|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
1-377 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 629.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17387 37 MNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 EHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQAD 160
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPISWEQAD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 161 PFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKN 240
Cdd:cd17387 197 PFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 241 TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:cd17387 277 TILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFV 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 755503381 321 FYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGACSVLLALLVALFIP 377
Cdd:cd17387 357 FYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAISVLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
1-324 |
2.71e-60 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 199.34 E-value: 2.71e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADI 78
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRnlWLLFLARFLDGLTGGNVSVAQAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 79 TQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPeslpekmrpaswgapisweq 158
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP-------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 159 adpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGN 238
Cdd:cd17330 175 --------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 239 KNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:cd17330 241 RKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLA 320
|
....*..
gi 755503381 318 GFIFYIF 324
Cdd:cd17330 321 GPLYSFL 327
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
2-324 |
8.05e-43 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 154.33 E-value: 8.05e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 2 NGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADIT 79
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapiSWEQA 159
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF-----RWRRA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNK 239
Cdd:cd17388 194 NPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGF 319
Cdd:cd17388 274 RAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353
|
....*
gi 755503381 320 IFYIF 324
Cdd:cd17388 354 IFAAS 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-325 |
2.02e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.68 E-value: 2.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMKISPWWYFAVISV-SGVF-AVTFSVVFAYVAD 77
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAFATSYWQLLLARFlQGLAsAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKmrpaswgAPISWE 157
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 158 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIG 237
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
....*....
gi 755503381 317 YGFIFYIFH 325
Cdd:cd17325 344 GGFLYDAFG 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-312 |
1.91e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.60 E-value: 1.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPslWLLLAARFLQGLGaGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapisweqa 159
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:COG2814 198 ---GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRR 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755503381 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGL 312
Cdd:COG2814 274 RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
3-324 |
3.16e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 108.85 E-value: 3.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPaswgapiswEQA 159
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNK 239
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPV-ARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYG 318
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
....*.
gi 755503381 319 FIFYIF 324
Cdd:cd17329 347 LLLDLL 352
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-325 |
3.93e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.81 E-value: 3.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPsfWLLLLGRFLLGLGsGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFIL-VAVPESLPEKMRPaswgAPISWEQ 158
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILlLLVVPDPPESARA----KNEEASS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 159 ADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGN 238
Cdd:cd06174 190 KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 239 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:cd06174 270 KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
....*...
gi 755503381 318 GFIFYIFH 325
Cdd:cd06174 350 GFLLAATF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-314 |
6.28e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 6.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:pfam07690 35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALldICFILVAVPESLPEKMRPASWGApISWEQA 159
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEE-ARLSLI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRR 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755503381 240 NTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGP 314
Cdd:pfam07690 266 RRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
1-321 |
1.37e-19 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 89.59 E-value: 1.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFavIS-VSGVFAVTFSVVFAYVAD 77
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICfILVAVPESLPEKMRPASWGAPISWE 157
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 158 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 238 NKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 755503381 317 YGFIF 321
Cdd:cd17331 353 GGALL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-320 |
3.03e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 89.19 E-value: 3.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKISPWWYFAVISVsgVFAVTFSV 70
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 71 VF----AYVADITQE-HERSMAYGLVS-----ATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdICFILVAVpeS 140
Cdd:COG2211 127 VNipysALGAELTPDyEERTRLSSWRFafaglGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGL-LAFLLTFF--G 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 141 LPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGIL 220
Cdd:COG2211 204 TKERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 221 SIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ-- 295
Cdd:COG2211 277 ALLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWkt 355
|
330 340 350
....*....|....*....|....*....|
gi 755503381 296 -----GVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:COG2211 356 grrreGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
3-321 |
1.24e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVF-AVTFSVVFAYVADIT 79
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapisweqa 159
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGNK 239
Cdd:cd17324 187 -LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR-GGRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-AAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLGPALYG 318
Cdd:cd17324 265 ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGG 343
|
...
gi 755503381 319 FIF 321
Cdd:cd17324 344 LVL 346
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-320 |
1.25e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.05 E-value: 1.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGV-FAVTFSVVFAYVADIT 79
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMaYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapiswEQA 159
Cdd:COG0738 126 PETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:COG0738 198 GSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 240 NTILLGLGFQILQLAWYGFGSEPWM-MWAAGAVAAMSSITFPAVSALVSRTADADQQGVVqGMITGIRGLCNGLGPALYG 318
Cdd:COG0738 277 RLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIG 355
|
..
gi 755503381 319 FI 320
Cdd:COG0738 356 FL 357
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
3-320 |
2.79e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 79.58 E-value: 2.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17390 34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSriPLGIFKHTQSLCKAYLSDLVS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 EHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdICFILVAVpeslpekMRPASWgapisweqaD 160
Cdd:cd17390 114 EQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFI-LNAGLVWF-------LLSKLW---------D 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 161 PFaslkkvgqdSIVLLICITVFLSylpeagqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKN 240
Cdd:cd17390 177 LL---------LVRFLMGFSVLLF-------RSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 241 TILLGLGFQI-LQLAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYG 318
Cdd:cd17390 241 LLLLHSFILLaLSLLGLALAPSIWLLVLCLTpLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSG 320
|
..
gi 755503381 319 FI 320
Cdd:cd17390 321 LL 322
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-326 |
2.88e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.97 E-value: 2.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT-------VFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVF-AY 74
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATaialldICFILVAVPESLPEKMRPASWGAPI 154
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 155 SWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMR 234
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 235 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF-PAVSALVSRTADADQQGVVQGMITGIRGLCNGLG 313
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 755503381 314 PALYGFIFYIFHV 326
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
3-324 |
4.45e-16 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 79.24 E-value: 4.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSriVGGISKGNVSLSTAIVADVTS 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 EHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVV------LATAIALLDICFILVAVPESLPEKMRPASWGapi 154
Cdd:cd17389 147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFfsmpalFALVLALADLLFIFFFLPETLPSNLRRLGLV--- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 155 sweqadpfaslkkvgqdsivllicitVFLSYLPEAG-QYSSFFLyLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLm 233
Cdd:cd17389 224 --------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRI- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 234 RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGL 312
Cdd:cd17389 276 KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARAL 355
|
330
....*....|..
gi 755503381 313 GPALYGFIFYIF 324
Cdd:cd17389 356 GPIVACTVYWLA 367
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
8-321 |
1.54e-15 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 77.32 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 8 VKGLLSFLSAPLIGALSDVWGRKSFLLLTV--FFTCAPIPLMK------ISPWWYF---AVISVSGVFAVTFSVVFAYVA 76
Cdd:cd17386 38 MGSIPPLFSSLFLGSWSDRYGRKPPLLMSLvgLLLSSLILVLIvyfttvPSVWWFYlsaIPLALFGGFTAFLSASFAYIS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 77 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVpeslpekmrpaswgapisw 156
Cdd:cd17386 118 DISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 157 eqadpfaslkkvgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAvLGILSIIAQTIVLSLLMRSI 236
Cdd:cd17386 179 ---------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 237 GNKN---TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQqgvvQGMITGIRGLCNGLG 313
Cdd:cd17386 243 LKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSE----QGKIFSLLSVLESLS 318
|
....*...
gi 755503381 314 PALYGFIF 321
Cdd:cd17386 319 PLVASPIY 326
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-321 |
1.54e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.45 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 8 VKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF--AVTFSVVFAYVADITQEHE 83
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALatSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 84 RSMAYGLVSATFAASLVTSPAIGAYLGRVYG-DSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPisweqADPF 162
Cdd:cd17355 126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 163 ASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQImKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTI 242
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 243 LLGLGFQILQLAWYGFGSEP-WMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:cd17355 279 AASYALRALGLALLLLLPFPpLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
.
gi 755503381 321 F 321
Cdd:cd17355 359 Y 359
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-324 |
4.54e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.85 E-value: 4.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADIT 79
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDI--CFILVAVPESLPEKMRPASWGapiswe 157
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALllVFLVKDPPPVAAEEAEAGTRA------ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 158 qadPFASLKKVgqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQImkfSPESVAAFIAVLGILSIIAQTIVLSLLMRsIG 237
Cdd:cd17489 188 ---FRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDR-KG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
....*...
gi 755503381 317 YGFIFYIF 324
Cdd:cd17489 336 LGLVAELF 343
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
3-320 |
7.21e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 7.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCA---PIPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVAD 77
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLfflSLFFVAQIFWLLLLLVILGAFFsAPVVPLVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSmaYGLV----SATFAAslvTSPAIGAYLGRVYGD-SLVVVLATAIALLDICFILVAvpeslpeKMRPASWGA 152
Cdd:cd17335 115 YLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYkNYTIAFYVFAVLMLLALLLAL-------KFPFRPKHP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 153 PISWEQADPFASLKKVGqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQIMkfSPESVAAFIAVLGILSIIAQTIVLSLL 232
Cdd:cd17335 183 EPNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQDLG--GSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 233 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV----SALVSRTADADQQGVVQGMITgirGL 308
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---GL 330
|
330
....*....|..
gi 755503381 309 CNGLGPALYGFI 320
Cdd:cd17335 331 YFGLGGGLGSLI 342
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-326 |
1.37e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.68 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 15 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLVS 92
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 93 ATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLpekMRPASWGAPIsweqadpfaslkkvgqds 172
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLL---RRRNVLLANI------------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 173 IVLLICITVFLSY--LPEAGQYSSFFLYLRQIMkfspesVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI 250
Cdd:cd17504 185 TALLAGFGMFMVFqlLPQLLQLPTPTGFGLGIT------EAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755503381 251 LQLAWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 326
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-324 |
2.08e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 15 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLV 91
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLpgLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLY 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 92 SATFAASLVTSPAIGAYLGRV--YGDSLVVVLATAIALLDICFILvavpESLPEKMRPASWGAPISWEQADPFASLKKVG 169
Cdd:cd17474 129 EAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILFLL----PEPKEKAKSSSATKLRDLKKALRGRGLLTFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 170 QDSIVLLICITVFLSYLPeagqyssffLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQ 249
Cdd:cd17474 205 VSAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755503381 250 ILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-321 |
2.86e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.52 E-value: 2.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM--KISPWWYFAVISVSGVFA-VTFSVVFAYVADIT 79
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLalAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPEsLPEKMRPASwgapisweqA 159
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD-PPAGAAAAA---------K 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNK 239
Cdd:COG2223 193 ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 240 NTILLGLGFQILQLAW--YGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:COG2223 272 RVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
....
gi 755503381 318 GFIF 321
Cdd:COG2223 352 GALL 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-325 |
3.85e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 3.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfilvavpeslpekmrpasWGAPISWeqa 159
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL---------------------LALLRFW--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dpfaslkkvgqdsivlLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIG-- 237
Cdd:COG2271 184 ----------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrr 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326
|
....*....
gi 755503381 317 YGFIFYIFH 325
Cdd:COG2271 327 VGYLLDATG 335
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-137 |
4.69e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.75 E-value: 4.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGV-FAVTFSVVFAYVAD 77
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATsfWLLLLLLALLGLgLGLVFPATLALLAD 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAV 137
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
3-325 |
4.92e-11 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 64.02 E-value: 4.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApIPLMKISPWWYFAVISVSGVFAVTFSVVF--AYV 75
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 76 ADITQEHER--------SMAY--GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKM 145
Cdd:COG2270 134 PDIATPEEIgrvsglgwALGYlgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 146 RPASWGAPISWEQAdpFASLKKVGQDSIVL--LICITVFLSYLpeAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSII 223
Cdd:COG2270 214 APPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 224 AqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQGV----- 297
Cdd:COG2270 290 G-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffgly 368
|
330 340
....*....|....*....|....*....
gi 755503381 298 -VQGMITGIrglcngLGPALYGFIFYIFH 325
Cdd:COG2270 369 aLSGKAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-303 |
7.58e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 7.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 15 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLV 91
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDSLYALLASRALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 92 SATFAASLVTSPAIGAYLGR--------VYGDSLVVVLATAIAlldicfilvavpesLPEKMRPASwgapiswEQADPFA 163
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALAEigwrapflVYLLALPVLILVLLF--------------LPEPARKSK-------SAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 164 SLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTIL 243
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLA 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755503381 244 LGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMIT 303
Cdd:cd17473 268 IGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-322 |
7.96e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 7.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 18 PLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSAT 94
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLigLALFGLASLLCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 95 FAASLVTSPAIGAYLGRVYGDSLVVVLATAIALldICFILVavpeslpekmrPASWGApisweqadpfaslkkvgqdsiv 174
Cdd:cd17321 129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA-----------RTFSGA---------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 175 lliCITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 254
Cdd:cd17321 174 ---VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755503381 255 WYGFGSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 322
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-321 |
1.32e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.51 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 19 LIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 95
Cdd:cd17320 53 LYGPLSDRFGRRPVLLagLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 96 AASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGApisweqadPFASLKKVGQDSIVL 175
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSS--------LLRAYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 176 LICITVFLSYLPEAGQYS-SFFLYLrQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQI---- 250
Cdd:cd17320 205 GYALALGLSFAGLFAYLAaAPFIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLaaal 282
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755503381 251 --LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRtADADQQGVVQGMITGIRGLCNGLGPALYGFIF 321
Cdd:cd17320 283 vlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-327 |
3.94e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 3.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKISPWWYFAVISVS------GVFAvtfSVVFAYV 75
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 76 ADITQEHERSMAYGLVSA--TFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlPEKMRPaswgap 153
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEY-PRPPKL------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 154 iswEQADPFASLKKVGQDSIVLLICITVFlsylpEAGQYS-SFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLL 232
Cdd:cd17370 187 ---RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 233 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNG 311
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWL 337
|
330
....*....|....*.
gi 755503381 312 LGPALYGFIFYIFHVE 327
Cdd:cd17370 338 LASLIAGYLWDLISPS 353
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
3-321 |
1.02e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.46 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLL-SFLSAPLiGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTfSVVFAYVADIT 79
Cdd:cd17472 35 GLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILfgLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS-SVVMALLADLT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGapisweqa 159
Cdd:cd17472 113 REENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEK-------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dpfASLKKVGQDSIVLLICITVFLSYLpeagQYSSFF----LYLRQIMKFSPESVAAFIAVLgILSIIAqtIVLSLLMRS 235
Cdd:cd17472 185 ---KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLTQLGGGKGQLWKVYLPAI-LIGFIL--MVPFVIYAE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 236 IGN--KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF--PAVSALVSRTADADQQGVVQGMITGIRGLCNG 311
Cdd:cd17472 255 KKGkmKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLleALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSF 334
|
330
....*....|
gi 755503381 312 LGPALYGFIF 321
Cdd:cd17472 335 LGGALGGLLW 344
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
3-324 |
6.50e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 54.17 E-value: 6.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF-TCAPIPLMKISP----WWYFAVISV-----SGVFAVTFSVV 71
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILaAVLFLSVLFIPIsltfWWLALLVVLfsffwNAILPQFEVAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 72 FAYVADITQEHERSMAYGLVSatFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDicfilVAVPESLPEKMRPASWG 151
Cdd:pfam12832 117 LQHLGEKRKDYGRQRLWGSVG--FALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLS-----LLLPLAPPEMEYESKGG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 152 apisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQiMKFSPESVAAFIAVlGILSIIAQTIVLSL 231
Cdd:pfam12832 190 ---------SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLGALWAL-GVVAEIPLFFYAHR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 232 LMRSIGNKNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSA-LVSRTADADQQGVVQGMITGIR-GL 308
Cdd:pfam12832 259 LLRRFGHRNLLIIALLLTALRWLLYAFFVEnPWLVLPIQFLHAISFGLTHAAAIeYVRRIFPGSLQGTGQALYSGLYfGL 338
|
330
....*....|....*.
gi 755503381 309 CNGLGPALYGFIFYIF 324
Cdd:pfam12832 339 GGALGSLIGGQLWDLF 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
11-128 |
2.36e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 11 LLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLM-KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMA 87
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 755503381 88 YGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 128
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
15-321 |
4.47e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 51.84 E-value: 4.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 15 LSAPLIGALSD-------------VWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVF-AYVADITQ 80
Cdd:cd17332 50 INDPLMGYLIDrtrsrwgrfrpwlLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 E-HERS--MAYGLVSATFAASLVTS--PAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlpEKMRPASWGAPIS 155
Cdd:cd17332 130 DpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT--RERVVPPEEEKSK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 156 WEQADPFASLKKvgQDSIVLLICITVFLSYLPEAGQySSFFLYLRQIMKFSPESVAAFIAVLGILSIIaqTIVLSLLMRS 235
Cdd:cd17332 208 LPLLKSLKALLK--NRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWPPLKKR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 236 IGNKNTILLGLGFQILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ--QGV-VQGMITGIRGLC 309
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 755503381 310 NGLGPALYGFIF 321
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-137 |
1.87e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT---VFFTCAPIPLMKISPWWYFAVISVSGVFA-VTFSVVFAYVADI 78
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfalMALGLLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVPDI 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 755503381 79 TQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGdSLVVVLATAIALLDICFILVAV 137
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALVALVLTLL 381
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-237 |
2.20e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.04 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPspELLIAARALQGIGaGGLMPGALALIAELF 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDIcFILVAVPESLPEKMRPASWGAPISWEQA 159
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL-VLRLRLPESRGLLLALLALALAALLLAA 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755503381 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:COG0477 211 LALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-139 |
2.22e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI----SPWWYFAVISVSGVFA-VTFSVVFAYVAD 77
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPE 139
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
177-324 |
8.56e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 8.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 177 ICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWY 256
Cdd:cd06174 1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755503381 257 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
173-325 |
9.87e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 9.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 173 IVLLICITVFLSYLpEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755503381 253 LAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 325
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
3-320 |
1.58e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 EHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATaiALLDICFILVAVpeSLPEKMRPASWGAPISWEQAd 160
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITG--GLLFLAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 161 pfasLKKVGQDSIVLLICITVFLSylpeagQYSSFF------LYLRQIMkfSPESVAAFIA-----VLGILSIIAqTIVL 229
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLM--GDASNLAFISglvfsATGVSSLLS-APRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 230 SLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPW-MMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGL 308
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
330
....*....|..
gi 755503381 309 CNGLGPALYGFI 320
Cdd:cd17391 341 GNVAGPLLGSAI 352
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
1-279 |
2.73e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.01 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLM-KISPWWYFAVISVSGVFAVTFSVVF-AYVAD 77
Cdd:cd17477 32 LIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDS--LVVVLATAIALLDICFILVAVPESlpekmrpaswgapis 155
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALpfLIAAVLLLLALVPLLLTRRAAPEI--------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 156 wEQADPFASLKKVgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMkFSPESVAAFIAVLGILSIIAQTIVLSLLMRS 235
Cdd:cd17477 176 -EEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADRF 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 755503381 236 IGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 279
Cdd:cd17477 251 DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
19-265 |
3.17e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.62 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 19 LIGALSDVWG-RKSFLLLTVFF---TCAPIPLMKiSPWWYFAV-ISVSGVFAVTFSVVFAYVADITQEH---ERSMAYGL 90
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLALLAgalGYLLFAFLR-NYWVLLLVgVVLLSLGAAAFPQLFALAREYADRSsgrDATLFNSV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 91 VSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLKKVGQ 170
Cdd:cd17471 130 LRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 171 DSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFsPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI 250
Cdd:cd17471 198 NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG-SESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV 276
|
250
....*....|....*
gi 755503381 251 LQLAWYGFGSEPWMM 265
Cdd:cd17471 277 LFYLGLALATSLWQL 291
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
1-324 |
4.00e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVFAVTFSVVFAYVAD 77
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWgapiswe 157
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTEL------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 158 qadpfASLKKVGQDSIVLLICitvFLSYLPEAGQYSSFFLYLRQIMKfspeSVAAFIAVLGILS-------IIAQTIVLS 230
Cdd:cd17490 185 -----KELLSVLKDKKLLFFS---LLAILQQMITFSTTFGFTPLIAK----QLGASSFQLGLLSiiyllpnALASLLSGT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 231 LLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLC 309
Cdd:cd17490 253 LFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALG 332
|
330
....*....|....*
gi 755503381 310 NGLGPALYGFIFYIF 324
Cdd:cd17490 333 MFLGPVLVGIISEAF 347
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
18-325 |
4.45e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 45.38 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 18 PLIGALSD----VWGR-KSFLLLTVFFTCAPIPLMKISPWW-------YFAVISVSGVFAVTFSVV--FAYVADITQE-H 82
Cdd:pfam13347 51 PIVGHIIDrtrtRWGRrRPWLLLSAIILAVSFILLFTPPELgraplfiWLLATYILLRIAYTFFEIpyWSLGPELTRDyD 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 83 ERS---------MAYGLVSATFAASLVTSPAIGAYLGRVyGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAp 153
Cdd:pfam13347 131 ERTsltsyrsffSVGGGLLAAALAFPLVLILGGTGLERK-GYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQK- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 154 iswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFspESVAAFIAVLGILSIIAQTIVLSLLM 233
Cdd:pfam13347 209 ---EAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN--GFAASAFPLVFTIGALLGIPLWPPLA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 234 RSIGNKNTILLGLGFQI--LQLAWYGFGSEPWMMWAAGAVAAMSSIT-FPAVSALVSRTADADQ---QGVVQGMITGIRG 307
Cdd:pfam13347 284 KRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSsFFLPWSMLADVVDYGElrtGKRREGTFFAMWS 363
|
330 340
....*....|....*....|..
gi 755503381 308 LCN----GLGPALYGFIFYIFH 325
Cdd:pfam13347 364 FISklatGVGLGVSGLLLSAFG 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-321 |
4.57e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.25 E-value: 4.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADIT 79
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAGTALIGAgIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHeRSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlpekmRPASWGAPISWeqa 159
Cdd:COG2807 136 PDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dpfaSLKKVGQDSIVLLICITVFLSylpeAGQYSSFFLYLRQIMK---FSPESVAAFIAVLGILSIIAQTIVLSLLMRSI 236
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPPILRdagLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 237 GNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVS-RTADADQQGVVQGMITGIRGLCNGLGPA 315
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPL 358
|
....*.
gi 755503381 316 LYGFIF 321
Cdd:COG2807 359 LVGALH 364
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-327 |
1.43e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALAGIGSAAFHPEGARLASQAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 81 EHERSMAYGLVSA-----TFAASLVTSPAIGAYLGRVYgdSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPis 155
Cdd:cd17478 114 GGRRGLAMSIFSVggnlgFALGPLIAAALVALFGGLGL--LILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARST-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 156 weqadpfaslkKVGQDSIVLLICITVFLSYLPEAGqYSSFF-LYLRQiMKFSPESVAAFIAVLGILSIIAqTIVLSLLMR 234
Cdd:cd17478 190 -----------LKGVWRALLLLLIIVFLRSWVLSS-LTTFLpFYLVQ-RGYSLVFAGLLLSLFLFAGAIG-TLIGGPLSD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 235 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLGP 314
Cdd:cd17478 256 RFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGA 334
|
330
....*....|...
gi 755503381 315 ALYGFIFYIFHVE 327
Cdd:cd17478 335 PVLGALADAFGLE 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
173-324 |
1.58e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 173 IVLLICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2271 11 ILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755503381 253 LAWYGFGSEPWMMWAA-GAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:COG2271 89 TLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
11-278 |
2.90e-04 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 42.87 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 11 LLSFLSaPLIGALSDVWGRKSF----------LLLTVFFTCAP--IPLMKISPWW--YFAVISVSGVFAVTFSVV----F 72
Cdd:cd06176 47 LVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPfaALLLAGAAFWlgLALAVLAFLLYGIGVGAAgtafL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 73 AYVADITQEHERSMAYGLV-SATFAASLVTSPAIGAYLGRVYGDSL--VVVLATAIALLDICFILVAVpeslpEKMRPAS 149
Cdd:cd06176 126 ALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLLDPYSPERLiqVFQIVALVALLLALLALWGV-----ERRRSRA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 150 WGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqysSFFL-------YLRQIMKFSPESVAAFIAVLGILSI 222
Cdd:cd06176 201 ALAAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvilepFGGEVFGMSVGETTRLTAIWGGGTL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755503381 223 IAQTIVLSLLMRSIGNKNTILLGLGFQILQ---LAWYGFGSEPWM-------------MWAAGAVAAMSSIT 278
Cdd:cd06176 274 LGMLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfllglgngLFTVGALTLMMDLT 345
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
3-275 |
4.90e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 41.82 E-value: 4.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApipLMKISP--WWYFAVISVSGVFAVTFSVVF--A 73
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 74 YVADITQEHERsmayGLVSAT-FAASLVTS--PAIGAYLGRVYGDSLVVVLATAIallDICFILVAVpeslpekmrpasW 150
Cdd:cd17482 119 FLPDVASPERM----DRVSSLgYALGYIGGglLFAVNLVLILGPDAFGLDTAEAV---RLSFLSVAL------------W 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 151 GAPISweqadpfASLKKVGQDSIVLLICI----TVFLSylpeAGQYSSfflylrQIMKFSPESVAAFIAVLGILSIIAqT 226
Cdd:cd17482 180 WALFS-------IPLKQLLLFLIAYFFYIdgvqTIIRM----ATIYGA------EEGKLGSSALILALLLTQFVAFPG-A 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 755503381 227 IVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS 275
Cdd:cd17482 242 LLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLV 290
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-320 |
5.36e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.82 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 14 FLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 90
Cdd:cd17316 50 PIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPtpILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 91 VSATFAASLVTSpaigaylgrvygdSLVVVLATAIALLD----ICFILVAVPESLPEKMRPASWGAPISWeqadpfaslk 166
Cdd:cd17316 130 LQSGWALGALLA-------------ALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTLLLILLW---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 167 kvgqdsIVLLICITVFLSYLPEagqyssfflYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGL 246
Cdd:cd17316 187 ------FFISFGYYGLTTFLPT---------YLQTVLGLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGL 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755503381 247 GFQILQLAWYGF---GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:cd17316 251 ILSGILALPLFYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-103 |
7.05e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 7.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF------FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAY 74
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLllilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
90 100
....*....|....*....|....*....
gi 755503381 75 VADITQEHERSMAYGLVSATFAASLVTSP 103
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
10-128 |
1.36e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.74 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 10 GLLSFLSAPLIGALSDVWGRKSFLL-LTVFFTCAPIPLMKI-----SPWWYFAVISVSGVFAVTFSVVFAYV-ADITQEH 82
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLfFGIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 755503381 83 ER----SMAYGLVSATFAAslvTSPAIGAYLGRVYGDSLVVVLATAIALL 128
Cdd:cd17367 349 VRalgvGLPYALAVAIFGG---TAPYVALWLKSIGHEWVFFWYVAGLIAI 395
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-128 |
1.93e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 10 GLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMKI---SPWWYFAVISVSGVFAVTFSVVF-AYVADITQEHER 84
Cdd:cd17316 223 SLGALVGALIAGLLSDRIGRKKTLVIGlILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVR 302
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 755503381 85 SMAYGLVSAT-FAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 128
Cdd:cd17316 303 ATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-134 |
2.58e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.90 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 7 GVKGLLSFLSAPLIGALSDVWGRK---SFLLLTVFFTCAPIPLMKISPWWYFAVISVSGV-FAVTFSVVFAYVADITQEH 82
Cdd:cd17353 256 SILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTK 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 755503381 83 ERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFIL 134
Cdd:cd17353 336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
3-324 |
2.65e-03 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 39.60 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISpwwYFAVISVSGVFAVTFSVVFAYVAD----- 77
Cdd:cd17479 34 GIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLLYHQ---IFLLVLLVIIIWELLSAPLEKVADdslye 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 78 ------ITQEHERSMAYGLVSATFAASLVT----------SPAIGAYLGRVYGDSLVVVLATAIALLdicfilvaVPESL 141
Cdd:cd17479 111 yldfvdATERYGKLKVWSALGAAFGPCGITllvdnldcflPPKISRILLHFYTYGGFMILTFLLSFF--------YPIPV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 142 PEKMRPASWGapisweqadpFASLKKVGQDSIVLLICITVFLSYLPeAGQYSSFFLYLRQIMKFSPESVAAFIAVlGILS 221
Cdd:cd17479 183 PKKEEHSSKV----------VKGLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIAL-ALLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 222 IIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPA---------VSALVSRTADA 292
Cdd:cd17479 251 EILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWavnsqveflASPGMERSLQL 330
|
330 340 350
....*....|....*....|....*....|..
gi 755503381 293 dqqgVVQGMitgIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17479 331 ----VLRAL---YYGIGFALGSFVSGFIYDRF 355
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
3-320 |
3.06e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVF-AYVADIT 79
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALAlfLFGAANGALDVAMnAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHER---SMAYGLVSA-TFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEkmRPASWGAPIS 155
Cdd:cd17393 117 RAYGRpimSSLHAMWSLgGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAED--RPDGAGKPGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 156 weqadpfaslkkVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRS 235
Cdd:cd17393 195 ------------LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGR-LFGDRLVDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 236 IGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-----AAMSSITFPAVSALVSRTADAdqqGVVQGMITGIRGLCn 310
Cdd:cd17393 262 FGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALmglglSVVVPLAFSAAGALPGLAAGI---AVARVATLGYLGFL- 337
|
330
....*....|
gi 755503381 311 gLGPALYGFI 320
Cdd:cd17393 338 -VGPPLIGFL 346
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
173-321 |
3.83e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.09 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 173 IVLLICITVFLSYLPEAGqYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2223 6 VLLLATLAFFLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLR-IPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 253 LAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 321
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
2-319 |
4.14e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 2 NGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADIT 79
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQniWQFLILRALLGLLGGFVPNANALIATQV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGdsLVVVLATAIALLDICFILVAVpeSLPEKMRPASWGAPISWEQA 159
Cdd:PRK09874 136 PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG--LRPVFFITASVLFLCFLVTLF--CIRENFQPVSKKEMLHMREV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 160 dpFASLKkvgQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQI------MKFSPESVAAFIAVLGILSiiaqTIVLSLLM 233
Cdd:PRK09874 212 --VTSLK---NPKLVLSLFVTTLIIQVATGSIAPILTLYVRELagnvsnIAFISGMIASVPGVAALLS----APRLGKLG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 234 RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAG-AVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGL 312
Cdd:PRK09874 283 DRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRfLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVT 362
|
330
....*....|....
gi 755503381 313 GP-------ALYGF 319
Cdd:PRK09874 363 GPlmgaaisANYGF 376
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
3-305 |
4.81e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.15 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDV----WG-RKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVF----- 72
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLALGDGPRTWALVLFVLGivlld 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 73 -----------AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYL------GRVYGDSLVVVLATAIALLDICFI-- 133
Cdd:cd17313 117 famnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwfGFALGGNLKVPFYIGAIILLVCVLvt 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 134 LVAVPEslpEKMRPASWGAPISWEQADPFASLKKV--GQDSIVLLICITVFLSYLpeAGQYSSFF--LYLRQIMKFSP-- 207
Cdd:cd17313 197 LFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWWI--AFFPFELFftDYMGEEVYHGTsa 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 208 --------ESVAAFIavLGILSIIAQ--TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI 277
Cdd:cd17313 272 asshygagVRMGAWG--LLIFSLAFLifSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349
|
330 340
....*....|....*....|....*....
gi 755503381 278 TFPAVS-ALVSRTADADQQGvvQGMITGI 305
Cdd:cd17313 350 TININPyPLVSDYHSESGRG--QGTDTGL 376
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
3-324 |
5.61e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.73 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-----KISPWWYFAVIS---VSGVFAVTFSVVFAY 74
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVarfLIGVGAGNVAVLRAY 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGA------YLGRVYGDSLVVVLATAIALLDICFILVAVpeslpekmrpa 148
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftpigYPGYVIGIKLRFNMYTAPAWLMAILGIINI----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 149 swgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLY------LRQIM-----KFSPESVAAFIAVL 217
Cdd:cd17326 188 ------------------------ILILFFFKEVVCIFLFFVVLFIFANLetigtpLTMDMygwtrEEAVLYNGIILAVS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 218 GILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYgfgsepwMMWAAGAVAAMsSITFPAVS----ALVSRTADAD 293
Cdd:cd17326 244 GVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPIGNvmlyTLYSKILGPK 315
|
330 340 350
....*....|....*....|....*....|.
gi 755503381 294 QQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17326 316 PQGTMQGVLTASGSLARTLGPIFVTAIYTHF 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
3-136 |
8.36e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755503381 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLL---LTVFFTCAPIPLMKISPWWYFAVISVSGVFAVT-FSVVFAYVADI 78
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLgcaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 755503381 79 TQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLvvvLATAIALLDICFILVA 136
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHG---LFLFLAAVALLFLLFL 360
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