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Conserved domains on  [gi|768014130|ref|XP_011527612|]
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ral GTPase-activating protein subunit alpha-2 isoform X6 [Homo sapiens]

Protein Classification

GTPase-activating protein( domain architecture ID 10489639)

GTPase-activating protein functions as a GTPase activator for small GTPases, similar to Ral GTPase-activating protein subunit alpha and Rap1 GTPase-activating protein 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1550-1722 1.02e-63

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 214.68  E-value: 1.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1550 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1627
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1628 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1702
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|
gi 768014130  1703 ASRAVkclipLYQSFYEERA 1722
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
 372-496 5.57e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


:

Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.43  E-value: 5.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130   372 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 449
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 768014130   450 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 496
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1550-1722 1.02e-63

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 214.68  E-value: 1.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1550 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1627
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1628 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1702
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|
gi 768014130  1703 ASRAVkclipLYQSFYEERA 1722
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
 372-496 5.57e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.43  E-value: 5.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130   372 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 449
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 768014130   450 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 496
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1550-1722 1.02e-63

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 214.68  E-value: 1.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1550 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1627
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130  1628 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1702
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|
gi 768014130  1703 ASRAVkclipLYQSFYEERA 1722
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
 372-496 5.57e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.43  E-value: 5.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014130   372 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 449
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 768014130   450 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 496
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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