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Conserved domains on  [gi|755563134|ref|XP_011245527|]
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nicotinamide riboside kinase 1 isoform X1 [Mus musculus]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 1-96 1.93e-46

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd02024:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 187  Bit Score: 148.63  E-value: 1.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563134   1 MEKMMSAVSCWMENP-----------------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLT 57
Cdd:cd02024   59 MEAMMSTLDYWRETGhfpkflrshgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLR 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755563134  58 VPYEECKRRRSTRVYEP------PDPPGYFDGHVWPMYLKHRQEM 96
Cdd:cd02024  139 VPYETCKRRREARTGYVtlegfwPDPPGYFDGHVWPMYLKHHAEM 183
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 1-96 1.93e-46

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 148.63  E-value: 1.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563134   1 MEKMMSAVSCWMENP-----------------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLT 57
Cdd:cd02024   59 MEAMMSTLDYWRETGhfpkflrshgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLR 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755563134  58 VPYEECKRRRSTRVYEP------PDPPGYFDGHVWPMYLKHRQEM 96
Cdd:cd02024  139 VPYETCKRRREARTGYVtlegfwPDPPGYFDGHVWPMYLKHHAEM 183
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 31-92 1.30e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.82  E-value: 1.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563134  31 PILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRR-----STRVYEPPDPPGYFDGHVWPMYLKH 92
Cdd:COG0572  108 DVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIEQYWATVRPGHEQY 174
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 1-96 1.93e-46

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 148.63  E-value: 1.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563134   1 MEKMMSAVSCWMENP-----------------------GSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLT 57
Cdd:cd02024   59 MEAMMSTLDYWRETGhfpkflrshgnendpekefiedaQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLR 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755563134  58 VPYEECKRRRSTRVYEP------PDPPGYFDGHVWPMYLKHRQEM 96
Cdd:cd02024  139 VPYETCKRRREARTGYVtlegfwPDPPGYFDGHVWPMYLKHHAEM 183
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 31-92 1.30e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.82  E-value: 1.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563134  31 PILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRR-----STRVYEPPDPPGYFDGHVWPMYLKH 92
Cdd:COG0572  108 DVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIEQYWATVRPGHEQY 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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