|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
412-716 |
2.43e-76 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 257.15 E-value: 2.43e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 412 RLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSG 491
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 492 TGKLVHTYEEHSEQVNCCHFTNKSNhlLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTL 571
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 572 KLWDVRSANEKKSInvkrfflssedppEDVEVIVKCCSWSADGDRIIVAAKNK-VLLLDIHTSGLLTEiHTGHHSTIQYC 650
Cdd:COG2319 271 RLWDLATGELLRTL-------------TGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGAVRSV 336
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672058299 651 DFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETR 716
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
411-714 |
1.48e-74 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 248.02 E-value: 1.48e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 411 SRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDS 490
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 491 GTGKLVHTYEEHSEQVNCCHFTNksNHLLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGT 570
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 571 LKLWDVRsanekkSINVKRFFLSSEDPpedveviVKCCSWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYC 650
Cdd:cd00200 159 IKLWDLR------TGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672058299 651 DFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 714
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
257-391 |
1.79e-73 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 238.86 E-value: 1.79e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 257 LQDLHRKMVTQFQRYHQPHTLSPGQEDCMYWYNFLAYHMASAGMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHI 336
Cdd:pfam17908 1 LQDLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 672058299 337 LDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQE 391
Cdd:pfam17908 81 LDENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
609-1039 |
3.82e-69 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 237.12 E-value: 3.82e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 609 SWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSW 688
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 689 VHGVMFSPDGSSFLTASDDQTIRVWETRkvcknsaivlkqeidvvfqenemmvlavdnirglqliAGKTGQIDYLPEAQV 768
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLA-------------------------------------TGLLLRTLTGHTGAV 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 769 SCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVF-LQAH 847
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGH 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 848 QETVKDFRLLRDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHE 926
Cdd:COG2319 204 TGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 927 LKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHlcapisieeGTATHGGWVTDVCFSPDRKMLVSAG--GYL 1004
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKTLASGSddGTV 354
|
410 420 430
....*....|....*....|....*....|....*
gi 672058299 1005 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVT 1039
Cdd:COG2319 355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
765-1039 |
3.20e-60 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 207.96 E-value: 3.20e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 765 EAQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVF- 843
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 844 LQAHQETVKDFRLLRDSRLLSWS-FDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPS 922
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 923 PLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLCAPisieegtatHGGWVTDVCFSPDRKMLVSAG- 1001
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---------HENGVNSVAFSPDGYLLASGSe 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 672058299 1002 -GYLKWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVT 1039
Cdd:cd00200 240 dGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
3-178 |
5.80e-41 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 150.99 E-value: 5.80e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 3 LQNLCTRLGQEESFSQRlplnieEAKDRLRVLMLRKhpRSLLILDDVWD--PW-----VLKAFDNQCQILLTTRDKSVTD 75
Cdd:pfam00931 71 LQNLGLSEDDWDNKEEG------ELARKIRRALLTK--RFLLVLDDVWDeeDWdkigiPLPDRENGCRVLLTTRSEEVAG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 76 SVMGPKYVIPVESgLGKEKGLEILSLFVNMK----KEDLPVEAHSIIKECKGSPLVVSLVGALL--RDFPNRWAYYLRQL 149
Cdd:pfam00931 143 RVGGPSDPHEVEL-LEPDEAWELFENKVFPKtlgeCELLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVL 221
|
170 180
....*....|....*....|....*....
gi 672058299 150 QNKQfkrirKSSSYDYEALDEAMSISVEM 178
Cdd:pfam00931 222 QSEL-----KSNSYSLNSVRSILQLSYEN 245
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
427-576 |
3.14e-12 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 70.89 E-value: 3.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 427 FSQDGQRIASCGADKTLQVFKAETGEK--------LLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHT 498
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 499 YEEHSEQVNCCHFTNkSNHLLLATGSNDSFLKLWDLNQK-------------------------------------ECRN 541
Cdd:PLN00181 571 MKEHEKRVWSIDYSS-ADPTLLASGSDDGSVKLWSINQGvsigtiktkaniccvqfpsesgrslafgsadhkvyyyDLRN 649
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 672058299 542 ------TMFGHTNSVTHCRFSpDDELLASCSADGTLKLWDV 576
Cdd:PLN00181 650 pklplcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
536-575 |
3.00e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.17 E-value: 3.00e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 672058299 536 QKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWD 575
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
537-575 |
1.22e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 54.27 E-value: 1.22e-09
10 20 30
....*....|....*....|....*....|....*....
gi 672058299 537 KECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWD 575
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
922-959 |
1.66e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 1.66e-06
10 20 30
....*....|....*....|....*....|....*...
gi 672058299 922 SPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWN 959
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
922-959 |
3.83e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.64 E-value: 3.83e-06
10 20 30
....*....|....*....|....*....|....*...
gi 672058299 922 SPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWN 959
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
860-1026 |
9.33e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 49.70 E-value: 9.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 860 SRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISS-DATKFSSTSADKTAKIWSFELPSPLHELKGH-NSCvrCS 937
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKaNIC--CV 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 938 AFSLD-GILLATGDDNGEIRIWNVSDGQlLHLCAPISieegtatHGGWVTDVCFSpDRKMLVSAG--GYLKWWNV---VT 1011
Cdd:PLN00181 624 QFPSEsGRSLAFGSADHKVYYYDLRNPK-LPLCTMIG-------HSKTVSYVRFV-DSSTLVSSStdNTLKLWDLsmsIS 694
|
170
....*....|....*..
gi 672058299 1012 G--ESSQTFYTNGTNLK 1026
Cdd:PLN00181 695 GinETPLHSFMGHTNVK 711
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
412-716 |
2.43e-76 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 257.15 E-value: 2.43e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 412 RLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSG 491
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 492 TGKLVHTYEEHSEQVNCCHFTNKSNhlLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTL 571
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 572 KLWDVRSANEKKSInvkrfflssedppEDVEVIVKCCSWSADGDRIIVAAKNK-VLLLDIHTSGLLTEiHTGHHSTIQYC 650
Cdd:COG2319 271 RLWDLATGELLRTL-------------TGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGAVRSV 336
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672058299 651 DFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETR 716
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
427-1011 |
6.65e-76 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 255.61 E-value: 6.65e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 427 FSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEHSEQV 506
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 507 NCCHFTnkSNHLLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSIn 586
Cdd:COG2319 82 LSVAFS--PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 587 vkrfflssedppedvevivkccswsadgdriivaaknkvllldihtsgllteihtghhstiqycdfspydhlavialsqy 666
Cdd:COG2319 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 667 cvelwnidsrvkvadcRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETRkvcknsaivlkqeidvvfqenemmvlavdn 746
Cdd:COG2319 159 ----------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------------------------------ 192
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 747 irglqliagkTGQidylpeaqvsccclsphleyvafgdeegaiKIIELPnnrvfssgiGHKKAVRHIQFTADGKTLISSS 826
Cdd:COG2319 193 ----------TGK------------------------------LLRTLT---------GHTGAVRSVAFSPDGKLLASGS 223
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 827 EDSVIQVWNWQTEEYVF-LQAHQETVKDFRLLRDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKF 904
Cdd:COG2319 224 ADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 905 SSTSADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLcapisieegTATHGGW 984
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---------LTGHTGA 374
|
570 580
....*....|....*....|....*....
gi 672058299 985 VTDVCFSPDRKMLVSAG--GYLKWWNVVT 1011
Cdd:COG2319 375 VTSVAFSPDGRTLASGSadGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
411-714 |
1.48e-74 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 248.02 E-value: 1.48e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 411 SRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDS 490
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 491 GTGKLVHTYEEHSEQVNCCHFTNksNHLLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGT 570
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 571 LKLWDVRsanekkSINVKRFFLSSEDPpedveviVKCCSWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYC 650
Cdd:cd00200 159 IKLWDLR------TGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672058299 651 DFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 714
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
257-391 |
1.79e-73 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 238.86 E-value: 1.79e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 257 LQDLHRKMVTQFQRYHQPHTLSPGQEDCMYWYNFLAYHMASAGMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHI 336
Cdd:pfam17908 1 LQDLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 672058299 337 LDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQE 391
Cdd:pfam17908 81 LDENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
412-838 |
5.95e-73 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 247.52 E-value: 5.95e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 412 RLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSG 491
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 492 TGKLVHTYEEHSEQVNCCHFTNKSNhlLLATGSNDSFLKLWDLNQKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTL 571
Cdd:COG2319 151 TGKLLRTLTGHSGAVTSVAFSPDGK--LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 572 KLWDVRSANEKKSINVKRFFlssedppedveviVKCCSWSADGDRIIVAAKNKVllldihtsgllteihtghhstiqycd 651
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGS-------------VRSVAFSPDGRLLASGSADGT-------------------------- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 652 fspydhlavialsqycVELWNIDSRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWetrkvcknsaivlkqeid 731
Cdd:COG2319 270 ----------------VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW------------------ 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 732 vvfqenemmvlavdNIRGLQLIAGKTGQIDylpeaQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVR 811
Cdd:COG2319 316 --------------DLATGKLLRTLTGHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
|
410 420
....*....|....*....|....*..
gi 672058299 812 HIQFTADGKTLISSSEDSVIQVWNWQT 838
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
609-1039 |
3.82e-69 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 237.12 E-value: 3.82e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 609 SWSADGDRIIVAAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRVKVADCRGHLSW 688
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 689 VHGVMFSPDGSSFLTASDDQTIRVWETRkvcknsaivlkqeidvvfqenemmvlavdnirglqliAGKTGQIDYLPEAQV 768
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLA-------------------------------------TGLLLRTLTGHTGAV 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 769 SCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVF-LQAH 847
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGH 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 848 QETVKDFRLLRDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHE 926
Cdd:COG2319 204 TGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 927 LKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHlcapisieeGTATHGGWVTDVCFSPDRKMLVSAG--GYL 1004
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKTLASGSddGTV 354
|
410 420 430
....*....|....*....|....*....|....*
gi 672058299 1005 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVT 1039
Cdd:COG2319 355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
765-1039 |
3.20e-60 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 207.96 E-value: 3.20e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 765 EAQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVF- 843
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 844 LQAHQETVKDFRLLRDSRLLSWS-FDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPS 922
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 923 PLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLCAPisieegtatHGGWVTDVCFSPDRKMLVSAG- 1001
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---------HENGVNSVAFSPDGYLLASGSe 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 672058299 1002 -GYLKWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVT 1039
Cdd:cd00200 240 dGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
457-875 |
9.35e-55 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 192.16 E-value: 9.35e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 457 IKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEHSEQVNCCHFTNKSNhlLLATGSNDSFLKLWDLNQ 536
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT--YLASGSSDKTIRLWDLET 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 537 KECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSInvkrfflssedppedvevivkccswsadgdr 616
Cdd:cd00200 83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL------------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 617 iivaaknkvllldihtsgllteihtghhstiqycdfspydhlavialsqycvelwnidsrvkvadcRGHLSWVHGVMFSP 696
Cdd:cd00200 132 ------------------------------------------------------------------RGHTDWVNSVAFSP 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 697 DGSSFLTASDDQTIRVWETRkvcknsaivlkqeidvvfqenemmvlavdNIRGLQLIAGKTGqidylpeaQVSCCCLSPH 776
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLR-----------------------------TGKCVATLTGHTG--------EVNSVAFSPD 188
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 777 LEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVF-LQAHQETVKDFR 855
Cdd:cd00200 189 GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQtLSGHTNSVTSLA 268
|
410 420
....*....|....*....|.
gi 672058299 856 LLRD-SRLLSWSFDGTVKVWN 875
Cdd:cd00200 269 WSPDgKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
773-1051 |
1.02e-52 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 190.51 E-value: 1.02e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 773 LSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQT-EEYVFLQAHQETV 851
Cdd:COG2319 44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATgLLLRTLTGHTGAV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 852 KDFRLLRD-SRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGH 930
Cdd:COG2319 124 RSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 931 NSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLcapisieegTATHGGWVTDVCFSPDRKMLVSAG--GYLKWWN 1008
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT---------LTGHSGSVRSVAFSPDGRLLASGSadGTVRLWD 274
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 672058299 1009 VVTGESSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQV 1051
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
683-1008 |
5.56e-52 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 184.46 E-value: 5.56e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 683 RGHLSWVHGVMFSPDGSSFLTASDDQTIRVWetrkvcknsaivlkqeidvvfqenemmvlavdNIRGLQLIAGKTGQIDy 762
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVW--------------------------------DLETGELLRTLKGHTG- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 763 lpeaQVSCCCLSPHLEYVAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYV 842
Cdd:cd00200 53 ----PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 843 F-LQAHQETVKDFRLLRDSRLL-SWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFEL 920
Cdd:cd00200 129 TtLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 921 PSPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHlcapiSIEEgtatHGGWVTDVCFSPDRKMLVSA 1000
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ-----TLSG----HTNSVTSLAWSPDGKRLASG 279
|
330
....*....|
gi 672058299 1001 G--GYLKWWN 1008
Cdd:cd00200 280 SadGTIRIWD 289
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
3-178 |
5.80e-41 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 150.99 E-value: 5.80e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 3 LQNLCTRLGQEESFSQRlplnieEAKDRLRVLMLRKhpRSLLILDDVWD--PW-----VLKAFDNQCQILLTTRDKSVTD 75
Cdd:pfam00931 71 LQNLGLSEDDWDNKEEG------ELARKIRRALLTK--RFLLVLDDVWDeeDWdkigiPLPDRENGCRVLLTTRSEEVAG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 76 SVMGPKYVIPVESgLGKEKGLEILSLFVNMK----KEDLPVEAHSIIKECKGSPLVVSLVGALL--RDFPNRWAYYLRQL 149
Cdd:pfam00931 143 RVGGPSDPHEVEL-LEPDEAWELFENKVFPKtlgeCELLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVL 221
|
170 180
....*....|....*....|....*....
gi 672058299 150 QNKQfkrirKSSSYDYEALDEAMSISVEM 178
Cdd:pfam00931 222 QSEL-----KSNSYSLNSVRSILQLSYEN 245
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
883-1048 |
3.92e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.79 E-value: 3.92e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 883 RDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSD 962
Cdd:cd00200 3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 963 GQLLHlcapisieegT-ATHGGWVTDVCFSPDRKMLVSAG--GYLKWWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVT 1039
Cdd:cd00200 83 GECVR----------TlTGHTSYVSSVAFSPDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152
|
....*....
gi 672058299 1040 VDNLGILYI 1048
Cdd:cd00200 153 SSQDGTIKL 161
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
427-576 |
3.14e-12 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 70.89 E-value: 3.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 427 FSQDGQRIASCGADKTLQVFKAETGEK--------LLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHT 498
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTE 570
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 499 YEEHSEQVNCCHFTNkSNHLLLATGSNDSFLKLWDLNQK-------------------------------------ECRN 541
Cdd:PLN00181 571 MKEHEKRVWSIDYSS-ADPTLLASGSDDGSVKLWSINQGvsigtiktkaniccvqfpsesgrslafgsadhkvyyyDLRN 649
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 672058299 542 ------TMFGHTNSVTHCRFSpDDELLASCSADGTLKLWDV 576
Cdd:PLN00181 650 pklplcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
923-1018 |
1.13e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 66.59 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 923 PLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLCapisieegtATHGGWVTDVCFSPDRKMLVSAG- 1001
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---------KGHTGPVRDVAASADGTYLASGSs 71
|
90
....*....|....*...
gi 672058299 1002 -GYLKWWNVVTGESSQTF 1018
Cdd:cd00200 72 dKTIRLWDLETGECVRTL 89
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
536-575 |
3.00e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.17 E-value: 3.00e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 672058299 536 QKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWD 575
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
537-575 |
1.22e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 54.27 E-value: 1.22e-09
10 20 30
....*....|....*....|....*....|....*....
gi 672058299 537 KECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWD 575
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
450-489 |
2.61e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.47 E-value: 2.61e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 672058299 450 TGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWD 489
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
451-489 |
1.93e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 51.19 E-value: 1.93e-08
10 20 30
....*....|....*....|....*....|....*....
gi 672058299 451 GEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWD 489
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
465-673 |
1.64e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 55.48 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 465 LCCA--FSSDDSYIATCSVDKKVKIWDSGT----GKLVH----TYEEHSEQVNCCHftNKSNHLLLATGSNDSFLKLWDL 534
Cdd:PLN00181 485 LVCAigFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELASRSKLSGICW--NSYIKSQVASSNFEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 535 NQKECRNTMFGHTNSVTHCRFSP-DDELLASCSADGTLKLWDVRSANEKKSINVKrfflssedppedveVIVKCCSWSAD 613
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK--------------ANICCVQFPSE 628
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672058299 614 GDRIIV--AAKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLaVIALSQYCVELWNI 673
Cdd:PLN00181 629 SGRSLAfgSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTL-VSSSTDNTLKLWDL 689
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
675-714 |
5.16e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 5.16e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 672058299 675 SRVKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 714
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
922-959 |
1.66e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 1.66e-06
10 20 30
....*....|....*....|....*....|....*...
gi 672058299 922 SPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWN 959
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
492-533 |
3.36e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.61 E-value: 3.36e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 672058299 492 TGKLVHTYEEHSEQVNCCHFTNKSNHllLATGSNDSFLKLWD 533
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKY--LASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
922-959 |
3.83e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.64 E-value: 3.83e-06
10 20 30
....*....|....*....|....*....|....*...
gi 672058299 922 SPLHELKGHNSCVRCSAFSLDGILLATGDDNGEIRIWN 959
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
679-714 |
8.57e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.49 E-value: 8.57e-06
10 20 30
....*....|....*....|....*....|....*.
gi 672058299 679 VADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWE 714
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
860-1026 |
9.33e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 49.70 E-value: 9.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 860 SRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISS-DATKFSSTSADKTAKIWSFELPSPLHELKGH-NSCvrCS 937
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKaNIC--CV 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 938 AFSLD-GILLATGDDNGEIRIWNVSDGQlLHLCAPISieegtatHGGWVTDVCFSpDRKMLVSAG--GYLKWWNV---VT 1011
Cdd:PLN00181 624 QFPSEsGRSLAFGSADHKVYYYDLRNPK-LPLCTMIG-------HSKTVSYVRFV-DSSTLVSSStdNTLKLWDLsmsIS 694
|
170
....*....|....*..
gi 672058299 1012 G--ESSQTFYTNGTNLK 1026
Cdd:PLN00181 695 GinETPLHSFMGHTNVK 711
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
914-969 |
2.26e-05 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 43.81 E-value: 2.26e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 672058299 914 KIWSFELPsplhelkGHNSCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHLC 969
Cdd:pfam12894 28 RVWTLSPD-------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
493-533 |
3.39e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 3.39e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 672058299 493 GKLVHTYEEHSEQVNCCHFTnkSNHLLLATGSNDSFLKLWD 533
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFS--PDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
428-623 |
7.56e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.00 E-value: 7.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 428 SQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDeVLCCAFSSDDSY-IATCSVDKKVKIWDSGTGKL-VHTYEEHSEQ 505
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRsLAFGSADHKVYYYDLRNPKLpLCTMIGHSKT 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 506 VNCCHFTNKSNhllLATGSNDSFLKLWDLN------QKECRNTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWdvrsa 579
Cdd:PLN00181 664 VSYVRFVDSST---LVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY----- 735
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 672058299 580 NEKKSINVKRFFLSSEDPPEDVEV-----IVKCCSWSADGDRIIVAAKN 623
Cdd:PLN00181 736 HKAFPMPVLSYKFKTIDPVSGLEVddasqFISSVCWRGQSSTLVAANST 784
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
434-538 |
1.23e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 46.04 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 434 IASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEH-SEQVNCCHFT 512
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWA 220
|
90 100
....*....|....*....|....*....
gi 672058299 513 NKSNhLLLATGSNDS---FLKLWDLNQKE 538
Cdd:PTZ00421 221 KRKD-LIITLGCSKSqqrQIMLWDTRKMA 248
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
414-447 |
1.28e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 1.28e-04
10 20 30
....*....|....*....|....*....|....
gi 672058299 414 VVRPHTDAVYHACFSQDGQRIASCGADKTLQVFK 447
Cdd:smart00320 7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
878-917 |
1.43e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 1.43e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 672058299 878 TGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWS 917
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
805-835 |
2.93e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.22 E-value: 2.93e-04
10 20 30
....*....|....*....|....*....|.
gi 672058299 805 GHKKAVRHIQFTADGKTLISSSEDSVIQVWN 835
Cdd:smart00320 10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
805-835 |
3.32e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.87 E-value: 3.32e-04
10 20 30
....*....|....*....|....*....|.
gi 672058299 805 GHKKAVRHIQFTADGKTLISSSEDSVIQVWN 835
Cdd:pfam00400 9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
879-917 |
4.72e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.48 E-value: 4.72e-04
10 20 30
....*....|....*....|....*....|....*....
gi 672058299 879 GRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWS 917
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
981-1008 |
1.13e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 1.13e-03
10 20 30
....*....|....*....|....*....|
gi 672058299 981 HGGWVTDVCFSPDRKMLVSAG--GYLKWWN 1008
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
414-446 |
1.62e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.94 E-value: 1.62e-03
10 20 30
....*....|....*....|....*....|...
gi 672058299 414 VVRPHTDAVYHACFSQDGQRIASCGADKTLQVF 446
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
436-489 |
2.73e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 41.21 E-value: 2.73e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 672058299 436 SCGA-DKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVDKKVKIWD 489
Cdd:pfam20426 98 SCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWE 152
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
818-915 |
2.86e-03 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 41.42 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 818 DGKTLISSSEDSVIQVWNWQTE--------EYVFLQAHQETVK--DFRLLRDSRLLSWSFDGTVKVWNVITGRIERDFTC 887
Cdd:PTZ00421 87 DPQKLFTASEDGTIMGWGIPEEgltqnisdPIVHLQGHTKKVGivSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKC 166
|
90 100
....*....|....*....|....*...
gi 672058299 888 HQGTVLSCAISSDATKFSSTSADKTAKI 915
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNI 194
|
|
| eIF2A |
pfam08662 |
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ... |
555-735 |
4.12e-03 |
|
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.
Pssm-ID: 462552 [Multi-domain] Cd Length: 194 Bit Score: 39.56 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 555 FSPDD-ELLASCSADGTLKLWDVRSANEKKSI--NVKRFFLSSEDPPEDV-----EVIVKCCSWSADGDRIIVA---AKN 623
Cdd:pfam08662 4 FKADKvQLKWNKNGTYLLVLTDTDVDKTGKSYygETNLYLIGETGGPDCVveldkEGPIHDVAWSPNGKEFAVIygyMPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 624 KVLLLDiHTSGLLTEIHTGHHSTIQycdFSPYDHLAVIA----LSQYcVELWNIDSRVKVADCRGhlSWVHGVMFSPDGS 699
Cdd:pfam08662 84 KVSFFD-LKGNVIHSFGEQPRNTIF---WSPFGRLVLLAgfgnLAGD-IEFWDVVNKKKIATAEA--SNATLCEWSPDGR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 672058299 700 SFLTASD------DQTIRVWETrkvckNSAIVLKQEIDVVFQ 735
Cdd:pfam08662 157 YFLTATTaprlrvDNGFKIWHY-----NGALVYKYDFDELYQ 193
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
472-578 |
4.95e-03 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 40.65 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 472 DDSYIATCSVDKKVKIWD--------SGTGKLVHtYEEHSEQVNCCHFTNKSNHLLLATGSnDSFLKLWDLNQKECRNTM 543
Cdd:PTZ00421 87 DPQKLFTASEDGTIMGWGipeegltqNISDPIVH-LQGHTKKVGIVSFHPSAMNVLASAGA-DMVVNVWDVERGKAVEVI 164
|
90 100 110
....*....|....*....|....*....|....*
gi 672058299 544 FGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRS 578
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
|
|
| Nup160 |
pfam11715 |
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ... |
410-600 |
6.53e-03 |
|
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Pssm-ID: 432020 [Multi-domain] Cd Length: 540 Bit Score: 40.52 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 410 LSRLVVRPHTDAVYHACFSQDGQRIASCGadktLQVFKAETGEKLLDikAHEDEVL----CCAFSSDDSYIATCSVDKKV 485
Cdd:pfam11715 173 LLKLTRSSDGGAWKESTFEPASWLQSLSG----LLGWLADPTIRYSG--SSVALSLsaapAVTTVGGQNFLFTLSLDHTL 246
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058299 486 KIWDSGTGKLVHTYEehseqvncchftnksnhLLLATGSNDSFLKLwdlnqkecrnTMfGHTNSVTHCRFSPDDELLA-- 563
Cdd:pfam11715 247 RVWDLLTGKCLATID-----------------LLDLELPQDSSSWL----------TL-DPAPSSLIRVSGSFRAYLVlt 298
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170 180 190
....*....|....*....|....*....|....*...
gi 672058299 564 -SCSADGTLKLWDVRSANEkKSINVKRFFLSSEDPPED 600
Cdd:pfam11715 299 ySPSSNGQFKFWKVKSNDT-SELSLVDLFTDQTIRPAD 335
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