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Conserved domains on  [gi|568945179|ref|XP_006539758|]
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neutral amino acid transporter B(0) isoform X1 [Mus musculus]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
25-229 5.11e-74

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 232.31  E-value: 5.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKDvrQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:COG1301  185 KLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSE 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:COG1301  263 ATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGA 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568945179 185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGA 229
Cdd:COG1301  343 GLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVAT 387
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
25-229 5.11e-74

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 232.31  E-value: 5.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKDvrQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:COG1301  185 KLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSE 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:COG1301  263 ATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGA 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568945179 185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGA 229
Cdd:COG1301  343 GLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVAT 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
25-232 5.65e-72

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 226.25  E-value: 5.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179   25 RYAPVGILFLVASKIVEMkdVRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:pfam00375 180 KLAPIGVFALIANTVGTY--GLGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:pfam00375 258 ATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGG 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 568945179  185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLL 232
Cdd:pfam00375 338 GLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIV 385
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 25-258 3.56e-23

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 98.30  E-value: 3.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKDVRqlFISLGKYILCCLLGHAIHGLLVLPLIYFLFtRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:PRK11283 205 RYAPVGVFALIAVTVANFGFAS--LWPLAKLVLLVYFAILFFALVVLGIVARLC-GLSIWILIRILKDELILAYSTASSE 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEeKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:PRK11283 282 TVLPRIIEKME-AYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGV 360

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568945179 185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSY---VDRTKMPSSEPELIQVKNEVSLN 258
Cdd:PRK11283 361 SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWehkFDRKKALAYEREVLGKFDKTADQ 437
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
25-229 5.11e-74

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 232.31  E-value: 5.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKDvrQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:COG1301  185 KLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSE 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:COG1301  263 ATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGA 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568945179 185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGA 229
Cdd:COG1301  343 GLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVAT 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
25-232 5.65e-72

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 226.25  E-value: 5.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179   25 RYAPVGILFLVASKIVEMkdVRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:pfam00375 180 KLAPIGVFALIANTVGTY--GLGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:pfam00375 258 ATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGG 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 568945179  185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLL 232
Cdd:pfam00375 338 GLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIV 385
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 25-258 3.56e-23

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 98.30  E-value: 3.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKDVRqlFISLGKYILCCLLGHAIHGLLVLPLIYFLFtRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:PRK11283 205 RYAPVGVFALIAVTVANFGFAS--LWPLAKLVLLVYFAILFFALVVLGIVARLC-GLSIWILIRILKDELILAYSTASSE 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEeKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAG 184
Cdd:PRK11283 282 TVLPRIIEKME-AYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGV 360

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568945179 185 GVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSY---VDRTKMPSSEPELIQVKNEVSLN 258
Cdd:PRK11283 361 SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWehkFDRKKALAYEREVLGKFDKTADQ 437
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 50-213 3.69e-23

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 98.05  E-value: 3.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  50 ISLGKYILCCLLGHAIHGLLVLPLI--YFLFtrkNPYRFLWGIMTPLATAFGTSSSSATLPLMMKCVEeKNGVAKHISRF 127
Cdd:PRK01663 217 VQLGQLIGCFYITCILFVFVVLGAIarLTGF---SIFKFIRYIKEELLIVLGTSSSESALPRMMEKME-KLGCKKSVVGL 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 128 ILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAV-SLPVKDISLI 206
Cdd:PRK01663 293 VIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLSIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVpHIPVAGLALI 372


                 ....*..
gi 568945179 207 LAVDWLV 213
Cdd:PRK01663 373 LGIDRFM 379
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 25-213 6.00e-20

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 88.96  E-value: 6.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVE--MKDVRQLFISLGKYILCCL------LGHA--IHGLLVLPLIYFLftrknpyrflwgiMTPL 94
Cdd:PRK13027 194 KLAPLGVLGAIAFTTGKygVGSLKQLGMLVAVFYLTCFvfvvvvLGAVmrLAGFSVFKLIRYL-------------REEL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  95 ATAFGTSSSSATLPLMMKCVEeKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATAS 174
Cdd:PRK13027 261 LIVLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVSLVT 339

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568945179 175 SVGAAGIPAGGVLTLAIILEAV-SLPVKDISLILAVDWLV 213
Cdd:PRK13027 340 SKGAHGIPGSAIVILAATLSAIpAIPVLGLVLILPVDWFM 379
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 25-189 2.87e-16

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 77.98  E-value: 2.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEMKdvrqlFISLGKY--ILCCLLG-HAIHGLLVLPLIYFLFTRKNPYRFLW------GImtpla 95
Cdd:PRK13628 188 RFAPIGIFGLVASTLAETG-----FSALAGYaqLLAVLVGcMLFVALVVNPLIVFWKIRRNPYPLVFtclresGV----- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  96 TAFGTSSSSATLPLMMK-CveEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATAS 174
Cdd:PRK13628 258 TAFFTRSSAANIPVNMAlC--EKLGLDEDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAIS 335

                        170
                 ....*....|....*
gi 568945179 175 SVGAAGIpAGGVLTL 189
Cdd:PRK13628 336 ACGASGV-AGGSLLL 349
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 25-234 3.38e-16

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 78.33  E-value: 3.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVAsKIVEMKDVRQLfISLGKYILCCLLGHAIhgLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSS 104
Cdd:COG1823  235 RLTPYGVLALMT-KVVATSDFADI-LNLGKFVVASYVALII--MFIVHLLLLALAGLNPLTYFKKVWPVLTFAFTSRSSA 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 105 ATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDG-AALFQCVAAVFIAQLNGVS-LDFVKIITILVTATASSVGAAGIp 182
Cdd:COG1823  311 GTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGcAGIYPAMLAVMIAPTVGINpLDPSFILTLIAVVTISSFGVAGV- 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568945179 183 aGGVLTLA--IILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGdAFGAGLLQS 234
Cdd:COG1823  390 -GGGATFAalIVLSAMGLPVALAGLLISIEPLIDMGRTALNVSG-SMTAGTVTS 441
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
25-189 1.18e-14

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 73.28  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  25 RYAPVGILFLVASKIVEmkdvrQLFISLGKY--ILCCLLG-HAIHGLLVLPLIYFLFTRKNPYRFLW------GImtpla 95
Cdd:COG3633  187 RFAPLGIFGLVASTVAT-----TGFSALLGYahLLAVLVGcMLFVALVVNPLIVFLKIRRNPYPLVFtclresGI----- 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  96 TAFGTSSSSATLPLMMK-CveEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATAS 174
Cdd:COG3633  257 TAFFTRSSAANIPVNMAlC--EKLGLDEDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIEVDLPTALLLSVVAAVS 334

                        170
                 ....*....|....*
gi 568945179 175 SVGAAGIpAGGVLTL 189
Cdd:COG3633  335 ACGASGV-AGGSLLL 348
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 27-240 4.88e-12

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 65.07  E-value: 4.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179  27 APVGILFLVAsKIVEMKDVRQLfISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIM-TPLATAFGTSSSSA 105
Cdd:PRK14695 104 APFGILGLVF-KTISDKGVGSL-ANYGILLVLLVTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLrVSGVTAFFTRSSAT 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945179 106 TLPLMMKCVEEKnGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAGG 185
Cdd:PRK14695 182 NIPVNMKLCHDL-GLNPDTYSVSIPLGSTINMAGVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGS 260

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568945179 186 VLTLAI------ILEAVSLPVKDISLILAVdwLVDRSCTVLNVEGDAFGAGLLQSYVDRTK 240
Cdd:PRK14695 261 LLLIPVacslfgISNDIAIQIVGVGFVIGV--IQDSCETALNSSTDVLFTAVAEYAATRKK 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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