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Conserved domains on  [gi|755533157|ref|XP_011241496|]
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amine sulfotransferase isoform X1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-280 2.49e-97

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 286.55  E-value: 2.49e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   36 DDDIFIVTYPKSGTIWTQQILSLIYFEGH------------RNRTENIETIDRAPFFEYNIHKLDYAKMPSPRIFSSHIP 103
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDfekseephlfnnHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  104 YYLVPKGLKDKKAKILYIYRNPKDVLISYFHFSNLMLIFQNPDTVESFMQTFLDGDVVGSLWFDHIRGWYEHRHDFNIMF 183
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  184 MSFEDMKKDLRSSVLKICSFLEKELSEEDVDAVVRQATFQKMKADPRANYEHIIKdelgtrnEMGSFLRKGVVGDWKHYL 263
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-------EVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*..
gi 755533157  264 TVDQSERFDKIFHRNMK 280
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMK 250
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-280 2.49e-97

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 286.55  E-value: 2.49e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   36 DDDIFIVTYPKSGTIWTQQILSLIYFEGH------------RNRTENIETIDRAPFFEYNIHKLDYAKMPSPRIFSSHIP 103
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDfekseephlfnnHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  104 YYLVPKGLKDKKAKILYIYRNPKDVLISYFHFSNLMLIFQNPDTVESFMQTFLDGDVVGSLWFDHIRGWYEHRHDFNIMF 183
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  184 MSFEDMKKDLRSSVLKICSFLEKELSEEDVDAVVRQATFQKMKADPRANYEHIIKdelgtrnEMGSFLRKGVVGDWKHYL 263
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-------EVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*..
gi 755533157  264 TVDQSERFDKIFHRNMK 280
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMK 250
PLN02164 PLN02164
sulfotransferase
 5-280 4.18e-27

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 108.08  E-value: 4.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   5 DEYLLNFKGYNFQKTLVKmEVVENIENYEIRDDDIFIVTYPKSGTIWTQqilSLIYFEGHRNRTENIETidraPFFEYNI 84
Cdd:PLN02164  49 KEPLIEYGGHWWLQPLLE-GLLHAQEFFQARPNDFLVCSYPKTGTTWLK---ALTFAIANRSRFDDSSN----PLLKRNP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  85 HKL------DYAKMPSPRI--------FSSHIPYYLVPKGLKDKKAKILYIYRNPKDVLISYFHFSNLMLIFQNP-DTVE 149
Cdd:PLN02164 121 HEFvpyieiDFPFFPSVDVlkdkgntlFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157 150 SFMQTFLDGDVVGSLWFDHIRGW---YEHRHDfNIMFMSFEDMKKDLRSSVLKICSFLEKELSEED-----VDAVVRQAT 221
Cdd:PLN02164 201 ESFDMFCRGLSVYGPYLDHVLGYwkaYQENPD-RILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCS 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755533157 222 FQKMKaDPRANYEHIIKDELGTRNEMGSFLRKGVVGDWKHYLTVDQSERFDKIFHRNMK 280
Cdd:PLN02164 280 FETLK-NLEANKGEKDREDRPAVYANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFK 337
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-280 2.49e-97

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 286.55  E-value: 2.49e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   36 DDDIFIVTYPKSGTIWTQQILSLIYFEGH------------RNRTENIETIDRAPFFEYNIHKLDYAKMPSPRIFSSHIP 103
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDfekseephlfnnHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  104 YYLVPKGLKDKKAKILYIYRNPKDVLISYFHFSNLMLIFQNPDTVESFMQTFLDGDVVGSLWFDHIRGWYEHRHDFNIMF 183
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  184 MSFEDMKKDLRSSVLKICSFLEKELSEEDVDAVVRQATFQKMKADPRANYEHIIKdelgtrnEMGSFLRKGVVGDWKHYL 263
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-------EVSPFFRKGLVGDWKNYF 233

                         250
                  ....*....|....*..
gi 755533157  264 TVDQSERFDKIFHRNMK 280
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMK 250
PLN02164 PLN02164
sulfotransferase
 5-280 4.18e-27

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 108.08  E-value: 4.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   5 DEYLLNFKGYNFQKTLVKmEVVENIENYEIRDDDIFIVTYPKSGTIWTQqilSLIYFEGHRNRTENIETidraPFFEYNI 84
Cdd:PLN02164  49 KEPLIEYGGHWWLQPLLE-GLLHAQEFFQARPNDFLVCSYPKTGTTWLK---ALTFAIANRSRFDDSSN----PLLKRNP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  85 HKL------DYAKMPSPRI--------FSSHIPYYLVPKGLKDKKAKILYIYRNPKDVLISYFHFSNLMLIFQNP-DTVE 149
Cdd:PLN02164 121 HEFvpyieiDFPFFPSVDVlkdkgntlFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157 150 SFMQTFLDGDVVGSLWFDHIRGW---YEHRHDfNIMFMSFEDMKKDLRSSVLKICSFLEKELSEED-----VDAVVRQAT 221
Cdd:PLN02164 201 ESFDMFCRGLSVYGPYLDHVLGYwkaYQENPD-RILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCS 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755533157 222 FQKMKaDPRANYEHIIKDELGTRNEMGSFLRKGVVGDWKHYLTVDQSERFDKIFHRNMK 280
Cdd:PLN02164 280 FETLK-NLEANKGEKDREDRPAVYANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFK 337
Sulfotransfer_3 pfam13469
Sulfotransferase family;
39-210 7.11e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 56.92  E-value: 7.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157   39 IFIVTYPKSGTIWTQQILSLiyFEGHRNRTENIETIDRAP--------FFEYNIHKLDYA-----KMPSpriFSSHIPYy 105
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAA--HPDVRPPEETWFVIPRILallqawgkSLEALARVPSYArwlcdKSPS---HLFHLDL- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533157  106 lvpkgLKDK--KAKILYIYRNPKDVLISyfhfsNLMLIFQNPDTVESFMQTFLDGDVVgSLWFDHIRGWYEHRHDF---N 180
Cdd:pfam13469  75 -----LLKAfpDAKFIHLHRDPVDTVIS-----SYCSLFGFTLSSYSTAFLRDIGLAL-ARWSRAYERLMAARARVppgR 143

                         170       180       190
                  ....*....|....*....|....*....|
gi 755533157  181 IMFMSFEDMKKDLRSSVLKICSFLEKELSE 210
Cdd:pfam13469 144 FLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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