|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02677 |
PLN02677 |
mevalonate kinase |
10-377 |
9.37e-79 |
|
mevalonate kinase
Pssm-ID: 215363 [Multi-domain] Cd Length: 387 Bit Score: 247.82 E-value: 9.37e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQS----NGKVSVNLPNIGIKQVWDVGMLQRLdTSFLEQGDVSVPTL 85
Cdd:PLN02677 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPPsaenDDTLKLQLKDLGLEFSWPLARIKEA-LPDLGTPCPSTPTS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 86 EQLEKLKKMGDLPRDRAGNEG-MALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEV 164
Cdd:PLN02677 86 CSEETLKSIAALVEEQNIPEAkIWLSSGVSAFLWLYTSILGFNPATVVVTSELPLGSGLGSSAAFCVALSAALLAASDSI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 165 SNPlKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTK 244
Cdd:PLN02677 166 SVS-TGGNGWSSLDETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTRVGRNTK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 245 ALVAAVRSRLTKFPEIVAPLLTSIDAISLEcervLGEMVAAPVPEQYLV------LEELIDMNQHHLNALGVGHNSLDQL 318
Cdd:PLN02677 245 ALVAGVSERALRHPDAMKSVFNAVDSISEE----LATIIQSPAEDELSItekeekLKELMEMNQGLLQCMGVSHSSIETV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936904 319 CQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGV 377
Cdd:PLN02677 321 LRTTLKYKLVSKLTGAGGGGCVLTLLPTLLSGTVVDKVIAELESSGFQCFTAGIGGNGV 379
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
10-332 |
1.59e-54 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 181.33 E-value: 1.59e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGkvsvnlpnigikqvwdvgmlQRLDTSFLEQGDVSVPtlEQLE 89
Cdd:TIGR00549 1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDG--------------------SFIESDLGRGSLDDAP--DELD 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 90 KLKKMGDLPRDRAGNEgmallaflylylaicrkqrTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACeevsnplk 169
Cdd:TIGR00549 59 GLKYVLAEFLSRFSEL-------------------NPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYF-------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 170 dGVSVSRwpEEdlksINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG-TMSSLKSLPSLQILLTNTKVPRSTKALVA 248
Cdd:TIGR00549 112 -GSELSK--EE----LAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGeGEFTKLISLDGYFVIADTGVSGSTKEAVA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 249 AVRSRLTKFPEIVAPLLTSIDAISLECERVL--GEMVAapvpeqylvLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG 326
Cdd:TIGR00549 185 RVRQLLERFPELIDSIMDAIGELTLEAKAALqdGDVES---------LGELMNINQGLLKALGVSHPKLDQLVEIARKAG 255
|
....*..
gi 568936904 327 -LHSKLT 332
Cdd:TIGR00549 256 aLGAKLT 262
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
10-332 |
5.03e-53 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 177.34 E-value: 5.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKqvWDVGMLQRLDTSFLEQgdvsvpTLEQLE 89
Cdd:COG1577 1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGT--LDLDPLADAALRYIKA------AIEAAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 90 klkkmgdlprDRAGnegmallaflylylaicrkqRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEvsnplk 169
Cdd:COG1577 73 ----------EYLG--------------------LPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGV------ 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 170 dgvsvsrwpEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGT-MSSLKSLPSLQILLTNTKVPRSTKALVA 248
Cdd:COG1577 117 ---------ELSKEELFKLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGVPASTKELVA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 249 AVRSRLTKFPEIVAPLLTSIDAISLECERVLGEmvaapvpEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-L 327
Cdd:COG1577 188 KVRKLKERNPELYEAFLEEIGDLVEEAIEALEE-------GDLEALGELMNENHGLLRALGVSTPELDRLVEAARKAGaL 260
|
....*
gi 568936904 328 HSKLT 332
Cdd:COG1577 261 GAKLT 265
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
130-212 |
1.01e-10 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 56.79 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 130 DMVVWSELPPGAGLGSSAAYSVCLAAALLTACEevsnplkdgvsvsrwpeedlKSINKWAFEGERVIH-GNPSGVDNAVS 208
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNELFG--------------------LPLAKLALEAEELAGgGRGGGMDVAAS 60
|
....
gi 568936904 209 TWGG 212
Cdd:pfam00288 61 LYGG 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02677 |
PLN02677 |
mevalonate kinase |
10-377 |
9.37e-79 |
|
mevalonate kinase
Pssm-ID: 215363 [Multi-domain] Cd Length: 387 Bit Score: 247.82 E-value: 9.37e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQS----NGKVSVNLPNIGIKQVWDVGMLQRLdTSFLEQGDVSVPTL 85
Cdd:PLN02677 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPPsaenDDTLKLQLKDLGLEFSWPLARIKEA-LPDLGTPCPSTPTS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 86 EQLEKLKKMGDLPRDRAGNEG-MALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEV 164
Cdd:PLN02677 86 CSEETLKSIAALVEEQNIPEAkIWLSSGVSAFLWLYTSILGFNPATVVVTSELPLGSGLGSSAAFCVALSAALLAASDSI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 165 SNPlKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTK 244
Cdd:PLN02677 166 SVS-TGGNGWSSLDETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTRVGRNTK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 245 ALVAAVRSRLTKFPEIVAPLLTSIDAISLEcervLGEMVAAPVPEQYLV------LEELIDMNQHHLNALGVGHNSLDQL 318
Cdd:PLN02677 245 ALVAGVSERALRHPDAMKSVFNAVDSISEE----LATIIQSPAEDELSItekeekLKELMEMNQGLLQCMGVSHSSIETV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936904 319 CQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGV 377
Cdd:PLN02677 321 LRTTLKYKLVSKLTGAGGGGCVLTLLPTLLSGTVVDKVIAELESSGFQCFTAGIGGNGV 379
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
10-332 |
1.59e-54 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 181.33 E-value: 1.59e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGkvsvnlpnigikqvwdvgmlQRLDTSFLEQGDVSVPtlEQLE 89
Cdd:TIGR00549 1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDG--------------------SFIESDLGRGSLDDAP--DELD 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 90 KLKKMGDLPRDRAGNEgmallaflylylaicrkqrTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACeevsnplk 169
Cdd:TIGR00549 59 GLKYVLAEFLSRFSEL-------------------NPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYF-------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 170 dGVSVSRwpEEdlksINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG-TMSSLKSLPSLQILLTNTKVPRSTKALVA 248
Cdd:TIGR00549 112 -GSELSK--EE----LAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGeGEFTKLISLDGYFVIADTGVSGSTKEAVA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 249 AVRSRLTKFPEIVAPLLTSIDAISLECERVL--GEMVAapvpeqylvLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG 326
Cdd:TIGR00549 185 RVRQLLERFPELIDSIMDAIGELTLEAKAALqdGDVES---------LGELMNINQGLLKALGVSHPKLDQLVEIARKAG 255
|
....*..
gi 568936904 327 -LHSKLT 332
Cdd:TIGR00549 256 aLGAKLT 262
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
10-332 |
5.03e-53 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 177.34 E-value: 5.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 10 APGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKqvWDVGMLQRLDTSFLEQgdvsvpTLEQLE 89
Cdd:COG1577 1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGT--LDLDPLADAALRYIKA------AIEAAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 90 klkkmgdlprDRAGnegmallaflylylaicrkqRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEvsnplk 169
Cdd:COG1577 73 ----------EYLG--------------------LPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGV------ 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 170 dgvsvsrwpEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGT-MSSLKSLPSLQILLTNTKVPRSTKALVA 248
Cdd:COG1577 117 ---------ELSKEELFKLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGVPASTKELVA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 249 AVRSRLTKFPEIVAPLLTSIDAISLECERVLGEmvaapvpEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-L 327
Cdd:COG1577 188 KVRKLKERNPELYEAFLEEIGDLVEEAIEALEE-------GDLEALGELMNENHGLLRALGVSTPELDRLVEAARKAGaL 260
|
....*
gi 568936904 328 HSKLT 332
Cdd:COG1577 261 GAKLT 265
|
|
| PRK03926 |
PRK03926 |
mevalonate kinase; Provisional |
7-332 |
1.11e-39 |
|
mevalonate kinase; Provisional
Pssm-ID: 179677 [Multi-domain] Cd Length: 302 Bit Score: 143.27 E-value: 1.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 7 LVSAPGKVILHGEHAVVHGKVALAAALNLRTFLllrpqsngKVSVNLPNIGIkqvwdvgmlqrlDTSFLEQGDVsvptle 86
Cdd:PRK03926 3 LCSAPGKIYLFGEHAVVYGKPAIACAIDLRTYV--------RAEFNDDSIYI------------ESDYGKTGEK------ 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 87 qleklkkmgdLPRDRAGNEGMallaflylylaicRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALltaceevSN 166
Cdd:PRK03926 57 ----------HPYVSAAIEKM-------------REEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGAL-------NR 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 167 PLKDGVSvsrwpeedLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGtmSSLKsLPSLQILLTNTKVPRSTKAL 246
Cdd:PRK03926 107 LLGLGLS--------LEEIAKLGHKVELLVQGAASPTDTYVSTMGGFVTIPDR--KKLP-FPECGIVVGYTGSSGSTKEL 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 247 VAAVRSRLTKFPEIVAPLLTSIDAISLECERVLgemvaapVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG 326
Cdd:PRK03926 176 VANVRKLKEEYPELIEPILSSIGKISEKGEELI-------LSGDYVSLGELMNINQGLLDALGVSTKELSELIYAARTAG 248
|
....*..
gi 568936904 327 -LHSKLT 332
Cdd:PRK03926 249 aLGAKIT 255
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
130-212 |
1.01e-10 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 56.79 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 130 DMVVWSELPPGAGLGSSAAYSVCLAAALLTACEevsnplkdgvsvsrwpeedlKSINKWAFEGERVIH-GNPSGVDNAVS 208
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNELFG--------------------LPLAKLALEAEELAGgGRGGGMDVAAS 60
|
....
gi 568936904 209 TWGG 212
Cdd:pfam00288 61 LYGG 64
|
|
| GalK |
COG0153 |
Galactokinase [Carbohydrate transport and metabolism]; |
3-242 |
4.26e-09 |
|
Galactokinase [Carbohydrate transport and metabolism];
Pssm-ID: 439923 [Multi-domain] Cd Length: 380 Bit Score: 57.86 E-value: 4.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 3 SEALLVSAPGKVILHGEHavV---HGKVaLAAALNLRTFLLLRPQSNGKV---SVNLPnigikqvwdvgmlqrldtsfle 76
Cdd:COG0153 16 EPEGVFSAPGRVNLIGEH--TdynGGFV-LPAAIDRGTYAAARPRDDRKVrvySADFD---------------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 77 qGDVSVpTLEQLEKLKKMG--DLPRdragneGMALLaflylylaICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLA 154
Cdd:COG0153 71 -EEVEF-DLDDLEPGEEDGwaNYVR------GVAWA--------LQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 155 AALLTACeevsnplkdGVSVSRWpeeDLKSINKWAfegERVIHGNPSGV-DNAVSTWGG---ALRFQQGTMSSLK---SL 227
Cdd:COG0153 135 LALNDLF---------GLGLDPV---ELAKIGQRA---ENEFVGVPCGImDQFASALGKkghALLLDCRSLEYEYvplPL 199
|
250
....*....|....*
gi 568936904 228 PSLQILLTNTKVPRS 242
Cdd:COG0153 200 EGYALVIVDTNVKHS 214
|
|
| PTZ00298 |
PTZ00298 |
mevalonate kinase; Provisional |
12-332 |
1.43e-08 |
|
mevalonate kinase; Provisional
Pssm-ID: 240351 [Multi-domain] Cd Length: 328 Bit Score: 56.01 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 12 GKVILHGEHAVVHGKVALAAALNLRT---FLLLRPQSNGKVSVNLPNIG--IKQVWDvgmlqrldtsflEQGDVSVPTLE 86
Cdd:PTZ00298 17 GKVILFGEHFVVYGAEAIVAGIDEYTecrLELTKGVPGLQVVDQRPAVPgyIVEKRE------------EQRKAHQLVLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 87 QLEKlkkmgDLPRDragnegmallaflylylaicrkqrtlpSLDMVVWSELPPGAGLGSSAAYSVCLAAALltaCEEVSN 166
Cdd:PTZ00298 85 HLNI-----DTSVD---------------------------GLKMHLGGPLVPSSGIGASASDVVSLSRAL---SELYQL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 167 PLKDgvsvsrwpeedlKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQ----GTMSSLKSLPSLQILLTNTKVPRS 242
Cdd:PTZ00298 130 NLTE------------EEVNLSAFVGEGGYHGTPSGADNTAATYGGLISYRRvngkSVFKRIAFQQPLYLVVCSTGITAS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 243 TKALVAAVRSRLTKFPEIVAPLLTSIDAIslecervLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVT 322
Cdd:PTZ00298 198 TTKVVGDVRKLKENQPTWFNRLLENYNAC-------VSEAKEALQKGNLFRVGELMNANHDLCQKLTVSCRELDSIVQTC 270
|
330
....*....|.
gi 568936904 323 AAHG-LHSKLT 332
Cdd:PTZ00298 271 RTYGaLGAKMS 281
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
119-170 |
3.49e-04 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 42.06 E-value: 3.49e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568936904 119 ICRKQRTLPSLDMVVWSELPPGAGLGSSAAysvCLAAALLTACEEVSNPLKD 170
Cdd:PRK01212 72 FLEKLGKPPGLRIELEKNIPLGRGLGSSAA---SIVAGLVAANELAGLPLSK 120
|
|
| COG2605 |
COG2605 |
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ... |
127-279 |
1.28e-03 |
|
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];
Pssm-ID: 442017 [Multi-domain] Cd Length: 328 Bit Score: 40.55 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 127 PSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEvsnplkdgvsvsRWPEEDLKSInkwAFEGERVIHGNPSGV-DN 205
Cdd:COG2605 85 DGLEITTDSDAPAGSGLGSSSALTVALLNALHALLGL------------PLSPYDLARL---AYEIERNDLGEPGGKqDQ 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936904 206 AVSTWGG--ALRFQQGTMSSLKSLP-------SLQ--ILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLE 274
Cdd:COG2605 150 YAAAFGGfnFIEFGPDGRVIVNPLRispeilnELEsnLLLFYTGITRESSDILKEQVKNVEDGDEATLEALHEMKELALE 229
|
....*
gi 568936904 275 CERVL 279
Cdd:COG2605 230 MKEAL 234
|
|
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
121-170 |
1.31e-03 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 40.47 E-value: 1.31e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568936904 121 RKQRTLPSLDMVVWSELPPGAGLGSSAAysvCLAAALLTACEEVSNPLKD 170
Cdd:COG0083 71 KLGKEPPGLRIEIEKGIPLGRGLGSSAA---AIVAGLVAANALLGLPLSK 117
|
|
| GalKase_gal_bdg |
pfam10509 |
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ... |
3-43 |
2.93e-03 |
|
Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.
Pssm-ID: 463125 [Multi-domain] Cd Length: 50 Bit Score: 35.51 E-value: 2.93e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 568936904 3 SEALLVSAPGKVILHGEHAV-VHGKVaLAAALNLRTFLLLRP 43
Cdd:pfam10509 10 EPVGVASAPGRVNLIGEHTDyNGGFV-LPAAINLDTYVAVSP 50
|
|
| |
