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Conserved domains on  [gi|755496560|ref|XP_011237233|]
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REST corepressor 3 isoform X4 [Mus musculus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10412582)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 25-69 1.82e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11661:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 46  Bit Score: 64.17  E-value: 1.82e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755496560  25 EWTVEDKVLFEQAFSFHGKSFHRIQQ-MLPDKTIASLVKYYYSWKK 69
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 226-269 2.64e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 2.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496560  226 RWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYR 269
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 269-420 2.24e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496560  269 RRRFNLEEVlqewEAEQGTQASNADASALGEETQSASKVPSGKSTDEEAEAQTPQAPRTLGPSPPAPSSTPTPTVPIATL 348
Cdd:pfam09770 191 RKMMSLEEV----EAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIL 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755496560  349 N-----QPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPtlNQPPPPLIRPANSMPPRLNPRPvlTTVGGQQPPSL 420
Cdd:pfam09770 267 QrpqspQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP--NRLSAARVGYPQNPQPGVQPAP--AHQAHRQQGSF 339
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 25-69 1.82e-13

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 64.17  E-value: 1.82e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755496560  25 EWTVEDKVLFEQAFSFHGKSFHRIQQ-MLPDKTIASLVKYYYSWKK 69
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 226-269 2.64e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 2.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496560  226 RWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYR 269
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 226-268 9.88e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.04  E-value: 9.88e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 755496560 226 RWTTEEQLLAVQGVRKYG-KDFQAIADVIGNKTVGQVKNFFVNY 268
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
226-271 4.38e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.14  E-value: 4.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 755496560   226 RWTTEEQLLAVQGVRKYG-KDFQAIADVIGNKTVGQVKNFFVNYRRR 271
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 25-68 1.03e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.19  E-value: 1.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496560   25 EWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWK 68
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
24-70 9.73e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.60  E-value: 9.73e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 755496560    24 DEWTVEDKVLFEQAFSFHG-KSFHRIQQMLPDKTIASLVKYYYSWKKT 70
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 211-260 1.15e-03

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 41.02  E-value: 1.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755496560 211 IEEFKP-PESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQ 260
Cdd:COG5259  265 SSDFKPvTISLLIRDKNWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQ 315
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 269-420 2.24e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496560  269 RRRFNLEEVlqewEAEQGTQASNADASALGEETQSASKVPSGKSTDEEAEAQTPQAPRTLGPSPPAPSSTPTPTVPIATL 348
Cdd:pfam09770 191 RKMMSLEEV----EAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIL 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755496560  349 N-----QPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPtlNQPPPPLIRPANSMPPRLNPRPvlTTVGGQQPPSL 420
Cdd:pfam09770 267 QrpqspQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP--NRLSAARVGYPQNPQPGVQPAP--AHQAHRQQGSF 339
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 25-69 1.82e-13

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 64.17  E-value: 1.82e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755496560  25 EWTVEDKVLFEQAFSFHGKSFHRIQQ-MLPDKTIASLVKYYYSWKK 69
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 226-269 2.64e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 2.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496560  226 RWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYR 269
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 226-268 9.88e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.04  E-value: 9.88e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 755496560 226 RWTTEEQLLAVQGVRKYG-KDFQAIADVIGNKTVGQVKNFFVNY 268
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
226-271 4.38e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.14  E-value: 4.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 755496560   226 RWTTEEQLLAVQGVRKYG-KDFQAIADVIGNKTVGQVKNFFVNYRRR 271
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 25-68 1.03e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.19  E-value: 1.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496560   25 EWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWK 68
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 25-68 4.71e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 43.33  E-value: 4.71e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 755496560  25 EWTVEDKVLFEQAFSFHG-KSFHRIQQMLPDKTIASLVKYYYSWK 68
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
24-70 9.73e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.60  E-value: 9.73e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 755496560    24 DEWTVEDKVLFEQAFSFHG-KSFHRIQQMLPDKTIASLVKYYYSWKKT 70
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 211-260 1.15e-03

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 41.02  E-value: 1.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755496560 211 IEEFKP-PESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQ 260
Cdd:COG5259  265 SSDFKPvTISLLIRDKNWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQ 315
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 227-268 1.16e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 36.90  E-value: 1.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755496560  227 WTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNY 268
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRK 42
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 269-420 2.24e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496560  269 RRRFNLEEVlqewEAEQGTQASNADASALGEETQSASKVPSGKSTDEEAEAQTPQAPRTLGPSPPAPSSTPTPTVPIATL 348
Cdd:pfam09770 191 RKMMSLEEV----EAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIL 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755496560  349 N-----QPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPtlNQPPPPLIRPANSMPPRLNPRPvlTTVGGQQPPSL 420
Cdd:pfam09770 267 QrpqspQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP--NRLSAARVGYPQNPQPGVQPAP--AHQAHRQQGSF 339
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 227-265 4.63e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 4.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 755496560 227 WTTEEQLLAVQGVRKYGKDFQAI-ADVIGNKTVGQVKNFF 265
Cdd:cd11661    2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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