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Conserved domains on  [gi|767940299|ref|XP_011513023|]
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p21-activated protein kinase-interacting protein 1 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-297 1.79e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  63 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 139
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 140 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 213
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 214 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 290
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 767940299 291 GFIKMWK 297
Cdd:cd00200  283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-297 1.79e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  63 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 139
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 140 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 213
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 214 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 290
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 767940299 291 GFIKMWK 297
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
49-299 1.21e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  49 PQQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDG 125
Cdd:COG2319  149 LATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 126 LICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVVI 204
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 205 --IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiP 279
Cdd:COG2319  306 gsDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS---P 382

                        250       260
                 ....*....|....*....|
gi 767940299 280 EHHVIVSASSDGFIKMWKLK 299
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-173 5.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767940299   134 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 173
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-173 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767940299  135 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 76-293 1.31e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  76 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 144
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 145 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 219
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 220 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 291
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 767940299 292 FI 293
Cdd:PLN00181 722 YI 723
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-297 1.79e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  63 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 139
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 140 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 213
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 214 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 290
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 767940299 291 GFIKMWK 297
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
49-299 1.21e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  49 PQQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDG 125
Cdd:COG2319  149 LATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 126 LICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVVI 204
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 205 --IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiP 279
Cdd:COG2319  306 gsDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS---P 382

                        250       260
                 ....*....|....*....|
gi 767940299 280 EHHVIVSASSDGFIKMWKLK 299
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
47-304 1.73e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 1.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  47 QAPQQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDG 125
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgKTLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 126 LICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNA-HIVEWSPRGeQYVVI 204
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDG-KLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 205 --IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiP 279
Cdd:COG2319  222 gsADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVaFS---P 298

                        250       260
                 ....*....|....*....|....*
gi 767940299 280 EHHVIVSASSDGFIKMWKLKQDKKV 304
Cdd:COG2319  299 DGKLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
48-304 3.25e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 3.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  48 APQQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF-YGNRHLISGAEDGL 126
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 127 ICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKQNAHIVE---WSPRGeQYVV 203
Cdd:COG2319  102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTsvaFSPDG-KLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 204 I--IQNKIDIYQLDTASISGTITN-EKRISSVKFLSES-VLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfei 278
Cdd:COG2319  179 SgsDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVaFS--- 255

                        250       260
                 ....*....|....*....|....*.
gi 767940299 279 PEHHVIVSASSDGFIKMWKLKQDKKV 304
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-173 4.14e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 4.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  59 THHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKW 135
Cdd:cd00200  172 TLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTG 251

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767940299 136 ECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 173
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-178 6.07e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 6.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  61 HAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWEC 137
Cdd:cd00200  132 RGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKC 211

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767940299 138 LKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 178
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-304 1.25e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  96 EHGALVHHSGTITCLKF-YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 174
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFsPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 175 VEGRSAFIknikQNAHI-----VEWSPRGeQYVV--IIQNKIDIYQLDTASISGTITN-EKRISSVKFL-SESVLAVAGD 245
Cdd:cd00200   81 ETGECVRT----LTGHTsyvssVAFSPDG-RILSssSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSpDGTFVASSSQ 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 246 EEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWKLKQDKKV 304
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLTGHTGEVNSVaFS---PDGEKLLSSSSDGTIKLWDLSTGKCL 212
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 76-227 5.39e-06

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 48.10  E-value: 5.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  76 FVVTGSKDETIHIYDMK-----KKIEHGALVH-HSGTITCLKFYGNrhlISGAEDGLICIWDAKKWECLKSIKAhKGQVT 149
Cdd:cd20718  210 FIVASQGSNTMWVLDLKtgkvvARIPTGKTPHpGPGATWGRKGVTA---TPHLGEGIVTVWDLDTWKPVKYIPT-PGPGR 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 150 FLSIHPSGKLalsVGTDKTLRTWN-----LVEGRS----AFIKNIKQN-AHIVEWSPRGEqYVVII---QNKIDIYQLDT 216
Cdd:cd20718  286 FVRTHPSSPY---VWADTVFGPENadeiyVIDKETlkvvKTLIPKPGKrALHPEFTRDGK-YVYVSvwdGGEVVVYDAET 361

                        170
                 ....*....|.
gi 767940299 217 ASISGTITNEK 227
Cdd:cd20718  362 LELVKRIPAET 372
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-173 5.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767940299   134 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 173
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-173 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767940299  135 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 76-293 1.31e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299  76 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 144
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 145 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 219
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940299 220 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 291
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 767940299 292 FI 293
Cdd:PLN00181 722 YI 723
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-131 1.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767940299   100 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 131
Cdd:smart00320   8 LKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
100-131 4.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.30e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767940299  100 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 131
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-297 4.62e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.62e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767940299   256 SLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWK 297
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVaFS---PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
259-296 7.55e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767940299  259 CLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMW 296
Cdd:pfam00400   3 LLKTLEGHTGSVTSLaFS---PDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 58-90 8.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767940299    58 FTHHAHTASLSAVAV--NSRFVVTGSKDETIHIYD 90
Cdd:smart00320   6 KTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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