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Conserved domains on  [gi|755498803|ref|XP_011237619|]
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potassium voltage-gated channel subfamily H member 7 isoform X13 [Mus musculus]

Protein Classification

cyclic nucleotide-gated ion channel( domain architecture ID 11997992)

cyclic nucleotide-gated ion channel is a nonselective channel that is opened by the direct binding of cyclic nucleotides, cAMP and cGMP

Gene Ontology:  GO:0016020|GO:0030551|GO:0005216
PubMed:  12087135|17601606

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 241-352 1.12e-23

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 96.24  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 241 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD-----IVVAILGKNDIFGEMVHLYAKPg 315
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDedgreQIVGFLGPGDLFGELALLGNGP- 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755498803 316 kSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFL 352
Cdd:cd00038   80 -RSATVRALTDSELLVLPRSDFRRLLQEYPELARRLL 115
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 7-166 2.19e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803    7 LTVAWGQTTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHWLACIWYAIGNverpyltdkigwld 84
Cdd:pfam00520  83 LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIGY-------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   85 slgtQI-GKRYNDSDSSSGPSIK-DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-------IFSICVMLIGSLMYASIFG 155
Cdd:pfam00520 149 ----QLfGGKLKTWENPDNGRTNfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIA 224

                         170
                  ....*....|.
gi 755498803  156 NVSAIIQRLYS 166
Cdd:pfam00520 225 VIIDNFQELTE 235
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 241-352 1.12e-23

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 96.24  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 241 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD-----IVVAILGKNDIFGEMVHLYAKPg 315
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDedgreQIVGFLGPGDLFGELALLGNGP- 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755498803 316 kSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFL 352
Cdd:cd00038   80 -RSATVRALTDSELLVLPRSDFRRLLQEYPELARRLL 115
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 242-358 1.22e-21

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 90.54  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   242 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKD-----DIVVAILGKNDIFGEMVHLYAKPGK 316
Cdd:smart00100   2 FKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVledgeEQIVGTLGPGDFFGELALLTNSRRA 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 755498803   317 SNADVRALTYCDLHKIQREDLLEvldMYPEFSDHFLTNLELT 358
Cdd:smart00100  82 ASAAAVALELATLLRIDFRDFLQ---LLPELPQLLLELLLEL 120
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 7-166 2.19e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803    7 LTVAWGQTTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHWLACIWYAIGNverpyltdkigwld 84
Cdd:pfam00520  83 LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIGY-------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   85 slgtQI-GKRYNDSDSSSGPSIK-DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-------IFSICVMLIGSLMYASIFG 155
Cdd:pfam00520 149 ----QLfGGKLKTWENPDNGRTNfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIA 224

                         170
                  ....*....|.
gi 755498803  156 NVSAIIQRLYS 166
Cdd:pfam00520 225 VIIDNFQELTE 235
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 8-379 1.15e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 81.07  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   8 TVAWGQTTTLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFALIAHWLACIWYAIGNverPYLTDKIGWLD 84
Cdd:PLN03192 161 TVKLNLSYSLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLFLVHCAGCLYYLIAD---RYPHQGKTWIG 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803  85 SLGTQIGKryndsdsssgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 164
Cdd:PLN03192 237 AVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEMIFIIFYMLFNLGLTAYLIGNMTNLVVEG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 165 YSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNgidMNME-VLKGFPECLQADICLHLNQTLLQNCKAFR 243
Cdd:PLN03192 307 TRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAES---LNQQqLIDQLPKSICKSICQHLFLPVVEKVYLFK 383

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 244 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL----KDDIVVAILGKNDIFGEMVHLYAKPGKSNA 319
Cdd:PLN03192 384 GVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIdsegEKERVVGTLGCGDIFGEVGALCCRPQSFTF 463

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 320 DVRALTycDLHKIQREDLLEVLDMYPEFSDHFLTNleltFNLRHESAKSQSVNDSEGDTG 379
Cdd:PLN03192 464 RTKTLS--QLLRLKTSTLIEAMQTRQEDNVVILKN----FLQHHKELHDLNVGDLLGDNG 517
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 242-356 2.19e-15

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 75.41  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 242 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK-----DDIVVAILGKNDIFGEMVHLYAKPgk 316
Cdd:COG0664    1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRisedgREQILGFLGPGDFFGELSLLGGEP-- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755498803 317 SNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLE 356
Cdd:COG0664   79 SPATAEALEDSELLRIPREDLEELLERNPELARALLRLLA 118
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 261-344 1.16e-12

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 64.17  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803  261 HAPPGDTLVHCGDVLTALYFLSRGSIEILKDD-----IVVAILGKNDIFGEMVHLYAKPgkSNADVRALTYCDLHKIQRE 335
Cdd:pfam00027   3 SYKAGEVIFREGDPADSLYIVLSGKVKVYRTLedgreQILAVLGPGDFFGELALLGGEP--RSATVVALTDSELLVIPRE 80


                  ....*....
gi 755498803  336 DLLEVLDMY 344
Cdd:pfam00027  81 DFLELLERD 89
PRK10537 PRK10537
voltage-gated potassium channel protein;
103-182 4.78e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 46.17  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 103 PSIKDkYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA----SIFGNV-SAIIQRLYSGTARyhmQMLR 177
Cdd:PRK10537 164 PPIES-LSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisAIFGPViRGNLKRLVKGRIS---HMHR 239


                 ....*
gi 755498803 178 VKEFI 182
Cdd:PRK10537 240 KDHFI 244
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 241-352 1.12e-23

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 96.24  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 241 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD-----IVVAILGKNDIFGEMVHLYAKPg 315
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDedgreQIVGFLGPGDLFGELALLGNGP- 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755498803 316 kSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFL 352
Cdd:cd00038   80 -RSATVRALTDSELLVLPRSDFRRLLQEYPELARRLL 115
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 242-358 1.22e-21

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 90.54  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   242 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKD-----DIVVAILGKNDIFGEMVHLYAKPGK 316
Cdd:smart00100   2 FKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVledgeEQIVGTLGPGDFFGELALLTNSRRA 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 755498803   317 SNADVRALTYCDLHKIQREDLLEvldMYPEFSDHFLTNLELT 358
Cdd:smart00100  82 ASAAAVALELATLLRIDFRDFLQ---LLPELPQLLLELLLEL 120
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 7-166 2.19e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803    7 LTVAWGQTTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHWLACIWYAIGNverpyltdkigwld 84
Cdd:pfam00520  83 LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIGY-------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   85 slgtQI-GKRYNDSDSSSGPSIK-DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-------IFSICVMLIGSLMYASIFG 155
Cdd:pfam00520 149 ----QLfGGKLKTWENPDNGRTNfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIA 224

                         170
                  ....*....|.
gi 755498803  156 NVSAIIQRLYS 166
Cdd:pfam00520 225 VIIDNFQELTE 235
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 8-379 1.15e-15

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 81.07  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803   8 TVAWGQTTTLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFALIAHWLACIWYAIGNverPYLTDKIGWLD 84
Cdd:PLN03192 161 TVKLNLSYSLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLFLVHCAGCLYYLIAD---RYPHQGKTWIG 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803  85 SLGTQIGKryndsdsssgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 164
Cdd:PLN03192 237 AVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEMIFIIFYMLFNLGLTAYLIGNMTNLVVEG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 165 YSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNgidMNME-VLKGFPECLQADICLHLNQTLLQNCKAFR 243
Cdd:PLN03192 307 TRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAES---LNQQqLIDQLPKSICKSICQHLFLPVVEKVYLFK 383

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 244 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL----KDDIVVAILGKNDIFGEMVHLYAKPGKSNA 319
Cdd:PLN03192 384 GVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIdsegEKERVVGTLGCGDIFGEVGALCCRPQSFTF 463

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 320 DVRALTycDLHKIQREDLLEVLDMYPEFSDHFLTNleltFNLRHESAKSQSVNDSEGDTG 379
Cdd:PLN03192 464 RTKTLS--QLLRLKTSTLIEAMQTRQEDNVVILKN----FLQHHKELHDLNVGDLLGDNG 517
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 242-356 2.19e-15

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 75.41  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 242 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK-----DDIVVAILGKNDIFGEMVHLYAKPgk 316
Cdd:COG0664    1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRisedgREQILGFLGPGDFFGELSLLGGEP-- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755498803 317 SNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLE 356
Cdd:COG0664   79 SPATAEALEDSELLRIPREDLEELLERNPELARALLRLLA 118
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 261-344 1.16e-12

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 64.17  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803  261 HAPPGDTLVHCGDVLTALYFLSRGSIEILKDD-----IVVAILGKNDIFGEMVHLYAKPgkSNADVRALTYCDLHKIQRE 335
Cdd:pfam00027   3 SYKAGEVIFREGDPADSLYIVLSGKVKVYRTLedgreQILAVLGPGDFFGELALLGGEP--RSATVVALTDSELLVIPRE 80


                  ....*....
gi 755498803  336 DLLEVLDMY 344
Cdd:pfam00027  81 DFLELLERD 89
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 109-163 3.40e-11

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 59.59  E-value: 3.40e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755498803  109 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQR 163
Cdd:pfam07885  24 FLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
263-347 5.08e-09

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 56.91  E-value: 5.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 263 PPGDTLVHCGDVLTALYFLSRGSIEIL-KDD----IVVAILGKNDIFGEMvHLYAKPGKSNADVRALTYCDLHKIQREDL 337
Cdd:PRK11753  26 PAKSTLIHAGEKAETLYYIVKGSVAVLiKDEegkeMILSYLNQGDFIGEL-GLFEEGQERSAWVRAKTACEVAEISYKKF 104

                         90
                 ....*....|
gi 755498803 338 LEVLDMYPEF 347
Cdd:PRK11753 105 RQLIQVNPDI 114
PRK10537 PRK10537
voltage-gated potassium channel protein;
103-182 4.78e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 46.17  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755498803 103 PSIKDkYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA----SIFGNV-SAIIQRLYSGTARyhmQMLR 177
Cdd:PRK10537 164 PPIES-LSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisAIFGPViRGNLKRLVKGRIS---HMHR 239


                 ....*
gi 755498803 178 VKEFI 182
Cdd:PRK10537 240 KDHFI 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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