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Conserved domains on  [gi|768004578|ref|XP_011526699|]
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syntaxin-10 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNARE_NTD_STX10 cd21446
N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble ...
 5-107 8.12e-64

N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble NSF attachment protein receptor (SNARE) complex involved in vesicular transport from the late endosomes to the trans-Golgi network, such as the transport of mannose 6-phosphate receptors from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This model corresponds to the N-terminal domain of STX10, which is a regulatory domain named Habc.


:

Pssm-ID: 410572 [Multi-domain]  Cd Length: 103  Bit Score: 189.61  E-value: 8.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21446    1 DPFFVVKGEVQKAVNTARGLYQRWCELLQESVAVSKEELDWTTNELRNSLRSIEWDLEDLEETIGIVESNPRKFKIDPGE 80

                         90       100
                 ....*....|....*....|...
gi 768004578  85 LQERKVFVERMREAVQEMKDHMV 107
Cdd:cd21446   81 LAERRAFVERTRESVKEMKDHMA 103
 
Name Accession Description Interval E-value
SNARE_NTD_STX10 cd21446
N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble ...
 5-107 8.12e-64

N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble NSF attachment protein receptor (SNARE) complex involved in vesicular transport from the late endosomes to the trans-Golgi network, such as the transport of mannose 6-phosphate receptors from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This model corresponds to the N-terminal domain of STX10, which is a regulatory domain named Habc.


Pssm-ID: 410572 [Multi-domain]  Cd Length: 103  Bit Score: 189.61  E-value: 8.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21446    1 DPFFVVKGEVQKAVNTARGLYQRWCELLQESVAVSKEELDWTTNELRNSLRSIEWDLEDLEETIGIVESNPRKFKIDPGE 80

                         90       100
                 ....*....|....*....|...
gi 768004578  85 LQERKVFVERMREAVQEMKDHMV 107
Cdd:cd21446   81 LAERRAFVERTRESVKEMKDHMA 103
Syntaxin-6_N pfam09177
Syntaxin 6, N-terminal; Members of this family, which are found in the amino terminus of ...
 5-103 2.30e-40

Syntaxin 6, N-terminal; Members of this family, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport.


Pssm-ID: 462706 [Multi-domain]  Cd Length: 99  Bit Score: 129.99  E-value: 2.30e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578    5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:pfam09177   1 DPFFEVKEEVQESLDKLESLYRSWLRLLSLTSSSSSPELDELRRELRTALESLEWDLEDLEEAVRIVESNPSKFGLDEAE 80

                          90
                  ....*....|....*....
gi 768004578   85 LQERKVFVERMREAVQEMK 103
Cdd:pfam09177  81 LSRRRQFVEAIRNEISDMK 99
 
Name Accession Description Interval E-value
SNARE_NTD_STX10 cd21446
N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble ...
 5-107 8.12e-64

N-terminal domain of syntaxin-10; Syntaxin-10 (STX10), also called Syn10, is part of a soluble NSF attachment protein receptor (SNARE) complex involved in vesicular transport from the late endosomes to the trans-Golgi network, such as the transport of mannose 6-phosphate receptors from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This model corresponds to the N-terminal domain of STX10, which is a regulatory domain named Habc.


Pssm-ID: 410572 [Multi-domain]  Cd Length: 103  Bit Score: 189.61  E-value: 8.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21446    1 DPFFVVKGEVQKAVNTARGLYQRWCELLQESVAVSKEELDWTTNELRNSLRSIEWDLEDLEETIGIVESNPRKFKIDPGE 80

                         90       100
                 ....*....|....*....|...
gi 768004578  85 LQERKVFVERMREAVQEMKDHMV 107
Cdd:cd21446   81 LAERRAFVERTRESVKEMKDHMA 103
SNARE_NTD_STX6_STX10 cd21443
N-terminal domain of syntaxin-6, syntaxin-10, and similar proteins; This subfamily includes ...
 5-106 3.43e-57

N-terminal domain of syntaxin-6, syntaxin-10, and similar proteins; This subfamily includes two soluble NSF attachment protein receptor (SNARE) proteins, syntaxin-6 (STX6) and syntaxin-10 (STX10). STX6 is involved in intracellular vesicle trafficking. STX10, also called Syn10, is involved in vesicular transport from the late endosomes to the trans-Golgi network. This model corresponds to the N-terminal domain of STX6 and STX10, which is a regulatory domain named Habc.


Pssm-ID: 410569 [Multi-domain]  Cd Length: 103  Bit Score: 172.79  E-value: 3.43e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21443    1 DPFFVVKDEVEKALNKAQELYERWRELQDEDSTSSNEELEWTTNELRNSLRSIEWDLEDLEETIGIVEKNPSKFKLDAEE 80

                         90       100
                 ....*....|....*....|..
gi 768004578  85 LQERKVFVERMREAVQEMKDHM 106
Cdd:cd21443   81 IQARRQFIEETRQEVKEIKDEL 102
SNARE_NTD_STX6 cd21447
N-terminal domain of syntaxin-6; Syntaxin-6 (STX6) is a component of a soluble NSF attachment ...
 5-106 4.40e-52

N-terminal domain of syntaxin-6; Syntaxin-6 (STX6) is a component of a soluble NSF attachment protein receptor (SNARE) complex involved in intracellular vesicle trafficking and in the fusion of retrograde transport carriers with the trans-Golgi network (TGN). This model corresponds to N-terminal domain of STX6, which is a regulatory domain named Habc.


Pssm-ID: 410573 [Multi-domain]  Cd Length: 103  Bit Score: 159.70  E-value: 4.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21447    1 DPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSSATKEEIDWTTNELRNSLRSIEWDLEDLDETISIVEANPRKFNLDPTE 80

                         90       100
                 ....*....|....*....|..
gi 768004578  85 LQERKVFVERMREAVQEMKDHM 106
Cdd:cd21447   81 LSIRKAFITSTRQVVREMKDQM 102
Syntaxin-6_N pfam09177
Syntaxin 6, N-terminal; Members of this family, which are found in the amino terminus of ...
 5-103 2.30e-40

Syntaxin 6, N-terminal; Members of this family, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport.


Pssm-ID: 462706 [Multi-domain]  Cd Length: 99  Bit Score: 129.99  E-value: 2.30e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578    5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:pfam09177   1 DPFFEVKEEVQESLDKLESLYRSWLRLLSLTSSSSSPELDELRRELRTALESLEWDLEDLEEAVRIVESNPSKFGLDEAE 80

                          90
                  ....*....|....*....
gi 768004578   85 LQERKVFVERMREAVQEMK 103
Cdd:pfam09177  81 LSRRRQFVEAIRNEISDMK 99
SNARE_NTD_STX6-like cd21442
N-terminal domain of syntaxin-6 and similar proteins; The family includes soluble NSF ...
 5-106 3.24e-35

N-terminal domain of syntaxin-6 and similar proteins; The family includes soluble NSF attachment protein receptor (SNARE) proteins, syntaxin-6 (STX6) and syntaxin-10 (STX10), and their homologs found in fungi and plants, such as Tlg1p, AtSYP61, and similar proteins. STX6 is involved in intracellular vesicle trafficking. STX10, also called Syn10, is involved in vesicular transport from the late endosomes to the trans-Golgi network. Tlg1p, also called syntaxin TLG1, is a SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. AtSYP61, also called osmotic stress-sensitive mutant 1 (OSM1), is a vesicle trafficking syntaxin protein that functions in the secretory pathway. It is involved in osmotic stress tolerance and in abscisic acid (ABA) regulation of stomatal responses in Arabidopsis.


Pssm-ID: 410568 [Multi-domain]  Cd Length: 103  Bit Score: 117.02  E-value: 3.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21442    1 DPFFEAKEEVQASLDRAESLYRSWLRIRKTAQSGSSEELSDARNELKTTLGTLEWDLEDLEESVRVVEADGKRFGISEDE 80

                         90       100
                 ....*....|....*....|..
gi 768004578  85 LQERKVFVERMREAVQEMKDHM 106
Cdd:cd21442   81 VSRRRQFVRRIRQQIEAMKKDV 102
SNARE_NTD_AtSYP61-like cd21445
N-terminal domain of Arabidopsis thaliana syntaxin-61 and similar proteins; Arabidopsis ...
 5-104 2.02e-16

N-terminal domain of Arabidopsis thaliana syntaxin-61 and similar proteins; Arabidopsis thaliana syntaxin-61 (AtSYP61), also called osmotic stress-sensitive mutant 1 (OSM1), is a vesicle trafficking syntaxin protein that functions in the secretory pathway. It is involved in osmotic stress tolerance and in abscisic acid (ABA) regulation of stomatal responses in Arabidopsis. This model corresponds to the N-terminal domain of AtSYP61, which shows high sequence similarity with the N-terminal domain of yeast Tlg1p, a soluble NSF attachment protein receptor (SNARE) protein (of Qc type) involved in membrane fusion.


Pssm-ID: 410571 [Multi-domain]  Cd Length: 99  Bit Score: 69.20  E-value: 2.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWcELLQESAAvgreELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21445    2 DPFYLVRDEIQESVDKLQQSFRRW-EGLPAGSA----ERARLARELESDCESLEWQVDELDRAVDVAERDPARFGLSAAE 76

                         90       100
                 ....*....|....*....|
gi 768004578  85 LQERKVFVERMREAVQEMKD 104
Cdd:cd21445   77 LESRRRWTSATRDQVSGIKE 96
SNARE_NTD_Tlg1p-like cd21444
N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins; ...
 5-106 6.18e-11

N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins; t-SNARE affecting a late Golgi compartment protein 1 (Tlg1p), also called syntaxin TLG1, is a soluble NSF attachment protein receptor (SNARE) protein (of Qc type) involved in membrane fusion, probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. The model corresponds to the N-terminal domain of Tlg1p, which consists of a three-helix bundle.


Pssm-ID: 410570 [Multi-domain]  Cd Length: 93  Bit Score: 54.89  E-value: 6.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004578   5 DPFFVVRGEVQKAVNTARGLYQRWcellqesaavGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGD 84
Cdd:cd21444    1 DPFNQVQEDAWSQLERLRQLLTSY----------LRIPTNEAKSDFENNIQELEETIEDLKQSVEISEADPERFGLDEEE 70

                         90       100
                 ....*....|....*....|..
gi 768004578  85 LQERKVFVERMREAVQEMKDHM 106
Cdd:cd21444   71 ISERERIVAELESQLDDLKEEW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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