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Conserved domains on  [gi|767908534|ref|XP_011507542|]
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leucine-rich repeat-containing protein 71 isoform X10 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1-91 8.95e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.91  E-value: 8.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   1 MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDK 80
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                         90
                 ....*....|.
gi 767908534  81 GALKLAEVLRA 91
Cdd:COG5238  336 GAIALAKALQE 346
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1-91 8.95e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.91  E-value: 8.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   1 MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDK 80
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                         90
                 ....*....|.
gi 767908534  81 GALKLAEVLRA 91
Cdd:COG5238  336 GAIALAKALQE 346
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-93 2.39e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.91  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   9 HLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNRIQDKGALKLAE 87
Cdd:cd00116  197 VLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAE 272


                 ....*.
gi 767908534  88 VLRAFE 93
Cdd:cd00116  273 VLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
36-58 4.37e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.83  E-value: 4.37e-04
                          10        20
                  ....*....|....*....|...
gi 767908534   36 NRTLVSLNLGFNHIGDEGAGYIA 58
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
64-91 8.40e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 8.40e-04
                           10        20
                   ....*....|....*....|....*...
gi 767908534    64 NRSLLWLSLAHNRIQDKGALKLAEVLRA 91
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1-91 8.95e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.91  E-value: 8.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   1 MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDK 80
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                         90
                 ....*....|.
gi 767908534  81 GALKLAEVLRA 91
Cdd:COG5238  336 GAIALAKALQE 346
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-90 2.78e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 73.29  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   6 TIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 85
Cdd:COG5238  237 SLTTLDLSNNQIGDEGVIALAEALKN----NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIAL 312


                 ....*
gi 767908534  86 AEVLR 90
Cdd:COG5238  313 AEGLQ 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-90 6.48e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 69.05  E-value: 6.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   6 TIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 85
Cdd:COG5238  209 TVTTLWLKRNPIGDEGAEILAEALKG----NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIAL 284


                 ....*
gi 767908534  86 AEVLR 90
Cdd:COG5238  285 AKALQ 289
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-89 3.36e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.12  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   5 STIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALK 84
Cdd:COG5238  320 KTLHTLNLAYNGIGAQGAIALAKALQE----NTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395


                 ....*
gi 767908534  85 LAEVL 89
Cdd:COG5238  396 LIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-89 7.41e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 65.97  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   5 STIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALK 84
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQG----NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIA 367


                 ....*
gi 767908534  85 LAEVL 89
Cdd:COG5238  368 LAKYL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-93 2.39e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.91  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   9 HLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNRIQDKGALKLAE 87
Cdd:cd00116  197 VLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAE 272


                 ....*.
gi 767908534  88 VLRAFE 93
Cdd:cd00116  273 VLAEKE 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-92 5.58e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 62.76  E-value: 5.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   9 HLSLRNNNIDDRGAQLLGQALSTLhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEV 88
Cdd:cd00116  225 VLNLGDNNLTDAGAAALASALLSP---NISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301


                 ....
gi 767908534  89 LRAF 92
Cdd:cd00116  302 LLEP 305
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 10-91 3.68e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534  10 LSLRNNNIDDRGAQLLGQALstLHSCNrtLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 89
Cdd:cd00116  170 LNLANNGIGDAGIRALAEGL--KANCN--LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245


                 ..
gi 767908534  90 RA 91
Cdd:cd00116  246 LS 247
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 3-90 3.92e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   3 LDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGA 82
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQ----NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGV 253


                 ....*...
gi 767908534  83 LKLAEVLR 90
Cdd:COG5238  254 IALAEALK 261
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 5-90 2.44e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   5 STIAHLSLRNNNIDDRGAQLLGQAL-------------------------STLHSCNRTLVSLNLGFNHIGDEGAGYIAD 59
Cdd:cd00116  108 SSLQELKLNNNGLGDRGLRLLAKGLkdlppaleklvlgrnrlegascealAKALRANRDLKELNLANNGIGDAGIRALAE 187

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767908534  60 GLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 90
Cdd:cd00116  188 GLKANCNLEVLDLNNNGLTDEGASALAETLA 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-93 8.99e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 8.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534   4 DSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRsLLWLSLAHNRIQDKGAL 83
Cdd:COG5238  347 NTTLHSLDLSDNQIGDEGAIALAKYLEG----NTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQ 421

                         90
                 ....*....|
gi 767908534  84 KLAEVLRAFE 93
Cdd:COG5238  422 RLEQLLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 21-90 3.70e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 3.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908534  21 GAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 90
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
LRR_6 pfam13516
Leucine Rich repeat;
36-58 4.37e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.83  E-value: 4.37e-04
                          10        20
                  ....*....|....*....|...
gi 767908534   36 NRTLVSLNLGFNHIGDEGAGYIA 58
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
64-91 8.40e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 8.40e-04
                           10        20
                   ....*....|....*....|....*...
gi 767908534    64 NRSLLWLSLAHNRIQDKGALKLAEVLRA 91
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
36-62 4.46e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 4.46e-03
                           10        20
                   ....*....|....*....|....*..
gi 767908534    36 NRTLVSLNLGFNHIGDEGAGYIADGLR 62
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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