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Conserved domains on  [gi|688576527|ref|XP_009304156|]
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histone-binding protein RBBP7 isoform X1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-313 1.69e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 158
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 159 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 238
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688576527 239 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 313
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-313 1.69e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 158
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 159 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 238
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688576527 239 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 313
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-312 3.87e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 3.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  31 HEGEVNRARYMPQNPcIIATKTPTSDVLVFDYTkhpskpdpsgDCSPDLRLRGHQKEGYGLSWNPNlSGNLLSASDDHTI 110
Cdd:cd00200    8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 111 CLWDISGapkeGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSvADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFN 190
Cdd:cd00200   76 RLWDLET----GECV---RTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 191 PYSEFIlATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETILASSGtDRRLNVWDLSKigeeqsaedaedg 270
Cdd:cd00200  145 PDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 688576527 271 pPELLFIHGGHTAKISDFSWNPNEPWvICSVSEDNIMQVWQM 312
Cdd:cd00200  209 -GKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDL 248
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 77-256 7.25e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 7.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  77 PDLRLRGHQKEGyGLSWNPNLSGNLLSASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSVAD 156
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA----RSQLV---TEMKEHEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 157 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 233
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 688576527 234 SphNETILASSGTDRRLNVWDLS 256
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-210 3.97e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.97e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 688576527   170 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 210
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
171-210 2.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.36e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 688576527  171 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 210
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-313 1.69e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 158
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 159 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 238
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688576527 239 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 313
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-312 3.87e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 3.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  31 HEGEVNRARYMPQNPcIIATKTPTSDVLVFDYTkhpskpdpsgDCSPDLRLRGHQKEGYGLSWNPNlSGNLLSASDDHTI 110
Cdd:cd00200    8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 111 CLWDISGapkeGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSvADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFN 190
Cdd:cd00200   76 RLWDLET----GECV---RTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 191 PYSEFIlATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETILASSGtDRRLNVWDLSKigeeqsaedaedg 270
Cdd:cd00200  145 PDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 688576527 271 pPELLFIHGGHTAKISDFSWNPNEPWvICSVSEDNIMQVWQM 312
Cdd:cd00200  209 -GKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-311 6.20e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 6.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  30 NHEGEVNRARYMPQNPCIIATkTPTSDVLVFDYTKhpskpdpsGDCSpdLRLRGHQKEGYGLSWNPNLSgNLLSASDDHT 109
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG-SSDKTIRLWDLET--------GECV--RTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 110 ICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLS 188
Cdd:cd00200  117 IKVWDV----ETGKCL---TTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 189 FNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsaedae 268
Cdd:cd00200  185 FSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT----------- 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 688576527 269 dgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 311
Cdd:cd00200  251 ---GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
80-313 1.17e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGN-LLSASDDHTICLWDISGapkeGKIVdakTIFTGHTAVVEDVSWH-----LLheslfgS 153
Cdd:COG2319  115 TLTGHTGAVRSVAFSPD--GKtLASGSADGTVRLWDLAT----GKLL---RTLTGHSGAVTSVAFSpdgklLA------S 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 154 VADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQW 233
Cdd:COG2319  180 GSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 234 SPhNETILASSGTDRRLNVWDLSkigeeqsaedaedgPPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 313
Cdd:COG2319  255 SP-DGRLLASGSADGTVRLWDLA--------------TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-314 1.08e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  81 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWDISGapkegkiVDAKTIFTGHTAVVEDVSWHLLHESLFgSVADDQKL 160
Cdd:cd00200    5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 161 MIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTI 240
Cdd:cd00200   76 RLWDL---ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDG-TF 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688576527 241 LASSGTDRRLNVWDLSKIGEEQSAEdaedgppellfihgGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMAE 314
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVATLT--------------GHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
80-256 1.02e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDISGapkeGKIVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQ 158
Cdd:COG2319  241 TLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLAT----GELL---RTLTGHSGGVNSVAFSPDGKLLA-SGSDDG 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 159 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 238
Cdd:COG2319  311 TVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DG 384

                        170
                 ....*....|....*...
gi 688576527 239 TILASSGTDRRLNVWDLS 256
Cdd:COG2319  385 RTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
79-313 8.64e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 8.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  79 LRLRGHQKEGYGLSWNPnLSGNLLSASDDHTICLWDISGAPkegkivdAKTIFTGHTAVVEDVSWHLLHESLfGSVADDQ 158
Cdd:COG2319   30 LLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 159 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 238
Cdd:COG2319  101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688576527 239 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 313
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-313 2.01e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 2.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 173 PSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETiLASSGTDRRLNV 252
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688576527 253 WDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMA 313
Cdd:cd00200   78 WDLET--------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
80-213 1.81e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 1.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  80 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQ 158
Cdd:COG2319  283 TLTGHSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLA----TGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDG 352

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 688576527 159 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRN 213
Cdd:COG2319  353 TVRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 77-256 7.25e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 7.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  77 PDLRLRGHQKEGyGLSWNPNLSGNLLSASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSVAD 156
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA----RSQLV---TEMKEHEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 157 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 233
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 688576527 234 SphNETILASSGTDRRLNVWDLS 256
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
 173-255 1.65e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 173 PSHSVDAHTAEVNCLSFNP-YSEfILATGSADKTVALWDLRN-------LKLKLHSFESHKDEIFQVQWSPHNETILASS 244
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcFSE-ILASGSEDLTIRVWEIPHndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|.
gi 688576527 245 GTDRRLNVWDL 255
Cdd:PTZ00420 145 GFDSFVNIWDI 155
PTZ00421 PTZ00421
coronin; Provisional
 91-266 3.07e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  91 LSWNPNLSGNLLSASDDHTICLWDIsgaPKEG---KIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTrs 167
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGI---PEEGltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV-- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 168 nNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQ-VQWSPHNETILA---S 243
Cdd:PTZ00421 156 -ERGKAVEVIKCHSDQITSLEWNLDGS-LLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQrCLWAKRKDLIITlgcS 232

                        170       180
                 ....*....|....*....|...
gi 688576527 244 SGTDRRLNVWDLSKIGEEQSAED 266
Cdd:PTZ00421 233 KSQQRQIMLWDTRKMASPYSTVD 255
PTZ00420 PTZ00420
coronin; Provisional
 69-215 3.71e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.57  E-value: 3.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  69 PDPSGDCSPDLRLRGHQKEGYGLSwnpnlsgnllsASDDHTICLWDISGAPKEGKIVDAKTI-------FTGHTAVVEDV 141
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEVEGGGLIGAIRLENQMrkppvikLKGHTSSILDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688576527 142 SWHLLHESLFGSVADDQKLMIWDTRSNNTS-----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 215
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 214-315 1.63e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 214 LKLKlhsfeSHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKigEEQSAEDAEDGppelLFIHGGHTAKISDFSWNPN 293
Cdd:PTZ00420  68 IKLK-----GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKDP----QCILKGHKKKISIIDWNPM 136

                         90       100
                 ....*....|....*....|..
gi 688576527 294 EPWVICSVSEDNIMQVWQMaEN 315
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-210 3.97e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.97e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 688576527   170 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 210
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 122-254 1.12e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 122 GKIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR----SNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 197
Cdd:PTZ00421  62 GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688576527 198 ATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 254
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
171-210 2.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.36e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 688576527  171 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 210
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 76-214 3.13e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527  76 SPDLRLRGHQKEGYGLSWNPNLSGNLLSASDDHTICLWDIsgapKEGKivdAKTIFTGHTAVVEDVSWHlLHESLFGSVA 155
Cdd:PTZ00421 116 DPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV----ERGK---AVEVIKCHSDQITSLEWN-LDGSLLCTTS 187

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688576527 156 DDQKLMIWDTRSnntSKPSHSVDAH--TAEVNCLsFNPYSEFILATG---SADKTVALWDLRNL 214
Cdd:PTZ00421 188 KDKKLNIIDPRD---GTIVSSVEAHasAKSQRCL-WAKRKDLIITLGcskSQQRQIMLWDTRKM 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-254 7.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 688576527   218 LHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 254
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 187-309 2.19e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688576527 187 LSFNPYSEFILATGSADKTVALWDL------RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK--I 258
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERgkA 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 688576527 259 GEEQSAedaedgppellfihggHTAKISDFSWNPNEPwVICSVSEDNIMQV 309
Cdd:PTZ00421 161 VEVIKC----------------HSDQITSLEWNLDGS-LLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 81-114 2.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 688576527    81 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWD 114
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-254 5.40e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 688576527  218 LHSFESHKDEIFQVQWSPhNETILASSGTDRRLNVWD 254
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
81-114 2.56e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 688576527   81 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWD 114
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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