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Conserved domains on  [gi|767994934|ref|XP_006721993|]
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U3 small nucleolar RNA-associated protein 18 homolog isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
252-478 1.30e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI 331
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 pvHQVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:COG2319  198 --RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 411 VNSRKCLNRFVDEGSlYGLSIATSRNGQYVACG----------LKLGKLLVYISLPPFANWSL-----------GGKASR 469
Cdd:COG2319  275 LATGELLRTLTGHSG-GVNSVAFSPDGKLLASGsddgtvrlwdLATGKLLRTLTGHTGAVRSVafspdgktlasGSDDGT 353


                 ....*....
gi 767994934 470 TRLWSLETR 478
Cdd:COG2319  354 VRLWDLATG 362
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
252-478 1.30e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI 331
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 pvHQVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:COG2319  198 --RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 411 VNSRKCLNRFVDEGSlYGLSIATSRNGQYVACG----------LKLGKLLVYISLPPFANWSL-----------GGKASR 469
Cdd:COG2319  275 LATGELLRTLTGHSG-GVNSVAFSPDGKLLASGsddgtvrlwdLATGKLLRTLTGHTGAVRSVafspdgktlasGSDDGT 353


                 ....*....
gi 767994934 470 TRLWSLETR 478
Cdd:COG2319  354 VRLWDLATG 362
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-452 2.62e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 230 SLPRGILKMKNCQHANAerptvarISSVQFHPGAQIVMVAGLDNAVSLFqvDGKTNPKIQSIYLERFPIFKACFSANGEe 309
Cdd:cd00200   37 DLETGELLRTLKGHTGP-------VRDVAASADGTYLASGSSDKTIRLW--DLETGECVRTLTGHTSYVSSVAFSPDGR- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 310 VLATSTHSKVLYVYDMLAGKLIPVhqVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAAS 388
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTT--LRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSV 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767994934 389 TFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFV-DEGSLYglSIATSRNGQYVACGLKLGKLLVY 452
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYLLASGSEDGTIRVW 246
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 349-420 6.25e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.87  E-value: 6.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767994934  349 VSPDGSFLLING-IAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSG-DGEVYVWDVNSRKCLNRF 420
Cdd:TIGR03866 132 VSPDGKIVVNTSeTTNMAHWIDTATYEIVDNTLVDARPRFAEFTADGKELWVSSEiGGTVTVIDVATRKVIKKI 205
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
252-478 1.30e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI 331
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 pvHQVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:COG2319  198 --RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 411 VNSRKCLNRFVDEGSlYGLSIATSRNGQYVACG----------LKLGKLLVYISLPPFANWSL-----------GGKASR 469
Cdd:COG2319  275 LATGELLRTLTGHSG-GVNSVAFSPDGKLLASGsddgtvrlwdLATGKLLRTLTGHTGAVRSVafspdgktlasGSDDGT 353


                 ....*....
gi 767994934 470 TRLWSLETR 478
Cdd:COG2319  354 VRLWDLATG 362
WD40 COG2319
WD40 repeat [General function prediction only];
252-443 8.13e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 8.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI 331
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 pvHQVRGLKEKiVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:COG2319  282 --RTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767994934 411 VNSRKCLNRFVD-EGSLYglSIATSRNGQYVACG 443
Cdd:COG2319  359 LATGELLRTLTGhTGAVT--SVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
252-413 3.63e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 3.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI 331
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 PVHQVRGlkeKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMK-INGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:COG2319  324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 ...
gi 767994934 411 VNS 413
Cdd:COG2319  401 LAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-452 2.62e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 230 SLPRGILKMKNCQHANAerptvarISSVQFHPGAQIVMVAGLDNAVSLFqvDGKTNPKIQSIYLERFPIFKACFSANGEe 309
Cdd:cd00200   37 DLETGELLRTLKGHTGP-------VRDVAASADGTYLASGSSDKTIRLW--DLETGECVRTLTGHTSYVSSVAFSPDGR- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 310 VLATSTHSKVLYVYDMLAGKLIPVhqVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAAS 388
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTT--LRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSV 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767994934 389 TFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFV-DEGSLYglSIATSRNGQYVACGLKLGKLLVY 452
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 254-443 7.21e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 7.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 254 ISSVQFHPGAQIVMVAGLDNAVSLFQVDgkTNPKIQSIYLERFPIFKACFSANGEeVLATSTHSKVLYVYDMLAGKLI-- 331
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVat 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 332 -PVHqvrglkEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVW 409
Cdd:cd00200  173 lTGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767994934 410 DVNSRKCLNRFV-DEGSLYglSIATSRNGQYVACG 443
Cdd:cd00200  247 DLRTGECVQTLSgHTNSVT--SLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 254-410 8.41e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 8.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 254 ISSVQFHPGAQIVMVAGLDNAVSLFqvDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSThSKVLYVYDMLAGKLIpv 333
Cdd:cd00200  138 VNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCL-- 212

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994934 334 HQVRGlKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWD 410
Cdd:cd00200  213 GTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
344-478 2.21e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 2.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 344 VRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI-NGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFvD 422
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-T 159

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994934 423 EGSLYGLSIATSRNGQYVACG----------LKLGKLLVYISLPPFANWSL-----------GGKASRTRLWSLETR 478
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGsddgtvrlwdLATGKLLRTLTGHTGAVRSVafspdgkllasGSADGTVRLWDLATG 236
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
262-414 2.29e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 262 GAQIVMVAGLDNAVSLFqvDGKTNPKIQSIYLERFPIFkACFSANGEEVLATSTHSKVLYVYDMLAGKL---IPVhqvrg 338
Cdd:COG3391   79 GRRLYVANSGSGRVSVI--DLATGKVVATIPVGGGPRG-LAVDPDGGRLYVADSGNGRVSVIDTATGKVvatIPV----- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 339 lkEKIVRSFEVSPDGSFLLI-----NGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVY--------ASSGDGE 405
Cdd:COG3391  151 --GAGPHGIAVDPDGKRLYVansgsNTVSVIVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYvanrgsntSNGGSNT 228


                 ....*....
gi 767994934 406 VYVWDVNSR 414
Cdd:COG3391  229 VSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
305-443 4.71e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.93  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 305 ANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLkekiVRSFEVSPDGSFLLI-NGIAGYLHLLAMKTKELIGSMKING 383
Cdd:COG3391   77 ADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG----PRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVATIPVGA 152

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994934 384 RVAASTFSSDSKKVY-ASSGDGE----VYVWDVNSRKCLNRfVDEGSlYGLSIATSRNGQ--YVACG 443
Cdd:COG3391  153 GPHGIAVDPDGKRLYvANSGSNTvsviVSVIDTATGKVVAT-IPVGG-GPVGVAVSPDGRrlYVANR 217
WD40 COG2319
WD40 repeat [General function prediction only];
344-477 1.60e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 344 VRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKIN-GRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVD 422
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHtAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767994934 423 EGSlYGLSIATSRNGQYVACG-----LKL-----GKLLVYISLPPFANWSL-----------GGKASRTRLWSLET 477
Cdd:COG2319  119 HTG-AVRSVAFSPDGKTLASGsadgtVRLwdlatGKLLRTLTGHSGAVTSVafspdgkllasGSDDGTVRLWDLAT 193
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 382-443 2.40e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994934 382 NGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVdEGSLYGLSIATSRNGQYVACG 443
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASG 69
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 304-417 2.60e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 39.92  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934 304 SANGEEVLATSTHSKVLYVYDMLAGKLiPVHqvrglKEKIVRSFEVSPDGSFLLI-NGIAGyLHLLAMKTKELIGSMK-- 380
Cdd:cd22850  201 DDHRKFKFVTGTRYGQVRLYDTSAGRR-PVF-----SEKPIKKPEEDLDGHTVYVgDTSGD-LALIDIRTGKLLGRLLgk 273

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767994934 381 -INGRVAASTFSSDSKKVYASSG-DGEVYVWDVNSRKCL 417
Cdd:cd22850  274 yGGSITGAVRHPELFDPYLASGGlDRYLRVFDIETRELL 312
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 294-415 4.25e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994934  294 ERFPIFkacfSANGEEVLATSTHSK--VLYVYDMLAGKliPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMK 371
Cdd:COG4946   345 ERLPAW----SPDGKSIAYFSDASGeyELYIAPADGSG--EPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLA 418

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767994934  372 TKE--LIGSMKINGRVAASTFSSDSKKV-YASSGD---GEVYVWDVNSRK 415
Cdd:COG4946   419 SGKvrKVDTDGYGDGISDLAWSPDSKWLaYSKPGPnqlSQIFLYDVETGK 468
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 349-420 6.25e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.87  E-value: 6.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767994934  349 VSPDGSFLLING-IAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSG-DGEVYVWDVNSRKCLNRF 420
Cdd:TIGR03866 132 VSPDGKIVVNTSeTTNMAHWIDTATYEIVDNTLVDARPRFAEFTADGKELWVSSEiGGTVTVIDVATRKVIKKI 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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