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Conserved domains on  [gi|767914836|ref|XP_011531260|]
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tetratricopeptide repeat protein 27 isoform X1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
474-641 1.76e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 82.75  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 474 ICYERAGQHGKAEEILRQELE-KKETPSLYCLLGDV---LGDH----SCYDKAWELSRyRSARAQRSKALLHLRNKEFQE 545
Cdd:COG0457   16 LAYRRLGRYEEAIEDYEKALElDPDDAEALYNLGLAylrLGRYeealADYEQALELDP-DDAEALNNLGLALQALGRYEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 546 CVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG0457   95 ALEDYDKALELDP-DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                        170
                 ....*....|....*.
gi 767914836 626 RDKYKDVQVLKILVRA 641
Cdd:COG0457  174 ALAALLAAALGEAALA 189
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
474-641 1.76e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 82.75  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 474 ICYERAGQHGKAEEILRQELE-KKETPSLYCLLGDV---LGDH----SCYDKAWELSRyRSARAQRSKALLHLRNKEFQE 545
Cdd:COG0457   16 LAYRRLGRYEEAIEDYEKALElDPDDAEALYNLGLAylrLGRYeealADYEQALELDP-DDAEALNNLGLALQALGRYEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 546 CVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG0457   95 ALEDYDKALELDP-DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                        170
                 ....*....|....*.
gi 767914836 626 RDKYKDVQVLKILVRA 641
Cdd:COG0457  174 ALAALLAAALGEAALA 189
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 437-622 9.04e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 9.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836  437 PPHWAIQRQLASLLFELGCTSSALQIFEK--------LEMWEDVVICYERAGQHGKAEEILRQELE-KKETPSLYCLLGd 507
Cdd:TIGR02917 530 PKNLRAILALAGLYLRTGNEEEAVAWLEKaaelnpqeIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPEAWLMLG- 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836  508 vlgdhscydkawelsryrsaRAQrskallhLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQE 587
Cdd:TIGR02917 609 --------------------RAQ-------LAAGDLNKAVSSFKKLLALQP-DSALALLLLADAYAVMKNYAKAITSLKR 660

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767914836  588 ALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRL 622
Cdd:TIGR02917 661 ALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSL 695
TPR_1 pfam00515
Tetratricopeptide repeat;
527-558 8.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 8.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914836  527 ARAQRSKALLHLRNKEFQECVECFERSVKINP 558
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNP 32
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
474-641 1.76e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 82.75  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 474 ICYERAGQHGKAEEILRQELE-KKETPSLYCLLGDV---LGDH----SCYDKAWELSRyRSARAQRSKALLHLRNKEFQE 545
Cdd:COG0457   16 LAYRRLGRYEEAIEDYEKALElDPDDAEALYNLGLAylrLGRYeealADYEQALELDP-DDAEALNNLGLALQALGRYEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 546 CVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG0457   95 ALEDYDKALELDP-DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                        170
                 ....*....|....*.
gi 767914836 626 RDKYKDVQVLKILVRA 641
Cdd:COG0457  174 ALAALLAAALGEAALA 189
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
502-629 5.73e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.43  E-value: 5.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 502 YCLLGDV---LGDH----SCYDKAWELSRyRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIR 574
Cdd:COG0457   11 YNNLGLAyrrLGRYeeaiEDYEKALELDP-DDAEALYNLGLAYLRLGRYEEALADYEQALELDP-DDAEALNNLGLALQA 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767914836 575 LKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKY 629
Cdd:COG0457   89 LGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDD 143
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
446-641 2.33e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 446 LASLLFELGCTSSALQIFEK-LEMWEDVV-------ICYERAGQHGKAEEILRQELEKK-ETPSLYCLLGDV---LGDHS 513
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKaLELDPDDAealynlgLAYLRLGRYEEALADYEQALELDpDDAEALNNLGLAlqaLGRYE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 514 ----CYDKAWELsRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEAL 589
Cdd:COG0457   94 ealeDYDKALEL-DPDDAEALYNLGLALLELGRYDEAIEAYERALELDP-DDADALYNLGIALEKLGRYEEALELLEKLE 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767914836 590 KCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQVLKILVRA 641
Cdd:COG0457  172 AAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELL 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
527-629 1.32e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 527 ARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTS 606
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDP-DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|...
gi 767914836 607 TDVGEFSEAIKAYHRLLDLRDKY 629
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDD 109
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 526-636 2.05e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 2.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 526 SARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILT 605
Cdd:COG4235   16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDP-DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLA 94

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767914836 606 STDVGEFSEAIKAYHRLLDLRDKYKDVQVLK 636
Cdd:COG4235   95 AFQQGDYAEAIAAWQKLLALLPADAPARLLE 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 518-626 4.54e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 4.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 518 AWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQ 597
Cdd:COG3914   69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNP-DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAE 147

                         90       100
                 ....*....|....*....|....*....
gi 767914836 598 IWENYILTSTDVGEFSEAIKAYHRLLDLR 626
Cdd:COG3914  148 AYLNLGEALRRLGRLEEAIAALRRALELD 176
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
536-628 6.80e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.41  E-value: 6.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 536 LHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAfRTLQEALKCNYEHWQIWENYILTSTDVGEFSEA 615
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDP-DNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEA 78

                         90
                 ....*....|...
gi 767914836 616 IKAYHRLLDLRDK 628
Cdd:COG3063   79 LAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 474-625 1.02e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.21  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 474 ICYERAGQHGKAEEILRQELEKKET-PSLYCLLGDVLgdhscydkawelsryrsaraqrskallhLRNKEFQECVECFER 552
Cdd:COG4783   12 QALLLAGDYDEAEALLEKALELDPDnPEAFALLGEIL----------------------------LQLGDLDEAIVLLHE 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767914836 553 SVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG4783   64 ALELDP-DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 437-625 1.29e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 437 PPHWAIQRQLASLLFELGCTSSALQIFEKL--------EMWEDVVICYERAGQHGKAEEILRQELEKKET-PSLYCLLGD 507
Cdd:COG2956   39 PETVEAHLALGNLYRRRGEYDRAIRIHQKLlerdpdraEALLELAQDYLKAGLLDRAEELLEKLLELDPDdAEALRLLAE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 508 VLGDHSCYDKAWE-LSRYR-----SARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKA 581
Cdd:COG2956  119 IYEQEGDWEKAIEvLERLLklgpeNAHAYCELAELYLEQGDYDEAIEALEKALKLDP-DCARALLLLAELYLEQGDYEEA 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767914836 582 FRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG2956  198 IAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 441-626 2.74e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 2.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 441 AIQRQLASLLFELGCTSSALQIFEKLEMWEDVVICYERAGQHGKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWE 520
Cdd:COG3914   11 ALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 521 LSRYRSARAQRSKAL---------------LHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTL 585
Cdd:COG3914   91 LGRYEEALALYRRALalnpdnaealfnlgnLLLALGRLEEALAALRRALALNP-DFAEAYLNLGEALRRLGRLEEAIAAL 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767914836 586 QEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLR 626
Cdd:COG3914  170 RRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 515-625 2.94e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.59  E-value: 2.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 515 YDKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYE 594
Cdd:COG5010   42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDP-NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD 120

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767914836 595 HWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG5010  121 NPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 525-625 6.10e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.89  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 525 RSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYIL 604
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDP-DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100
                 ....*....|....*....|.
gi 767914836 605 TSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG4783   81 ALLKAGDYDEALALLEKALKL 101
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 476-635 8.53e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 8.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 476 YERAGQHGKAEEILRQELEK-KETPSLYCLLGDVL---GDhscYDKAWE-LSRYRSARAQRSKALLHL-----RNKEFQE 545
Cdd:COG2956   18 YLLNGQPDKAIDLLEEALELdPETVEAHLALGNLYrrrGE---YDRAIRiHQKLLERDPDRAEALLELaqdylKAGLLDR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 546 CVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG2956   95 AEELLEKLLELDP-DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL 173

                        170
                 ....*....|
gi 767914836 626 RDKYKDVQVL 635
Cdd:COG2956  174 DPDCARALLL 183
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 476-638 1.47e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.55  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 476 YERAGQHGKAEEILRQELEKKET-PSLYCLLGDVL---GDH----SCYDKAWELsRYRSARAQRSKALLHLRNKEFQECV 547
Cdd:COG3914   88 LQALGRYEEALALYRRALALNPDnAEALFNLGNLLlalGRLeealAALRRALAL-NPDFAEAYLNLGEALRRLGRLEEAI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 548 ECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRD 627
Cdd:COG3914  167 AALRRALELDP-DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALAR 245

                        170
                 ....*....|.
gi 767914836 628 KYKDVQVLKIL 638
Cdd:COG3914  246 GPSELSPFALL 256
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 533-711 1.94e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.28  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 533 KALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEF 612
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 613 SEAIKAYHRLLDLRDkyKDVQVLKILVRAVIdgmtdRSGDVAtglkgKLQELFGRVTSRVTNDGEIWRLYAHVYgngqsE 692
Cdd:COG2956   93 DRAEELLEKLLELDP--DDAEALRLLAEIYE-----QEGDWE-----KAIEVLERLLKLGPENAHAYCELAELY-----L 155

                        170
                 ....*....|....*....
gi 767914836 693 KPDENEKAFQCLSKAYKCD 711
Cdd:COG2956  156 EQGDYDEAIEALEKALKLD 174
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 485-592 2.70e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 485 AEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSrYRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEA 564
Cdd:COG5010   47 RDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD-PNNPELYYNLALLYSRSGDKDEAKEYYEKALALSP-DNPNA 124

                         90       100
                 ....*....|....*....|....*...
gi 767914836 565 WNNLSTSYIRLKQKVKAFRTLQEALKCN 592
Cdd:COG5010  125 YSNLAALLLSLGQDDEAKAALQRALGTS 152
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 471-590 3.56e-07

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 52.99  E-value: 3.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 471 DVVICY----ERAGQHGKAEEILRQELEKKETPSLYCLLGDVLGDHscYDKA------WELSRYRSARAQRSKALLHLRN 540
Cdd:COG3071  194 ELAAAYaralIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGD--PAKQlkraekWLKKHPNDPDLLLALGRLCLRN 271

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767914836 541 KEFQECVECFERSVKINPmqNAEAWNNLSTSYIRLKQKVKAFRTLQEALK 590
Cdd:COG3071  272 QLWGKAREYLEAALALRP--SAEAYAELARLLEQLGDPEEAAEHYRKALA 319
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
501-597 7.24e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 7.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 501 LYCLLGDVLGDHSCYDKAWELSRyRSARAQRSKALLHLRNKEFQECVEcFERSVKINPmQNAEAWNNLSTSYIRLKQKVK 580
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDP-DNADALNNLGLLLLEQGRYDEAIA-LEKALKLDP-NNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|....*..
gi 767914836 581 AFRTLQEALKCNYEHWQ 597
Cdd:COG3063   78 ALAYLERALELDPSALR 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
554-629 1.05e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 1.05e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767914836 554 VKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKY 629
Cdd:COG0457    1 LELDP-DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 547-625 9.06e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 9.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767914836 547 VECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDL 625
Cdd:COG4235    3 IARLRQALAANP-NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 560-702 2.34e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 560 QNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQVLKILV 639
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767914836 640 RAvidgmtdRSGDVATGLkgklqELFGRVTSRVTNDGEIWRLYAHVYgnGQSEKPDENEKAFQ 702
Cdd:COG4783   82 LL-------KAGDYDEAL-----ALLEKALKLDPEHPEAYLRLARAY--RALGRPDEAIAALE 130
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 437-622 9.04e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 9.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836  437 PPHWAIQRQLASLLFELGCTSSALQIFEK--------LEMWEDVVICYERAGQHGKAEEILRQELE-KKETPSLYCLLGd 507
Cdd:TIGR02917 530 PKNLRAILALAGLYLRTGNEEEAVAWLEKaaelnpqeIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPEAWLMLG- 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836  508 vlgdhscydkawelsryrsaRAQrskallhLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQE 587
Cdd:TIGR02917 609 --------------------RAQ-------LAAGDLNKAVSSFKKLLALQP-DSALALLLLADAYAVMKNYAKAITSLKR 660

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767914836  588 ALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRL 622
Cdd:TIGR02917 661 ALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSL 695
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
516-628 1.22e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 516 DKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPmQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEH 595
Cdd:COG4785   62 RIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDP-DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDY 140

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767914836 596 WQIWENYILTSTDVGEFSEAIKAYHRLLDLRDK 628
Cdd:COG4785  141 AYAYLNRGIALYYLGRYELAIADLEKALELDPN 173
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 443-558 1.50e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 443 QRQLASLLFELGCTSSALQIFEKL--------EMWEDVVICYERAGQHGKAEEILRQELEK-KETPSLYCLLGDVLGDHS 513
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKAleldpdnpEAFALLGEILLQLGDLDEAIVLLHEALELdPDEPEARLNLGLALLKAG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767914836 514 CYDKAWEL------SRYRSARAQRSKALLHLRNKEFQECVECFERSVKINP 558
Cdd:COG4783   87 DYDEALALlekalkLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 466-560 2.02e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914836 466 LEMWEDVVICYERAGQHGKAEEILRQELE-KKETPSLYCLLGDVL---GDH----SCYDKAWELSRyRSARAQRSKALLH 537
Cdd:COG5010   54 FAIESPSDNLYNKLGDFEESLALLEQALQlDPNNPELYYNLALLYsrsGDKdeakEYYEKALALSP-DNPNAYSNLAALL 132

                         90       100
                 ....*....|....*....|...
gi 767914836 538 LRNKEFQECVECFERSVKINPMQ 560
Cdd:COG5010  133 LSLGQDDEAKAALQRALGTSPLK 155
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 559-632 3.50e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 3.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767914836 559 MQNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDV 632
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNA 124
TPR_1 pfam00515
Tetratricopeptide repeat;
527-558 8.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 8.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914836  527 ARAQRSKALLHLRNKEFQECVECFERSVKINP 558
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNP 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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