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Conserved domains on  [gi|688531583|ref|XP_009304699|]
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DNA repair protein complementing XP-A cells isoform X2 [Danio rerio]

Protein Classification

rad14 family protein( domain architecture ID 11489407)

rad14 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 106-276 4.18e-77

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273164  Cd Length: 172  Bit Score: 231.61  E-value: 4.18e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  106 CEECQKPFMDSYLSNSFDLSVCDKCRDNEVKHKLISRTEAKKNYLLKDCDLDKREPPLRFILRKNPHNPRWGDMKLYLKT 185
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  186 QVEKRSVEVWGSDEALEEAKETREENKEVQKQKRFNKKVKELRRTVRSSMF--KKDTSIHQHDYGPdELLDEEEDLYRKV 263
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGP-ETNGVEEDTYRRT 159

                         170
                  ....*....|...
gi 688531583  264 CQTCGHQLTFEKM 276
Cdd:TIGR00598 160 CTTCGLEETYEKM 172
 
Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 106-276 4.18e-77

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273164  Cd Length: 172  Bit Score: 231.61  E-value: 4.18e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  106 CEECQKPFMDSYLSNSFDLSVCDKCRDNEVKHKLISRTEAKKNYLLKDCDLDKREPPLRFILRKNPHNPRWGDMKLYLKT 185
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  186 QVEKRSVEVWGSDEALEEAKETREENKEVQKQKRFNKKVKELRRTVRSSMF--KKDTSIHQHDYGPdELLDEEEDLYRKV 263
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGP-ETNGVEEDTYRRT 159

                         170
                  ....*....|...
gi 688531583  264 CQTCGHQLTFEKM 276
Cdd:TIGR00598 160 CTTCGLEETYEKM 172
DBD_XPA cd21076
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar ...
 102-208 2.70e-73

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar proteins; XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.


Pssm-ID: 410962 [Multi-domain]  Cd Length: 107  Bit Score: 219.43  E-value: 2.70e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 102 DYLMCEECQKPFMDSYLSNSFDLSVCDKCRDNEVKHKLISRTEAKKNYLLKDCDLDKREPPLRFILRKNPHNPRWGDMKL 181
Cdd:cd21076    1 DYLICEECGKEFMDSYLYNHFDLPVCDNCRDADGKHKLITKTEAKQEYLLKDCDLDKREPPLKFILKKNPHNSRWGDMKL 80

                         90       100
                 ....*....|....*....|....*..
gi 688531583 182 YLKTQVEKRSVEVWGSDEALEEAKETR 208
Cdd:cd21076   81 YLKLQVEKRALEVWGSEEALEEEKEKR 107
RAD14 COG5145
DNA excision repair protein [DNA replication, recombination, and repair];
89-247 7.94e-27

DNA excision repair protein [DNA replication, recombination, and repair];


Pssm-ID: 227474  Cd Length: 292  Bit Score: 105.86  E-value: 7.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  89 KRVVQQPAPVMEPDYLM--CEECQKPFMDSYLSNSFDLSVCDKCRDN-EVKHKLISRTEAKKNYLLKDCDLdKREPPLRF 165
Cdd:COG5145  100 RKEVREDAPILLPIALApkCKECLQIELDDELEDTFGISVCRSCRHSmPDKYKLLTKTECKSDYLLTDPEL-KDQELFRR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 166 ILRKNPHNPRWGDMKLYLKTQVEKRSVEVWGSDEALEEAKETREENKEVQKQKRFNKKVKELRRTVRSS----MFKKDTS 241
Cdd:COG5145  179 LQKPNPHKGTWSKMHLYLREEVEQFAIKKWGSLEELDREKQRREKMKDDRKEKKLEKKIKELRRKTRTSnysrMDVREKE 258


                 ....*.
gi 688531583 242 IHQHDY 247
Cdd:COG5145  259 KHVHVF 264
XPA_C pfam05181
XPA protein C-terminus;
136-187 4.98e-25

XPA protein C-terminus;


Pssm-ID: 461572  Cd Length: 51  Bit Score: 94.14  E-value: 4.98e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 688531583  136 KHKLISRTEAKKNYLLKDCDLDKREPpLRFILRKNPHNPRWGDMKLYLKTQV 187
Cdd:pfam05181   1 KYSLITKTEAKEDYLLTDCDLKDREL-LRFLKKPNPHNGTWGDMKLYLRLQV 51
 
Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 106-276 4.18e-77

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273164  Cd Length: 172  Bit Score: 231.61  E-value: 4.18e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  106 CEECQKPFMDSYLSNSFDLSVCDKCRDNEVKHKLISRTEAKKNYLLKDCDLDKREPPLRFILRKNPHNPRWGDMKLYLKT 185
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  186 QVEKRSVEVWGSDEALEEAKETREENKEVQKQKRFNKKVKELRRTVRSSMF--KKDTSIHQHDYGPdELLDEEEDLYRKV 263
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGP-ETNGVEEDTYRRT 159

                         170
                  ....*....|...
gi 688531583  264 CQTCGHQLTFEKM 276
Cdd:TIGR00598 160 CTTCGLEETYEKM 172
DBD_XPA cd21076
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar ...
 102-208 2.70e-73

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar proteins; XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.


Pssm-ID: 410962 [Multi-domain]  Cd Length: 107  Bit Score: 219.43  E-value: 2.70e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 102 DYLMCEECQKPFMDSYLSNSFDLSVCDKCRDNEVKHKLISRTEAKKNYLLKDCDLDKREPPLRFILRKNPHNPRWGDMKL 181
Cdd:cd21076    1 DYLICEECGKEFMDSYLYNHFDLPVCDNCRDADGKHKLITKTEAKQEYLLKDCDLDKREPPLKFILKKNPHNSRWGDMKL 80

                         90       100
                 ....*....|....*....|....*..
gi 688531583 182 YLKTQVEKRSVEVWGSDEALEEAKETR 208
Cdd:cd21076   81 YLKLQVEKRALEVWGSEEALEEEKEKR 107
RAD14 COG5145
DNA excision repair protein [DNA replication, recombination, and repair];
89-247 7.94e-27

DNA excision repair protein [DNA replication, recombination, and repair];


Pssm-ID: 227474  Cd Length: 292  Bit Score: 105.86  E-value: 7.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583  89 KRVVQQPAPVMEPDYLM--CEECQKPFMDSYLSNSFDLSVCDKCRDN-EVKHKLISRTEAKKNYLLKDCDLdKREPPLRF 165
Cdd:COG5145  100 RKEVREDAPILLPIALApkCKECLQIELDDELEDTFGISVCRSCRHSmPDKYKLLTKTECKSDYLLTDPEL-KDQELFRR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 166 ILRKNPHNPRWGDMKLYLKTQVEKRSVEVWGSDEALEEAKETREENKEVQKQKRFNKKVKELRRTVRSS----MFKKDTS 241
Cdd:COG5145  179 LQKPNPHKGTWSKMHLYLREEVEQFAIKKWGSLEELDREKQRREKMKDDRKEKKLEKKIKELRRKTRTSnysrMDVREKE 258


                 ....*.
gi 688531583 242 IHQHDY 247
Cdd:COG5145  259 KHVHVF 264
XPA_C pfam05181
XPA protein C-terminus;
136-187 4.98e-25

XPA protein C-terminus;


Pssm-ID: 461572  Cd Length: 51  Bit Score: 94.14  E-value: 4.98e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 688531583  136 KHKLISRTEAKKNYLLKDCDLDKREPpLRFILRKNPHNPRWGDMKLYLKTQV 187
Cdd:pfam05181   1 KYSLITKTEAKEDYLLTDCDLKDREL-LRFLKKPNPHNGTWGDMKLYLRLQV 51
DBD_Rad14 cd21077
DNA-binding domain found in yeast DNA repair protein Rad14 and similar proteins; Rad14 is ...
 106-208 1.54e-22

DNA-binding domain found in yeast DNA repair protein Rad14 and similar proteins; Rad14 is involved in nucleotide excision repair. It binds specifically to damaged DNA and is required for the incision step. Rad14 is a component of the nucleotide excision repair factor 1 (NEF1) complex consisting of Rad1, Rad10 and Rad14.


Pssm-ID: 410963 [Multi-domain]  Cd Length: 105  Bit Score: 89.38  E-value: 1.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 106 CEECQKPFMDSYLSNSFDLSVCDKCRDNEV-KHKLISRTEAKKNYLLKDCDLDKREPpLRFILRKNPHNPRWGDMKLYLK 184
Cdd:cd21077    3 CRECGSNEIDDVLHDVFGVSVCKACKEKHPeKYSLLTKTECKEDYLLTDPELNDEEL-LPHLEKPNPHKSTWSDMQLFLR 81

                         90       100
                 ....*....|....*....|....
gi 688531583 185 TQVEKRSVEVWGSDEALEEAKETR 208
Cdd:cd21077   82 CQVEAFALKKWGSPEALDEEFERR 105
DBD_XPA-like cd21075
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA ...
 138-208 2.77e-21

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14 and similar proteins; The family includes DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14, zinc transporter 9 (ZNT9) and similar proteins. XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Rad14 is involved in nucleotide excision repair. It binds specifically to damaged DNA and is required for the incision step. Rad14 is a component of the nucleotide excision repair factor 1 (NEF1) complex consisting of Rad1, Rad10 and Rad14. ZNT9, also known as solute carrier family 30 member 9 (SLC30A9), may act as a zinc transporter involved in intracellular zinc homeostasis and may also play a role as nuclear receptor coactivator. The model corresponds to the DNA-binding domain found in XPA and Rad14. It consists of a conserved N-terminal zinc-binding subdomain and a C-terminal alpha/beta fold subdomain. ZNT9 contains only C-terminal alpha/beta fold subdomain but lacks of N-terminal zinc-binding subdomain.


Pssm-ID: 410961  Cd Length: 67  Bit Score: 84.56  E-value: 2.77e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688531583 138 KLISRTEAKKNYLLKDCDLDKreppLRFILRKNPHNPRWGDMKLYLKTQVEKRSVEVWGSDEALEEAKETR 208
Cdd:cd21075    1 RLITKTDAKKEYRLTDKDLAG----LPYEEKPNPHGPSAAPMKLYLEREVERLAWRKHGGPEGLEAALEKR 67
XPA_N pfam01286
XPA protein N-terminal;
103-134 3.97e-14

XPA protein N-terminal;


Pssm-ID: 460148  Cd Length: 32  Bit Score: 64.87  E-value: 3.97e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 688531583  103 YLMCEECQKPFMDSYLSNSFDLSVCDKCRDNE 134
Cdd:pfam01286   1 APKCLECGKPFLDSYLLDNFDYPVCDKCRDKE 32
NTD_ZNT9 cd21078
N-terminal domain found in zinc transporter 9 (ZNT9) and similar proteins; ZNT9, also known as ...
 138-225 4.20e-12

N-terminal domain found in zinc transporter 9 (ZNT9) and similar proteins; ZNT9, also known as solute carrier family 30 member 9 (SLC30A9), may act as a zinc transporter involved in intracellular zinc homeostasis and may also play a role as nuclear receptor coactivator.


Pssm-ID: 410964  Cd Length: 89  Bit Score: 60.67  E-value: 4.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688531583 138 KLISRTEAKKNYLLKDCDLDKreppLRFILRKNPHNpRWGDMKLYLKTQVEKRSVEVWGSDEALEEAKETREENKEVQKQ 217
Cdd:cd21078    3 NYITAVRAMNEYLLKPSDLEG----LRKIKRRSPYD-DEPPITVYLRSDVEAKAIEKWGSLEALEKERKKRKEIEEAYRE 77


                 ....*...
gi 688531583 218 KRFNKKVK 225
Cdd:cd21078   78 YLFLLKKL 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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