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Conserved domains on  [gi|767950192|ref|XP_011533072|]
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rho guanine nucleotide exchange factor 10 isoform X13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40_2 super family cl41045
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
862-1133 5.63e-167

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


The actual alignment was detected with superfamily member pfam19056:

Pssm-ID: 465964  Cd Length: 487  Bit Score: 502.63  E-value: 5.63e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   862 VMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSC-THQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVP 940
Cdd:pfam19056    1 VFMSKQQEFKLECALHNPEPSALLGFSADSTSLPQGYLWVGSCgTSQMGQIEIFSLNRSSPRVVKSFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   941 vEEKRREPGAPPDPETPAVRASdvPTICVGTEEGSISIYKSSQGSKKVRLQHFfTPEKSTVMSLACTSQSLYAGLVNGAV 1020
Cdd:pfam19056   81 -EEPEPEEEEAVRAERTAKKPG--PTICLGLEDGSISVYGSVDTAKKCLLQHF-TPERSPVLCLKHSPQFLFAGLVNGKV 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  1021 ASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWI 1100
Cdd:pfam19056  157 AVYARAEDGLWDPEPPKLVKLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGGGVWM 236
                          250       260       270
                   ....*....|....*....|....*....|...
gi 767950192  1101 AFTSGSTLRLFHTETLKHLQDINIATPVHNMLP 1133
Cdd:pfam19056  237 AFSSGSSIRLFHTETLEHLQDINIATRVHFMLP 269
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
605-754 4.48e-71

PH domain; This entry contains a PH domain found in RhoGEF proteins.


:

Pssm-ID: 465965  Cd Length: 151  Bit Score: 233.50  E-value: 4.48e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   605 YLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR-VMSSQRYLLKWSVPLGHVDA 683
Cdd:pfam19057    1 FSNKLLSSGQRYLIRQDDVVETVYNERGEVLKSKERRLFLLNDLLVCVTVNSKSGSDFGsLPGGEKYKLKWSVPLSDVEV 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767950192   684 IEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQ 754
Cdd:pfam19057   81 VESGQSPNTSNASSLNAGGSAKRLKSVVNAKPSKVDMGPPHLYQELNDLLHDLEVVGQISKLVGTLKGTYQ 151
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
398-582 1.50e-49

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


:

Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 173.64  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  398 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKvLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWD-SVEMIGD 476
Cdd:cd00160     1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLP-LSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  477 VFVASFSKsmvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKqEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKN 556
Cdd:cd00160    80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLE-KAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                         170       180
                  ....*....|....*....|....*.
gi 767950192  557 TSKGHPDRLPLQMALTELETLAEKLN 582
Cdd:cd00160   156 TPDGHEDREDLKKALEAIKEVASQVN 181
PTZ00441 super family cl25523
sporozoite surface protein 2 (SSP2); Provisional
3-250 7.06e-03

sporozoite surface protein 2 (SSP2); Provisional


The actual alignment was detected with superfamily member PTZ00441:

Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.33  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    3 QREPLP-PAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADrQAPSAPETGGAGASeapaPTGGEDGAGAETTPVAEPT 81
Cdd:PTZ00441  285 EPEPLPvPAPVPPTPEDDNPRPTDDEFAVPNFNEGLDVPDNP-QDPVPPPNEGKDGN----PNEENLFPPGDDEVPDESN 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   82 KLVLPMKV--NPYSVIDITPFQEDQPPTPVPSAEEENvglhvpcgylVPVPCGYAVPSNLPLllpaysSPVIICATSLDe 159
Cdd:PTZ00441  360 VPPNPPNVpgGSNSEFSSDVENPPNPPNPDIPEQEPN----------IPEDSNKEVPEDVPM------EPEDDRDNNFN- 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  160 EAETPEVTEDRQPNSLS--------SEEPPTSEDQVGREDSALARWAADPANTawmenpeeAIYDDVPRENSDSePDEMI 231
Cdd:PTZ00441  423 EPKKPENKGDGQNEPVIpkpldnerDQSNKNKQVNPGNRHNSEDRYTRPHGRN--------NENRNYNNKNSDI-PKHPE 493
                         250
                  ....*....|....*....
gi 767950192  232 YDDVENGDEGGNSSLEYGW 250
Cdd:PTZ00441  494 RSEHEQPEDKKKKSSNNGY 512
 
Name Accession Description Interval E-value
WD40_2 pfam19056
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
862-1133 5.63e-167

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


Pssm-ID: 465964  Cd Length: 487  Bit Score: 502.63  E-value: 5.63e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   862 VMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSC-THQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVP 940
Cdd:pfam19056    1 VFMSKQQEFKLECALHNPEPSALLGFSADSTSLPQGYLWVGSCgTSQMGQIEIFSLNRSSPRVVKSFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   941 vEEKRREPGAPPDPETPAVRASdvPTICVGTEEGSISIYKSSQGSKKVRLQHFfTPEKSTVMSLACTSQSLYAGLVNGAV 1020
Cdd:pfam19056   81 -EEPEPEEEEAVRAERTAKKPG--PTICLGLEDGSISVYGSVDTAKKCLLQHF-TPERSPVLCLKHSPQFLFAGLVNGKV 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  1021 ASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWI 1100
Cdd:pfam19056  157 AVYARAEDGLWDPEPPKLVKLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGGGVWM 236
                          250       260       270
                   ....*....|....*....|....*....|...
gi 767950192  1101 AFTSGSTLRLFHTETLKHLQDINIATPVHNMLP 1133
Cdd:pfam19056  237 AFSSGSSIRLFHTETLEHLQDINIATRVHFMLP 269
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
605-754 4.48e-71

PH domain; This entry contains a PH domain found in RhoGEF proteins.


Pssm-ID: 465965  Cd Length: 151  Bit Score: 233.50  E-value: 4.48e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   605 YLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR-VMSSQRYLLKWSVPLGHVDA 683
Cdd:pfam19057    1 FSNKLLSSGQRYLIRQDDVVETVYNERGEVLKSKERRLFLLNDLLVCVTVNSKSGSDFGsLPGGEKYKLKWSVPLSDVEV 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767950192   684 IEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQ 754
Cdd:pfam19057   81 VESGQSPNTSNASSLNAGGSAKRLKSVVNAKPSKVDMGPPHLYQELNDLLHDLEVVGQISKLVGTLKGTYQ 151
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
398-582 1.50e-49

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 173.64  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  398 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKvLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWD-SVEMIGD 476
Cdd:cd00160     1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLP-LSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  477 VFVASFSKsmvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKqEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKN 556
Cdd:cd00160    80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLE-KAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                         170       180
                  ....*....|....*....|....*.
gi 767950192  557 TSKGHPDRLPLQMALTELETLAEKLN 582
Cdd:cd00160   156 TPDGHEDREDLKKALEAIKEVASQVN 181
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
401-583 3.85e-46

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 163.63  E-value: 3.85e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    401 ILGSVVDSEKNYVDALKRILEQYEKPLSEMEpKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWD-SVEMIGDVFV 479
Cdd:smart00325    1 VLKELLQTERNYVRDLKLLVEVFLKPLKKEL-KLLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDdSVERIGDVFL 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    480 ASfskSMVLDAYSEYVNNFSTAVAVLKKtCATKPAFLEFLKqEQEASP--DRTTLYSLMMKPIQRFPQFILLLQDMLKNT 557
Cdd:smart00325   80 KL---EEFFKIYSEYCSNHPDALELLKK-LKKNPRFQKFLK-EIESSPqcRRLTLESLLLKPVQRLTKYPLLLKELLKHT 154
                           170       180
                    ....*....|....*....|....*.
gi 767950192    558 SKGHPDRLPLQMALTELETLAEKLNE 583
Cdd:smart00325  155 PEDHEDREDLKKALKAIKELANQVNE 180
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
405-582 2.38e-42

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 152.84  E-value: 2.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   405 VVDSEKNYVDALKRILEQYEKPlsEMEPKVLSERKLKTVFYRVKEILQCHSlfQIALASRVSEWDSVEMIGDVFVASFSK 484
Cdd:pfam00621    5 LLQTERSYVRDLEILVEVFLPP--NSKPLSESEEEIKTIFSNIEEIYELHR--QLLLEELLKEWISIQRIGDIFLKFAPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   485 smvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLkQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHP 562
Cdd:pfam00621   81 ---FKVYSTYCSNYPKALKLLKKLLKKNPKFRAFL-EELEANPEcrGLDLNSFLIKPVQRIPRYPLLLKELLKHTPPDHP 156
                          170       180
                   ....*....|....*....|
gi 767950192   563 DRLPLQMALTELETLAEKLN 582
Cdd:pfam00621  157 DYEDLKKALEAIKEVAKQIN 176
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
366-605 1.28e-12

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 72.62  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  366 EEEQNLFIdvdckhpEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMepKVLSERK----LK 441
Cdd:COG5422   460 DEEKNLWT-------LSVPKEVWESLPKQEIKRQEAIYEVIYTERDFVKDLEYLRDTWIKPLEES--NIIPENArrnfIK 530
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  442 TVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKsmvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQ 521
Cdd:COG5422   531 HVFANINEIYAVNSKLLKALTNRQCLSPIVNGIADIFLDYVPK---FEPFIKYGASQPYAKYEFEREKSVNPNFARFDHE 607
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  522 -EQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKA 600
Cdd:COG5422   608 vERLDESRKLELDGYLTKPTTRLARYPLLLEEVLKFTDPDNPDTEDIPKVIDMLREFLSRLNFESGKAENRGDLFHLNQQ 687

                  ....*...
gi 767950192  601 I---NERY 605
Cdd:COG5422   688 LlfkPEYV 695
PH_BCR-related cd01228
Breakpoint Cluster Region-related pleckstrin homology (PH) domain; The BCR gene is one of the ...
615-679 2.56e-03

Breakpoint Cluster Region-related pleckstrin homology (PH) domain; The BCR gene is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 22 and 9. BCR is a GTPase-activating protein (GAP) for RAC1 (primarily) and CDC42. The Dbl region of BCR has the most RhoGEF activity for Cdc42, and less activity towards Rac and Rho. Since BCR possesses both GAP and GEF activities, it may function to temporally regulate the activity of these GTPases. It also displays serine/threonine kinase activity. The BCR protein contains multiple domains including an N-terminal kinase domain, a RhoGEF domain, a PH domain, a C1 domain, a C2 domain, and a C-terminal RhoGAP domain. ABR, a related smaller protein, is structurally similar to BCR, but lacks the N-terminal kinase domain and has GAP activity for both Rac and Cdc42. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269935  Cd Length: 166  Bit Score: 40.02  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767950192  615 RYLIRSDDMIETVYNDRgeivktKERRVFMLNDVLMCATVSSrpshdSRVMSSQRYLLKWSVPLG 679
Cdd:cd01228     1 RQLVKDGFLVELSEGSR------KLRHLFLFTDVLLCAKLKS-----AGRGFQGQYECKWYIPLR 54
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
3-250 7.06e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.33  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    3 QREPLP-PAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADrQAPSAPETGGAGASeapaPTGGEDGAGAETTPVAEPT 81
Cdd:PTZ00441  285 EPEPLPvPAPVPPTPEDDNPRPTDDEFAVPNFNEGLDVPDNP-QDPVPPPNEGKDGN----PNEENLFPPGDDEVPDESN 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   82 KLVLPMKV--NPYSVIDITPFQEDQPPTPVPSAEEENvglhvpcgylVPVPCGYAVPSNLPLllpaysSPVIICATSLDe 159
Cdd:PTZ00441  360 VPPNPPNVpgGSNSEFSSDVENPPNPPNPDIPEQEPN----------IPEDSNKEVPEDVPM------EPEDDRDNNFN- 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  160 EAETPEVTEDRQPNSLS--------SEEPPTSEDQVGREDSALARWAADPANTawmenpeeAIYDDVPRENSDSePDEMI 231
Cdd:PTZ00441  423 EPKKPENKGDGQNEPVIpkpldnerDQSNKNKQVNPGNRHNSEDRYTRPHGRN--------NENRNYNNKNSDI-PKHPE 493
                         250
                  ....*....|....*....
gi 767950192  232 YDDVENGDEGGNSSLEYGW 250
Cdd:PTZ00441  494 RSEHEQPEDKKKKSSNNGY 512
 
Name Accession Description Interval E-value
WD40_2 pfam19056
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
862-1133 5.63e-167

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


Pssm-ID: 465964  Cd Length: 487  Bit Score: 502.63  E-value: 5.63e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   862 VMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSC-THQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVP 940
Cdd:pfam19056    1 VFMSKQQEFKLECALHNPEPSALLGFSADSTSLPQGYLWVGSCgTSQMGQIEIFSLNRSSPRVVKSFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   941 vEEKRREPGAPPDPETPAVRASdvPTICVGTEEGSISIYKSSQGSKKVRLQHFfTPEKSTVMSLACTSQSLYAGLVNGAV 1020
Cdd:pfam19056   81 -EEPEPEEEEAVRAERTAKKPG--PTICLGLEDGSISVYGSVDTAKKCLLQHF-TPERSPVLCLKHSPQFLFAGLVNGKV 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  1021 ASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWI 1100
Cdd:pfam19056  157 AVYARAEDGLWDPEPPKLVKLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGGGVWM 236
                          250       260       270
                   ....*....|....*....|....*....|...
gi 767950192  1101 AFTSGSTLRLFHTETLKHLQDINIATPVHNMLP 1133
Cdd:pfam19056  237 AFSSGSSIRLFHTETLEHLQDINIATRVHFMLP 269
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
605-754 4.48e-71

PH domain; This entry contains a PH domain found in RhoGEF proteins.


Pssm-ID: 465965  Cd Length: 151  Bit Score: 233.50  E-value: 4.48e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   605 YLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR-VMSSQRYLLKWSVPLGHVDA 683
Cdd:pfam19057    1 FSNKLLSSGQRYLIRQDDVVETVYNERGEVLKSKERRLFLLNDLLVCVTVNSKSGSDFGsLPGGEKYKLKWSVPLSDVEV 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767950192   684 IEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQ 754
Cdd:pfam19057   81 VESGQSPNTSNASSLNAGGSAKRLKSVVNAKPSKVDMGPPHLYQELNDLLHDLEVVGQISKLVGTLKGTYQ 151
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
398-582 1.50e-49

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 173.64  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  398 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKvLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWD-SVEMIGD 476
Cdd:cd00160     1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLP-LSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  477 VFVASFSKsmvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKqEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKN 556
Cdd:cd00160    80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLE-KAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                         170       180
                  ....*....|....*....|....*.
gi 767950192  557 TSKGHPDRLPLQMALTELETLAEKLN 582
Cdd:cd00160   156 TPDGHEDREDLKKALEAIKEVASQVN 181
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
401-583 3.85e-46

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 163.63  E-value: 3.85e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    401 ILGSVVDSEKNYVDALKRILEQYEKPLSEMEpKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWD-SVEMIGDVFV 479
Cdd:smart00325    1 VLKELLQTERNYVRDLKLLVEVFLKPLKKEL-KLLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDdSVERIGDVFL 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    480 ASfskSMVLDAYSEYVNNFSTAVAVLKKtCATKPAFLEFLKqEQEASP--DRTTLYSLMMKPIQRFPQFILLLQDMLKNT 557
Cdd:smart00325   80 KL---EEFFKIYSEYCSNHPDALELLKK-LKKNPRFQKFLK-EIESSPqcRRLTLESLLLKPVQRLTKYPLLLKELLKHT 154
                           170       180
                    ....*....|....*....|....*.
gi 767950192    558 SKGHPDRLPLQMALTELETLAEKLNE 583
Cdd:smart00325  155 PEDHEDREDLKKALKAIKELANQVNE 180
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
405-582 2.38e-42

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 152.84  E-value: 2.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   405 VVDSEKNYVDALKRILEQYEKPlsEMEPKVLSERKLKTVFYRVKEILQCHSlfQIALASRVSEWDSVEMIGDVFVASFSK 484
Cdd:pfam00621    5 LLQTERSYVRDLEILVEVFLPP--NSKPLSESEEEIKTIFSNIEEIYELHR--QLLLEELLKEWISIQRIGDIFLKFAPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   485 smvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLkQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHP 562
Cdd:pfam00621   81 ---FKVYSTYCSNYPKALKLLKKLLKKNPKFRAFL-EELEANPEcrGLDLNSFLIKPVQRIPRYPLLLKELLKHTPPDHP 156
                          170       180
                   ....*....|....*....|
gi 767950192   563 DRLPLQMALTELETLAEKLN 582
Cdd:pfam00621  157 DYEDLKKALEAIKEVAKQIN 176
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
366-605 1.28e-12

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 72.62  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  366 EEEQNLFIdvdckhpEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMepKVLSERK----LK 441
Cdd:COG5422   460 DEEKNLWT-------LSVPKEVWESLPKQEIKRQEAIYEVIYTERDFVKDLEYLRDTWIKPLEES--NIIPENArrnfIK 530
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  442 TVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKsmvLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQ 521
Cdd:COG5422   531 HVFANINEIYAVNSKLLKALTNRQCLSPIVNGIADIFLDYVPK---FEPFIKYGASQPYAKYEFEREKSVNPNFARFDHE 607
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  522 -EQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKA 600
Cdd:COG5422   608 vERLDESRKLELDGYLTKPTTRLARYPLLLEEVLKFTDPDNPDTEDIPKVIDMLREFLSRLNFESGKAENRGDLFHLNQQ 687

                  ....*...
gi 767950192  601 I---NERY 605
Cdd:COG5422   688 LlfkPEYV 695
PH_BCR-related cd01228
Breakpoint Cluster Region-related pleckstrin homology (PH) domain; The BCR gene is one of the ...
615-679 2.56e-03

Breakpoint Cluster Region-related pleckstrin homology (PH) domain; The BCR gene is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 22 and 9. BCR is a GTPase-activating protein (GAP) for RAC1 (primarily) and CDC42. The Dbl region of BCR has the most RhoGEF activity for Cdc42, and less activity towards Rac and Rho. Since BCR possesses both GAP and GEF activities, it may function to temporally regulate the activity of these GTPases. It also displays serine/threonine kinase activity. The BCR protein contains multiple domains including an N-terminal kinase domain, a RhoGEF domain, a PH domain, a C1 domain, a C2 domain, and a C-terminal RhoGAP domain. ABR, a related smaller protein, is structurally similar to BCR, but lacks the N-terminal kinase domain and has GAP activity for both Rac and Cdc42. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269935  Cd Length: 166  Bit Score: 40.02  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767950192  615 RYLIRSDDMIETVYNDRgeivktKERRVFMLNDVLMCATVSSrpshdSRVMSSQRYLLKWSVPLG 679
Cdd:cd01228     1 RQLVKDGFLVELSEGSR------KLRHLFLFTDVLLCAKLKS-----AGRGFQGQYECKWYIPLR 54
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
3-250 7.06e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.33  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192    3 QREPLP-PAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADrQAPSAPETGGAGASeapaPTGGEDGAGAETTPVAEPT 81
Cdd:PTZ00441  285 EPEPLPvPAPVPPTPEDDNPRPTDDEFAVPNFNEGLDVPDNP-QDPVPPPNEGKDGN----PNEENLFPPGDDEVPDESN 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192   82 KLVLPMKV--NPYSVIDITPFQEDQPPTPVPSAEEENvglhvpcgylVPVPCGYAVPSNLPLllpaysSPVIICATSLDe 159
Cdd:PTZ00441  360 VPPNPPNVpgGSNSEFSSDVENPPNPPNPDIPEQEPN----------IPEDSNKEVPEDVPM------EPEDDRDNNFN- 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950192  160 EAETPEVTEDRQPNSLS--------SEEPPTSEDQVGREDSALARWAADPANTawmenpeeAIYDDVPRENSDSePDEMI 231
Cdd:PTZ00441  423 EPKKPENKGDGQNEPVIpkpldnerDQSNKNKQVNPGNRHNSEDRYTRPHGRN--------NENRNYNNKNSDI-PKHPE 493
                         250
                  ....*....|....*....
gi 767950192  232 YDDVENGDEGGNSSLEYGW 250
Cdd:PTZ00441  494 RSEHEQPEDKKKKSSNNGY 512
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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