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Conserved domains on  [gi|755528464|ref|XP_011240729|]
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roundabout homolog 3 isoform X5 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 8.66e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 8.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063    9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                 ....*..
gi 755528464 130 vSEPVQT 136
Cdd:cd00063   88 -SVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 9.28e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 258 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 336
Cdd:cd00063    2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 755528464 337 TSAGVGVASAPVLVQ 351
Cdd:cd00063   78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 165-248 3.53e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 165 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 243
Cdd:cd00063    8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                 ....*
gi 755528464 244 SPFVT 248
Cdd:cd00063   86 SESVT 90
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 8.66e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 8.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063    9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                 ....*..
gi 755528464 130 vSEPVQT 136
Cdd:cd00063   88 -SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
51-128 7.70e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 7.70e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755528464   51 VTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPS 128
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 51-125 2.19e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 2.19e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755528464    51 VTEVTANSITLTWKPNPQSGATA--TSYVIEafSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLS 125
Cdd:smart00060   9 VTDVTSTSVTLSWEPPPDDGITGyiVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 9.28e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 258 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 336
Cdd:cd00063    2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 755528464 337 TSAGVGVASAPVLVQ 351
Cdd:cd00063   78 NGGGESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
51-297 5.98e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 5.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWKPNPQSGatATSYVIEAfSQAAGNTWRTVADgVQLETYTISGLQPNTIYLFLVRAVGAWGlsEPSPV 130
Cdd:COG3401  241 ATADTPGSVTLSWDPVTESD--ATGYRVYR-SNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAP 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 131 SEPVQTQADSSLSRPAEDpwkgqrglaeVAVrmqepTVLGPRTLQVSWT-VDGPvqLVQGFRVsWRIAGLDqGSWTMLDl 209
Cdd:COG3401  315 SNVVSVTTDLTPPAAPSG----------LTA-----TAVGSSSITLSWTaSSDA--DVTGYNV-YRSTSGG-GTYTKIA- 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 210 QSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPP---QGVAVALGGDRNSSVTVSWEPPLPSQ 286
Cdd:COG3401  375 ETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESltaSVDAVPLTDVAGATAAASAASNPGVS 454

                        250
                 ....*....|.
gi 755528464 287 RNGVITEYQIW 297
Cdd:COG3401  455 AAVLADGGDTG 465
fn3 pfam00041
Fibronectin type III domain;
258-345 1.31e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  258 GPPQGVAVAlgGDRNSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 336
Cdd:pfam00041   1 SAPSNLTVT--DVTSTSLTVSWTPPPDG--NGPITGYEVeYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 755528464  337 TSAGVGVAS 345
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 258-342 1.52e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464   258 GPPQGVAVALGGDrnSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHlNRSAAGWARSVTFSGLLPGQIYRALVAAAT 337
Cdd:smart00060   2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 755528464   338 SAGVG 342
Cdd:smart00060  79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 165-248 3.53e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 165 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 243
Cdd:cd00063    8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                 ....*
gi 755528464 244 SPFVT 248
Cdd:cd00063   86 SESVT 90
fn3 pfam00041
Fibronectin type III domain;
167-244 1.92e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  167 TVLGPRTLQVSWT----VDGPVQlvqGFRVSWRIAGlDQGSWTMLDLqSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGA 242
Cdd:pfam00041   9 TDVTSTSLTVSWTpppdGNGPIT---GYEVEYRPKN-SGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                  ..
gi 755528464  243 ES 244
Cdd:pfam00041  84 PS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 51-136 8.66e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 8.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWKPNPQSGATATSYVIEaFSQAAGNTWRTVADGVQLET-YTISGLQPNTIYLFLVRAVGAWGLSEPSP 129
Cdd:cd00063    9 VTDVTSTSVTLSWTPPEDDGGPITGYVVE-YREKGSGDWKEVEVTPGSETsYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                 ....*..
gi 755528464 130 vSEPVQT 136
Cdd:cd00063   88 -SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
51-128 7.70e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 7.70e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755528464   51 VTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPS 128
Cdd:pfam00041   8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 51-125 2.19e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 2.19e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755528464    51 VTEVTANSITLTWKPNPQSGATA--TSYVIEafSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLS 125
Cdd:smart00060   9 VTDVTSTSVTLSWEPPPDDGITGyiVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 9.28e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 9.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 258 GPPQGVAVALGGDrnSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 336
Cdd:cd00063    2 SPPTNLRVTDVTS--TSVTLSWTPPEDD--GGPITGYVVeYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 755528464 337 TSAGVGVASAPVLVQ 351
Cdd:cd00063   78 NGGGESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
51-297 5.98e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 5.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWKPNPQSGatATSYVIEAfSQAAGNTWRTVADgVQLETYTISGLQPNTIYLFLVRAVGAWGlsEPSPV 130
Cdd:COG3401  241 ATADTPGSVTLSWDPVTESD--ATGYRVYR-SNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAP 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 131 SEPVQTQADSSLSRPAEDpwkgqrglaeVAVrmqepTVLGPRTLQVSWT-VDGPvqLVQGFRVsWRIAGLDqGSWTMLDl 209
Cdd:COG3401  315 SNVVSVTTDLTPPAAPSG----------LTA-----TAVGSSSITLSWTaSSDA--DVTGYNV-YRSTSGG-GTYTKIA- 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 210 QSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPP---QGVAVALGGDRNSSVTVSWEPPLPSQ 286
Cdd:COG3401  375 ETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESltaSVDAVPLTDVAGATAAASAASNPGVS 454

                        250
                 ....*....|.
gi 755528464 287 RNGVITEYQIW 297
Cdd:COG3401  455 AAVLADGGDTG 465
fn3 pfam00041
Fibronectin type III domain;
258-345 1.31e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  258 GPPQGVAVAlgGDRNSSVTVSWEPPLPSqrNGVITEYQI-WCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 336
Cdd:pfam00041   1 SAPSNLTVT--DVTSTSLTVSWTPPPDG--NGPITGYEVeYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 755528464  337 TSAGVGVAS 345
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 258-342 1.52e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464   258 GPPQGVAVALGGDrnSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHlNRSAAGWARSVTFSGLLPGQIYRALVAAAT 337
Cdd:smart00060   2 SPPSNLRVTDVTS--TSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 755528464   338 SAGVG 342
Cdd:smart00060  79 GAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
54-365 7.03e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 7.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  54 VTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEP 133
Cdd:COG3401  147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 134 vqTQADSSLSRPAedpwkgqrGLAEVAVrmqeptvlGPRTLQVSWTvDGPVQLVQGFRVSWRIAGldQGSWTMLDlqSPH 213
Cdd:COG3401  227 --TTPTTPPSAPT--------GLTATAD--------TPGSVTLSWD-PVTESDATGYRVYRSNSG--DGPFTKVA--TVT 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 214 KQSTVLRGLPPGAQIQIKVQVQGQEGL-GAESPFVTRSIPEEAPSgPPQGVAVALGGdrNSSVTVSWEPPLpsqrNGVIT 292
Cdd:COG3401  284 TTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASS----DADVT 356

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 293 EYQIWclgnesrfhlnRSAAG---WAR--------SVTFSGLLPGQIYRALVAAATSAG----------VGVASAPVLVQ 351
Cdd:COG3401  357 GYNVY-----------RSTSGggtYTKiaetvtttSYTDTGLTPGTTYYYKVTAVDAAGnesapseevsATTASAASGES 425

                        330
                 ....*....|....
gi 755528464 352 LPFPPAAEPGPEVS 365
Cdd:COG3401  426 LTASVDAVPLTDVA 439
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 165-248 3.53e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 165 EPTVLGPRTLQVSWT-VDGPVQLVQGFRVSWRIAglDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAE 243
Cdd:cd00063    8 RVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREK--GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                 ....*
gi 755528464 244 SPFVT 248
Cdd:cd00063   86 SESVT 90
fn3 pfam00041
Fibronectin type III domain;
167-244 1.92e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  167 TVLGPRTLQVSWT----VDGPVQlvqGFRVSWRIAGlDQGSWTMLDLqSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGA 242
Cdd:pfam00041   9 TDVTSTSLTVSWTpppdGNGPIT---GYEVEYRPKN-SGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                  ..
gi 755528464  243 ES 244
Cdd:pfam00041  84 PS 85
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
51-350 7.29e-05

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 45.92  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464  51 VTEVTANSITLTWkpnpqSGATATSYVIEAFSQAAGNTWRTVADGVqleTYTISGLQPNTIYLFLVRAVGAWG-LSEPSP 129
Cdd:COG3979   11 ASNVTSSSVSLSW-----DASTDNVGVTGYDVYRGGDQVATVTGLT---AWTVTGLTPGTEYTFTVGACDAAGnVSAASG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 130 VSEP--VQTQADSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTML 207
Cdd:COG3979   83 TSTAmfGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTTTIITTGVEGG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755528464 208 DLqSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQR 287
Cdd:COG3979  163 GG-SKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGTTATGGTVGITSAY 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755528464 288 NGVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLV 350
Cdd:COG3979  242 GAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGG 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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