTESQLVSDP 799
Cdd:PHA03247 3067 AHEPDP-ATPE---AGARESPSSQFGPPP 3091
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
388-923 |
7.39e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 7.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 388 VLGAPSSTEL---------PLQTSQGQASVPSSPRletHVPSPGLTHPaKQPVVPTHPGaRLTPLVLPPKKKDGPVDPPA 458
Cdd:PHA03247 2459 ILGAPFSLSLllgelfpgaPVYRRPAEARFPFAAG---AAPDPGGGGP-PDPDAPPAPS-RLAPAILPDEPVGEPVHPRM 2533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 459 ATVLPMVRSEHVTVPGQPP------APSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 532
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPpplppaAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 533 trkevvqgssasaaSSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAalfPTWKEVVKGPGAPDASFPtwKEVVKGPGAP 612
Cdd:PHA03247 2614 --------------PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPAPGRVSRP--RRARRLGRAA 2674
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 613 AASSPTQKEVVQGSGAPAAlSTTPKEVVKGPGAPAASSPTqkevvkgPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQ 692
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVG-SLTSLADPPPPPPTPEPAPH-------ALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 693 GPKGSSSIQKEAvqgiagslAPPLTKeetvqGPIAPATSlpkqdkgvQDSEGSPISSLTQKEVV---QDPDALPAPSSSV 769
Cdd:PHA03247 2747 GPATPGGPARPA--------RPPTTA-----GPPAPAPP--------AAPAAGPPRRLTRPAVAslsESRESLPSPWDPA 2805
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 770 DRVSPSPGGTPAPVPTGAEAS-----TESQLVSDPTEGKTCTETSREEDEVALAADLEifldtlRSMEPPEILRTHRLPR 844
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGplpppTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR------RRPPSRSPAAKPAAPA 2879
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767904870 845 APRSSYLSMYATLPAIEEDQLGPwvLGPGPQEVPSLEEKeeeeeeepenPYLSDDEKLQRRQEKAGPSPSRDLHPARPT 923
Cdd:PHA03247 2880 RPPVRRLARPAVSRSTESFALPP--DQPERPPQPQAPPP----------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
350-799 |
8.40e-08 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 57.23 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 350 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 426
Cdd:pfam05109 445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 427 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 506
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 507 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 582
Cdd:pfam05109 568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 583 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 662
Cdd:pfam05109 648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 663 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 739
Cdd:pfam05109 715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 740 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 799
Cdd:pfam05109 785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
318-824 |
1.28e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.45 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 318 PRSTGLGSTVGAAL----RQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAAcpdrDQGRAPDARAcelwqvlgAPS 393
Cdd:PRK07764 365 PSASDDERGLLARLerleRRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAA----AAAPAPAAAP--------QPA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 394 STELPLQTSQGQASVPSSPRLETHVPSPGLT-HPAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTV 472
Cdd:PRK07764 433 PAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSaQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 473 PGQPPAPSTTRRKDVPSPGGLSAPssprnkfvqnseNVPVLPFTQREVV----KGPGAPAASSPTRKEVVQGSSASAASS 548
Cdd:PRK07764 513 RERWPEILAAVPKRSRKTWAILLP------------EATVLGVRGDTLVlgfsTGGLARRFASPGNAEVLVTALAEELGG 580
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 549 pTWK-EVVKGPGAPAASSPTQKEVVQGSSAPAALFPTwkevvkgpgAPDAsfptwkevvkgPGAPAASSPTqkevvQGSG 627
Cdd:PRK07764 581 -DWQvEAVVGPAPGAAGGEGPPAPASSGPPEEAARPA---------APAA-----------PAAPAAPAPA-----GAAA 634
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 628 APAALSTTpkevvkgPGAPAASSPTQKEVVKGPCAPAASSPTQKEVvqGSGAPAALSPKSTEVVQGPKGSSSiqkeavqg 707
Cdd:PRK07764 635 APAEASAA-------PAPGVAAPEHHPKHVAVPDASDGGDGWPAKA--GGAAPAAPPPAPAPAAPAAPAGAA-------- 697
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 708 iAGSLAPPLTKEETVQGPIAPATSLPKQDKG-VQDSEGSPISSLTQKEVVQDPDALPAPSSSVDRVSPSPGGTPAPVPTG 786
Cdd:PRK07764 698 -PAQPAPAPAATPPAGQADDPAAQPPQAAQGaSAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
|
490 500 510
....*....|....*....|....*....|....*...
gi 767904870 787 AEASTESQLVSDPTEGkTCTETSREEDEVALAADLEIF 824
Cdd:PRK07764 777 SPPSEEEEMAEDDAPS-MDDEDRRDAEEVAMELLEEEL 813
|
|
| beta-trefoil_Ricin-like |
cd00161 |
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ... |
1587-1713 |
2.11e-06 |
|
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.
Pssm-ID: 467293 [Multi-domain] Cd Length: 134 Bit Score: 48.91 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1587 YFRLWNAALGGFLAVPDHveDMKAG-RVVVADPQAGGSCIWYYED-----GLLKNqMAPTMSLQVIG-PPSPGSKVVLWA 1659
Cdd:cd00161 2 TYRIVNAASGKCLDVAGG--STANGaPVQQWTCNGGANQQWTLTPvgdgyYTIRN-VASGKCLDVAGgSTANGANVQQWT 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 767904870 1660 ESRLPRQTWSISESG----HICSQMfEGQILDVKGGRGYDRDHVVLWePDEDRASQIW 1713
Cdd:cd00161 79 CNGGDNQQWRLEPVGdgyyRIVNKH-SGKCLDVSGGSTANGANVQQW-TCNGGANQQW 134
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
364-799 |
4.98e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.71 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 364 DAPAACPDRDQGRAPDARACeLWQVLGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPvvPTHPGARLTPL 443
Cdd:PHA03307 47 SAELAAVTVVAGAAACDRFE-PPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPP 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 444 VLPPKkkdgPVDPPAATVLPMVRSeHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKG 523
Cdd:PHA03307 124 ASPPP----SPAPDLSEMLRPVGS-PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 524 PGAPAASSPTRKEVVQGSSASAASSPTwkevvKGPGAPAASSPTqkevvqGSSAPAALFPTWKEVVKGPGAPDASF--PT 601
Cdd:PHA03307 199 PAAASPRPPRRSSPISASASSPAPAPG-----RSAADDAGASSS------DSSSSESSGCGWGPENECPLPRPAPItlPT 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 602 WKEVVKGPGAPAASSPTQKEvvqgSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA 681
Cdd:PHA03307 268 RIWEASGWNGPSSRPGPASS----SSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 682 ALSPKStevvqGPKGSSSiqkeavqgiAGSLAPPLTKEETVQGPIAPATSLPKqdkgvqdseGSPISSLTQKevvqdpdA 761
Cdd:PHA03307 344 GPSPSR-----SPSPSRP---------PPPADPSSPRKRPRPSRAPSSPAASA---------GRPTRRRARA-------A 393
|
410 420 430
....*....|....*....|....*....|....*...
gi 767904870 762 LPAPSSSVDRVSPSPGGTPAPVPTGAEASTESQLVSDP 799
Cdd:PHA03307 394 VAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYP 431
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1626-1713 |
6.19e-06 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 47.14 E-value: 6.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1626 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1703
Cdd:pfam00652 40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
|
90
....*....|
gi 767904870 1704 PDEDRASQIW 1713
Cdd:pfam00652 117 CDSGNPNQQW 126
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
305-681 |
7.79e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 50.84 E-value: 7.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 305 PPASHLPRPTAGGP---------RSTGLGSTVGAALRQLPETGTAELK------DSSALASTGIPASAHLPKNQDAPAAC 369
Cdd:PHA03378 526 PPSPPQPRAGRRAPcvytedldiESDEPASTEPVHDQLLPAPGLGPLQiqpltsPTTSQLASSAPSYAQTPWPVPHPSQT 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 370 PD--RDQGRAPDARACELWQVLGAPSSTElPLQTSQGQASVP------SSPRLETHVPSPGLTHPAKQPVVPTHPGARLT 441
Cdd:PHA03378 606 PEppTTQSHIPETSAPRQWPMPLRPIPMR-PLRMQPITFNVLvfptphQPPQVEITPYKPTWTQIGHIPYQPSPTGANTM 684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 442 plvLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKD-------VPSPGGLSAPSSPRNKFVQNSENVPVLP 514
Cdd:PHA03378 685 ---LPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaaapgrARPPAAAPGRARPPAAAPGRARPPAAAP 761
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 515 FTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPTWKE-------VVKGPGAPAASSPTQKEVVQG------SSAPAAL 581
Cdd:PHA03378 762 GRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPqagptsmQLMPRAAPGQQGPTKQILRQLltggvkRGRPSLK 841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 582 FPTWKEVVKGPG-APDASFPTWKEVVKGP-GAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKG 659
Cdd:PHA03378 842 KPAALERQAAAGpTPSPGSGTSDKIVQAPvFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGVGPMHPTDIPP 921
|
410 420
....*....|....*....|..
gi 767904870 660 PCAPAASSPTQKEVVQGSGAPA 681
Cdd:PHA03378 922 SKRAKTDAYVESQPPHGGQSHS 943
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
530-800 |
2.03e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.53 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 530 SSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPG---------APDASFP 600
Cdd:pfam05109 430 TSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSprdngteskAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 601 TWKEVVKGPGA----PAASSPTQKevvqgSGAPAALSTTPKEVVKGPgAPAASSPTqkevvkgpcaPAASSPTQKEVVQG 676
Cdd:pfam05109 510 TSAVTTPTPNAtsptPAVTTPTPN-----ATSPTLGKTSPTSAVTTP-TPNATSPT----------PAVTTPTPNATIPT 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 677 SGAPaalSPKSTEVVQGPKGSSSiqkeavqgIAGSLAPPL-TKEETVQGPIAP--ATSLPKQDKGVQDSEGSPISSLTQK 753
Cdd:pfam05109 574 LGKT---SPTSAVTTPTPNATSP--------TVGETSPQAnTTNHTLGGTSSTpvVTSPPKNATSAVTTGQHNITSSSTS 642
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 767904870 754 EVVQDPDALP---APSSSVDRVSPSPGGTPAPvPTGAEASTESQLVSDPT 800
Cdd:pfam05109 643 SMSLRPSSISetlSPSTSDNSTSHMPLLTSAH-PTGGENITQVTPASTST 691
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
426-651 |
3.21e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.72 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 426 PAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQ-PPAP---STTRRKDVPSPGGLSAPSSprn 501
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrSPAPealAAARQASARGPGGAPAPAP--- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 502 kfvqNSENVPVlpftqrevvkGPGAPAASSPtrkevvqgssasaassptwkevvKGPGAPAASSPTQKEVVQGSSAPAAL 581
Cdd:PRK12323 453 ----APAAAPA----------AAARPAAAGP-----------------------RPVAAAAAAAPARAAPAAAPAPADDD 495
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767904870 582 FPTWKEV-----VKGPGAPDASFPTW-KEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSP 651
Cdd:PRK12323 496 PPPWEELppefaSPAPAQPDAAPAGWvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
557-823 |
5.86e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.95 E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 557 GPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVkgpGAPAASSPtqkevvqgsgAPAALSTTP 636
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA---AAPARRSP----------APEALAAAR 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 637 KEVVKGPGAPAASSPTQkevvkgPCAPAASSPTQKEVVQGSGAPAALSPksteVVQGPKGSSSIQKEAVqgiagslaPPL 716
Cdd:PRK12323 438 QASARGPGGAPAPAPAP------AAAPAAAARPAAAGPRPVAAAAAAAP----ARAAPAAAPAPADDDP--------PPW 499
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 717 tkEETvqGPIAPATSLPKQDKGVQDSEGSPISsltqKEVVQDPDAlpapsssvDRVSPSPGGTPAPVPTGAEASTESQLV 796
Cdd:PRK12323 500 --EEL--PPEFASPAPAQPDAAPAGWVAESIP----DPATADPDD--------AFETLAPAPAAAPAPRAAAATEPVVAP 563
|
250 260
....*....|....*....|....*..
gi 767904870 797 SDPTEGKTCTETSREEDEVALAADLEI 823
Cdd:PRK12323 564 RPPRASASGLPDMFDGDWPALAARLPV 590
|
|
| beta-trefoil_Ricin_SCDase_rpt1 |
cd23499 |
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ... |
1587-1713 |
7.50e-05 |
|
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket. The model corresponds to the first lectin domain.
Pssm-ID: 467377 [Multi-domain] Cd Length: 131 Bit Score: 44.36 E-value: 7.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1587 YFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCI--WYY--EDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1662
Cdd:cd23499 2 FVRIVNRASGKCLDIPGNDNDVVNGANVILWDCADKSADqrWIYdaASGMLRNKANPSYCLDNRGQAYNGGEVVLWQCED 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 767904870 1663 LPRQTWSISeSGHICSQMFEGQILDVkGGRGYDrDHVVLWEpDEDRASQIW 1713
Cdd:cd23499 82 SDNLRWTYD-NGVLRSKHNPNIVLDA-YGRDNN-SQVGQWE-YHGGANQQW 128
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
419-660 |
8.38e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 47.38 E-value: 8.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 419 PSPGLTH-PAKQPVVPTHPGArltplvlpPKKKDGPVDP--PAATVLPMVRSEhvtvPGQPPAPSTTRRKDVP-SPGGLS 494
Cdd:PTZ00449 561 PGPAKEHkPSKIPTLSKKPEF--------PKDPKHPKDPeePKKPKRPRSAQR----PTRPKSPKLPELLDIPkSPKRPE 628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 495 APSSPRNkfvqnsenvPVLPftQRevvkgpgapaASSPTRKEvvqgssasaasSPTWKEVVKGPGAPAAS-SPTQKEVVQ 573
Cdd:PTZ00449 629 SPKSPKR---------PPPP--QR----------PSSPERPE-----------GPKIIKSPKPPKSPKPPfDPKFKEKFY 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 574 GSSAPAAlfPTWKEVVKGPGAPDASFPTWKEVVkgPGAPAASSPTQKEVvqgsgaPAALSTTPKEVVKGPGAPAASSPTQ 653
Cdd:PTZ00449 677 DDYLDAA--AKSKETKTTVVLDESFESILKETL--PETPGTPFTTPRPL------PPKLPRDEEFPFEPIGDPDAEQPDD 746
|
....*..
gi 767904870 654 KEVVKGP 660
Cdd:PTZ00449 747 IEFFTPP 753
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
589-790 |
9.01e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 47.54 E-value: 9.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 589 VKGPGAPDASFPTwkEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSP 668
Cdd:PRK07003 362 VTGGGAPGGGVPA--RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 669 TQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEEtvqgPIAPATSLPKQDKGVQDSEGSPIS 748
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE----PAPRAAAPSAATPAAVPDARAPAA 515
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 767904870 749 SLTQKEVVqdPDALPAPSSSvdrvSPSPG-GTPAPVPTGAEAS 790
Cdd:PRK07003 516 ASREDAPA--AAAPPAPEAR----PPTPAaAAPAARAGGAAAA 552
|
|
| beta-trefoil_Ricin_GllA-1 |
cd23454 |
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ... |
1612-1715 |
9.37e-05 |
|
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.
Pssm-ID: 467332 [Multi-domain] Cd Length: 136 Bit Score: 44.23 E-value: 9.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 1612 RVVVAD--PQAGGSCIWYYEDGLLKNQMaptmSLQVI----GPPSPGSKVVLWAESRLPR---QTWSISESGHICSQMFE 1682
Cdd:cd23454 26 KVVLAPlkTKDYESQLWRYDDGYLVNKA----SGLVLdiqgGVVKSGTRLVQSPKKPSKDannQRWGLTADGYIYLLSNP 101
|
90 100 110
....*....|....*....|....*....|....*
gi 767904870 1683 GQILDVKGGRGYDRDHVVLWE--PDEDRASQIWTI 1715
Cdd:cd23454 102 SLVLGIKGNETREGARVILQErkLQKDALNQRWTF 136
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
305-743 |
9.40e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 47.29 E-value: 9.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 305 PPASHLPRPTAGGPRSTGlgstVGAALRQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAACPDRDQGRAPDARAce 384
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAA----AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA-- 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 385 lwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTP------LVLPPKKKDGPVDP-- 456
Cdd:PRK07764 460 -----AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeILAAVPKRSRKTWAil 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 457 -PAATVLpMVRSEHVTVpgqppapsttrrkDVPSPGGLSAPSSPRN--KFVQNSENVPVLPFtQREVVKGPGAPAASSPT 533
Cdd:PRK07764 535 lPEATVL-GVRGDTLVL-------------GFSTGGLARRFASPGNaeVLVTALAEELGGDW-QVEAVVGPAPGAAGGEG 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 534 RKEVVQgssasaassPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKE--------VVKGPGAPDASFPTWKEV 605
Cdd:PRK07764 600 PPAPAS---------SGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgvaapehHPKHVAVPDASDGGDGWP 670
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 606 VK-GPGAPAASSPTQKEVVQGSGAPAAlsttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKevVQGSGAPAALS 684
Cdd:PRK07764 671 AKaGGAAPAAPPPAPAPAAPAAPAGAA----PAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP--AADDPVPLPPE 744
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 767904870 685 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSlPKQDKGVQDSE 743
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAP-SMDDEDRRDAE 802
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
490-783 |
1.26e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.77 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 490 PGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPtwkevvKGPGAPAASSPTQK 569
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP------AAPAPPATADRGDD 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 570 EVVQGSSAPAALfPTWKEVVKGPGAPDASFPTWKEVVKGPgAPAASSPTQKE------VVQGSGAPAALSTTPKEVVKGP 643
Cdd:PRK07003 442 AADGDAPVPAKA-NARASADSRCDERDAQPPADSGSASAP-ASDAPPDAAFEpapraaAPSAATPAAVPDARAPAAASRE 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 644 GAPAASSPTQKEVvkGPCAPAASSPTQKevvqGSGAPAAL-----------SPKSTEVVQGPK---GSSSIQKEAVQGIA 709
Cdd:PRK07003 520 DAPAAAAPPAPEA--RPPTPAAAAPAAR----AGGAAAALdvlrnagmrvsSDRGARAAAAAKpaaAPAAAPKPAAPRVA 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 710 GSLAPPLTKEETVQGPIAPATSLPKQdkgvQDSEGSP----------ISSLTQKEVVQDPDA--LPAPSSSVD--RVSPS 775
Cdd:PRK07003 594 VQVPTPRARAATGDAPPNGAARAEQA----AESRGAPppwedippddYVPLSADEGFGGPDDgfVPVFDSGPDdvRVAPK 669
|
....*...
gi 767904870 776 PGGTPAPV 783
Cdd:PRK07003 670 PADAPAPP 677
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
523-731 |
5.81e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.87 E-value: 5.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 523 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQG----SSAPAALFPTWKEVVKGPGAPDAS 598
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAparrSPAPEALAAARQASARGPGGAPAP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 599 FPTwkevvkgpgAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEvvqGSG 678
Cdd:PRK12323 451 APA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD---AAP 518
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767904870 679 APAALSPKSTEVVQGPKGSSSIQKEAvqGIAGSLAPPLTKEETVQGPIAPATS 731
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPA--PAAAPAPRAAAATEPVVAPRPPRAS 569
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
401-733 |
7.32e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 44.66 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 401 TSQGQASVPSSPrlETHVPSPGLTH--------PAKQ----PVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSE 468
Cdd:PHA03379 435 TSHGSAQVPEPP--PVHDLEPGPLHdqhsmapcPVAQlppgPLQDLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEAS 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 469 HVTVPGQPPAPSttrrkdvpSPGGLSAPSSPRNKFVQNSenvPVLPFTQREVVKGPGAPAASSPTRKevvqgssasaass 548
Cdd:PHA03379 513 LSQVPGVAFAPV--------MPQPMPVEPVPVPTVALER---PVCPAPPLIAMQGPGETSGIVRVRE------------- 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 549 pTWKEVVKGPGAPAASSPTQ--------KEVVQGSSAPAALFPTwkEVVKGPGAPDASFPTWKEVVKGPGAPAASSPtqk 620
Cdd:PHA03379 569 -RWRPAPWTPNPPRSPSQMSvrdrlarlRAEAQPYQASVEVQPP--QLTQVSPQQPMEYPLEPEQQMFPGSPFSQVA--- 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 621 EVVQGSGAPA------ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGP 694
Cdd:PHA03379 643 DVMRAGGVPAmqpqyfDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVP 722
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 767904870 695 K----GSSSIQKEAVQGIAGS--LAPPLTKEETVQGPIAPATSLP 733
Cdd:PHA03379 723 ErwmfQGATLSQSVRPGVAQSqyFDLPLTQPINHGAPAAHFLHQP 767
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
353-735 |
7.95e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.37 E-value: 7.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 353 IPASAHLPKNQDAPAACPDRDQGRAPDAracelwqvlGAPSSTELPLQTSQGQAS---VPSSPRLETH-VPSPgltHPAK 428
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPSAPSVPPQ---------GSPATSQPPNQTQSTAAPhtlIQQTPTLHPQrLPSP---HPPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 429 QPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQP-PAPSTTRRKDVPSPGGLSAPSSPRNKFVQ-N 506
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTpP 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 507 SENVPVLPFTQREVVKGPGA---PAASSPTRKEVVQGSSASAASSPtwkevvkgpgaPAASSPTQKEVVQGSSAPAALFP 583
Cdd:pfam03154 330 SQSQLQSQQPPREQPLPPAPlsmPHIKPPPTTPIPQLPNPQSHKHP-----------PHLSGPSPFQMNSNLPPPPALKP 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 584 TWKEVVKGPgaPDASFPTWKEVVKGPGAPaaSSPTQKEVV-QGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPca 662
Cdd:pfam03154 399 LSSLSTHHP--PSAHPPPLQLMPQSQQLP--PPPAQPPVLtQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGP-- 472
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767904870 663 PAASSPtqkevvqgSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQ 735
Cdd:pfam03154 473 PPITPP--------SGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPP 537
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
453-794 |
1.63e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 43.02 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 453 PVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 532
Cdd:pfam17823 115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 533 TRKEVVQGSSASAASSPTWKEVVkGPGAPAASSPTQKevvQGSSAPAalfptwkevvkgPGAPDASFPTWKEVVKGPGAP 612
Cdd:pfam17823 195 PTTAASSAPATLTPARGISTAAT-ATGHPAAGTALAA---VGNSSPA------------AGTVTAAVGTVTPAALATLAA 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 613 AASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAAsspTQKEVVQGSGAPAALSPKSTEVVQ 692
Cdd:pfam17823 259 AAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVS---TDQPVHNTAGEPTPSPSNTTLEPN 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 693 GPKGSSSIQKEAVqgiagSLAPPLTKEETVQG-PIAPATSLPKQDKGVQDSEGSPISSlTQKevVQDPDALPAP------ 765
Cdd:pfam17823 336 TPKSVASTNLAVV-----TTTKAQAKEPSASPvPVLHTSMIPEVEATSPTTQPSPLLP-TQG--AAGPGILLAPeqvate 407
|
330 340 350
....*....|....*....|....*....|...
gi 767904870 766 -SSSVDRVSPSP---GGTPAPVPTGAEASTESQ 794
Cdd:pfam17823 408 aTAGTASAGPTPrssGDPKTLAMASCQLSTQGQ 440
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
443-682 |
1.68e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 443 LVLPPKKKDGPVDPPAATVLPMVRsehVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQnsenvpvlpftqrevvk 522
Cdd:PRK12323 361 LAFRPGQSGGGAGPATAAAAPVAQ---PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA----------------- 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 523 gpGAPAASSPTRKEVvqgssasaasSPTWKEVVKGPGAPAASSPTQKEV-----------VQGSSAPAALFPTWKEVVKG 591
Cdd:PRK12323 421 --AAPARRSPAPEAL----------AAARQASARGPGGAPAPAPAPAAApaaaarpaaagPRPVAAAAAAAPARAAPAAA 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 592 PGAPDASFPTWKEVvkgPGAPAASSPTQKEvvqGSGAPAALSTTPKEvvkGPGAPAASSPTQKEVVKGPCAPAASSPTQK 671
Cdd:PRK12323 489 PAPADDDPPPWEEL---PPEFASPAPAQPD---AAPAGWVAESIPDP---ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
|
250
....*....|.
gi 767904870 672 EVVQGSGAPAA 682
Cdd:PRK12323 560 VVAPRPPRASA 570
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
608-729 |
1.77e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.16 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 608 GPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKS 687
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 767904870 688 TEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPA 729
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
|
|
| DUF959 |
pfam06121 |
Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' ... |
555-669 |
1.83e-03 |
|
Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' isoform of Collagen A.
Pssm-ID: 399255 [Multi-domain] Cd Length: 192 Bit Score: 41.35 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 555 VKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPdasfPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAAL-- 632
Cdd:pfam06121 41 VQPAAAPATHVAPQDDPAEQATAAASPELPLEELEAAPGRA----PGAPISAAAPAALAARPDMREENVAGVGAKILNia 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767904870 633 -----------STTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPT 669
Cdd:pfam06121 117 qgiqsfiqlwnDAAPTESPAGAGTLAASAPTDPLALAEPSGPAAESGT 164
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
523-689 |
2.12e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 523 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFP------TWKEVVKGPGAPD 596
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPaapappATADRGDDAADGD 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 597 ASFPTwKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEV-VQ 675
Cdd:PRK07003 447 APVPA-KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAA 525
|
170
....*....|....
gi 767904870 676 GSGAPAALSPKSTE 689
Cdd:PRK07003 526 APPAPEARPPTPAA 539
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
623-830 |
2.25e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 623 VQGSGAPAALSttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQK 702
Cdd:PRK07003 362 VTGGGAPGGGV--PARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 703 EAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEvvqdpdalPAPSSSVDRVSPSPGGTPAP 782
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE--------PAPRAAAPSAATPAAVPDAR 511
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 767904870 783 VPTGAEASTESQLVSDPTEgKTCTETSREEDEVALAADLEIFLDTLRS 830
Cdd:PRK07003 512 APAAASREDAPAAAAPPAP-EARPPTPAAAAPAARAGGAAAALDVLRN 558
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
583-683 |
3.16e-03 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 42.57 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 583 PTWKEV----VKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVk 658
Cdd:PRK12270 27 PSWREFfadyGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAA- 105
|
90 100
....*....|....*....|....*
gi 767904870 659 gpcAPAASSPTQKEVVQGSGAPAAL 683
Cdd:PRK12270 106 ---AAPAAAAVEDEVTPLRGAAAAV 127
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
555-794 |
4.14e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 555 VKGPGAPAASSPTQkeVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALST 634
Cdd:PRK07003 362 VTGGGAPGGGVPAR--VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 635 TPKEVVKGPGAPAASSPTQKEVVKGPCA--PAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIA--G 710
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDaqPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsrE 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 711 SLAPPLTKEETVQGPIAPATSLPKQDKG-------VQDSEGSPISSltqkEVVQDPDALPAPSSSVDRVSPSPGGTPA-P 782
Cdd:PRK07003 520 DAPAAAAPPAPEARPPTPAAAAPAARAGgaaaaldVLRNAGMRVSS----DRGARAAAAAKPAAAPAAAPKPAAPRVAvQ 595
|
250
....*....|...
gi 767904870 783 VPT-GAEASTESQ 794
Cdd:PRK07003 596 VPTpRARAATGDA 608
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
301-499 |
9.20e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 9.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 301 AGHSPPASHLPRPTAGGPRSTGLGSTVGAAlRQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAAcPDRDQGRAPDA 380
Cdd:PRK07764 596 GGEGPPAPASSGPPEEAARPAAPAAPAAPA-APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-SDGGDGWPAKA 673
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904870 381 RACElwQVLGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARltplvlPPKKKDGPVDPPAAT 460
Cdd:PRK07764 674 GGAA--PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASA------PSPAADDPVPLPPEP 745
|
170 180 190
....*....|....*....|....*....|....*....
gi 767904870 461 VLPMVRSEHVTVPGQPPAPSttrrkDVPSPGGLSAPSSP 499
Cdd:PRK07764 746 DDPPDPAGAPAQPPPPPAPA-----PAAAPAAAPPPSPP 779
|
|
| |
