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Conserved domains on  [gi|755538114|ref|XP_011247205|]
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putative transferase CAF17 homolog, mitochondrial isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-197 8.66e-33

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 120.00  E-value: 8.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114   1 MYKIRRKVTVEP-SPELHVWAVL-----PCVPQTSETAPLEERVEGTTMLIRDPRTArMGWRLLTQDDG-----PALVPR 69
Cdd:COG0354   96 KYRLRSKVEIEDaSDDLAVLGLAgpaaaAALAALGALADPAAHAVADGGTIRLPRPA-PGYLLIVPAAAaaalwEALAAG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114  70 GQLGDLQDYHKYRYQQGIPEGVCDLPPGmALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPa 149
Cdd:COG0354  175 AAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVARMHYRGKVKRRLVLLHLDGSAL- 252

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755538114 150 sgVSPGAivTVTATGQAAGK-----FRAGQGHVGLALLRSET--IKGPLHIKTSE 197
Cdd:COG0354  253 --PAPGT--ELLAGGRPVGTvtsaaRHPEGGPIALAVLRRDAadAGAELRVGGAA 303
 
Name Accession Description Interval E-value
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-197 8.66e-33

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 120.00  E-value: 8.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114   1 MYKIRRKVTVEP-SPELHVWAVL-----PCVPQTSETAPLEERVEGTTMLIRDPRTArMGWRLLTQDDG-----PALVPR 69
Cdd:COG0354   96 KYRLRSKVEIEDaSDDLAVLGLAgpaaaAALAALGALADPAAHAVADGGTIRLPRPA-PGYLLIVPAAAaaalwEALAAG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114  70 GQLGDLQDYHKYRYQQGIPEGVCDLPPGmALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPa 149
Cdd:COG0354  175 AAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVARMHYRGKVKRRLVLLHLDGSAL- 252

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755538114 150 sgVSPGAivTVTATGQAAGK-----FRAGQGHVGLALLRSET--IKGPLHIKTSE 197
Cdd:COG0354  253 --PAPGT--ELLAGGRPVGTvtsaaRHPEGGPIALAVLRRDAadAGAELRVGGAA 303
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 76-143 1.09e-28

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 102.23  E-value: 1.09e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755538114   76 QDYHKYRYQQGIPEGVCDLPpGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKL 143
Cdd:TIGR03317   1 EAWELLRIAAGIPEGGAETS-GEFIPQELNLDALGGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
PRK09559 PRK09559
putative global regulator; Reviewed
 43-139 8.25e-07

putative global regulator; Reviewed


Pssm-ID: 236567 [Multi-domain]  Cd Length: 327  Bit Score: 48.52  E-value: 8.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114  43 MLIRDPRTARMgwrLLTQDDGPAlvprgQLGDLQDYHKYRYQQGIPegVCDLP-PGMALPLESNLVFMNGVSFTKGCYIG 121
Cdd:PRK09559 162 LLVTDEATANM---LTEKLRGEA-----QLNNSQQWLALDIEAGFP--VIDAAnSGQFIPQATNLQALGGISFKKGCYTG 231

                         90
                 ....*....|....*...
gi 755538114 122 QELTARTHHTGVIRKRLF 139
Cdd:PRK09559 232 QEMVARAKFRGANKRALW 249
 
Name Accession Description Interval E-value
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-197 8.66e-33

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 120.00  E-value: 8.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114   1 MYKIRRKVTVEP-SPELHVWAVL-----PCVPQTSETAPLEERVEGTTMLIRDPRTArMGWRLLTQDDG-----PALVPR 69
Cdd:COG0354   96 KYRLRSKVEIEDaSDDLAVLGLAgpaaaAALAALGALADPAAHAVADGGTIRLPRPA-PGYLLIVPAAAaaalwEALAAG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114  70 GQLGDLQDYHKYRYQQGIPEGVCDLPPGmALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPa 149
Cdd:COG0354  175 AAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVARMHYRGKVKRRLVLLHLDGSAL- 252

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755538114 150 sgVSPGAivTVTATGQAAGK-----FRAGQGHVGLALLRSET--IKGPLHIKTSE 197
Cdd:COG0354  253 --PAPGT--ELLAGGRPVGTvtsaaRHPEGGPIALAVLRRDAadAGAELRVGGAA 303
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 76-143 1.09e-28

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 102.23  E-value: 1.09e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755538114   76 QDYHKYRYQQGIPEGVCDLPpGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKL 143
Cdd:TIGR03317   1 EAWELLRIAAGIPEGGAETS-GEFIPQELNLDALGGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
PRK09559 PRK09559
putative global regulator; Reviewed
 43-139 8.25e-07

putative global regulator; Reviewed


Pssm-ID: 236567 [Multi-domain]  Cd Length: 327  Bit Score: 48.52  E-value: 8.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114  43 MLIRDPRTARMgwrLLTQDDGPAlvprgQLGDLQDYHKYRYQQGIPegVCDLP-PGMALPLESNLVFMNGVSFTKGCYIG 121
Cdd:PRK09559 162 LLVTDEATANM---LTEKLRGEA-----QLNNSQQWLALDIEAGFP--VIDAAnSGQFIPQATNLQALGGISFKKGCYTG 231

                         90
                 ....*....|....*...
gi 755538114 122 QELTARTHHTGVIRKRLF 139
Cdd:PRK09559 232 QEMVARAKFRGANKRALW 249
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 101-185 5.37e-03

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 36.98  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755538114 101 PLESNLVFMngVSFTKGCYIGQELTARTHHTGViRKRLFPVKLEGPLPASG----VSPGAIV-TVTATGQAAgkfRAGQG 175
Cdd:COG0404  254 PLEAGLGWA--VKLDKGDFIGKEALLRQKEEGP-RRKLVGLELDGRGVPRAgapvLADGEVVgEVTSGTFSP---TLGKS 327

                         90
                 ....*....|
gi 755538114 176 hVGLALLRSE 185
Cdd:COG0404  328 -IALAYVPAG 336
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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