NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1691719341|ref|XP_008820344|]
View 

A-kinase anchoring protein 7 isoform X5 [Nannospalax galili]

Protein Classification

AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein( domain architecture ID 12106243)

AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 130-328 5.82e-61

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 195.57  E-value: 5.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 130 PNYFLSIPITNKKITGRIKILQNAILQQDQRLSQAM-VRDGSFHITLLVMQLLNEDEVNIGIDSLLELKPFIEEILKGKQ 208
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 209 LTLPFQGIGTFG-----SQVGFVKLAEGDHIDPLLEIAEMAKKTFQEKGILA-GDSRGFKPHLTFMKLSKAPALRKIGVK 282
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVkENNSRVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1691719341 283 KIEP-ELYEQFINHRFGEEILYRIDLCSMLKKKRSDGYYHCESSLVI 328
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 335-390 8.28e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


:

Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 8.28e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1691719341 335 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGSSVKAQEADRNGNDSDD 390
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 130-328 5.82e-61

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 195.57  E-value: 5.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 130 PNYFLSIPITNKKITGRIKILQNAILQQDQRLSQAM-VRDGSFHITLLVMQLLNEDEVNIGIDSLLELKPFIEEILKGKQ 208
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 209 LTLPFQGIGTFG-----SQVGFVKLAEGDHIDPLLEIAEMAKKTFQEKGILA-GDSRGFKPHLTFMKLSKAPALRKIGVK 282
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVkENNSRVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1691719341 283 KIEP-ELYEQFINHRFGEEILYRIDLCSMLKKKRSDGYYHCESSLVI 328
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 335-390 8.28e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 8.28e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1691719341 335 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGSSVKAQEADRNGNDSDD 390
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 132-266 3.51e-06

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 46.95  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPItNKKITGRIKILQNAiLQQDQRLSqaMVRDGSFHITLLVMQLLNEDEVNigidsllELKPFIEEILKG-KQLT 210
Cdd:COG1514     3 LFIALPP-PEELREALAALRAR-LKAAPGGR--WVRPENLHLTLAFLGEVDEERLE-------ALAEALARAAAGaPPFE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1691719341 211 LPFQGIGTFGSQVG---FVKLAEGDhidPLLEIAEMAKKTFQEKGiLAGDSRGFKPHLT 266
Cdd:COG1514    72 LRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT 126
PLN00108 PLN00108
unknown protein; Provisional
 132-326 3.29e-04

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 41.98  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPIT-NKKITGRIKILQNAILQQDQR--------------LSQAMVRDGSFHITLLVMQLLNEDEVNIGIDSLLEL 196
Cdd:PLN00108   38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstlaemgiEKSIFVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 197 KPFIEEILKGKQLTLPFQGIGTFG-----SQVGFVKLAEGDHIDPLLEIAEMAKKTFQEKGILAGDSRG-FKPHLTFMKL 270
Cdd:PLN00108  118 CSNVRQALKDRPVFIRLRGLDCMNgsldkTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 271 SkapaLRKIGVKKIEP----ELYEQFINHRFGEEILYRIDLcSMLKKKRSDGYYHCESSL 326
Cdd:PLN00108  198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
2_5_ligase TIGR02258
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
 132-273 5.74e-03

2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]


Pssm-ID: 274058 [Multi-domain]  Cd Length: 179  Bit Score: 37.65  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPITN---KKITGRIKILQnaILQQDQRLsqamVRDGSFHITLLVMQLLNEDEVNIGIDSLLELK--PFieeilkg 206
Cdd:TIGR02258   3 LFIAIDLPPeirEQLSRIQRKLK--SPLDGIKW----VPPENLHITLKFLGEVDEEQVEELEDALAKIAepPF------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1691719341 207 kqlTLPFQGIGTFGSQ----VGFVKLAEGDHIDPLleiAEMAKKTFQEKGILAgDSRGFKPHLTFMKLSKA 273
Cdd:TIGR02258  70 ---TLKLEGIGVFGNPkrprVLWAGVEQSEELTQL---HADLERELAKLGFSK-EERPFTPHITLARKKSG 133
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 130-328 5.82e-61

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 195.57  E-value: 5.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 130 PNYFLSIPITNKKITGRIKILQNAILQQDQRLSQAM-VRDGSFHITLLVMQLLNEDEVNIGIDSLLELKPFIEEILKGKQ 208
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 209 LTLPFQGIGTFG-----SQVGFVKLAEGDHIDPLLEIAEMAKKTFQEKGILA-GDSRGFKPHLTFMKLSKAPALRKIGVK 282
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVkENNSRVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1691719341 283 KIEP-ELYEQFINHRFGEEILYRIDLCSMLKKKRSDGYYHCESSLVI 328
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 335-390 8.28e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 8.28e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1691719341 335 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGSSVKAQEADRNGNDSDD 390
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 132-266 3.51e-06

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 46.95  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPItNKKITGRIKILQNAiLQQDQRLSqaMVRDGSFHITLLVMQLLNEDEVNigidsllELKPFIEEILKG-KQLT 210
Cdd:COG1514     3 LFIALPP-PEELREALAALRAR-LKAAPGGR--WVRPENLHLTLAFLGEVDEERLE-------ALAEALARAAAGaPPFE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1691719341 211 LPFQGIGTFGSQVG---FVKLAEGDhidPLLEIAEMAKKTFQEKGiLAGDSRGFKPHLT 266
Cdd:COG1514    72 LRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT 126
PLN00108 PLN00108
unknown protein; Provisional
 132-326 3.29e-04

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 41.98  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPIT-NKKITGRIKILQNAILQQDQR--------------LSQAMVRDGSFHITLLVMQLLNEDEVNIGIDSLLEL 196
Cdd:PLN00108   38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstlaemgiEKSIFVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 197 KPFIEEILKGKQLTLPFQGIGTFG-----SQVGFVKLAEGDHIDPLLEIAEMAKKTFQEKGILAGDSRG-FKPHLTFMKL 270
Cdd:PLN00108  118 CSNVRQALKDRPVFIRLRGLDCMNgsldkTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 271 SkapaLRKIGVKKIEP----ELYEQFINHRFGEEILYRIDLcSMLKKKRSDGYYHCESSL 326
Cdd:PLN00108  198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
2_5_ligase TIGR02258
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
 132-273 5.74e-03

2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]


Pssm-ID: 274058 [Multi-domain]  Cd Length: 179  Bit Score: 37.65  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 132 YFLSIPITN---KKITGRIKILQnaILQQDQRLsqamVRDGSFHITLLVMQLLNEDEVNIGIDSLLELK--PFieeilkg 206
Cdd:TIGR02258   3 LFIAIDLPPeirEQLSRIQRKLK--SPLDGIKW----VPPENLHITLKFLGEVDEEQVEELEDALAKIAepPF------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1691719341 207 kqlTLPFQGIGTFGSQ----VGFVKLAEGDHIDPLleiAEMAKKTFQEKGILAgDSRGFKPHLTFMKLSKA 273
Cdd:TIGR02258  70 ---TLKLEGIGVFGNPkrprVLWAGVEQSEELTQL---HADLERELAKLGFSK-EERPFTPHITLARKKSG 133
2_5_RNA_ligase2 pfam13563
2'-5' RNA ligase superfamily; This family contains proteins related to pfam02834. These ...
 172-279 6.74e-03

2'-5' RNA ligase superfamily; This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.


Pssm-ID: 433312 [Multi-domain]  Cd Length: 152  Bit Score: 37.02  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1691719341 172 HITLLVmQLLNEDevnigidSLLELKPFIEEILKG-KQLTLPFQGIGTFGSQVGFVKLAEGDhIDPLLEIAEMAKKTFQE 250
Cdd:pfam13563  27 HITLLY-PFVPDE-------LLPELLEALAEVAAEtEPFELTLGGFGTFGHRGGVVYLSVEG-SEPLRALHAALREALPP 97

                          90       100
                  ....*....|....*....|....*....
gi 1691719341 251 KGiLAGDSRGFKPHLTFMKLSKAPALRKI 279
Cdd:pfam13563  98 CL-LKQDSGPFTPHLTIAYKVDDAPAAEL 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH