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Conserved domains on  [gi|568956914|ref|XP_006531118|]
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leucine-rich repeat-containing protein 36 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.48e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  50 KSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                         90
                 ....*....|...
gi 568956914 129 KLDDRAVRDSERR 141
Cdd:cd21340  199 VLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.48e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  50 KSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                         90
                 ....*....|...
gi 568956914 129 KLDDRAVRDSERR 141
Cdd:cd21340  199 VLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
44-147 2.21e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.47  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914   44 DAFRNFKSLRSLDLSRNLITSL-KGI-QYLCSLQELNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDtDYRLFAV 121
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKP-HYRLYVI 136

                          90       100
                  ....*....|....*....|....*.
gi 568956914  122 YTLQTLEKLDDRAVRDSERRAAKLHF 147
Cdd:pfam14580 137 YKVPQLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 1.32e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  27 ESLSLQGSyagKIHSIGDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLvevSRLQPLPFLKELDLRL 106
Cdd:COG4886  208 EELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL---PPLANLTNLKTLDLSN 281


                 ...
gi 568956914 107 NPV 109
Cdd:COG4886  282 NQL 284
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.48e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  50 KSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                         90
                 ....*....|...
gi 568956914 129 KLDDRAVRDSERR 141
Cdd:cd21340  199 VLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
44-147 2.21e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.47  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914   44 DAFRNFKSLRSLDLSRNLITSL-KGI-QYLCSLQELNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDtDYRLFAV 121
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKP-HYRLYVI 136

                          90       100
                  ....*....|....*....|....*.
gi 568956914  122 YTLQTLEKLDDRAVRDSERRAAKLHF 147
Cdd:pfam14580 137 YKVPQLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 1.32e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  27 ESLSLQGSyagKIHSIGDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLvevSRLQPLPFLKELDLRL 106
Cdd:COG4886  208 EELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL---PPLANLTNLKTLDLSN 281


                 ...
gi 568956914 107 NPV 109
Cdd:COG4886  282 NQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-109 9.25e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 9.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  20 LEQPELVESLSLQGSyagKIHSIGDAFRNFKSLRSLDLSRNLITSL-KGIQYLCSLQELNLYYNNIPSLVEVsrLQPLPF 98
Cdd:COG4886  109 LSNLTNLESLDLSGN---QLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTN 183

                         90
                 ....*....|.
gi 568956914  99 LKELDLRLNPV 109
Cdd:COG4886  184 LKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-158 1.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  27 ESLSLQGSyagKIHSIGDAFRNFKSLRSLDLSRNLITSL-KGIQYLCSLQELNLYYNNIPSLVEVSRlqpLPFLKELDLR 105
Cdd:COG4886  185 KELDLSNN---QITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGN---LTNLEELDLS 258

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568956914 106 LNPVVrkdtdyRLFAVYTLQTLEKLDDRAVRDSERRAAKLHFSQLGNSENFLL 158
Cdd:COG4886  259 NNQLT------DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 2.03e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 2.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  27 ESLSLQGSyagKIHSIGDAFRNFKSLRSLDLSRNLITSL-KGIQYLCSLQELNLYYNNIPSLVEVsrLQPLPFLKELDLR 105
Cdd:COG4886  139 KELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLS 213


                 ....
gi 568956914 106 LNPV 109
Cdd:COG4886  214 GNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-109 6.01e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 6.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  41 SIGDAFRNFKSLRSLDLSRNLITSL-KGIQYLCSLQELNLYYNNIPSLVEVsrLQPLPFLKELDLRLNPV 109
Cdd:COG4886  104 SGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQL 171
LRR_8 pfam13855
Leucine rich repeat;
26-84 6.08e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.08e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568956914   26 VESLSLQGSYAGKIHsiGDAFRNFKSLRSLDLSRNLITSL--KGIQYLCSLQELNLYYNNI 84
Cdd:pfam13855   3 LRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-109 3.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568956914   51 SLRSLDLSRNLITSLKG--IQYLCSLQELNLYYNNIPSLVEVSrLQPLPFLKELDLRLNPV 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 50-83 6.10e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 6.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568956914   50 KSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNN 83
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 42-107 2.83e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568956914  42 IGDAFRNFKSLRSLDLSRNLITSlKGIQYLC--------SLQELNLYYNNIPSLVEVSRLQPL---PFLKELDLRLN 107
Cdd:cd00116  213 LAETLASLKSLEVLNLGDNNLTD-AGAAALAsallspniSLLTLSLSCNDITDDGAKDLAEVLaekESLLELDLRGN 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-104 1.91e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568956914  38 KIHSIgDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIpslVEVSRLQPLPFLKELDL 104
Cdd:cd21340   35 KITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI---SVVEGLENLTNLEELHI 97
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 20-145 2.90e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956914  20 LEQPELVESLSLQGSYAGKIH--SIGDAFRNFKSLRSLDLSRNLITS------LKGIQYLCSLQELNLYYNNIP-----S 86
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGaiALAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGaqgaiA 339

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568956914  87 LVEVsrLQPLPFLKELDLRLNPVvrKDTDYRLFAVY--TLQTLEKLDDRAVRDSERRAAKL 145
Cdd:COG5238  340 LAKA--LQENTTLHSLDLSDNQI--GDEGAIALAKYleGNTTLRELNLGKNNIGKQGAEAL 396
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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