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Conserved domains on  [gi|767947661|ref|XP_011514450|]
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WD repeat-containing protein 86 isoform X6 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-113 9.09e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 9.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFS-----PD---------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-113 9.09e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 9.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFS-----PD---------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 1.82e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSP--------------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 2.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.66e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947661    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 1.23e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947661   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-113 9.09e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 9.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFS-----PD---------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-113 1.08e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 1.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200   45 RTLKGHTGPVRDVAASA--------------DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-113 4.46e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 4.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   1 MSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSP--------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767947661  81 FTGSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-113 1.72e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 1.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   1 MSREFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD--------------GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL 66

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767947661  81 FTGSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV 99
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 1.82e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSP--------------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 5.76e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 5.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  114 RTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 3.37e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 3.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwDlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  240 RTLTGHSGSVRSVAFSP--D------------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 4.66e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 4.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPD--------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
3-113 9.10e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 9.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSP--------------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767947661  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 COG2319
WD40 repeat [General function prediction only];
32-113 1.86e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166


                 ..
gi 767947661 112 CL 113
Cdd:COG2319  167 SV 168
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-93 5.81e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 5.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   5 FRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 84
Cdd:cd00200  215 LRGHENGVNSVAFS-----PD---------GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*....
gi 767947661  85 TDATIRAWD 93
Cdd:cd00200  281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-94 3.02e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  324 RTLTGHTGAVRSVAFSP--------------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         90
                 ....*....|..
gi 767947661  83 GSTDATIRAWDI 94
Cdd:COG2319  390 GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
32-160 5.11e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 5.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947661  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767947661 112 CLERERSGGlqscpscrpslLLLAAGEPTRV-LW--QRGQDRQVLAGRHRGV 160
Cdd:COG2319  125 SVAFSPDGK-----------TLASGSADGTVrLWdlATGKLLRTLTGHSGAV 165
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 2.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.66e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947661    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 1.23e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947661   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 3-50 9.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 9.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767947661     3 REFRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVW 50
Cdd:smart00320   6 KTLKGHTGPVTSVAFS-----PD---------GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
3-50 3.37e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767947661    3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 50
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP--------------DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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