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Conserved domains on  [gi|767943080|ref|XP_011534221|]
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PH-interacting protein isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
118-497 2.60e-65

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.95  E-value: 2.60e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  118 VVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVyqhmkmHKRILGHLSSVYCVTFDRTGRR 197
Cdd:COG2319    61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  198 IFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSP 277
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  278 lcSGskRYLSSTGADGTIcfWLWDAGTlkinPRPAKFTERPRPGVQMIcsSFSAGGMFLATGSTDHIIRVYFFGSGQPek 357
Cdd:COG2319   215 --DG--KLLASGSADGTV--RLWDLAT----GKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATGEL-- 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQGIEDkitkmKVTMVAWDRHDN 437
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AVRSVAFSPDGK 343

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  438 TVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLA 497
Cdd:COG2319   344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
PLN03218 super family cl33664
maturation of RBCL 1; Provisional
 659-837 6.23e-03

maturation of RBCL 1; Provisional


The actual alignment was detected with superfamily member PLN03218:

Pssm-ID: 215636 [Multi-domain]  Cd Length: 1060  Bit Score: 40.63  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  659 SGEAVISNTSRLSRGSISSTSEVHsPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEE 738
Cdd:PLN03218   22 STIPPILPASTLRRDFLGCSHNLR-PPNSASRLRGGKSKSIRSRIRSPRLVVNASLGSGLVLVVVAVTAFSAISFAYLQH 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  739 WRTAKGEEEIKTyrseekrkhltvPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSS 818
Cdd:PLN03218  101 TRRRKSSPLVAT------------PSGGGISTLNREDVQSLDGDVHKGTSTEINVGFRDLVEEVEHTEEEKTHQAQERAL 168

                         170
                  ....*....|....*....
gi 767943080  819 SDEGEVVAVSGGTSEEEER 837
Cdd:PLN03218  169 MEEESVVVEGSESSRESVR 187
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
118-497 2.60e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.95  E-value: 2.60e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  118 VVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVyqhmkmHKRILGHLSSVYCVTFDRTGRR 197
Cdd:COG2319    61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  198 IFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSP 277
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  278 lcSGskRYLSSTGADGTIcfWLWDAGTlkinPRPAKFTERPRPGVQMIcsSFSAGGMFLATGSTDHIIRVYFFGSGQPek 357
Cdd:COG2319   215 --DG--KLLASGSADGTV--RLWDLAT----GKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATGEL-- 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQGIEDkitkmKVTMVAWDRHDN 437
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AVRSVAFSPDGK 343

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  438 TVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLA 497
Cdd:COG2319   344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-495 7.62e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 7.62e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  175 MHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISD-MAVNYeNTMIAAGSCDKMIRVWC 253
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  254 LRTCAPLAVLQGHSASITSLQFSPlcsgSKRYLSSTGADGTICFWLWDAGTLKINprpakFTERPRPGVqmiCSSFSAGG 333
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTT-----LRGHTDWVN---SVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  334 MFLATGSTDHIIRVYFFGSGQPEKisELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQ 413
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW------------DLSTGKCLG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  414 NLQGIEDkitkmKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIV 493
Cdd:cd00200   214 TLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRI 287


                  ..
gi 767943080  494 WD 495
Cdd:cd00200   288 WD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-392 4.67e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.67e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767943080    356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
215-252 2.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767943080   215 GRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVW 252
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-391 3.64e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  200 TGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCA-PLAVLQGHSASITSLQFSpl 278
Cdd:PLN00181  593 SGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-- 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  279 csgSKRYLSSTGADGTICFWLWDAGTLKINPRPA-KFTERPRPGvQMICSSFSAGgmFLATGSTDHIIRVYFFGSGQP-- 355
Cdd:PLN00181  671 ---DSSTLVSSSTDNTLKLWDLSMSISGINETPLhSFMGHTNVK-NFVGLSVSDG--YIATGSETNEVFVYHKAFPMPvl 744

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767943080  356 -------EKISELEFH--TDKVDSIQFSNTSNRFVSGSRDGTARI 391
Cdd:PLN00181  745 sykfktiDPVSGLEVDdaSQFISSVCWRGQSSTLVAANSTGNIKI 789
PLN03218 PLN03218
maturation of RBCL 1; Provisional
 659-837 6.23e-03

maturation of RBCL 1; Provisional


Pssm-ID: 215636 [Multi-domain]  Cd Length: 1060  Bit Score: 40.63  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  659 SGEAVISNTSRLSRGSISSTSEVHsPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEE 738
Cdd:PLN03218   22 STIPPILPASTLRRDFLGCSHNLR-PPNSASRLRGGKSKSIRSRIRSPRLVVNASLGSGLVLVVVAVTAFSAISFAYLQH 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  739 WRTAKGEEEIKTyrseekrkhltvPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSS 818
Cdd:PLN03218  101 TRRRKSSPLVAT------------PSGGGISTLNREDVQSLDGDVHKGTSTEINVGFRDLVEEVEHTEEEKTHQAQERAL 168

                         170
                  ....*....|....*....
gi 767943080  819 SDEGEVVAVSGGTSEEEER 837
Cdd:PLN03218  169 MEEESVVVEGSESSRESVR 187
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
118-497 2.60e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.95  E-value: 2.60e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  118 VVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVyqhmkmHKRILGHLSSVYCVTFDRTGRR 197
Cdd:COG2319    61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  198 IFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSP 277
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  278 lcSGskRYLSSTGADGTIcfWLWDAGTlkinPRPAKFTERPRPGVQMIcsSFSAGGMFLATGSTDHIIRVYFFGSGQPek 357
Cdd:COG2319   215 --DG--KLLASGSADGTV--RLWDLAT----GKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATGEL-- 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  358 ISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQGIEDkitkmKVTMVAWDRHDN 437
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AVRSVAFSPDGK 343

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  438 TVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLA 497
Cdd:COG2319   344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
180-530 8.19e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 215.93  E-value: 8.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  180 LGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAP 259
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  260 LAVLQGHSASITSLQFSPlcSGskRYLSSTGADGTIcfWLWDAGTLKinpRPAKFTERPRPgvqmICS-SFSAGGMFLAT 338
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSP--DG--KLLASGSDDGTV--RLWDLATGK---LLRTLTGHTGA----VRSvAFSPDGKLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  339 GSTDHIIRVYFFGSGQPekISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQGI 418
Cdd:COG2319   222 GSADGTVRLWDLATGKL--LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW------------DLATGELLRTLTGH 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  419 EDKITKmkvtmVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLAR 498
Cdd:COG2319   288 SGGVNS-----VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                         330       340       350
                  ....*....|....*....|....*....|...
gi 767943080  499 GVKIRSYfnmiegQGH-GAVFDCKCSPDGQHFA 530
Cdd:COG2319   362 GELLRTL------TGHtGAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-495 7.62e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 7.62e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  175 MHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISD-MAVNYeNTMIAAGSCDKMIRVWC 253
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  254 LRTCAPLAVLQGHSASITSLQFSPlcsgSKRYLSSTGADGTICFWLWDAGTLKINprpakFTERPRPGVqmiCSSFSAGG 333
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTT-----LRGHTDWVN---SVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  334 MFLATGSTDHIIRVYFFGSGQPEKisELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQ 413
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW------------DLSTGKCLG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  414 NLQGIEDkitkmKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIV 493
Cdd:cd00200   214 TLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRI 287


                  ..
gi 767943080  494 WD 495
Cdd:cd00200   288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
178-530 5.41e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 5.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  178 RILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTC 257
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  258 APLAVLQGHSASITSLQFSPlcSGskRYLSSTGADGTIcfWLWDAGTlkinPRPAKFTERPRPGVQmiCSSFSAGGMFLA 337
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSP--DG--KTLASGSADGTV--RLWDLAT----GKLLRTLTGHSGAVT--SVAFSPDGKLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  338 TGSTDHIIRVYFFGSGQPekISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQG 417
Cdd:COG2319   179 SGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW------------DLATGKLLRTLTG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  418 IEDkitkmKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLA 497
Cdd:COG2319   245 HSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLA 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 767943080  498 RGVKIRSYfnmiegQGH-GAVFDCKCSPDGQHFA 530
Cdd:COG2319   319 TGKLLRTL------TGHtGAVRSVAFSPDGKTLA 346
WD40 COG2319
WD40 repeat [General function prediction only];
191-541 2.95e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.77  E-value: 2.95e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  191 FDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASI 270
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  271 TSLQFSPLcsgsKRYLSSTGADGTIcfWLWDAGTLKINPRPAKFTERPRpGVqmicsSFSAGGMFLATGSTDHIIRVYFF 350
Cdd:COG2319    82 LSVAFSPD----GRLLASASADGTV--RLWDLATGLLLRTLTGHTGAVR-SV-----AFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  351 GSGQPekISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWqfkrrewksillDMATRPAGQNLQGIEDkitkmKVTMV 430
Cdd:COG2319   150 ATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AVRSV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  431 AWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLARGVKIRSYfnmie 510
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL----- 284

                         330       340       350
                  ....*....|....*....|....*....|..
gi 767943080  511 gQGH-GAVFDCKCSPDGQHFACTDSHGHLLIF 541
Cdd:COG2319   285 -TGHsGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-393 6.13e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 6.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  174 KMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWC 253
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  254 LRTCAPLAVLQGHSASITSLQFSPlcSGSKryLSSTGADGTIcfWLWDA------GTLKINPRPakfterprpgvqmICS 327
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSP--DGEK--LLSSSSDGTI--KLWDLstgkclGTLRGHENG-------------VNS 224

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943080  328 -SFSAGGMFLATGSTDHIIRVYFFGSGQPekISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQ 393
Cdd:cd00200   225 vAFSPDGYLLASGSEDGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-532 6.07e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 6.07e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943080  458 LIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWDLARGVKIRSYfnmiegQGH-GAVFDCKCSPDGQHFACT 532
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTL------KGHtGPVRDVAASADGTYLASG 69
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-392 4.67e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.67e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767943080    356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
215-252 2.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767943080   215 GRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVW 252
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-298 3.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767943080    256 TCAPLAVLQGHSASITSLQFSPlcsgSKRYLSSTGADGTICFW 298
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP----DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-210 3.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.63e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767943080    173 MKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIW 210
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 214-252 3.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.81e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767943080    214 DGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVW 252
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
177-210 4.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.99e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767943080   177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIW 210
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-495 7.08e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 7.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767943080    455 TGQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWD 495
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
356-392 7.69e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 7.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767943080   356 EKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
259-298 1.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 1.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767943080   259 PLAVLQGHSASITSLQFSPlcsgSKRYLSSTGADGTICFW 298
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP----DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
456-495 7.80e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 7.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767943080   456 GQLIHVLMGHEDEVFVLEPHPfDPRVLFSAGHDGNVIVWD 495
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-391 3.64e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  200 TGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCA-PLAVLQGHSASITSLQFSpl 278
Cdd:PLN00181  593 SGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-- 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  279 csgSKRYLSSTGADGTICFWLWDAGTLKINPRPA-KFTERPRPGvQMICSSFSAGgmFLATGSTDHIIRVYFFGSGQP-- 355
Cdd:PLN00181  671 ---DSSTLVSSSTDNTLKLWDLSMSISGINETPLhSFMGHTNVK-NFVGLSVSDG--YIATGSETNEVFVYHKAFPMPvl 744

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767943080  356 -------EKISELEFH--TDKVDSIQFSNTSNRFVSGSRDGTARI 391
Cdd:PLN00181  745 sykfktiDPVSGLEVDdaSQFISSVCWRGQSSTLVAANSTGNIKI 789
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 423-502 6.67e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.54  E-value: 6.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  423 TKMKVTMVAWDRHDNTVITAVN-NMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVK 501
Cdd:PLN00181  531 SRSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS 610


                  .
gi 767943080  502 I 502
Cdd:PLN00181  611 I 611
WD40 COG2319
WD40 repeat [General function prediction only];
177-214 1.30e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767943080  177 KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDD 214
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 221-298 2.65e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.47  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  221 LRGHAAEISDMAVN-YENTMIAAGSCDKMIRVWCLR--------TCAPLAVLQGHSASITSLQFSPLcsgSKRYLSSTGA 291
Cdd:PTZ00420   70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesvkeIKDPQCILKGHKKKISIIDWNPM---NYYIMCSSGF 146


                  ....*..
gi 767943080  292 DGTICFW 298
Cdd:PTZ00420  147 DSFVNIW 153
PTZ00421 PTZ00421
coronin; Provisional
 430-500 5.93e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  430 VAWDRHDNT-VITAVNNMTLKVWN--------SYTGQLIHvLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGV 500
Cdd:PTZ00421   81 VAFNPFDPQkLFTASEDGTIMGWGipeegltqNISDPIVH-LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159
PLN03218 PLN03218
maturation of RBCL 1; Provisional
 659-837 6.23e-03

maturation of RBCL 1; Provisional


Pssm-ID: 215636 [Multi-domain]  Cd Length: 1060  Bit Score: 40.63  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  659 SGEAVISNTSRLSRGSISSTSEVHsPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEE 738
Cdd:PLN03218   22 STIPPILPASTLRRDFLGCSHNLR-PPNSASRLRGGKSKSIRSRIRSPRLVVNASLGSGLVLVVVAVTAFSAISFAYLQH 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943080  739 WRTAKGEEEIKTyrseekrkhltvPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSS 818
Cdd:PLN03218  101 TRRRKSSPLVAT------------PSGGGISTLNREDVQSLDGDVHKGTSTEINVGFRDLVEEVEHTEEEKTHQAQERAL 168

                         170
                  ....*....|....*....
gi 767943080  819 SDEGEVVAVSGGTSEEEER 837
Cdd:PLN03218  169 MEEESVVVEGSESSRESVR 187
PTZ00421 PTZ00421
coronin; Provisional
 461-514 8.01e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 8.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767943080  461 VLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDL-ARGVKIRSYFNMIEGQGH 514
Cdd:PTZ00421   70 ILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGLTQNISDPIVHLQGH 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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