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Conserved domains on  [gi|632967564|ref|XP_007900047|]
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ankyrin repeat domain-containing protein 13A [Callorhinchus milii]

Protein Classification

GPCR_chapero_1 domain-containing protein( domain architecture ID 12790908)

GPCR_chapero_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-472 1.45e-121

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


:

Pssm-ID: 463391  Cd Length: 298  Bit Score: 360.80  E-value: 1.45e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  156 RVDTTLLNFDNMRWERGRRSYMFKGEAG-WAEFVEVDHDNQVVNREHFElSQEREGLTltsvrptEDQVASRLTTPIVCT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDsPGSLLELDHDEKEVQLEGAG-AEASEEEV-------EEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  235 ALDTKNISFERNKSGfWGwRTDKTEVVQEYEAKVFTVNNVNVVTRSRTEHLTEEEKAKYK-------DNRNPLESLLGIA 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  308 EEHIGPQNGV-VTETATVNNPTSITPEEYFDPefelgnrdigrPTELCIKSRKFKATLWLCEDYPLSlTEQVIPIINLMA 386
Cdd:pfam11904 151 EEEKGWFGKTrEESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLS-LEQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  387 RSSAHFAKLRDFITLQFPPGFPVKIEIPLFHVLNARITFGNVNTCRTVEAASPTPKSSqaesttSASEDSKFEVDQSVFD 466
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELDPVEEFSTPIKSP------ERGSPSSCEIDDDPFE 292


                  ....*.
gi 632967564  467 IPASYH 472
Cdd:pfam11904 293 IPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-96 2.03e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  13 LHLRVWQNDYRELEAEIRKH-HIEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVM 91
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170


                 ....*
gi 632967564  92 MVLQY 96
Cdd:COG0666  171 LLLEA 175
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-472 1.45e-121

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 360.80  E-value: 1.45e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  156 RVDTTLLNFDNMRWERGRRSYMFKGEAG-WAEFVEVDHDNQVVNREHFElSQEREGLTltsvrptEDQVASRLTTPIVCT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDsPGSLLELDHDEKEVQLEGAG-AEASEEEV-------EEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  235 ALDTKNISFERNKSGfWGwRTDKTEVVQEYEAKVFTVNNVNVVTRSRTEHLTEEEKAKYK-------DNRNPLESLLGIA 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  308 EEHIGPQNGV-VTETATVNNPTSITPEEYFDPefelgnrdigrPTELCIKSRKFKATLWLCEDYPLSlTEQVIPIINLMA 386
Cdd:pfam11904 151 EEEKGWFGKTrEESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLS-LEQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  387 RSSAHFAKLRDFITLQFPPGFPVKIEIPLFHVLNARITFGNVNTCRTVEAASPTPKSSqaesttSASEDSKFEVDQSVFD 466
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELDPVEEFSTPIKSP------ERGSPSSCEIDDDPFE 292


                  ....*.
gi 632967564  467 IPASYH 472
Cdd:pfam11904 293 IPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-96 2.03e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  13 LHLRVWQNDYRELEAEIRKH-HIEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVM 91
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170


                 ....*
gi 632967564  92 MVLQY 96
Cdd:COG0666  171 LLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-96 1.81e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564   13 LHLRVWQNDYRELEAEIRKHH-IEEVDPRGRTALHLAISLGHLECATVLLRNNASvtKENAKGWTVLQEAISTGDPDLVM 91
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                  ....*
gi 632967564   92 MVLQY 96
Cdd:pfam12796  79 LLLEK 83
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 38-85 5.96e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.96e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 632967564  38 DPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTG 85
Cdd:PLN03192 555 DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 40-69 9.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 9.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 632967564    40 RGRTALHLAISLGHLECATVLLRNNASVTK 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-472 1.45e-121

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 360.80  E-value: 1.45e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  156 RVDTTLLNFDNMRWERGRRSYMFKGEAG-WAEFVEVDHDNQVVNREHFElSQEREGLTltsvrptEDQVASRLTTPIVCT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDsPGSLLELDHDEKEVQLEGAG-AEASEEEV-------EEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  235 ALDTKNISFERNKSGfWGwRTDKTEVVQEYEAKVFTVNNVNVVTRSRTEHLTEEEKAKYK-------DNRNPLESLLGIA 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  308 EEHIGPQNGV-VTETATVNNPTSITPEEYFDPefelgnrdigrPTELCIKSRKFKATLWLCEDYPLSlTEQVIPIINLMA 386
Cdd:pfam11904 151 EEEKGWFGKTrEESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLS-LEQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  387 RSSAHFAKLRDFITLQFPPGFPVKIEIPLFHVLNARITFGNVNTCRTVEAASPTPKSSqaesttSASEDSKFEVDQSVFD 466
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELDPVEEFSTPIKSP------ERGSPSSCEIDDDPFE 292


                  ....*.
gi 632967564  467 IPASYH 472
Cdd:pfam11904 293 IPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-96 2.03e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  13 LHLRVWQNDYRELEAEIRKH-HIEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVM 91
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170


                 ....*
gi 632967564  92 MVLQY 96
Cdd:COG0666  171 LLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-96 2.22e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.81  E-value: 2.22e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 632967564  34 IEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVMMVLQY 96
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-127 2.78e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 2.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564  34 IEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVMMVLQYRDYDRVNSQLNGVPELL 113
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         90
                 ....*....|....
gi 632967564 114 SKIQKASDFYVEMK 127
Cdd:COG0666  259 AAAAGAALIVKLLL 272
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-96 1.81e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632967564   13 LHLRVWQNDYRELEAEIRKHH-IEEVDPRGRTALHLAISLGHLECATVLLRNNASvtKENAKGWTVLQEAISTGDPDLVM 91
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                  ....*
gi 632967564   92 MVLQY 96
Cdd:pfam12796  79 LLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-107 1.48e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.48e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 632967564   45 LHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVMMVLQYRDYDRVNSQLN 107
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT 63
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-96 4.72e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 4.72e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 632967564  25 LEAEIRKHHIEEVDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVMMVLQY 96
Cdd:COG0666   71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
Ank_4 pfam13637
Ankyrin repeats (many copies);
41-90 1.76e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 1.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 632967564   41 GRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLV 90
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 38-85 5.96e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.96e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 632967564  38 DPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTG 85
Cdd:PLN03192 555 DSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-71 2.49e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 2.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 632967564   36 EVDPRGRTALHLAISLGHLECATVLLRNNASVTKEN 71
Cdd:pfam12796  56 NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
38-81 1.52e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 632967564   38 DPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEA 81
Cdd:pfam13857  13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 40-71 1.96e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.96e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 632967564   40 RGRTALHLAI-SLGHLECATVLLRNNASVTKEN 71
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 37-111 5.65e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 5.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 632967564  37 VDPRGRTALHLAISLGHLECATVLLRNNASVTKENAKGWTVLQEAISTGDPDLVMMVLQYRDYDRvNSQLNGVPE 111
Cdd:PTZ00322 111 RDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHF-ELGANAKPD 184
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 40-69 9.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 9.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 632967564    40 RGRTALHLAISLGHLECATVLLRNNASVTK 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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