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Conserved domains on  [gi|568972755|ref|XP_006532816|]
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X2 [Mus musculus]

Protein Classification

beta3GnTL1_like domain-containing protein( domain architecture ID 10161044)

beta3GnTL1_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 1-203 1.94e-151

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


:

Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 423.79  E-value: 1.94e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   1 MSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDV 80
Cdd:cd06913   17 ESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAIAQSSGRYLCFLDSDDV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  81 MMPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTERYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSHVGPFDE 160
Cdd:cd06913   97 MMPQRIRLQYEAALQHPNSIIGCQVRRIPEDSTERYTRWINTLTREQLLTQVYTSHGPTVIMPTWFCSREWFSHVGPFDE 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568972755 161 GGQGVPEDLLFFYEHLRKGGGVFRVDHSLLLYRYHLYAATHSV 203
Cdd:cd06913  177 GGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
 
Name Accession Description Interval E-value
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 1-203 1.94e-151

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 423.79  E-value: 1.94e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   1 MSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDV 80
Cdd:cd06913   17 ESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAIAQSSGRYLCFLDSDDV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  81 MMPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTERYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSHVGPFDE 160
Cdd:cd06913   97 MMPQRIRLQYEAALQHPNSIIGCQVRRIPEDSTERYTRWINTLTREQLLTQVYTSHGPTVIMPTWFCSREWFSHVGPFDE 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568972755 161 GGQGVPEDLLFFYEHLRKGGGVFRVDHSLLLYRYHLYAATHSV 203
Cdd:cd06913  177 GGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 2-154 4.81e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 74.35  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755    2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKleDSGISVVIgghdSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:pfam00535  19 SLLNQTYP-NFEIIVVDDGSTDGTVEIAEEYAKK--DPRVRVIR----LPENRGKAGARNAGLRAATGDYIAFLDADDEV 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568972755   82 MPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTE--RYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSH 154
Cdd:pfam00535  92 PPDWLEKLVEALEEDGADVVVGSRYVIFGETGEyrRASRITLSRLPFFLGLRLLGLNLPFLIGGFALYRREALEE 166
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 2-195 2.85e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 73.20  E-value: 2.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGAmELSVFNDASKDKSRAIIEKWKVKleDSGISVVigghDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:COG0463   23 SLLAQTYPDF-EIIVVDDGSTDGTAEILRELAAK--DPRIRVI----RLERNRGKGAARNAGLAAARGDYIAFLDADDQL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  82 MPQRVRMQYEAAGQHPTSIIGCQVRRDppDSTERYTRWINHLTS-DQLLTQVFTSHGPTVIMptwfcSRAWFSHVGpFDE 160
Cdd:COG0463   96 DPEKLEELVAALEEGPADLVYGSRLIR--EGESDLRRLGSRLFNlVRLLTNLPDSTSGFRLF-----RREVLEELG-FDE 167

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568972755 161 ggqGVPEDLLFFYeHLRKGGGVFRVDHsllLYRYH 195
Cdd:COG0463  168 ---GFLEDTELLR-ALRHGFRIAEVPV---RYRAG 195
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-84 4.33e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 47.73  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKL--------EDSGISVvigghdspsprgvgySKNQAVAQSTGSYLC 73
Cdd:PRK10073  27 SLIAQTWT-ALEIIIVNDGSTDNSVEIAKHYAENYphvrllhqANAGVSV---------------ARNTGLAVATGKYVA 90

                         90
                 ....*....|.
gi 568972755  74 FLDSDDVMMPQ 84
Cdd:PRK10073  91 FPDADDVVYPT 101
 
Name Accession Description Interval E-value
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 1-203 1.94e-151

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 423.79  E-value: 1.94e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   1 MSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDV 80
Cdd:cd06913   17 ESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAIAQSSGRYLCFLDSDDV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  81 MMPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTERYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSHVGPFDE 160
Cdd:cd06913   97 MMPQRIRLQYEAALQHPNSIIGCQVRRIPEDSTERYTRWINTLTREQLLTQVYTSHGPTVIMPTWFCSREWFSHVGPFDE 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568972755 161 GGQGVPEDLLFFYEHLRKGGGVFRVDHSLLLYRYHLYAATHSV 203
Cdd:cd06913  177 GGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 2-184 1.96e-16

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 75.24  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKledsGISVVIggHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:cd00761   18 SLLAQTYP-NFEVIVVDDGSTDGTLEILEEYAKK----DPRVIR--VINEENQGLAAARNAGLKAARGEYILFLDADDLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  82 MPQRVRMQYEAAGQHPT-SIIGCQvrrdppdsterytrwinhltsdqlltqvftshgptvimPTWFCSRAWFSHVGPFDE 160
Cdd:cd00761   91 LPDWLERLVAELLADPEaDAVGGP--------------------------------------GNLLFRRELLEEIGGFDE 132

                        170       180
                 ....*....|....*....|....
gi 568972755 161 GGQGVPEDLLFFYEHLRKGGGVFR 184
Cdd:cd00761  133 ALLSGEEDDDFLLRLLRGGKVAFR 156
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 2-154 4.81e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 74.35  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755    2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKleDSGISVVIgghdSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:pfam00535  19 SLLNQTYP-NFEIIVVDDGSTDGTVEIAEEYAKK--DPRVRVIR----LPENRGKAGARNAGLRAATGDYIAFLDADDEV 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568972755   82 MPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTE--RYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSH 154
Cdd:pfam00535  92 PPDWLEKLVEALEEDGADVVVGSRYVIFGETGEyrRASRITLSRLPFFLGLRLLGLNLPFLIGGFALYRREALEE 166
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 2-195 2.85e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 73.20  E-value: 2.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGAmELSVFNDASKDKSRAIIEKWKVKleDSGISVVigghDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:COG0463   23 SLLAQTYPDF-EIIVVDDGSTDGTAEILRELAAK--DPRIRVI----RLERNRGKGAARNAGLAAARGDYIAFLDADDQL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  82 MPQRVRMQYEAAGQHPTSIIGCQVRRDppDSTERYTRWINHLTS-DQLLTQVFTSHGPTVIMptwfcSRAWFSHVGpFDE 160
Cdd:COG0463   96 DPEKLEELVAALEEGPADLVYGSRLIR--EGESDLRRLGSRLFNlVRLLTNLPDSTSGFRLF-----RREVLEELG-FDE 167

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568972755 161 ggqGVPEDLLFFYeHLRKGGGVFRVDHsllLYRYH 195
Cdd:COG0463  168 ---GFLEDTELLR-ALRHGFRIAEVPV---RYRAG 195
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 2-195 2.06e-12

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 65.26  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKL------EDSGISVVIgghdspsprgvgyskNQAVAQSTGSYLCFL 75
Cdd:cd06433   19 SVLSQTYP-NIEYIVIDGGSTDGTVDIIKKYEDKItywisePDKGIYDAM---------------NKGIALATGDIIGFL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  76 DSDDVMMPQRVRMQYEAAGQHPTS--IIGCQVRRDPPDSTERYTRWINHLTSDqLLTQVFTSHgptvimPTWFCSRAWFS 153
Cdd:cd06433   83 NSDDTLLPGALLAVVAAFAEHPEVdvVYGDVLLVDENGRVIGRRRPPPFLDKF-LLYGMPICH------QATFFRRSLFE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568972755 154 HVGPFDE----GGqgvpeDLLFFYEHLRKGGGVFRVDHSLLLYRYH 195
Cdd:cd06433  156 KYGGFDEsyriAA-----DYDLLLRLLLAGKIFKYLPEVLAAFRLG 196
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-87 1.49e-08

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 55.13  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDF-EGAMELSVFNDASKDKSRAIIEKWKvkLEDSGISVVigghDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDV 80
Cdd:COG1215   50 SLLAQDYpKEKLEVIVVDDGSTDETAEIARELA--AEYPRVRVI----ERPENGGKAAALNAGLKAARGDIVVFLDADTV 123


                 ....*..
gi 568972755  81 MMPQRVR 87
Cdd:COG1215  124 LDPDWLR 130
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
2-212 1.72e-07

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 50.76  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGAmELSVFNDASKDKSRAIIEKWKvkleDSGISVVigghDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:COG1216   24 SLLAQTYPPF-EVIVVDNGSTDGTAELLAALA----FPRVRVI----RNPENLGFAAARNLGLRAAGGDYLLFLDDDTVV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  82 MPQrvrmqyeaagqhptsiigcqvrrdppdsterytrWInhltsDQLLTQVFtshgptvimptWFCSRAWFSHVGPFDE- 160
Cdd:COG1216   95 EPD----------------------------------WL-----ERLLAAAC-----------LLIRREVFEEVGGFDEr 124

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568972755 161 -GGQGvpEDLLFFYEHLRKGGGVFRVDHSLLlyrYHLYAATHSVLEMTIWTHR 212
Cdd:COG1216  125 fFLYG--EDVDLCLRLRKAGYRIVYVPDAVV---YHLGGASSGPLLRAYYLGR 172
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-84 4.33e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 47.73  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKL--------EDSGISVvigghdspsprgvgySKNQAVAQSTGSYLC 73
Cdd:PRK10073  27 SLIAQTWT-ALEIIIVNDGSTDNSVEIAKHYAENYphvrllhqANAGVSV---------------ARNTGLAVATGKYVA 90

                         90
                 ....*....|.
gi 568972755  74 FLDSDDVMMPQ 84
Cdd:PRK10073  91 FPDADDVVYPT 101
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 2-195 3.55e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 44.16  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGAmELSVFNDASKDKSRAIIEKWkVKLEDSGISVVIGGHdspsprGVGYSKN--QAVAQSTGSYLCFLDSDD 79
Cdd:cd04196   19 SILAQTYKND-ELIISDDGSTDGTVEIIKEY-IDKDPFIIILIRNGK------NLGVARNfeSLLQAADGDYVFFCDQDD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  80 VMMPQRVRMQYEAAGQHP--------TSII---GCQVRRDPPDsterYTRWINHLTSDQLLTQVFTShGPTVIMptwfcS 148
Cdd:cd04196   91 IWLPDKLERLLKAFLKDDkpllvysdLELVdenGNPIGESFFE----YQKIKPGTSFNNLLFQNVVT-GCTMAF-----N 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568972755 149 RAWFSHVGPFDEGGQGVPEDLLffYEHLRKGGGVFRVDHSLLLYRYH 195
Cdd:cd04196  161 RELLELALPFPDADVIMHDWWL--ALLASAFGKVVFLDEPLILYRQH 205
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 2-171 4.74e-05

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 43.71  E-value: 4.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVkledsgisVVIgghdsPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:cd02522   19 ASLRRLNPLPLEIIVVDGGSTDGTVAIARSAGV--------VVI-----SSPKGRARQMNAGAAAARGDWLLFLHADTRL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755  82 MPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTER--------YTRWINHLTSDQLLtqvftshgptvimptwFCSRAWFS 153
Cdd:cd02522   86 PPDWDAAIIETLRADGAVAGAFRLRFDDPGPRLRllelganlRSRLFGLPYGDQGL----------------FIRRELFE 149

                        170       180
                 ....*....|....*....|
gi 568972755 154 HVGPFDEggqgVP--EDLLF 171
Cdd:cd02522  150 ELGGFPE----LPlmEDVEL 165
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 1-78 2.90e-04

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 41.40  E-value: 2.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568972755   1 MSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLedSGISVVIgghDSPSPRGVGYSKNQAVAQSTGSYLCFLDSD 78
Cdd:cd04188   20 VEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKN--PALIRVL---TLPKNRGKGGAVRAGMLAARGDYILFADAD 92
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 2-121 5.68e-04

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 40.29  E-value: 5.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEgAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHdspspRGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:cd06423   18 SLLALDYP-KLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKEN-----GGKAGALNAGLRHAKGDIVVVLDADTIL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568972755  82 MPQRVRMQYEAAGQHPTsIIGCQVRRDPPDSTERY-TRWIN 121
Cdd:cd06423   92 EPDALKRLVVPFFADPK-VGAVQGRVRVRNGSENLlTRLQA 131
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
2-86 1.92e-03

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 39.21  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972755   2 SVLQQDFEGaMELSVFNDASKDKSRaiIEKWKVKLEDSGISVVIGGHDSpsprGVGYSKNQAVAQSTGSYLCFLDSDDVM 81
Cdd:PRK10018  26 SVLRQDYSN-WEMIIVDDCSTSWEQ--LQQYVTALNDPRITYIHNDINS----GACAVRNQAIMLAQGEYITGIDDDDEW 98


                 ....*
gi 568972755  82 MPQRV 86
Cdd:PRK10018  99 TPNRL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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