|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
216-506 |
1.23e-52 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 186.31 E-value: 1.23e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 216 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 295
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 296 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 375
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 376 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 455
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 456 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 506
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-270 |
2.90e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.46 E-value: 2.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhws 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA---------- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 99 AYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTV 178
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI---VKLLLEAGAD---VNARDNDGETPLHLAAENGHLEI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 179 VDVLTSYEScNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHP 258
Cdd:COG0666 202 VKLLLEAGA-DVNAKDNDGKTALDLAAENG----NLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLAL 275
|
250
....*....|..
gi 568926103 259 SVKDDSDLEGRT 270
Cdd:COG0666 276 LLLAAALLDLLT 287
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
282-500 |
5.43e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 282 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 354
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 355 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 432
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926103 433 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 500
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
340-432 |
4.07e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.72 E-value: 4.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 340 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 419
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 568926103 420 VLMENNADPNIQD 432
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
32-363 |
1.38e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 90.08 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQTALhwsayynnpEHAK 108
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL---------DVIK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 109 LLIKHDSNIGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVV 179
Cdd:PHA03095 102 LLIKAGADVNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 180 DVLTSyESCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQH 257
Cdd:PHA03095 171 RLLID-AGADVYAVDDRFRSLLH--HHLQSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 258 PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKH 337
Cdd:PHA03095 247 GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAA 321
|
330 340 350
....*....|....*....|....*....|....
gi 568926103 338 TpLFRACEMGHRD--------VIQTLIKGGARVD 363
Cdd:PHA03095 322 T-LNTASVAGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
19-121 |
2.39e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHSRrtalhlaaqkqTALHWS 98
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-----------TALHYA 68
|
90 100
....*....|....*....|...
gi 568926103 99 AYYNNPEHAKLLIKHDSNIGIPD 121
Cdd:pfam12796 69 ARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
559-832 |
7.87e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 7.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 559 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 638
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 639 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 717
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 718 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 783
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 784 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 832
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
237-443 |
7.69e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 237 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 307
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 308 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 370
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 371 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 440
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 568926103 441 WSC 443
Cdd:cd22192 240 WTY 242
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
43-280 |
1.03e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.79 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 43 KEDRFGRTPLMYCVLADRVDCADALLKAgadvNKTDHSRRTALhlaaqKQTALHWSAYYNNPEHAKLLikhdsnigipdv 122
Cdd:cd22192 12 QQKRISESPLLLAAKENDVQAIKKLLKC----PSCDLFQRGAL-----GETALHVAALYDNLEAAVVL------------ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 123 egkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDVLTSYESCNIT------- 191
Cdd:cd22192 71 ------------------------MEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRELIARGADVVSpratgtf 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 192 ---SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQGATPLHY---AAQSNFA-ETVKVFLQHPSVK 261
Cdd:cd22192 125 frpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSLGNTVLHIlvlQPNKTFAcQMYDLILSYDKED 199
|
250 260
....*....|....*....|....*
gi 568926103 262 DDSDLE------GRTSFMWAAGKGN 280
Cdd:cd22192 200 DLQPLDlvpnnqGLTPFKLAAKEGN 224
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
853-878 |
4.35e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.35e-05
10 20
....*....|....*....|....*.
gi 568926103 853 RKELFRRKNKAAAVIQRAWRSYQLRK 878
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.86e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.86e-04
10 20
....*....|....*....|....*....
gi 568926103 48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
368-397 |
3.57e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.57e-04
10 20 30
....*....|....*....|....*....|
gi 568926103 368 DGHSLLHWAALGGNADVCQILIENKINPNV 397
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
499-525 |
5.44e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.44e-04
10 20
....*....|....*....|....*..
gi 568926103 499 AIQDIAAFKIQAVYKGYKVRKAFRDRK 525
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
170-423 |
6.37e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 170 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 248
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 249 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 327
Cdd:TIGR00870 95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 328 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 384
Cdd:TIGR00870 153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568926103 385 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 423
Cdd:TIGR00870 230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
73-291 |
7.00e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 73 DVNKTDHSRRTALHLAAQKQtalhwsayyNNPEHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAP 151
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIEN---------ENLELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 152 TES----LLNWQD----YEGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTf 210
Cdd:TIGR00870 109 RKSgpleLANDQYtsefTPGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 211 grhAQIVHLLLErNKSGTIPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMW 274
Cdd:TIGR00870 188 ---PSIVALLSE-DPADILTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKL 263
|
250
....*....|....*..
gi 568926103 275 AAGKGNDDVLRTMLSLK 291
Cdd:TIGR00870 264 AAKEGRIVLFRLKLAIK 280
|
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
860-906 |
6.59e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.59e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 860 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 906
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
216-506 |
1.23e-52 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 186.31 E-value: 1.23e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 216 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 295
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 296 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 375
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 376 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 455
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 456 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 506
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
252-540 |
1.42e-49 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 177.45 E-value: 1.42e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 252 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 331
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 332 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 411
Cdd:COG0666 83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 412 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLE 491
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568926103 492 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAA 540
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
146-439 |
3.76e-45 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 164.74 E-value: 3.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 146 ILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALlgtfgRHAQIVHLLLERNK 225
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL-----AGDLLVALLLLAAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 226 SGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRtMLsLKSDIDINMSDKYGGT 305
Cdd:COG0666 78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 306 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 385
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568926103 386 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 439
Cdd:COG0666 236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-270 |
2.90e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.46 E-value: 2.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhws 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA---------- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 99 AYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTV 178
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI---VKLLLEAGAD---VNARDNDGETPLHLAAENGHLEI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 179 VDVLTSYEScNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHP 258
Cdd:COG0666 202 VKLLLEAGA-DVNAKDNDGKTALDLAAENG----NLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLAL 275
|
250
....*....|..
gi 568926103 259 SVKDDSDLEGRT 270
Cdd:COG0666 276 LLLAAALLDLLT 287
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
282-500 |
5.43e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 282 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 354
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 355 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 432
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926103 433 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 500
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
59-494 |
2.80e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 102.83 E-value: 2.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQkqtalhwsayYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDps 138
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAE----------RGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN-- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 139 aVHTVRCILDaapTESLLNWQDyegrtpLHFAVADGNLTVVDVLTSYES-CNITSYDNLFRTPLHWAALLGTFGRhaqIV 217
Cdd:PHA02876 224 -IDTIKAIID---NRSNINKND------LSLLKAIRNEDLETSLLLYDAgFSVNSIDDCKNTPLHHASQAPSLSR---LV 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 218 HLLLERNkSGTIPSDSQGATPLHYAAQSNFaetvkvflqhpsvkddsDLEGrtsfmwaagkgnddvLRTMLSLKSdiDIN 297
Cdd:PHA02876 291 PKLLERG-ADVNAKNIKGETPLYLMAKNGY-----------------DTEN---------------IRTLIMLGA--DVN 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 298 MSDKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA 376
Cdd:PHA02876 336 AADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 377 ALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNGYLDAIKLLL 455
Cdd:PHA02876 416 LCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNCKLDVIEMLL 463
|
410 420 430
....*....|....*....|....*....|....*....
gi 568926103 456 DFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 494
Cdd:PHA02876 464 DNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
340-432 |
4.07e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.72 E-value: 4.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 340 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 419
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 568926103 420 VLMENNADPNIQD 432
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
373-464 |
5.67e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 90.95 E-value: 5.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 373 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 452
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|..
gi 568926103 453 LLLDFAAFPNQM 464
Cdd:pfam12796 79 LLLEKGADINVK 90
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
307-399 |
4.33e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 88.63 E-value: 4.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 307 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 386
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 568926103 387 ILIENKINPNVQD 399
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
239-333 |
3.61e-20 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 85.94 E-value: 3.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 239 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLksdIDINMSDkYGGTALHAAALSGHVST 318
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 568926103 319 VKLLLDNDAQVDATD 333
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
406-494 |
2.27e-19 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 83.63 E-value: 2.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 406 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 485
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*....
gi 568926103 486 IQFMLEHGA 494
Cdd:pfam12796 77 VKLLLEKGA 85
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
32-363 |
1.38e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 90.08 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQTALhwsayynnpEHAK 108
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL---------DVIK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 109 LLIKHDSNIGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVV 179
Cdd:PHA03095 102 LLIKAGADVNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 180 DVLTSyESCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQH 257
Cdd:PHA03095 171 RLLID-AGADVYAVDDRFRSLLH--HHLQSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 258 PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKH 337
Cdd:PHA03095 247 GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAA 321
|
330 340 350
....*....|....*....|....*....|....
gi 568926103 338 TpLFRACEMGHRD--------VIQTLIKGGARVD 363
Cdd:PHA03095 322 T-LNTASVAGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
194-441 |
1.97e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 89.70 E-value: 1.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 194 DNLFRTPLHwaALLGTF-GRHAQIVHLLLER----NKSgtipsDSQGATPLHYAAQsnFAETVkvflqhpsvkddsdleg 268
Cdd:PHA03095 44 GEYGKTPLH--LYLHYSsEKVKDIVRLLLEAgadvNAP-----ERCGFTPLHLYLY--NATTL----------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 269 rtsfmwaagkgndDVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL----- 340
Cdd:PHA03095 98 -------------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllk 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 341 FRACEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCM 418
Cdd:PHA03095 162 SRNANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCK 236
|
250 260
....*....|....*....|....*..
gi 568926103 419 AVLM----ENNADPNIQDKEGRTALHW 441
Cdd:PHA03095 237 RSLVlpllIAGISINARNRYGQTPLHY 263
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
153-367 |
2.00e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 82.79 E-value: 2.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 153 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLG-TFGRHAQIVHLLLERNKSGTIPs 231
Cdd:PHA03100 25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKyNLTDVKEIVKLLLEYGANVNAP- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 232 DSQGATPLHYAAQ--SNFAETVKVFLQHPSVKDDSDLEGRTSF-MWAAGKGND-DVLRTMLS--------------LKSD 293
Cdd:PHA03100 103 DNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLhLYLESNKIDlKILKLLIDkgvdinaknrvnylLSYG 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926103 294 IDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 367
Cdd:PHA03100 183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
108-406 |
1.11e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 80.84 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 108 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 186
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 187 SCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHyaaqsnfaetvkVFLQHPSVkddsdl 266
Cdd:PHA03095 107 GADVNAKDKVGRTPLH--VYLSGFNINPKVIRLLLRKGADVN-ALDLYGMTPLA------------VLLKSRNA------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 267 egrtsfmwaagkgNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRAC 344
Cdd:PHA03095 166 -------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMA 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926103 345 EMG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 406
Cdd:PHA03095 231 TGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
290-494 |
3.45e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 79.30 E-value: 3.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 290 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 363
Cdd:PHA03095 34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 364 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 436
Cdd:PHA03095 112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 437 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 494
Cdd:PHA03095 189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
24-423 |
1.15e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 77.70 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 24 NGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVN----KTDHSRRTALHLAAQKQTalhwsa 99
Cdd:PHA02874 11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINhintKIPHPLLTAIKIGAHDII------ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 100 yynnpehaKLLIKH--DSNI-GIPDVEGKiplhwaanhkdpsavhTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNL 176
Cdd:PHA02874 85 --------KLLIDNgvDTSIlPIPCIEKD----------------MIKTILDCGID---VNIKDAELKTFLHYAIKKGDL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 177 TVVDVLTSYES-CNItsydnlfrtplhwaallgtfgrhaqivhlllernksgtipSDSQGATPLHYAAQSNFAETVKVFL 255
Cdd:PHA02874 138 ESIKMLFEYGAdVNI----------------------------------------EDDNGCYPIHIAIKHNFFDIIKLLL 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 256 QHPSVkddsdlegrtsfmwaagkgnddvlrtmlslksdidINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVM 335
Cdd:PHA02874 178 EKGAY-----------------------------------ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 336 KHTPLFRACeMGHRDVIQTLIKgGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY 414
Cdd:PHA02874 223 GFTPLHNAI-IHNRSAIELLIN-NASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF--KY 298
|
....*....
gi 568926103 415 INCMAVLME 423
Cdd:PHA02874 299 INKDPVIKD 307
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
280-478 |
1.42e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 77.31 E-value: 1.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 280 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 359
Cdd:PHA02874 103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 360 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 439
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 568926103 440 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 478
Cdd:PHA02874 259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
296-503 |
2.10e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 76.54 E-value: 2.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 296 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 352
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 353 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 432
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926103 433 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 503
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
19-121 |
2.39e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHSRrtalhlaaqkqTALHWS 98
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-----------TALHYA 68
|
90 100
....*....|....*....|...
gi 568926103 99 AYYNNPEHAKLLIKHDSNIGIPD 121
Cdd:pfam12796 69 ARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
95-194 |
2.77e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 95 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 174
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72
|
90 100
....*....|....*....|
gi 568926103 175 NLTVVDVLTSYEsCNITSYD 194
Cdd:pfam12796 73 HLEIVKLLLEKG-ADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
316-494 |
3.28e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.86 E-value: 3.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 316 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 390
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 391 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 466
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 568926103 467 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 494
Cdd:PHA03100 175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
167-265 |
3.50e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 68.99 E-value: 3.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 167 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGtipSDSQGATPLHYAAQSN 246
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG----HLEIVKLLLEHADVN---LKDNGRTALHYAARSG 72
|
90
....*....|....*....
gi 568926103 247 FAETVKVFLQHPSVKDDSD 265
Cdd:pfam12796 73 HLEIVKLLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
307-475 |
3.77e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.80 E-value: 3.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 307 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 383
Cdd:PHA02875 72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 384 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 462
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229
|
170
....*....|....
gi 568926103 463 QMENNE-ERYTPLD 475
Cdd:PHA02875 230 IMFMIEgEECTILD 243
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
157-397 |
6.04e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.03 E-value: 6.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 157 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGTfgrhAQIVHLLLERNKSGTIPSDSQGA 236
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGD----VKAVEELLDLGKFADDVFYKDGM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 237 TPLHYAAQSNfaetvkvflqhpsvkddsdlegrtsfmwaagkgNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHV 316
Cdd:PHA02875 104 TPLHLATILK---------------------------------KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 317 STVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINP 395
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228
|
..
gi 568926103 396 NV 397
Cdd:PHA02875 229 NI 230
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
62-357 |
1.72e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 73.84 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 62 DCADALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayyNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHkdpSAVH 141
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKK----------GDLESIKMLFEYGADVNIEDDNGCYPIHIAIKH---NFFD 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 142 TVRCILDAApteSLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTPLHWAALlgtfgrHAQIVHLLL 221
Cdd:PHA02874 172 IIKLLLEKG---AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAII------HNRSAIELL 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 222 ERNKSGTIpSDSQGATPLHYAaqsnfaetvkvfLQHPSVKddsdlegrtsfmwaagkgndDVLRTMLSLKSDIDINmsDK 301
Cdd:PHA02874 242 INNASIND-QDIDGSTPLHHA------------INPPCDI--------------------DIIDILLYHKADISIK--DN 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568926103 302 YGGTALHAA-ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 357
Cdd:PHA02874 287 KGENPIDTAfKYINKDPVIKDIIANAVLIKEADKLKDSDFLEHIEIKDNKEFSDFIK 343
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
170-444 |
3.32e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 72.72 E-value: 3.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 170 AVADGNLTVVD-VLTSYESCNITSYDNLfrTPLHWAALLgtfgRHAQIVHLLLernKSGTIPSDSQGA--TPLHYAAQSN 246
Cdd:PHA02875 9 AILFGELDIARrLLDIGINPNFEIYDGI--SPIKLAMKF----RDSEAIKLLM---KHGAIPDVKYPDieSELHDAVEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 247 FAETVKVFLQHPSVKDDSDL-EGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVKLLLDN 325
Cdd:PHA02875 80 DVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 326 DAQVDATDVMKHTPLFracemghrdviqtlikggarvdlvdqdghsllhWAALGGNADVCQILIENKINPNvqdYAGRTP 405
Cdd:PHA02875 158 KACLDIEDCCGCTPLI---------------------------------IAMAKGDIAICKMLLDSGANID---YFGKNG 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568926103 406 ---LQCAAY-GGYINCMAVLMENNADPNIQ---DKEGRTALHWSCN 444
Cdd:PHA02875 202 cvaALCYAIeNNKIDIVRLFIKRGADCNIMfmiEGEECTILDMICN 247
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
200-479 |
4.65e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 72.61 E-value: 4.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 200 PLHWAALlgtfGRHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWaaGKG 279
Cdd:PHA02878 40 PLHQAVE----ARNLDVVKSLLTRGHNVNQP-DHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAF--NNR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 280 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVstVKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKG 358
Cdd:PHA02878 113 NVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 359 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-E 434
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiL 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 568926103 435 GRTALHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTPLDYALL 479
Cdd:PHA02878 269 GLTALHSSIKSE--RKLKLLLEYGADINSL--NSYKLTPLSSAVK 309
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
166-439 |
3.12e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 3.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 166 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAA----LLGtfgrhaqIVHLLLERNKSGTIPSDSQGATPLHY 241
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICkepnKLG-------MKEMIRSINKCSVFYTLVAIKDAFNN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 242 aaqsNFAETVKVFL--QHPSVKDDSDLEGRTsfmwaagKGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGH 315
Cdd:PHA02878 112 ----RNVEIFKIILtnRYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 316 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKIN 394
Cdd:PHA02878 181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVD 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568926103 395 PNVQDYA-GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 439
Cdd:PHA02878 261 VNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
128-224 |
3.95e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.21 E-value: 3.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 128 LHWAANHKDPSAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 206
Cdd:pfam12796 1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70
|
90
....*....|....*...
gi 568926103 207 LGtfgrHAQIVHLLLERN 224
Cdd:pfam12796 71 SG----HLEIVKLLLEKG 84
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
559-832 |
7.87e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 7.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 559 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 638
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 639 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 717
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 718 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 783
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 784 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 832
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
18-261 |
1.52e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 64.66 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVD--CADALLKAGADVNKTDHSRRTALHLAAQKQTAl 95
Cdd:PHA03095 87 LHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAVLLKSRNA- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 96 hwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDPSAVHT-VRCILDAAPTESLlnwqdyeGRTPLHFAVA 172
Cdd:PHA03095 166 -------NVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRElIRAGCDPAATDML-------GNTPLHSMAT 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 173 DG---NLTVVDVLTSYESCNITsyDNLFRTPLHWAAllgTFGRHAQIVHLLlernKSGTIPS--DSQGATPLHYAAQSNF 247
Cdd:PHA03095 232 GSsckRSLVLPLLIAGISINAR--NRYGQTPLHYAA---VFNNPRACRRLI----ALGADINavSSDGNTPLSLMVRNNN 302
|
250
....*....|....*
gi 568926103 248 AETVKVFL-QHPSVK 261
Cdd:PHA03095 303 GRAVRAALaKNPSAE 317
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
244-427 |
1.70e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 65.27 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 244 QSNFAETVKVFLQH--------------PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHA 309
Cdd:PLN03192 487 QEDNVVILKNFLQHhkelhdlnvgdllgDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHI 564
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 310 AALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILI 389
Cdd:PLN03192 565 AASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELL 642
|
170 180 190
....*....|....*....|....*....|....*...
gi 568926103 390 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 427
Cdd:PLN03192 643 KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
316-475 |
1.78e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 64.47 E-value: 1.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 316 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 385
Cdd:PHA02798 18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 386 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 459
Cdd:PHA02798 93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172
|
170
....*....|....*.
gi 568926103 460 FPNQMeNNEERYTPLD 475
Cdd:PHA02798 173 DINTH-NNKEKYDTLH 187
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
220-423 |
3.17e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 64.12 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 220 LLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSfMW------------------------- 274
Cdd:PLN03192 544 LLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifrilyhfasisdpha 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 275 -------AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPLFRAC 344
Cdd:PLN03192 622 agdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdDDFSPTELRELL 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 345 ---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTPLQCAAYGGYINC 417
Cdd:PLN03192 700 qkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNERCCNEAGKLINL 769
|
....*.
gi 568926103 418 MAVLME 423
Cdd:PLN03192 770 PPSLEE 775
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
369-421 |
3.48e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.51 E-value: 3.48e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568926103 369 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 421
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
303-356 |
4.72e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.13 E-value: 4.72e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568926103 303 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 356
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
268-323 |
6.97e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.36 E-value: 6.97e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568926103 268 GRTSFMWAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 323
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
402-455 |
1.06e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.97 E-value: 1.06e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568926103 402 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 455
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
281-504 |
4.91e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 60.46 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 281 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 360
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 361 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 410
Cdd:PHA02876 236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 411 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 488
Cdd:PHA02876 316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393
|
250
....*....|....*.
gi 568926103 489 MLEHGALSIAAIQDIA 504
Cdd:PHA02876 394 LLDYGADIEALSQKIG 409
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
372-455 |
5.96e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.91 E-value: 5.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 372 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 451
Cdd:PTZ00322 86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164
|
....
gi 568926103 452 KLLL 455
Cdd:PTZ00322 165 QLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
306-494 |
6.66e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 6.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 306 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 384
Cdd:PHA02875 5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 385 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 464
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163
|
170 180 190
....*....|....*....|....*....|
gi 568926103 465 ENNEErYTPLDYALLGERHEVIQFMLEHGA 494
Cdd:PHA02875 164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
420-492 |
7.32e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.53 E-value: 7.32e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926103 420 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 492
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
237-443 |
7.69e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 237 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 307
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 308 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 370
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 371 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 440
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 568926103 441 WSC 443
Cdd:cd22192 240 WTY 242
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
16-190 |
1.01e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.85 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 16 SQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKQtal 95
Cdd:PHA02875 70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG--- 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 96 hwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTesllnwQDYEGRTP----LHFAV 171
Cdd:PHA02875 147 -------DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD---IAICKMLLDSGAN------IDYFGKNGcvaaLCYAI 210
|
170 180
....*....|....*....|
gi 568926103 172 ADGNLTVVDVLTSYES-CNI 190
Cdd:PHA02875 211 ENNKIDIVRLFIKRGAdCNI 230
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
164-346 |
2.97e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 57.31 E-value: 2.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 164 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHwaalLGTFGRHAQIVHLLLERNKSGTIPSDSQgATPL 239
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLH----LATILKKLDIMKLLIARGADPDIPNTDK-FSPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 240 HYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSlkSDIDINMSDKYGGTALHAAALSGH-VST 318
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDI 217
|
170 180 190
....*....|....*....|....*....|.
gi 568926103 319 VKLLLDNDAQVD-ATDVM--KHTPLFRACEM 346
Cdd:PHA02875 218 VRLFIKRGADCNiMFMIEgeECTILDMICNM 248
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
67-222 |
4.37e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.81 E-value: 4.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 67 LLKAGADVNKTD-HSRRTALHLAAQKQtalhwsayynNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVrc 145
Cdd:PHA02878 153 LLSYGADINMKDrHKGNTALHYATENK----------DQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHIL-- 220
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926103 146 ILDAAPTesllNWQDYEGRTPLHFAVAD-GNLTVVDVLTSYESC-NITSYDNLFrTPLHWAAllgtfgRHAQIVHLLLE 222
Cdd:PHA02878 221 LENGAST----DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDvNAKSYILGL-TALHSSI------KSERKLKLLLE 288
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
51-402 |
5.24e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.43 E-value: 5.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 51 PLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAqkqtalhwsayynnpehaklliKHDSNIGIPDVegkiplhw 130
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIC----------------------KEPNKLGMKEM-------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 131 AANHKDPSAVHTVRCILDAapteslLNWQDYEGRTPLHFAVADGNLTVVDVltsyESCNITSYDNLfrtplhwaallgtf 210
Cdd:PHA02878 90 IRSINKCSVFYTLVAIKDA------FNNRNVEIFKIILTNRYKNIQTIDLV----YIDKKSKDDII-------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 211 grHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSL 290
Cdd:PHA02878 146 --EAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 291 KSDIDInmSDKYGGTALHAAalSGHV---STVKLLLDNDAQVDA-TDVMKHTPLFRAceMGHRDVIQTLIKGGARVDLVD 366
Cdd:PHA02878 224 GASTDA--RDKCGNTPLHIS--VGYCkdyDILKLLLEHGVDVNAkSYILGLTALHSS--IKSERKLKLLLEYGADINSLN 297
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 568926103 367 QDGHSLLHWAALG-GNADVCQILIEN-----KINPNVQDYAG 402
Cdd:PHA02878 298 SYKLTPLSSAVKQyLCINIGRILISNicllkRIKPDIKNSEG 339
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
238-494 |
7.09e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.04 E-value: 7.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 238 PLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHaaalSGHVS 317
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 318 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 391
Cdd:PHA02878 116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 392 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 471
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245
|
250 260
....*....|....*....|...
gi 568926103 472 tpLDYallgerhEVIQFMLEHGA 494
Cdd:PHA02878 246 --KDY-------DILKLLLEHGV 259
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
376-462 |
8.20e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.41 E-value: 8.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 376 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 455
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
....*..
gi 568926103 456 DFAAFPN 462
Cdd:PLN03192 612 HFASISD 618
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
43-280 |
1.03e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.79 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 43 KEDRFGRTPLMYCVLADRVDCADALLKAgadvNKTDHSRRTALhlaaqKQTALHWSAYYNNPEHAKLLikhdsnigipdv 122
Cdd:cd22192 12 QQKRISESPLLLAAKENDVQAIKKLLKC----PSCDLFQRGAL-----GETALHVAALYDNLEAAVVL------------ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 123 egkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDVLTSYESCNIT------- 191
Cdd:cd22192 71 ------------------------MEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRELIARGADVVSpratgtf 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 192 ---SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQGATPLHY---AAQSNFA-ETVKVFLQHPSVK 261
Cdd:cd22192 125 frpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSLGNTVLHIlvlQPNKTFAcQMYDLILSYDKED 199
|
250 260
....*....|....*....|....*
gi 568926103 262 DDSDLE------GRTSFMWAAGKGN 280
Cdd:cd22192 200 DLQPLDlvpnnqGLTPFKLAAKEGN 224
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
338-389 |
1.09e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.20 E-value: 1.09e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568926103 338 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 389
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
388-440 |
5.84e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 47.34 E-value: 5.84e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568926103 388 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 440
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
425-477 |
2.05e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.80 E-value: 2.05e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568926103 425 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 477
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
311-388 |
2.17e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.82 E-value: 2.17e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926103 311 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 388
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
358-409 |
2.92e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.42 E-value: 2.92e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568926103 358 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 409
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
290-357 |
3.17e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 3.17e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926103 290 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 357
Cdd:PTZ00322 102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
435-490 |
3.84e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.96 E-value: 3.84e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568926103 435 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 490
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
181-269 |
7.63e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 49.90 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 181 VLTSYESCNITSYDNlfRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPsv 260
Cdd:PTZ00322 101 LLTGGADPNCRDYDG--RTPLHIACANG----HVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS-- 171
|
....*....
gi 568926103 261 KDDSDLEGR 269
Cdd:PTZ00322 172 QCHFELGAN 180
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
48-111 |
1.09e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 1.09e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926103 48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAaqkqtalhwsAYYNNPEHAKLLI 111
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFA----------ASNGNVEVLKLLL 54
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
558-822 |
3.03e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.14 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 558 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 637
Cdd:PHA03378 575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 638 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHRRCEEGPSSARQPLC--TGSGRPAEKGEDSSPAV 714
Cdd:PHA03378 652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQPPPRAPTPMRPPAAppGRAQRPAAATGRARPPA 728
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 715 ASASQQDHP-------RKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 768
Cdd:PHA03378 729 AAPGRARPPaaapgraRPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568926103 769 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 822
Cdd:PHA03378 809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
853-878 |
4.35e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.35e-05
10 20
....*....|....*....|....*.
gi 568926103 853 RKELFRRKNKAAAVIQRAWRSYQLRK 878
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
352-422 |
5.21e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.20 E-value: 5.21e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926103 352 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 422
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
335-494 |
7.54e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 46.52 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 335 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 414
Cdd:PHA02875 1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 415 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 493
Cdd:PHA02875 81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
.
gi 568926103 494 A 494
Cdd:PHA02875 159 A 159
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
65-182 |
8.88e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 46.40 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 65 DALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayyNNPEHAKLLIKHDSNIGIPDVEGKIPLhW---AANH------- 134
Cdd:PLN03192 542 EELLKAKLDPDIGDSKGRTPLHIAASK----------GYEDCVLVLLKHACNVHIRDANGNTAL-WnaiSAKHhkifril 610
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926103 135 ------KDPSAVHTVRCIL----DAAPTESLL------NWQDYEGRTPLHFAVADGNLTVVDVL 182
Cdd:PLN03192 611 yhfasiSDPHAAGDLLCTAakrnDLTAMKELLkqglnvDSEDHQGATALQVAMAEDHVDMVRLL 674
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
302-333 |
1.31e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.31e-04
10 20 30
....*....|....*....|....*....|...
gi 568926103 302 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 333
Cdd:pfam00023 1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.86e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.86e-04
10 20
....*....|....*....|....*....
gi 568926103 48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
48-79 |
2.32e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.19 E-value: 2.32e-04
10 20 30
....*....|....*....|....*....|...
gi 568926103 48 GRTPLMYCVL-ADRVDCADALLKAGADVNKTDH 79
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
293-340 |
2.38e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 2.38e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 568926103 293 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 340
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
198-255 |
2.92e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.57 E-value: 2.92e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 568926103 198 RTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFL 255
Cdd:pfam13637 2 LTALHAAAASG----HLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
160-357 |
3.37e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 43.88 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 160 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLgtfgRHAQIVHLLLernKSGTIPS--DSQG 235
Cdd:PHA02791 27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATL----EDTKIVKILL---FSGMDDSqfDDKG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 236 ATPLHYAAQSNFAETVKVFLQHP-SVKDDSDLEGRTSFMWAAGKGNDDVLRTMLS-LKSDIDINMSDkyggTALHAAALS 313
Cdd:PHA02791 95 NTALYYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKN 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 568926103 314 GHVSTVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 357
Cdd:PHA02791 171 GHVDMMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
368-397 |
3.57e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.57e-04
10 20 30
....*....|....*....|....*....|
gi 568926103 368 DGHSLLHWAALGGNADVCQILIENKINPNV 397
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
163-221 |
3.85e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.18 E-value: 3.85e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 568926103 163 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 221
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
499-525 |
5.44e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.44e-04
10 20
....*....|....*....|....*..
gi 568926103 499 AIQDIAAFKIQAVYKGYKVRKAFRDRK 525
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
33-88 |
5.66e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 5.66e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568926103 33 LIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLA 88
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
59-147 |
5.84e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 43.50 E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 59 DRVDCadaLLKAGADVNKTDHSRRTALHLAAqkqtalhwsaYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAA--NHKD 136
Cdd:PHA03100 173 NRVNY---LLSYGVPINIKDVYGFTPLHYAV----------YNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIlnNNKE 239
|
90 100
....*....|....*....|
gi 568926103 137 ---------PSAVHTVRCIL 147
Cdd:PHA03100 240 ifklllnngPSIKTIIETLL 259
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
262-310 |
6.37e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 6.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 568926103 262 DDSDLEGRTSFMWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAA 310
Cdd:pfam13857 10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
170-423 |
6.37e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 170 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 248
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 249 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 327
Cdd:TIGR00870 95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 328 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 384
Cdd:TIGR00870 153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568926103 385 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 423
Cdd:TIGR00870 230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
434-462 |
6.75e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.95 E-value: 6.75e-04
10 20
....*....|....*....|....*....
gi 568926103 434 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 462
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
67-131 |
6.96e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 6.96e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926103 67 LLKAG-ADVNKTDHSRRTALHLAaqkqtalhwsAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 131
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVA----------AKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
73-291 |
7.00e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 73 DVNKTDHSRRTALHLAAQKQtalhwsayyNNPEHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAP 151
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIEN---------ENLELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 152 TES----LLNWQD----YEGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTf 210
Cdd:TIGR00870 109 RKSgpleLANDQYtsefTPGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 211 grhAQIVHLLLErNKSGTIPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMW 274
Cdd:TIGR00870 188 ---PSIVALLSE-DPADILTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKL 263
|
250
....*....|....*..
gi 568926103 275 AAGKGNDDVLRTMLSLK 291
Cdd:TIGR00870 264 AAKEGRIVLFRLKLAIK 280
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
368-399 |
9.95e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 9.95e-04
10 20 30
....*....|....*....|....*....|...
gi 568926103 368 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 399
Cdd:pfam00023 1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
368-397 |
1.08e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.08e-03
10 20 30
....*....|....*....|....*....|
gi 568926103 368 DGHSLLHWAALGGNADVCQILIENKINPNV 397
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
402-433 |
1.20e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 1.20e-03
10 20 30
....*....|....*....|....*....|...
gi 568926103 402 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 433
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
47-129 |
1.25e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 41.34 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 47 FGRTPLMYCVLADRV--DCADALLKAGADVN-KTDHSRRTALHlaaqkqtalHWSAYYNN--PEHAKLLIKHDSNIGIPD 121
Cdd:PHA02859 50 LYETPIFSCLEKDKVnvEILKFLIENGADVNfKTRDNNLSALH---------HYLSFNKNvePEILKILIDSGSSITEED 120
|
....*...
gi 568926103 122 VEGKIPLH 129
Cdd:PHA02859 121 EDGKNLLH 128
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
402-430 |
1.27e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.18 E-value: 1.27e-03
10 20
....*....|....*....|....*....
gi 568926103 402 GRTPLQCAAYGGYINCMAVLMENNADPNI 430
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
93-141 |
2.07e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 2.07e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 568926103 93 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 141
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
268-443 |
2.14e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 41.79 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 268 GRTSFMWAAGKGNDDVLRTML----------SLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 332
Cdd:cd21882 26 GKTCLHKAALNLNDGVNEAIMllleaapdsgNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 333 DVMKHTPL-----------FRACeMGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----I 387
Cdd:cd21882 106 RFFRKSPGnlfyfgelplsLAAC-TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllL 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926103 388 LIENKINPNVQ-----DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 443
Cdd:cd21882 185 SYGAHLDPTQQleeipNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
305-331 |
2.20e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.20e-03
10 20
....*....|....*....|....*..
gi 568926103 305 TALHAAALSGHVSTVKLLLDNDAQVDA 331
Cdd:smart00248 4 TPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
47-76 |
2.20e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.20e-03
10 20 30
....*....|....*....|....*....|
gi 568926103 47 FGRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PRK12678 |
PRK12678 |
transcription termination factor Rho; Provisional |
501-751 |
2.49e-03 |
|
transcription termination factor Rho; Provisional
Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 41.81 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 501 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 576
Cdd:PRK12678 21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 577 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 652
Cdd:PRK12678 101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 653 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 732
Cdd:PRK12678 181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255
|
250
....*....|....*....
gi 568926103 733 AARPRGASQKRRThqlRDR 751
Cdd:PRK12678 256 EGRGGRRGRRFRD---RDR 271
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
584-827 |
2.51e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.08 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 584 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 663
Cdd:PHA03307 12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 664 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 743
Cdd:PHA03307 86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 744 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 814
Cdd:PHA03307 164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238
|
250
....*....|...
gi 568926103 815 ICASPETGVAHGP 827
Cdd:PHA03307 239 SSSSESSGCGWGP 251
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
127-182 |
2.84e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 2.84e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568926103 127 PLHWAANHKDPSAVHtvRCILDAAPteslLNWQDYEGRTPLHFAVADGNLTVVDVL 182
Cdd:pfam13637 4 ALHAAAASGHLELLR--LLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
302-331 |
3.07e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.08 E-value: 3.07e-03
10 20 30
....*....|....*....|....*....|
gi 568926103 302 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 331
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
351-527 |
3.14e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 351 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 430
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 431 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 509
Cdd:PHA02876 240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306
|
170
....*....|....*...
gi 568926103 510 AVYKGYKVRKAFRDRKNL 527
Cdd:PHA02876 307 GETPLYLMAKNGYDTENI 324
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
42-185 |
3.19e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 42 DKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKtdhsrrtalhLAAQKQTALHWSAYYNNP-EHAKLLIKHDSNIGIP 120
Cdd:PHA02876 369 NARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA----------LSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSK 438
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926103 121 DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTESLLNWQDyegRTPLHFAVadGNLTVVDVLTSY 185
Cdd:PHA02876 439 NKDLSTPLHYAC--KKNCKLDVIEMLLDNGADVNAINIQN---QYPLLIAL--EYHGIVNILLHY 496
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
155-204 |
3.50e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.56 E-value: 3.50e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568926103 155 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 204
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
90-117 |
5.22e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.26 E-value: 5.22e-03
10 20
....*....|....*....|....*...
gi 568926103 90 QKQTALHWSAYYNNPEHAKLLIKHDSNI 117
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
860-906 |
6.59e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.59e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 568926103 860 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 906
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
32-206 |
7.76e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 39.86 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 32 RLIVGNSALRDKEDR-FGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKqtalhwsayYNNPEhAKLL 110
Cdd:PHA02878 151 KLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKH---------YNKPI-VHIL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926103 111 IKHDSNIGIPDVEGKIPLHWAANH-KDpsaVHTVRCILDAAPTeslLNWQDY-EGRTPLHFAVADGNltVVDVLTSYES- 187
Cdd:PHA02878 221 LENGASTDARDKCGNTPLHISVGYcKD---YDILKLLLEHGVD---VNAKSYiLGLTALHSSIKSER--KLKLLLEYGAd 292
|
170
....*....|....*....
gi 568926103 188 CNITSYDNLfrTPLHWAAL 206
Cdd:PHA02878 293 INSLNSYKL--TPLSSAVK 309
|
|
| |
