NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755512281|ref|XP_011247712|]
View 

glomulin isoform X2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Kinetochor_Ybp2 super family cl07251
Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein ...
 14-221 4.18e-43

Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS). The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12.


The actual alignment was detected with superfamily member pfam08568:

Pssm-ID: 400745  Cd Length: 624  Bit Score: 155.72  E-value: 4.18e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   14 EHIEVFLQRTEQSIYS-----KGLELLETSLLR--LEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQL 86
Cdd:pfam08568 386 DAIYLYLRFTGPSLYSpffqnKGLEDSLLYWLWvaLTSNSIELAELPDKVFKVFLQALLLITCRQPNPELRYITLTLLTR 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   87 FIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQI----------DLSFKKTYNKWFAGAQLISLLDLVLSLPEGA- 155
Cdd:pfam08568 466 LLHLHPEDVRFKFIRDTLENCPYESAKGSAIGILKDLMlkalkssqssELQLPPRPNIFLTPHRLSELLSLVLNSPDGLl 545

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755512281  156 -----ETDLLQNSDRIMASLNLLRYLVIKDNeddnqtgLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKN 221
Cdd:pfam08568 546 ndesnKTDLQQNLDLILAYLNLLYYLKKKWD-------LRVTLPVFLKEYLEPLKTLLNSSEAELEAEKEP 609
 
Name Accession Description Interval E-value
Kinetochor_Ybp2 pfam08568
Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein ...
 14-221 4.18e-43

Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS). The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12.


Pssm-ID: 400745  Cd Length: 624  Bit Score: 155.72  E-value: 4.18e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   14 EHIEVFLQRTEQSIYS-----KGLELLETSLLR--LEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQL 86
Cdd:pfam08568 386 DAIYLYLRFTGPSLYSpffqnKGLEDSLLYWLWvaLTSNSIELAELPDKVFKVFLQALLLITCRQPNPELRYITLTLLTR 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   87 FIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQI----------DLSFKKTYNKWFAGAQLISLLDLVLSLPEGA- 155
Cdd:pfam08568 466 LLHLHPEDVRFKFIRDTLENCPYESAKGSAIGILKDLMlkalkssqssELQLPPRPNIFLTPHRLSELLSLVLNSPDGLl 545

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755512281  156 -----ETDLLQNSDRIMASLNLLRYLVIKDNeddnqtgLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKN 221
Cdd:pfam08568 546 ndesnKTDLQQNLDLILAYLNLLYYLKKKWD-------LRVTLPVFLKEYLEPLKTLLNSSEAELEAEKEP 609
 
Name Accession Description Interval E-value
Kinetochor_Ybp2 pfam08568
Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein ...
 14-221 4.18e-43

Uncharacterized protein family, YAP/Alf4/glomulin; This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS). The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12.


Pssm-ID: 400745  Cd Length: 624  Bit Score: 155.72  E-value: 4.18e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   14 EHIEVFLQRTEQSIYS-----KGLELLETSLLR--LEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQL 86
Cdd:pfam08568 386 DAIYLYLRFTGPSLYSpffqnKGLEDSLLYWLWvaLTSNSIELAELPDKVFKVFLQALLLITCRQPNPELRYITLTLLTR 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512281   87 FIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQI----------DLSFKKTYNKWFAGAQLISLLDLVLSLPEGA- 155
Cdd:pfam08568 466 LLHLHPEDVRFKFIRDTLENCPYESAKGSAIGILKDLMlkalkssqssELQLPPRPNIFLTPHRLSELLSLVLNSPDGLl 545

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755512281  156 -----ETDLLQNSDRIMASLNLLRYLVIKDNeddnqtgLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKN 221
Cdd:pfam08568 546 ndesnKTDLQQNLDLILAYLNLLYYLKKKWD-------LRVTLPVFLKEYLEPLKTLLNSSEAELEAEKEP 609
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH