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Conserved domains on  [gi|767948580|ref|XP_011514821|]
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solute carrier family 13 member 1 isoform X7 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 41-154 1.73e-27

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member cd01115:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 382  Bit Score: 110.75  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  41 LFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP 120
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948580 121 AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAV 154
Cdd:cd01115   84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGL 117
 
Name Accession Description Interval E-value
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 41-154 1.73e-27

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 110.75  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  41 LFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP 120
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948580 121 AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAV 154
Cdd:cd01115   84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGL 117
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 33-161 3.65e-17

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 82.03  E-value: 3.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   33 KEAECAYTLFVVATFWLTEALPLSVTALLP-SLMLPMFGIMPSKK---VASAYFKDFHLLLIGVICLATSIEKWNLHKRI 108
Cdd:pfam00939  29 KAWHLFAIFIATIVGWILEPLPMAVIALFAiSLSAILIGTLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767948580  109 ALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINA 161
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
90-158 1.65e-16

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 79.43  E-value: 1.65e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767948580  90 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI 158
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL 69
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-155 9.23e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 71.61  E-value: 9.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   41 LFVVATFWLTEALPLSVTALLP----SLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMV 116
Cdd:TIGR00785  17 FVAAIVGWILEPLPLPVTALLAipiiAVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKM 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767948580  117 GVNPAWLTL-GFMSSTAFLSMWLSNTS-TAAMVMPIAEAVV 155
Cdd:TIGR00785  97 GGTTLGLGYfLVFLETLLAPMWPSNTArAGGILLPIIKSLL 137
 
Name Accession Description Interval E-value
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 41-154 1.73e-27

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 110.75  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  41 LFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP 120
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948580 121 AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAV 154
Cdd:cd01115   84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGL 117
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 33-161 3.65e-17

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 82.03  E-value: 3.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   33 KEAECAYTLFVVATFWLTEALPLSVTALLP-SLMLPMFGIMPSKK---VASAYFKDFHLLLIGVICLATSIEKWNLHKRI 108
Cdd:pfam00939  29 KAWHLFAIFIATIVGWILEPLPMAVIALFAiSLSAILIGTLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767948580  109 ALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINA 161
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
90-158 1.65e-16

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 79.43  E-value: 1.65e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767948580  90 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI 158
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL 69
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 47-157 3.67e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 78.83  E-value: 3.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  47 FWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMmVGVNPAWLTLG 126
Cdd:cd00625    3 LIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLAR-ASKGSRRLLLL 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767948580 127 FMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQ 157
Cdd:cd00625   82 LMLLTAALSAFFSNDATAVLLTPIVLALLRK 112
CitMHS pfam03600
Citrate transporter;
47-157 1.21e-14

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 73.89  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   47 FWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLG 126
Cdd:pfam03600   3 LIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVA 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767948580  127 FMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQ 157
Cdd:pfam03600  83 LMLATALLSAFLSNDGTVLIMIPIVLALARR 113
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-155 9.23e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 71.61  E-value: 9.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   41 LFVVATFWLTEALPLSVTALLP----SLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMV 116
Cdd:TIGR00785  17 FVAAIVGWILEPLPLPVTALLAipiiAVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKM 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767948580  117 GVNPAWLTL-GFMSSTAFLSMWLSNTS-TAAMVMPIAEAVV 155
Cdd:TIGR00785  97 GGTTLGLGYfLVFLETLLAPMWPSNTArAGGILLPIIKSLL 137
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
40-158 6.09e-08

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 53.62  E-value: 6.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  40 TLFVVATFWLTEA---LPLSVTALLPSLMLPMFGIMPSKKVASAYfkDFHLLLI--GVICLATSIEKWNLHKRIALKMV- 113
Cdd:COG0471  180 IFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYKSI--PWGVLLLfgGGLALGAALEKTGLAAWLADALLp 257

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767948580 114 MMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI 158
Cdd:COG0471  258 LLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
CitMHS pfam03600
Citrate transporter;
7-171 7.77e-08

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 53.08  E-value: 7.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580    7 ILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFH 86
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   87 LLLIGVICLATSIEKWNLHKRIALkmVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVE 166
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPL 335


                  ....*
gi 767948580  167 ATQMT 171
Cdd:pfam03600 336 AWALA 340
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 44-158 1.70e-06

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 49.12  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  44 VATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVasayFKDFH----LLLIGVICLATSIEKWNLHKRIALKMVMMVGVN 119
Cdd:cd01115  202 AALAAITGLLPVSVAIAIGAIVLVFGGVLLTKED----YKSIDwgiiFLFAGGIPLGKALESSGAAALIAEALISLLGGL 277

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767948580 120 PAWLTLG-FMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI 158
Cdd:cd01115  278 PPFAILLlLCLLTLVLTNFISNTATAVLLAPIALSIALSL 317
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
40-157 5.46e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 41.65  E-value: 5.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580  40 TLFVVATFWLteALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVN 119
Cdd:COG1055   12 TYLLIILEPR--GLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGS 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767948580 120 PAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQ 157
Cdd:COG1055   90 PRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARR 127
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 47-156 2.39e-03

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 39.63  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948580   47 FWLTEALPLSVTALLPSLMLPMFGIMPSKKVASaYFKDFHLLLI--GVICLATSIEKWNLHKRIALKMVMMVGVNPAWLT 124
Cdd:TIGR00785 264 FGGSLGINASVVALLAVVLMLFLGIVTWKDIQK-NKVAWNTLILfgGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIA 342

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767948580  125 LGF--MSSTAFLSMWLSNTSTAAMVMPIAEAVVQ 156
Cdd:TIGR00785 343 VLVlvVLFYIILYFFASNTAHTAALVPIFFSVAS 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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