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Conserved domains on  [gi|741983770|ref|XP_010820491|]
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ankyrin repeat and SOCS box protein 11 isoform X3 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-246 3.58e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.15  E-value: 3.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  28 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 107
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 186
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741983770 187 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 246
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 246-287 6.85e-17

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 72.52  E-value: 6.85e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-246 3.58e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.15  E-value: 3.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  28 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 107
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 186
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741983770 187 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 246
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-232 7.54e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 86.27  E-value: 7.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  24 MYCwadRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN------------------- 84
Cdd:PHA02876 176 IYC---ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairned 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  85 ----------GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHEAVKRG-NRECMEILLANNV 151
Cdd:PHA02876 253 letslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGyDTENIRTLIMLGA 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 152 NIDQEVPHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 229
Cdd:PHA02876 333 DVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTAL 412


                 ...
gi 741983770 230 DLA 232
Cdd:PHA02876 413 HFA 415
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 246-287 6.85e-17

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 72.52  E-value: 6.85e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-222 1.83e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  131 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 210
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 741983770  211 LIDYGANLKCKN 222
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 247-285 1.65e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 1.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 741983770  247 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 285
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-287 9.90e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.93  E-value: 9.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 741983770   249 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 287
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 97-229 1.89e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  97 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 168
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741983770 169 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 229
Cdd:cd22192   98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 193-218 6.26e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 6.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 741983770   193 DTPLHAAAKQNSVEIIHLLIDYGANL 218
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-246 3.58e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.15  E-value: 3.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  28 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 107
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 186
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741983770 187 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 246
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-246 3.90e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 3.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  28 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 107
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AACVNVLLEFGAK-AQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 186
Cdd:COG0666  100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741983770 187 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 246
Cdd:COG0666  180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-187 2.09e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 2.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  29 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSA 108
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 109 ACVNVLLEFGAKAQLEVHL-ASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN 187
Cdd:COG0666  200 EIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-232 7.54e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 86.27  E-value: 7.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  24 MYCwadRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN------------------- 84
Cdd:PHA02876 176 IYC---ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairned 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  85 ----------GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHEAVKRG-NRECMEILLANNV 151
Cdd:PHA02876 253 letslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGyDTENIRTLIMLGA 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 152 NIDQEVPHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 229
Cdd:PHA02876 333 DVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTAL 412


                 ...
gi 741983770 230 DLA 232
Cdd:PHA02876 413 HFA 415
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 25-248 6.72e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.79  E-value: 6.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  25 YCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGVTVHGATPL 99
Cdd:PHA03100  31 SYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 100 FNA--CCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNR--ECMEILLANNVNIDQEvphlgtplyaactyqrlD 174
Cdd:PHA03100 111 LYAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAK-----------------N 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741983770 175 CVKKLLELGANVN----HGqwlDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVE-QALLLREGP 248
Cdd:PHA03100 174 RVNYLLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 246-287 6.85e-17

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 72.52  E-value: 6.85e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 31-243 1.08e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.03  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  31 SPLHEAAAQGRLLAL-KTLIAQGVNVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGVTVHGATPLFNACC-SGS 107
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPL-YAACTYQRLDCVKKLLELGAN 185
Cdd:PHA02876 355 KDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 186 VN-HGQWLDTPLHAAAKQN-SVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALL 243
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILL 494
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
27-164 1.17e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  27 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSG 106
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 741983770 107 SAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPL 164
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDkDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-232 1.26e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  45 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 123
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 124 EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRldCVKKLLELGANVNHgQWLD--TPLHAAAK 201
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190
                 ....*....|....*....|....*....|..
gi 741983770 202 QN-SVEIIHLLIDYGANLKCKNAQGQSALDLA 232
Cdd:PHA02874 264 PPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-222 1.83e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  131 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 210
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 741983770  211 LIDYGANLKCKN 222
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-155 6.13e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 6.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770   66 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVHLASPIHEAVKRGNRECMEI 145
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 741983770  146 LLANNVNIDQ 155
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
33-120 1.21e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770   33 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgVTVHGATPLFNACCSGSAACVN 112
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 741983770  113 VLLEFGAK 120
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 246-287 2.05e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.28  E-value: 2.05e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-237 3.38e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 3.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  79 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILLANNVNIDQE 156
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 157 VPHLGTPLYAACTY-QRLDCVKKLLELGANVNHGQWLD--TPLHAAAKqnSVEIIHLLIDYGANLKCKNAQGQSALDLAA 233
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 741983770 234 PKSS 237
Cdd:PHA02878 309 KQYL 312
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 40-233 8.75e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 8.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  40 GRLLALKTLIAQGVN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFG 118
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 119 AKAQLevhlaSPIHEAvkrgNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN----HGQWldt 194
Cdd:PHA02874  92 VDTSI-----LPIPCI----EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNieddNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 741983770 195 PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 233
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 31-217 2.95e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 2.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  31 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH-GATPLFNACCSGSAA 109
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 110 CVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH 188
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 741983770 189 -GQWLD-TPLHAAAKQNSVEIIHLLIDYGAN 217
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-239 1.09e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  65 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGNRECM 143
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 144 EILLANNVNIDQEVPHLG-TPLYAACTYQRLDCVKKLLELGANVNHGQwLD--TPLHAAAKQNSVEIIHLLIDYGANLKC 220
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 741983770 221 KNAQGQSALDLAAPKSSVE 239
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-226 1.11e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  33 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 112
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 113 VLLEFGAKAQLEVHLA-SPIHEAVKRgNRECMEiLLANNVNIDQEVPHLGTPLYAACTYQ-RLDCVKKLLELGANV---- 186
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAIIH-NRSAIE-LLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADIsikd 285

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 741983770 187 NHGQwldTPLHAAAKQ-NSVEIIHLLIdygANLKCKNAQGQ 226
Cdd:PHA02874 286 NKGE---NPIDTAFKYiNKDPVIKDII---ANAVLIKEADK 320
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-222 5.18e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 5.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  31 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVhgatPLFNAccsgsaAC 110
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI----PCIEK------DM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 111 VNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGA--NVN 187
Cdd:PHA02874 107 IKTILDCGIDVNIkDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVK 186

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 741983770 188 HgQWLDTPLHAAAKQNSVEIIHLLIDYGANL--KCKN 222
Cdd:PHA02874 187 D-NNGESPLHNAAEYGDYACIKLLIDHGNHImnKCKN 222
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 248-287 9.07e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 55.94  E-value: 9.07e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 247-285 1.65e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.17  E-value: 1.65e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 741983770  247 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 285
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 97-246 2.57e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  97 TPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNID-QEVPHLGTplyaactyqrlD 174
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSiLPIPCIEK-----------D 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 741983770 175 CVKKLLELGANVN-HGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 246
Cdd:PHA02874 106 MIKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-233 3.49e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  59 TINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKR 137
Cdd:PHA02876 142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiIALDDLSVLECAVDS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 138 GNRECMEILLANNVNIDQEvphlGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSV-EIIHLLIDYG 215
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSLsRLVPKLLERG 297

                        170
                 ....*....|....*...
gi 741983770 216 ANLKCKNAQGQSALDLAA 233
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMA 315
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
112-244 5.07e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.12  E-value: 5.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 112 NVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH-GQ 190
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAkDD 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 741983770 191 WLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 244
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-230 5.68e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.57  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  35 EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGVTVHGATPLFnaCCSGSAACV 111
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLH--LYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 112 NVllefgakaqlevhlaspiheavkrgnrecMEILLANNVNIDQEVPHLGTPLYAACTYQRLD--CVKKLLELGANVN-- 187
Cdd:PHA03095  98 DV-----------------------------IKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNal 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 741983770 188 --HGQwldTPLHAAAKQN--SVEIIHLLIDYGANLKCKNAQGQSALD 230
Cdd:PHA03095 149 dlYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 99-244 6.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 6.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  99 LFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVK 177
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741983770 178 KLLELGANVNHGQWLD--TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 244
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 36-188 4.11e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.10  E-value: 4.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  36 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 115
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 741983770 116 EFGAKAqlEVHLASPIH-EAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH 188
Cdd:PLN03192 612 HFASIS--DPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-160 6.31e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 6.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  31 SPLHEAAAQGR--LLALKTLIAQGVNVNLvtINRVsslheaclgghvacaKALLENGAHVNGVTVHGATPLFNACCSGSA 108
Cdd:PHA03100 143 NLLHLYLESNKidLKILKLLIDKGVDINA--KNRV---------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNP 205

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 741983770 109 ACVNVLLEFGA----KAQLEVhlaSPIHEAVKRGNRECMEILLANNVNIDQEVPHL 160
Cdd:PHA03100 206 EFVKYLLDLGAnpnlVNKYGD---TPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 29-212 9.27e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 9.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  29 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLfnaccsgsa 108
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL--------- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 109 acvnvllefgakaqlevhlaspiHEAVKR-GNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQRLdcVKKLLELGANV 186
Cdd:PHA02878 239 -----------------------HISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKSERK--LKLLLEYGADI 293

                        170       180
                 ....*....|....*....|....*...
gi 741983770 187 NHGQWL-DTPLHAAAKQNS-VEIIHLLI 212
Cdd:PHA02878 294 NSLNSYkLTPLSSAVKQYLcINIGRILI 321
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 78-147 3.54e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 3.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741983770  78 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILL 147
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 246-287 7.46e-07

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 45.24  E-value: 7.46e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
30-82 7.64e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 7.64e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 741983770   30 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 82
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-185 7.90e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 7.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  32 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAAcV 111
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741983770 112 NVLLEFGAKAQLEVHLASPIHEAVKRG-NRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKllELGAN 185
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK--DIIAN 311
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 248-287 1.50e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 44.22  E-value: 1.50e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-188 2.08e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  45 LKTLIAQGVNVNLVTINRVSSLHeACLGG---HVACAKALLENGAHVNGVTVHGATPLfnACCSGSAAC----VNVLLEF 117
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 118 GAKAQ---------LEVHLASP------IHEAVKRG-----------------------NRECMEILLANNVNIDQEVPH 159
Cdd:PHA03095 177 GADVYavddrfrslLHHHLQSFkprariVRELIRAGcdpaatdmlgntplhsmatgsscKRSLVLPLLIAGISINARNRY 256

                        170       180       190
                 ....*....|....*....|....*....|
gi 741983770 160 LGTPL-YAACTYQRLDCVKkLLELGANVNH 188
Cdd:PHA03095 257 GQTPLhYAAVFNNPRACRR-LIALGADINA 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
30-89 6.31e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 6.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770   30 RSPLHEAAAQGRLLALKTLIAQgVNVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 89
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 66-247 7.03e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 7.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  66 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS--------------------- 107
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 --------------------------AACVNVLLEFGAKAQL--EVHLASPIHEAVKRGNRECMEILLANNVNIDqeVPH 159
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVN--IPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 160 LG--TPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLH-AAAKQNSVEIIHLLIDYGAnlkCKNAQ----GQSALDL 231
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGV---DVNAKsyilGLTALHS 275

                        250
                 ....*....|....*.
gi 741983770 232 AApKSSVEQALLLREG 247
Cdd:PHA02878 276 SI-KSERKLKLLLEYG 290
Ank_4 pfam13637
Ankyrin repeats (many copies);
162-212 8.31e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 8.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 741983770  162 TPLYAACTYQRLDCVKKLLELGANVNH--GQWlDTPLHAAAKQNSVEIIHLLI 212
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLLL 54
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 248-287 1.21e-05

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 41.79  E-value: 1.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
179-232 1.65e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 741983770  179 LLELG-ANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLA 232
Cdd:pfam13857   1 LLEHGpIDLNRlDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 248-287 1.82e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 41.25  E-value: 1.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
194-244 3.43e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 741983770  194 TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 244
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 248-285 7.21e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 39.73  E-value: 7.21e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 285
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 33-121 7.89e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  33 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 112
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 741983770 113 VLL-------EFGAKA 121
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 248-286 8.29e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 39.38  E-value: 8.29e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLY 286
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-120 8.77e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  25 YCwaDRSPLHEAAAQGRL----------------------------------LALKTLIAQGVNVNLVTINRVSSLHEAC 70
Cdd:PHA02876 373 YC--DKTPIHYAAVRNNVviintlldygadiealsqkigtalhfalcgtnpyMSVKTLIDRGANVNSKNKDLSTPLHYAC 450

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 741983770  71 LGG-HVACAKALLENGAHVNGVTVHGATPLFNACcsGSAACVNVLLEFGAK 120
Cdd:PHA02876 451 KKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE 499
Ank_4 pfam13637
Ankyrin repeats (many copies);
62-115 9.84e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 9.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 741983770   62 RVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 115
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-287 9.90e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.93  E-value: 9.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 741983770   249 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 287
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 248-287 1.15e-04

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 38.81  E-value: 1.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 165-247 1.50e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 165 YAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHA---AAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQ 240
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFrGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLD 98


                 ....*....
gi 741983770 241 --ALLLREG 247
Cdd:PHA03095  99 viKLLIKAG 107
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 97-229 1.89e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  97 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 168
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741983770 169 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 229
Cdd:cd22192   98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-155 2.14e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  31 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLggHVACAKALLENGAHVNGVTVHGATPLFNAC---CSGS 107
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAInppCDID 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 741983770 108 AacVNVLLEFGAKAQLEVHLA-SPIHEAVKRGNRE-CMEILLANNVNIDQ 155
Cdd:PHA02874 270 I--IDILLYHKADISIKDNKGeNPIDTAFKYINKDpVIKDIIANAVLIKE 317
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 145-237 4.42e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 145 ILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNhgqWLD----TPLHAAAKQNSVEIIHLLI-------D 213
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT---LLDkdgkTPLELAEENGFREVVQLLSrhsqchfE 176

                         90       100
                 ....*....|....*....|....
gi 741983770 214 YGANLKCKNAQGQSALDLAAPKSS 237
Cdd:PTZ00322 177 LGANAKPDSFTGKPPSLEDSPISS 200
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 193-218 6.26e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 6.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 741983770   193 DTPLHAAAKQNSVEIIHLLIDYGANL 218
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 174-227 2.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 39.34  E-value: 2.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 174 DCVKKLLELGANVNHGQWLDTPLHAAAKQNSV------EIIHLLIDYGANLKCKNAQGQS 227
Cdd:PHA02989  51 KIVKLLIDNGADVNYKGYIETPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVS 110
Ank_2 pfam12796
Ankyrin repeats (3 copies);
196-233 2.11e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 2.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 741983770  196 LHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 233
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA 38
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 248-287 2.24e-03

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 35.32  E-value: 2.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741983770 248 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
PHA02798 PHA02798
ankyrin-like protein; Provisional
 79-229 2.36e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.05  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770  79 KALLENGAHVNGVTVHGATPLfnaCCSGSAACVNVL------LEFGAKAQLevhlaspiheaVKRGNRECMEILLANNVN 152
Cdd:PHA02798  93 KILIENGADINKKNSDGETPL---YCLLSNGYINNLeillfmIENGADTTL-----------LDKDGFTMLQVYLQSNHH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 153 IDqevphlgtplyaactyqrLDCVKKLLELGANVN-HGQWLD-TPLHAAAKQN----SVEIIHLLIDYGANLKCKNAQGQ 226
Cdd:PHA02798 159 ID------------------IEIIKLLLEKGVDINtHNNKEKyDTLHCYFKYNidriDADILKLFVDNGFIINKENKSHK 220


                 ...
gi 741983770 227 SAL 229
Cdd:PHA02798 221 KKF 223
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 193-222 3.56e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 3.56e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 741983770  193 DTPLHAAAKQ-NSVEIIHLLIDYGANLKCKN 222
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 246-287 3.76e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 34.61  E-value: 3.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 741983770 246 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 246-287 3.94e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 34.82  E-value: 3.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 741983770 246 EGPPALSQLCRLCVRKCLGR---NCHKTIHKLYLPDPLEKFLLYQ 287
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
Ank_4 pfam13637
Ankyrin repeats (many copies);
129-180 4.08e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 4.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 741983770  129 SPIHEAVKRGNRECMEILLANNVNIDqEVPHLG-TPLYAACTYQRLDCVKKLL 180
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGeTALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 179-239 4.48e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 4.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 741983770 179 LLELGANVNHGQ-WLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVE 239
Cdd:PHA02876 164 LLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID 225
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 129-229 5.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 37.49  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 129 SPIHEAV--KRGNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQR---LDCVKKLLELGANVNHgqwLD----TPLHA 198
Cdd:PHA02859  53 TPIFSCLekDKVNVEILKFLIENGADVNFKTRDNNlSALHHYLSFNKnvePEILKILIDSGSSITE---EDedgkNLLHM 129

                         90       100       110
                 ....*....|....*....|....*....|...
gi 741983770 199 AAKQNSV--EIIHLLIDYGANLKCKNAQGQSAL 229
Cdd:PHA02859 130 YMCNFNVriNVIKLLIDSGVSFLNKDFDNNNIL 162
Ank_5 pfam13857
Ankyrin repeats (many copies);
48-99 5.05e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 5.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 741983770   48 LIAQG-VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL 99
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 33-94 6.87e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.93  E-value: 6.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 741983770  33 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH 94
Cdd:PLN03192 626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 162-187 7.38e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.38e-03
                           10        20
                   ....*....|....*....|....*.
gi 741983770   162 TPLYAACTYQRLDCVKKLLELGANVN 187
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 193-251 8.55e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.68  E-value: 8.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 741983770 193 DTPLHAAAKQNSVE-IIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPAL 251
Cdd:cd22192   18 ESPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPEL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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