NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|688608299|ref|XP_009294369|]
View 

renin receptor isoform X1 [Danio rerio]

Protein Classification

Renin_r domain-containing protein( domain architecture ID 10545182)

Renin_r domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 290-398 4.25e-53

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


:

Pssm-ID: 462287  Cd Length: 97  Bit Score: 171.72  E-value: 4.25e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688608299  290 VYGNNAVVEVVTVKTFEVPLTRKSRSILESKQmgsrrtnrfknvPSNPGSPYNLAYKYNFDYAVIFNIVLWLMIVLALAV 369
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQ------------ANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLAL 68

                          90       100
                  ....*....|....*....|....*....
gi 688608299  370 IAISYNLWNMDPGYDSIIYRMTNQKIRLD 398
Cdd:pfam07850  69 IVISYGLWNMDPGRDSIIYRMTTTRMKKD 97
 
Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 290-398 4.25e-53

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


Pssm-ID: 462287  Cd Length: 97  Bit Score: 171.72  E-value: 4.25e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688608299  290 VYGNNAVVEVVTVKTFEVPLTRKSRSILESKQmgsrrtnrfknvPSNPGSPYNLAYKYNFDYAVIFNIVLWLMIVLALAV 369
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQ------------ANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLAL 68

                          90       100
                  ....*....|....*....|....*....
gi 688608299  370 IAISYNLWNMDPGYDSIIYRMTNQKIRLD 398
Cdd:pfam07850  69 IVISYGLWNMDPGRDSIIYRMTTTRMKKD 97
 
Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 290-398 4.25e-53

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


Pssm-ID: 462287  Cd Length: 97  Bit Score: 171.72  E-value: 4.25e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688608299  290 VYGNNAVVEVVTVKTFEVPLTRKSRSILESKQmgsrrtnrfknvPSNPGSPYNLAYKYNFDYAVIFNIVLWLMIVLALAV 369
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQ------------ANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLAL 68

                          90       100
                  ....*....|....*....|....*....
gi 688608299  370 IAISYNLWNMDPGYDSIIYRMTNQKIRLD 398
Cdd:pfam07850  69 IVISYGLWNMDPGRDSIIYRMTTTRMKKD 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH