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Conserved domains on  [gi|755504256|ref|XP_011238497|]
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RWD domain-containing protein 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 140-247 4.80e-55

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467815  Cd Length: 110  Bit Score: 172.80  E-value: 4.80e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256 140 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 219
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 755504256 220 SETKVQT-EHKRFLAFEVKEYSTLEELQK 247
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 8-112 2.43e-38

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


:

Pssm-ID: 467655  Cd Length: 106  Bit Score: 130.14  E-value: 2.43e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   8 ELSALAAIFCGPNEWEMLSCSET-DGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEK 86
Cdd:cd23819    2 ELSVLQAIFCGPGEFEVLSSSETsDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDS 80

                         90       100
                 ....*....|....*....|....*.
gi 755504256  87 LLGEARKLVSEPMVHELVLWIQQNLR 112
Cdd:cd23819   81 LLEYANSLLGEPMVLELVLWLQENLL 106
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 140-247 4.80e-55

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 172.80  E-value: 4.80e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256 140 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 219
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 755504256 220 SETKVQT-EHKRFLAFEVKEYSTLEELQK 247
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 8-112 2.43e-38

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 130.14  E-value: 2.43e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   8 ELSALAAIFCGPNEWEMLSCSET-DGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEK 86
Cdd:cd23819    2 ELSVLQAIFCGPGEFEVLSSSETsDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDS 80

                         90       100
                 ....*....|....*....|....*.
gi 755504256  87 LLGEARKLVSEPMVHELVLWIQQNLR 112
Cdd:cd23819   81 LLEYANSLLGEPMVLELVLWLQENLL 106
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 3-111 6.16e-16

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 71.59  E-value: 6.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256    3 EEVRQELSALAAIFcgPNEWEMLSCSETDGAVFRIHTTAEGLVGE---DVPLELAFHLPVGYPLCLPGISVTS-EHLTRA 78
Cdd:pfam05773   1 EEQEEELEALESIY--PDEFEVISDSPYESLEIEIKLSLDSDESDsshLPPLVLKFTLPEDYPDEPPKISLSSpWNLSDE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 755504256   79 QCVTAKEKLLGEARKLVSEPMVHELVLWIQQNL 111
Cdd:pfam05773  79 QVLSLLEELEELAEENLGEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 8-112 5.22e-12

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 60.83  E-value: 5.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256     8 ELSALAAIFCGPNEWeMLSCSETDGAVFRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEK 86
Cdd:smart00591   1 ELEALESIYPEDFEV-IDEDARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNsEGLSDEQLAELLKK 79

                           90       100
                   ....*....|....*....|....*.
gi 755504256    87 LLGEARKLVSEPMVHELVLWIQQNLR 112
Cdd:smart00591  80 LEEIAEENLGEVMIFELVEKLQEFLS 105
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 146-258 6.11e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 36.11  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256  146 LDHMRARTKyvkaVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 219
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755504256  220 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELF 258
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 140-247 4.80e-55

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 172.80  E-value: 4.80e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256 140 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 219
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 755504256 220 SETKVQT-EHKRFLAFEVKEYSTLEELQK 247
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 8-112 2.43e-38

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 130.14  E-value: 2.43e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   8 ELSALAAIFCGPNEWEMLSCSET-DGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEK 86
Cdd:cd23819    2 ELSVLQAIFCGPGEFEVLSSSETsDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDS 80

                         90       100
                 ....*....|....*....|....*.
gi 755504256  87 LLGEARKLVSEPMVHELVLWIQQNLR 112
Cdd:cd23819   81 LLEYANSLLGEPMVLELVLWLQENLL 106
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 140-246 1.43e-36

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 125.84  E-value: 1.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256 140 WMTLLRLDHMRARTKYVKAVEKWAsELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGK--------KC 211
Cdd:cd24140    2 HCKVFHFKHLQNKKKRFKIKENSK-ELSLKGLCMRIRDPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHtntgdikeKC 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755504256 212 KEKMISVLSETKVQT--EHKRFLAFEVKEYSTLEELQ 246
Cdd:cd24140   81 HNNSISKTWEGYLQDckFKGWFLKVCNDQYSLLRTLG 117
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 3-111 6.16e-16

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 71.59  E-value: 6.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256    3 EEVRQELSALAAIFcgPNEWEMLSCSETDGAVFRIHTTAEGLVGE---DVPLELAFHLPVGYPLCLPGISVTS-EHLTRA 78
Cdd:pfam05773   1 EEQEEELEALESIY--PDEFEVISDSPYESLEIEIKLSLDSDESDsshLPPLVLKFTLPEDYPDEPPKISLSSpWNLSDE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 755504256   79 QCVTAKEKLLGEARKLVSEPMVHELVLWIQQNL 111
Cdd:pfam05773  79 QVLSLLEELEELAEENLGEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 8-112 5.22e-12

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 60.83  E-value: 5.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256     8 ELSALAAIFCGPNEWeMLSCSETDGAVFRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEK 86
Cdd:smart00591   1 ELEALESIYPEDFEV-IDEDARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNsEGLSDEQLAELLKK 79

                           90       100
                   ....*....|....*....|....*.
gi 755504256    87 LLGEARKLVSEPMVHELVLWIQQNLR 112
Cdd:smart00591  80 LEEIAEENLGEVMIFELVEKLQEFLS 105
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 3-111 4.71e-11

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 58.77  E-value: 4.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   3 EEVRQELSALAAIFcgPNEWEMLSCSETDGA--VFRIHTTAEGLVGE--DVPLELAFHLPVGYPLCLPGISVTSEH-LTR 77
Cdd:cd23823    2 EEQEEELEALQSIY--GDDFEDLSSKKAVWSppEFRIRLRPQEGESEenHVSVDLHVKFPPTYPDVPPEIELENVKgLSD 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755504256  78 AQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNL 111
Cdd:cd23823   80 EQLEELLKELEELAKELLGEEMIFELAEAVQEFL 113
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 11-107 7.08e-10

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 54.88  E-value: 7.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256  11 ALAAIFCGpnewEMLSCSETDGAVFRIHTTAEGLvGEDVPLELAFHLPVGY-PLCLPGISVTSEHLTRAQCVTA-KEKLL 88
Cdd:cd11605    1 ALESIYGD----ELEVLSDDSPLRFSIRLSPEEE-EDDPPLELEFTLPPGYpPEEPPLITLRSPKLSSAERLSLlKLELE 75

                         90
                 ....*....|....*....
gi 755504256  89 GEARKLVSEPMVHELVLWI 107
Cdd:cd11605   76 EAAEENLGEPMLFDLVEAL 94
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 7-111 1.51e-08

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 51.81  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   7 QELSALAAIFCGPNEWEM------------LSCsETDGAV-----FRIHTTAEGlvgEDVPLELAFHLPVGYPLCLPGIS 69
Cdd:cd23829    7 SEIEMLQSMFPNEGELKLddpsavadlkrfLEG-DTDSPLpsrleFTINLKIEE---PKVKVELSVTLPHEYPSVPPEIF 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 755504256  70 VTSEHLTRAQcvtakEKLLGEA-----RKL-VSEPMVHELVLWIQQNL 111
Cdd:cd23829   83 VRSDSLSRSQ-----QRQLNEDlseyiSSLeRGELCILQIVQWLQDNA 125
RWD_YLR419W-like cd23827
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related ...
 6-115 1.79e-08

RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; YLR419W (EC 3.6.4.13) may act as an ATP-binding RNA helicase. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467662  Cd Length: 104  Bit Score: 51.09  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   6 RQELSALAAIFcgPNEWEMLSCSEtdgavFRIHTTAEGlvGEDVPLELAFHLPVGYPLCLPGISVTSE---------HLT 76
Cdd:cd23827    2 DEEIEALEAIY--GEKFEVISDDS-----CEITLNSPT--KTKPSLKLKFYKSSSYPNSLPGIFISSSdklpayiklAII 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755504256  77 RaQCVT-AKEKLLGearklvsEPMVHELVLWIQQNLRLVL 115
Cdd:cd23827   73 R-QLLQyARDNLLG-------DPMIFSIVEWLEENIEEII 104
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 148-261 1.49e-06

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 46.10  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256 148 HMRARTKyVKAVEKWASELRLTGRLMFmGKLILILLQGDRSNIKEYL-ILQKTSKvdvdssgKKCK---EKMISVLSETK 223
Cdd:cd24163   10 HIYSKKK-RKDIVEWAKELGLTGFSKP-GKPGVICVEGDEEDVDEYVrRIRRLRW-------KKIQvrgEEVIEVPRFFG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755504256 224 VQTEHKRFLAFEVKEYST--LEELQKEFGAAGLGELFSEC 261
Cdd:cd24163   81 EEEDEERALPGGFRELHEdlMGELAAFLEEAGLEELFLTL 120
RWD_RNF25 cd23818
RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also ...
 5-104 1.98e-04

RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein of the E2 ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and is predominantly localized in the nucleus. RNF25 activates nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity.


Pssm-ID: 467654  Cd Length: 109  Bit Score: 39.83  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   5 VRQELSALAAIFcgPNEWEMLSCSEtDGAVFRIH---TTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTSEH-LTRAQC 80
Cdd:cd23818    1 LEEELEALEAIY--PDELKVVSEDG-APTELSITlhpATADDESEQYVRLTLVITLPPGYPEEPPKISLRNPRgLSDARL 77

                         90       100
                 ....*....|....*....|....
gi 755504256  81 VTAKEKLLGEARKLVSEPMVHELV 104
Cdd:cd23818   78 ARLLSLLKELAEERAGEPMLFELI 101
RWD_IMPACT cd23821
RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene ...
 6-111 2.61e-04

RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene protein homolog, acts as a translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. It plays a role as a negative regulator of EIF2AK4/GCN2 kinase activity. It impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. IMPACT may be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, IMPACT plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.


Pssm-ID: 467657  Cd Length: 101  Bit Score: 39.14  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   6 RQELSALAAIFCGpnEWEMLScSETDGAVFRIHTTAEGLVgedvPLELAFHLPVGYP-LCLPGISVTSEHLTRAQCVTAK 84
Cdd:cd23821    1 AEEIEALEAIYGE--DFVVID-ESARSFVIRIELDGPHLP----PLVLRVHLPPDYPsHSPPIFELSAPWLSGEERSELC 73

                         90       100
                 ....*....|....*....|....*..
gi 755504256  85 EKLLGEARKLVSEPMVHELVLWIQQNL 111
Cdd:cd23821   74 AELDEIWEENAGEPVLFQWVEWLREYL 100
RWD_RWDD1 cd23816
RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called ...
 3-111 4.43e-03

RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called DRG family-regulatory protein 2 (DFRP2), or PTD013, interacts with DRG2 and protects DRG2 from proteolytic degradation. It is an androgen receptor-interacting protein that functions as a coactivator of androgen-dependent transcription.


Pssm-ID: 467652  Cd Length: 118  Bit Score: 36.12  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256   3 EEVRQELSALAAIFcgPNEWEMLscSETDGAVFRIHTTAEG--LVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQ 79
Cdd:cd23816    3 EEQRNELEALESIY--PDEFTVL--SEEPPISFTITVTSEEeeNEDETVSVTLKFTYTEKYPDEAPLIEIIShENLEDED 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755504256  80 CVTAKEKLLGEARKLVSEPMVHELVLWIQQNL 111
Cdd:cd23816   79 IEDLLELLEQQAEENLGMVMVFTIVSAVQEKL 110
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 146-258 6.11e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 36.11  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504256  146 LDHMRARTKyvkaVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 219
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755504256  220 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELF 258
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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