|
Name |
Accession |
Description |
Interval |
E-value |
| CNH |
smart00036 |
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2; |
1221-1517 |
1.30e-78 |
|
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
Pssm-ID: 214481 Cd Length: 302 Bit Score: 262.29 E-value: 1.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1221 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1293
Cdd:smart00036 2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1294 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1367
Cdd:smart00036 82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1368 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1443
Cdd:smart00036 161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936834 1444 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1517
Cdd:smart00036 233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
|
|
| CNH |
pfam00780 |
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ... |
1229-1481 |
3.78e-68 |
|
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Pssm-ID: 459938 Cd Length: 261 Bit Score: 230.60 E-value: 3.78e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1229 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1307
Cdd:pfam00780 1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1308 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1385
Cdd:pfam00780 77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1386 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1465
Cdd:pfam00780 157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226
|
250
....*....|....*.
gi 568936834 1466 YLFVTHFNSLEVIEIQ 1481
Cdd:pfam00780 227 YLLAFHDNFIEIRDVE 242
|
|
| CRIK |
cd20814 |
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ... |
972-1027 |
3.93e-38 |
|
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410364 Cd Length: 56 Bit Score: 136.61 E-value: 3.93e-38
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 972 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1027
Cdd:cd20814 1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
64-807 |
1.12e-24 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 112.84 E-value: 1.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 64 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 129
Cdd:TIGR02168 197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 130 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 209
Cdd:TIGR02168 277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 210 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 281
Cdd:TIGR02168 342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 282 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 353
Cdd:TIGR02168 422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 354 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKL 430
Cdd:TIGR02168 502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLD 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 431 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------ 480
Cdd:TIGR02168 580 SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpgg 659
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 481 ------TELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLE 554
Cdd:TIGR02168 660 vitggsAKTNSSILERRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELS 725
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 555 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTM 634
Cdd:TIGR02168 726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 635 LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEI 713
Cdd:TIGR02168 805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNER 882
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 714 LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFR 785
Cdd:TIGR02168 883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENK 962
|
810 820
....*....|....*....|..
gi 568936834 786 LTQGLQEALDRADLLKTERSDL 807
Cdd:TIGR02168 963 IEDDEEEARRRLKRLENKIKEL 984
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
257-826 |
5.09e-23 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 106.94 E-value: 5.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 257 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 328
Cdd:COG1196 172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 329 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 408
Cdd:COG1196 248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 409 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 478
Cdd:COG1196 321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 479 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 558
Cdd:COG1196 401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 559 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 622
Cdd:COG1196 481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 623 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 698
Cdd:COG1196 561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 699 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 778
Cdd:COG1196 641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 568936834 779 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 826
Cdd:COG1196 721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
194-808 |
6.35e-23 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 106.56 E-value: 6.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 194 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtme 273
Cdd:COG1196 209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE--- 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 274 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRH 353
Cdd:COG1196 281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE----LEEELEELEEELEEAEEELEEA 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 354 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAGKLEAQ 433
Cdd:COG1196 357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL---EELEEALAEL 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 434 NRKLEEQLEKISHQDhSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKt 513
Cdd:COG1196 434 EEEEEEEEEALEEAA-EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK- 511
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 514 eLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQL 591
Cdd:COG1196 512 -AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRAR 585
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 592 RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEAlkttctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFE 671
Cdd:COG1196 586 AALAAALARGAIGAAVDLVASDLREADARYYVLGDT-------LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 672 cRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSL 751
Cdd:COG1196 659 -GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREEL 737
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936834 752 QQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-------ALD-------RADLLKTERSDLE 808
Cdd:COG1196 738 LEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
195-907 |
9.25e-22 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 103.21 E-value: 9.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 195 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLHNREDSSEG--IKKKLVEAEERRHSLENKVKRletM 272
Cdd:TIGR02168 176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 273 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 349
Cdd:TIGR02168 252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 350 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 429
Cdd:TIGR02168 332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 430 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 509
Cdd:TIGR02168 398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 510 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 589
Cdd:TIGR02168 472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 590 QLRSEvdhLRREITE-----REMQLTSQKQAQLSAPDLQTmEALKTTCTMLEEQVL---DLEALNDELLEKERQWEAWRS 661
Cdd:TIGR02168 530 SVDEG---YEAAIEAalggrLQAVVVENLNAAKKAIAFLK-QNELGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAK 605
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 662 VLGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQ 723
Cdd:TIGR02168 606 DLVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEEL 682
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 724 KLKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE 803
Cdd:TIGR02168 683 EEKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKE 755
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 804 RSDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKA 883
Cdd:TIGR02168 756 LTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831
|
730 740
....*....|....*....|....
gi 568936834 884 RCAELEEALQKTRIELRSAREEAA 907
Cdd:TIGR02168 832 RIAATERRLEDLEEQIEELSEDIE 855
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
185-763 |
1.58e-18 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 92.01 E-value: 1.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL----HNREDSSEGIKKKLVEAEERRH 260
Cdd:TIGR04523 125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLekekLNIQKNIDKIKNKLLKLELLLS 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 261 SLENKVKR-------LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE---KIK 330
Cdd:TIGR04523 205 NLKKKIQKnkslesqISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQnnkKIK 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 331 VLDNQIKKDLADKESLENmmQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftqrnmkaqE 410
Cdd:TIGR04523 285 ELEKQLNQLKSEISDLNN--QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQL---------------------N 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 411 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLE---HEEQKLELKRQLTELQLSL 487
Cdd:TIGR04523 342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKiqnQEKLNQQKDEQIKKLQQEK 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 488 QERESQLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI-TDLEEQLNQLTEDNAE 566
Cdd:TIGR04523 422 ELLEKEIERLKETIIKNNSEIKDLT----NQDSVKELIIKNLDNTRESLETQLKVLSRSINKIkQNLEQKQKELKSKEKE 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 567 ---LNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQaqlsapDLQTMEalkttctmleeqvldlE 643
Cdd:TIGR04523 498 lkkLNEEKKELEEKVKD---LTKKISSLKEKIEKLESEKKEKESKISDLED------ELNKDD----------------F 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 644 ALNDELLEKERqweawrsvlgDEKSQfecrvrELQRMLDTEKQSRARADQritesrqvVELAVKEHKAEILALQQALKEQ 723
Cdd:TIGR04523 553 ELKKENLEKEI----------DEKNK------EIEELKQTQKSLKKKQEE--------KQELIDQKEKEKKDLIKEIEEK 608
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 568936834 724 KLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQ 763
Cdd:TIGR04523 609 EKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKlKQEVKQ 649
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1-757 |
1.77e-17 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 88.96 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 80
Cdd:TIGR02168 251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 81 KLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGT 158
Cdd:TIGR02168 331 KLDELAEElaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLE 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 159 ALDDLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 238
Cdd:TIGR02168 411 RLEDRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAA 480
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 239 HNREDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ-------------------------QM 293
Cdd:TIGR02168 481 ERELAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalggrlqavvvenlNA 557
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 294 ADKILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM--------------Q 351
Cdd:TIGR02168 558 AKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvvddldnaleL 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 352 RHEEEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMISELRQQKFYLETQ 426
Cdd:TIGR02168 638 AKKLRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIAELEKALAELRKE 706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 427 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAA 503
Cdd:TIGR02168 707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEE 786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 504 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSK 576
Cdd:TIGR02168 787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEE 866
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 577 QLDEASGANDEIVQLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLE-KERQ 655
Cdd:TIGR02168 867 LIEELESELEALLNERASLEEALALL-RSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNlQERL 945
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 656 WEAWRSVLGDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAVKEHKaEILALQQALKEQKlkaESLSDKLN 735
Cdd:TIGR02168 946 SEEYSLTLEEAEALENKIEDDEEEA----RRRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTAQK---EDLTEAKE 1017
|
810 820
....*....|....*....|..
gi 568936834 736 DLEKkhAMLEMNARSLQQKLET 757
Cdd:TIGR02168 1018 TLEE--AIEEIDREARERFKDT 1037
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
49-602 |
3.42e-17 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 88.07 E-value: 3.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 49 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 128
Cdd:COG1196 204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 129 AEEFKRKANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEvgeyskLEKINAEQQLKIQELQEKLE 208
Cdd:COG1196 276 LEELELELEEAQAEEYELLAELAR-----LEQDIARLEERRRELEERLEELEEE------LAELEEELEELEEELEELEE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 209 KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETME----RRENRLKDDIQ 284
Cdd:COG1196 345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEeallERLERLEEELE 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 285 TKSEQIQQMADKILELEEKHREAQ----------VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE 354
Cdd:COG1196 425 ELEEALAELEEEEEEEEEALEEAAeeeaeleeeeEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 355 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK-----FYLETQAGK 429
Cdd:COG1196 505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagratFLPLDKIRA 584
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 430 LEAQNRKLEEQLEK-----------------------------ISHQDHSDKSRLLELETRLREVSLEHEEQkleLKRQL 480
Cdd:COG1196 585 RAALAAALARGAIGaavdlvasdlreadaryyvlgdtllgrtlVAARLEAALRRAVTLAGRLREVTLEGEGG---SAGGS 661
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 481 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 560
Cdd:COG1196 662 LTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 568936834 561 TEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREI 602
Cdd:COG1196 742 LEEEEL-------LEEEALEELPEPPDLEELERELERLEREI 776
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
187-739 |
3.45e-17 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 88.07 E-value: 3.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 187 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 266
Cdd:COG1196 267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 267 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESL 346
Cdd:COG1196 347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 347 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAnsslftQRNMKAQEEMISELRQQKFYLETQ 426
Cdd:COG1196 427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE------AALAELLEELAEAAARLLLLLEAE 500
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 427 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEqkLELKRQLTELQLSLQERESQLTALQAARAA--- 503
Cdd:COG1196 501 ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATflp 578
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 504 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 583
Cdd:COG1196 579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 584 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSApdlqtmealkttctmLEEQVLDLEALNDELLEKERQWEAWRSVL 663
Cdd:COG1196 659 GGSLTGGSRRELLAALLEAEAELEELAERLAEEELE---------------LEEALLAEEEEERELAEAEEERLEEELEE 723
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 664 GDEKSQFE-CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI--------LALQQaLKEQKLKAESLSD 732
Cdd:COG1196 724 EALEEQLEaEREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgpvnlLAIEE-YEELEERYDFLSE 802
|
....*..
gi 568936834 733 KLNDLEK 739
Cdd:COG1196 803 QREDLEE 809
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2-510 |
5.86e-17 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 87.89 E-value: 5.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQAR-----MEVSQEDDKALQLLHDIR 76
Cdd:PTZ00121 1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKkadeaKKKAEEAKKKADAAKKKA 1338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 77 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV---SARRRSDLYESELRESRlAAEEFKRKANECQHK---LMKVVSHP 150
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKkkeEAKKKADAAKKKAEEKK-KADEAKKKAEEDKKKadeLKKAAAAK 1417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 151 PRGDSGGTALDDLHK---MQGHAGLTSAKDQGKPEVGEYSKLE--KINAEQQLKIQELQEKLEKAVKASteatELLQNIR 225
Cdd:PTZ00121 1418 KKADEAKKKAEEKKKadeAKKKAEEAKKADEAKKKAEEAKKAEeaKKKAEEAKKADEAKKKAEEAKKAD----EAKKKAE 1493
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 226 QAKERAErELEKLHNREDSSEGIKK--------KLVEAEERRHSLENK----------VKRLETMERRENRLKDDIQTKS 287
Cdd:PTZ00121 1494 EAKKKAD-EAKKAAEAKKKADEAKKaeeakkadEAKKAEEAKKADEAKkaeekkkadeLKKAEELKKAEEKKKAEEAKKA 1572
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 288 EQIQQMADKILE----LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKI 363
Cdd:PTZ00121 1573 EEDKNMALRKAEeakkAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEEL 1652
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 364 LSEQKaminamDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLEtQAGKLEAQNRKLEEQLEK 443
Cdd:PTZ00121 1653 KKAEE------ENKIKAAEEAKKA--EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK 1723
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 444 ishQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 510
Cdd:PTZ00121 1724 ---AEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
185-654 |
6.07e-17 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 87.04 E-value: 6.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLEN 264
Cdd:PRK03918 229 EVKELEELKEE----IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEE 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 265 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDN--QIKKDLAD 342
Cdd:PRK03918 305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-LEERHELYEEAKAKKEEleRLKKRLTG 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 343 K--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISE 415
Cdd:PRK03918 384 LtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKR 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 416 LRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLS 486
Cdd:PRK03918 464 IEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKS 543
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 487 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEE 555
Cdd:PRK03918 544 LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEK 619
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 556 QLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTML 635
Cdd:PRK03918 620 ELKKLEEE----------LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRR 689
|
490
....*....|....*....
gi 568936834 636 EEQVLDLEALNDELLEKER 654
Cdd:PRK03918 690 EEIKKTLEKLKEELEEREK 708
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
2-774 |
6.48e-17 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 87.33 E-value: 6.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 79
Cdd:pfam02463 264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 80 RKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShpprgdsggtA 159
Cdd:pfam02463 344 LKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ----------L 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 160 LDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKavKASTEATELLQNIRQAKERAERELEKLH 239
Cdd:pfam02463 410 LLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEK--QELKLLKDELELKKSEDLLKETQLVKLQ 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 240 -NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLkDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHL 318
Cdd:pfam02463 484 eQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI-ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEE 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 319 KQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS 398
Cdd:pfam02463 563 RQKLVRALTELPLGARKLRL-LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESA 641
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 399 SLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 478
Cdd:pfam02463 642 KAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEE 721
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 479 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 558
Cdd:pfam02463 722 LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEE 801
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 559 QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhlrreitEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQ 638
Cdd:pfam02463 802 ELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEE---------LALELKEEQKLEKLAEEELERLEEEITKEELLQEL 872
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 639 VLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRITESRQVVELAVKEHKAEILALQ 717
Cdd:pfam02463 873 LLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILLKYEEEPEELLLEEADEKEKEE 952
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 718 QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 774
Cdd:pfam02463 953 NNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
14-911 |
2.10e-16 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 85.79 E-value: 2.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 14 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 93
Cdd:pfam02463 143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 94 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEfKRKANECQHKLMKvvshpprgdsggtalddlhkmqghAGLT 173
Cdd:pfam02463 211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD-EQEEIESSKQEIE------------------------KEEE 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 174 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 253
Cdd:pfam02463 266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELK 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 254 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 333
Cdd:pfam02463 346 ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEK 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 334 NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMI 413
Cdd:pfam02463 426 KEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKA 505
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 414 SELrqqkfyletqAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLehEEQKLELKRQLTELQLSLQERESQ 493
Cdd:pfam02463 506 RSG----------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV--IVEVSATADEVEERQKLVRALTEL 573
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 494 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 573
Cdd:pfam02463 574 PLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVS 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 574 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKE 653
Cdd:pfam02463 654 LEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL--AKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQ 731
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 654 RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvvelAVKEHKAEILALQQALKEQKLKAESLSDK 733
Cdd:pfam02463 732 DKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKE-------LAEEREKTEKLKVEEEKEEKLKAQEEELR 804
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 734 LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLEN 813
Cdd:pfam02463 805 ALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEEL 879
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 814 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 893
Cdd:pfam02463 880 EEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEE 959
|
890
....*....|....*...
gi 568936834 894 KTRIELRSAREEAAHRKA 911
Cdd:pfam02463 960 ERNKRLLLAKEELGKVNL 977
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
185-808 |
6.59e-16 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 83.86 E-value: 6.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEQQlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEErrhsLEN 264
Cdd:TIGR00618 201 LRSQLLTLCTPCM--PDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE----LRA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 265 KVKRLETMERRENRlkddiQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVldnqiKKDLADKE 344
Cdd:TIGR00618 275 QEAVLEETQERINR-----ARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-----QSSIEEQR 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 345 SLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 421
Cdd:TIGR00618 345 RLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQG 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 422 YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLRevSLEHEEQKLELKRQLTelqlslqERESQLTALQAAR 501
Cdd:TIGR00618 425 QLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ--SLKEREQQLQTKEQIH-------LQETRKKAVVLAR 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 502 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------NFYLS 575
Cdd:TIGR00618 496 LLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQmqeiqqSFSIL 575
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 576 KQLDEASGANDEIV-QLRSEVDHLRREITEREMQLTSQKQAQLSA--PDLQTMEALKTTCTMLEEQVLDLEALNDELLE- 651
Cdd:TIGR00618 576 TQCDNRSKEDIPNLqNITVRLQDLTEKLSEAEDMLACEQHALLRKlqPEQDLQDVRLHLQQCSQELALKLTALHALQLTl 655
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 652 -KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 730
Cdd:TIGR00618 656 tQERVREHALSIRVLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 731 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 808
Cdd:TIGR00618 731 GSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2-767 |
9.43e-16 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 83.57 E-value: 9.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 81
Cdd:TIGR02168 266 EEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEK 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 82 LQEIKEqeyqaQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQHKLMKVVSHPPRGDSGGTALD 161
Cdd:TIGR02168 346 LEELKE-----ELESLEAELEELEAELEELESRLEELEEQL-------ETLRSKVAQLELQIASLNNEIERLEARLERLE 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 162 DLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR 241
Cdd:TIGR02168 414 DRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 242 EDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ-------------------------QMADK 296
Cdd:TIGR02168 484 LAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalggrlqavvvenlNAAKK 560
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 297 ILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM--------------QRHE 354
Cdd:TIGR02168 561 AIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvvddldnaleLAKK 640
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 355 EEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMISELRQQKFYLETQAGK 429
Cdd:TIGR02168 641 LRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIAELEKALAELRKELEE 709
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 430 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALES 506
Cdd:TIGR02168 710 LEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEA 789
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 507 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfylskqldEASGAND 586
Cdd:TIGR02168 790 QIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE-----------------QIEELSE 852
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 587 EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlqtmEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvLGDE 666
Cdd:TIGR02168 853 DIESLAAEIEELEELIEELESELEALLNERASLE-----EALALLRSELEELSEELRELESKRSELRRELEE----LREK 923
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 667 KSQFECRVRELQRMLDtEKQSRARADQRITEsrQVVELAVKEHKAEILALQQALK--EQKLKA------------ESLSD 732
Cdd:TIGR02168 924 LAQLELRLEGLEVRID-NLQERLSEEYSLTL--EEAEALENKIEDDEEEARRRLKrlENKIKElgpvnlaaieeyEELKE 1000
|
810 820 830
....*....|....*....|....*....|....*.
gi 568936834 733 KLNDLEKKHAMLEMNARSLQQKL-ETERELKQRLLE 767
Cdd:TIGR02168 1001 RYDFLTAQKEDLTEAKETLEEAIeEIDREARERFKD 1036
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
256-968 |
2.22e-15 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 82.09 E-value: 2.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 256 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSEQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 328
Cdd:pfam15921 81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 329 IKVLDNQIKKDLADK-ESLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 381
Cdd:pfam15921 157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 382 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS--- 453
Cdd:pfam15921 237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 454 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 532
Cdd:pfam15921 317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 533 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 594
Cdd:pfam15921 397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 595 VDHLRR---EITEREMQLTS-------------QKQAQLSAPD-------------LQTMEALKTTCTMLEEQVLDLEAL 645
Cdd:pfam15921 474 KEMLRKvveELTAKKMTLESsertvsdltaslqEKERAIEATNaeitklrsrvdlkLQELQHLKNEGDHLRNVQTECEAL 553
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 646 NDELLEKERQWEAWRSVLGD-----------------EKSQFECRVRELQRMLDTEKQSRARADQRITE-SRQVVELAVK 707
Cdd:pfam15921 554 KLQMAEKDKVIEILRQQIENmtqlvgqhgrtagamqvEKAQLEKEINDRRLELQEFKILKDKKDAKIRElEARVSDLELE 633
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 708 EHK-----AEILALQQALKEQKLK----AESLSDKLNDLEKKHAMLEMNARSLQQKLE-TERELKQRLLEEQAKLQQ--- 774
Cdd:pfam15921 634 KVKlvnagSERLRAVKDIKQERDQllneVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtTTNKLKMQLKSAQSELEQtrn 713
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 775 ---QMDLQKNHIFRLTQGLQEALD----RADLLKTERSDLEYQLENI---QVLYSHEKVKMegtiSQQTKLIDFLQAKMD 844
Cdd:pfam15921 714 tlkSMEGSDGHAMKVAMGMQKQITakrgQIDALQSKIQFLEEAMTNAnkeKHFLKEEKNKL----SQELSTVATEKNKMA 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 845 QPAKKKKGLFSRRKEDPAlptqvplqynELKLALEKEKARCAELEEALQktRIELRSAREEAAHR---KATDHP-HPSTP 920
Cdd:pfam15921 790 GELEVLRSQERRLKEKVA----------NMEVALDKASLQFAECQDIIQ--RQEQESVRLKLQHTldvKELQGPgYTSNS 857
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 568936834 921 ATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 968
Cdd:pfam15921 858 SMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
25-859 |
4.68e-15 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 81.34 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 25 ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIR-EQSRKLQEIKEQEYQAQVEEMRLMMNq 103
Cdd:PTZ00121 1132 EARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKaEEVRKAEELRKAEDARKAEAARKAEE- 1210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 104 lEEDLVSARRrsdlYESELR-ESRLAAEEFKRKANECQHklmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE 182
Cdd:PTZ00121 1211 -ERKAEEARK----AEDAKKaEAVKKAEEAKKDAEEAKK------AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARK 1279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 183 VGEYSKLEKINAEQQLKIQELQEKLEKAVKASTE---ATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR 259
Cdd:PTZ00121 1280 ADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEakkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEA 1359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 260 HSLENKVKRLETMERRENRLKDDIQTKSEQIQqmadKILELEEKHREAQVSAQhlevHLKQKEqhyEEKIKVldNQIKKD 339
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK----KADEAKKKAEEDKKKAD----ELKKAA---AAKKKA--DEAKKK 1426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 340 LADKESLENMMQRHEE--EAHEKGKILSEQKamiNAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQE--EMISE 415
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEakKADEAKKKAEEAK---KAEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEakKKADE 1501
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 416 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTElqlslQERESQLT 495
Cdd:PTZ00121 1502 AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE-----AKKAEEDK 1576
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 496 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR-KFDALRNSctviTDLEEQLNQLTEDNAELNNQNFYL 574
Cdd:PTZ00121 1577 NMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKiKAEELKKA----EEEKKKVEQLKKKEAEEKKKAEEL 1652
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 575 SKQlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlqtmealkttctmlEEQVLDLEALNDELLEKER 654
Cdd:PTZ00121 1653 KKA-EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKE---------------AEEAKKAEELKKKEAEEKK 1716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 655 QWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSD 732
Cdd:PTZ00121 1717 KAEELKK----AEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKaeEIRKEKEAVIEEELDEEDEKR 1792
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 733 KLnDLEKKHAMLEMNARSLQQ------------KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 800
Cdd:PTZ00121 1793 RM-EVDKKIKDIFDNFANIIEggkegnlvindsKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFN 1871
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 801 KtERSDLEYQLENIQVLYSHEKVK---MEGTISQQT---KLIDFLQAKMDQPAKKKKGLFSRRKE 859
Cdd:PTZ00121 1872 K-EKDLKEDDEEEIEEADEIEKIDkddIEREIPNNNmagKNNDIIDDKLDKDEYIKRDAEETREE 1935
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
4-808 |
5.82e-15 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 80.96 E-value: 5.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 4 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLlhdiREQSRKLQ 83
Cdd:PTZ00121 1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKK----AEDARKAE 1131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 84 EIKEQEYQAQVEEMRlmmnQLEED--LVSARRRSDLYESElrESRLAAE----EFKRKANECQHKlmkvvshpprgdsgg 157
Cdd:PTZ00121 1132 EARKAEDARKAEEAR----KAEDAkrVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRKA--------------- 1190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 158 talDDLHKmqghagltsAKDQGKPEvgEYSKLEKINAEQQLKIQELQEKLEkAVKASTEATELLQNIRQA-KERAERELE 236
Cdd:PTZ00121 1191 ---EELRK---------AEDARKAE--AARKAEEERKAEEARKAEDAKKAE-AVKKAEEAKKDAEEAKKAeEERNNEEIR 1255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 237 KLHNREDSSEGIKKKLVEAEERRHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMAD---KILELEEKHREAQVSAQH 313
Cdd:PTZ00121 1256 KFEEARMAHFARRQAAIKAEEARKADE--LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADA 1333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 314 LEVHLKQKEQHYEEKiKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 393
Cdd:PTZ00121 1334 AKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKK 1412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 394 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA---QNRKLEEQLEKISHQDHSDKSRLLELETRLREvslEHE 470
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD---EAK 1489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 471 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELeettaeaeeeiQALTAHRDEIQRKFDALRNSCTVI 550
Cdd:PTZ00121 1490 KKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAK-----------KADEAKKAEEKKKADELKKAEELK 1558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 551 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhlrREITEREMQLTSQKQAQLSAPDLQTMEALKT 630
Cdd:PTZ00121 1559 KAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYE-----EEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 631 TCTMLEEQVLDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHK 710
Cdd:PTZ00121 1634 KVEQLKKKEAE-EKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 711 AEILALQQALKEQ---KLKAESLSDKLNDLEKK---------------HAMLEMNARSLQQKLETERELKQRLLEEQAKL 772
Cdd:PTZ00121 1713 EEKKKAEELKKAEeenKIKAEEAKKEAEEDKKKaeeakkdeeekkkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR 1792
|
810 820 830
....*....|....*....|....*....|....*.
gi 568936834 773 QQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 808
Cdd:PTZ00121 1793 RMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEME 1828
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
194-893 |
6.14e-15 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 80.88 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 194 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgiKKKLVEAEERRHSLENKVKRLETME 273
Cdd:TIGR02169 166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLK--EKREYEGYELLKEKEALERQKEAIE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 274 RRENRLKDDIQTKSEQIQQMADKILELEEKHRE-------------AQVSAQHLEVH-----LKQKEQHYEEKIKVLDNQ 335
Cdd:TIGR02169 244 RQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkikdlgeeeqLRVKEKIGELEaeiasLERSIAEKERELEDAEER 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 336 IKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISE 415
Cdd:TIGR02169 324 LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE-------TRDELKDYREKLEK 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 416 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERES 492
Cdd:TIGR02169 397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQlaaDLSKYEQELYDLKE 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 493 QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR---------------------NSCTVIT 551
Cdd:TIGR02169 477 EYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAqlgsvgeryataievaagnrlNNVVVED 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 552 DL--EEQLNQLTEDNA------ELNN-QNFYLSKQLDEASGANDEIVQL--------------------RSEVDHLRR-- 600
Cdd:TIGR02169 557 DAvaKEAIELLKRRKAgratflPLNKmRDERRDLSILSEDGVIGFAVDLvefdpkyepafkyvfgdtlvVEDIEAARRlm 636
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 601 ----------EITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF 670
Cdd:TIGR02169 637 gkyrmvtlegELFEKSGAMTGGSRAPRGGILFSR--SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDA 714
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 671 ECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMn 747
Cdd:TIGR02169 715 SRKIGEIEKEIEQLEQEEEKLKERLEELEedlSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI- 793
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 748 aRSLQQKLETERELKQRLLEEQAKLQQqmDLQKNHIFR--LTQGLQEALDRADLLKTERSDLEYQLENIQVlyshEKVKM 825
Cdd:TIGR02169 794 -PEIQAELSKLEEEVSRIEARLREIEQ--KLNRLTLEKeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNG----KKEEL 866
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936834 826 EGTISQqtklidfLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 893
Cdd:TIGR02169 867 EEELEE-------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLE 927
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
225-826 |
9.80e-15 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 80.11 E-value: 9.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 225 RQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH 304
Cdd:PRK03918 144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 305 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 384
Cdd:PRK03918 224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 385 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLRE 464
Cdd:PRK03918 282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 465 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 539
Cdd:PRK03918 350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 540 FDALRNS------CTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM--QLTS 611
Cdd:PRK03918 428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELaeQLKE 507
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 612 QKQaQLSAPDLQTMEALKTTCTMLEEQVLDLEA----LNDELLEKErqweawrsvlgdeksQFECRVRELQRMLDTEKQS 687
Cdd:PRK03918 508 LEE-KLKKYNLEELEKKAEEYEKLKEKLIKLKGeiksLKKELEKLE---------------ELKKKLAELEKKLDELEEE 571
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 688 RARADQRITE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE 760
Cdd:PRK03918 572 LAELLKELEElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 761 LKQRLLEEQ-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 826
Cdd:PRK03918 652 LEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2-601 |
1.48e-14 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 79.60 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 81
Cdd:COG1196 252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 82 LQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKlmkvvshpprgdsggtA 159
Cdd:COG1196 332 LEELEEELEELEEELEEAEeeLEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA----------------A 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 160 LDDLHKMQGHAGLTSAKDQgkpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH 239
Cdd:COG1196 396 AELAAQLEELEEAEEALLE---------RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 240 NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQ---MADKILELEEKHREAQVSAQHLEV 316
Cdd:COG1196 467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVAVLIGVEAAYEAALEAALAA 546
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 317 HLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANK 393
Cdd:COG1196 547 ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRT 626
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 394 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEQK 473
Cdd:COG1196 627 LVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAE 702
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 474 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDL 553
Cdd:COG1196 703 EEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE----------LERL 772
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 554 EEQLNQL-------TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 601
Cdd:COG1196 773 EREIEALgpvnllaIEEYEELEERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
25-762 |
2.13e-14 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 78.96 E-value: 2.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 25 ELKASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY----------QAQV 94
Cdd:TIGR02169 231 EKEALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQlrvkekigelEAEI 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 95 EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHpprgdsggtalddlhkmqghagLTS 174
Cdd:TIGR02169 304 ASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE----------------------YAE 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 175 AKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVE 254
Cdd:TIGR02169 362 LKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKR---EINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINE 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 255 AEERRhslENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYEEKIKV 331
Cdd:TIGR02169 439 LEEEK---EDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEErvrGGRAVEEV 515
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 332 LDNQIKK-------------------DLADKESLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE---- 382
Cdd:TIGR02169 516 LKASIQGvhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSilse 595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 383 ----QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKSRLL 456
Cdd:TIGR02169 596 dgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRGG 665
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 457 ELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDE 535
Cdd:TIGR02169 666 ILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEED 745
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 536 IQRKFDALRNSCTVITDLEEQLNQLTED----NAELNNQNFYLSKQL-----DEASGANDEIVQLRSEVDHLRREITER- 605
Cdd:TIGR02169 746 LSSLEQEIENVKSELKELEARIEELEEDlhklEEALNDLEARLSHSRipeiqAELSKLEEEVSRIEARLREIEQKLNRLt 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 606 -EMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKE---RQWEAWRSVLGDEKSQFECRVRELQRML 681
Cdd:TIGR02169 826 lEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLKKERDELEAQLRELERKI 905
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 682 DTEKQSRARADQRI---TESRQVVELAVKEH--------------------KAEILALQ---QALKEQKLKA----ESLS 731
Cdd:TIGR02169 906 EELEAQIEKKRKRLselKAKLEALEEELSEIedpkgedeeipeeelsledvQAELQRVEeeiRALEPVNMLAiqeyEEVL 985
|
810 820 830
....*....|....*....|....*....|.
gi 568936834 732 DKLNDLEKKHAMLEMNARSLQQKLETERELK 762
Cdd:TIGR02169 986 KRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
11-606 |
1.21e-13 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 76.26 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 11 RVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqaRMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 90
Cdd:PRK03918 187 RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK--ELEELKEEIEELEKELESLEGSKRKLEEKIREL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 91 QAQVEEMRLMMNQLEEdlvSARRRSDLYESELRESRLaaEEFKRKANECQHKLMKvvshpprgdsggtalddlhkmqgha 170
Cdd:PRK03918 265 EERIEELKKEIEELEE---KVKELKELKEKAEEYIKL--SEFYEEYLDELREIEK------------------------- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 171 gltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAErELEKLHNREDSSEGIKK 250
Cdd:PRK03918 315 --------------RLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKK 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 251 KL--VEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEvhlkqkEQHYEEK 328
Cdd:PRK03918 380 RLtgLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKEL 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 329 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnm 406
Cdd:PRK03918 454 LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE---- 528
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 407 KAQEEMIsELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdHSDKSRLLELETRLREVSLEHEEqklELKRQLTELQ-- 484
Cdd:PRK03918 529 KLKEKLI-KLKGEIKSLKKELEKLEELKKKLAELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpf 600
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 485 ----LSLQERESQLTALQAARAALESQLRQAktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQL 560
Cdd:PRK03918 601 yneyLELKDAEKELEREEKELKKLEEELDKA----FEELAETEKRLEELRKELEELEKKYS------------EEEYEEL 664
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 568936834 561 TEDNAELNNQNFYLSKQLDEASGANDEIvqlRSEVDHLRREITERE 606
Cdd:PRK03918 665 REEYLELSRELAGLRAELEELEKRREEI---KKTLEKLKEELEERE 707
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
171-681 |
7.91e-13 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 73.54 E-value: 7.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 171 GLTSAKDQGKPEVGEYSKlEKINAEQQLkiQELQEKLEKAVKASTEATELLQNI---RQAKERAERELEKLHNR------ 241
Cdd:PRK02224 210 GLESELAELDEEIERYEE-QREQARETR--DEADEVLEEHEERREELETLEAEIedlRETIAETEREREELAEEvrdlre 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 242 --EDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKD-------DIQTKSEQIQQMADKILELEEKHREAQVSAQ 312
Cdd:PRK02224 287 rlEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDrleecrvAAQAHNEEAESLREDADDLEERAEELREEAA 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 313 HLEVHLKQKE---QHYEEKIKVLDNQI---KKDLAD-KESLENMMQRHEEEAHEKgkilSEQKAMINAMDSKIRSLEQRI 385
Cdd:PRK02224 367 ELESELEEAReavEDRREEIEELEEEIeelRERFGDaPVDLGNAEDFLEELREER----DELREREAELEATLRTARERV 442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 386 VELSEAnkLAANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhsdksRLLELETRLR 463
Cdd:PRK02224 443 EEAEAL--LEAGKCPECGQPVEGSPhvETIEEDRERVEELEAELEDLEEEVEEVEERLERAE--------DLVEAEDRIE 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 464 EVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKF 540
Cdd:PRK02224 513 RL----EERREDLEELIAERRETIEEKRERAEELRERAAELEAeaeEKREAAAEAEEEAEEAREEVAELNSKLAELKERI 588
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 541 DALRNSCTV---ITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRRE---------------I 602
Cdd:PRK02224 589 ESLERIRTLlaaIADAEDEIERLREKREALAELNDERRERLAEKR---ERKRELEAEFDEARIEearedkeraeeyleqV 665
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 603 TEREMQLTSQKQAQLSA-----PDLQTMEALKTTCTMLEEQVLDLEALNDELlekerqwEAWRSVLGDEKSQFECR-VRE 676
Cdd:PRK02224 666 EEKLDELREERDDLQAEigaveNELEELEELRERREALENRVEALEALYDEA-------EELESMYGDLRAELRQRnVET 738
|
....*
gi 568936834 677 LQRML 681
Cdd:PRK02224 739 LERML 743
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
176-616 |
1.48e-12 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 72.49 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 176 KDQGKPEVGEYSKLEKinAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKkklvE 254
Cdd:COG4717 60 KPQGRKPELNLKELKE--LEEELKeAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ----E 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 255 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSEQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 326
Cdd:COG4717 134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 327 EKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 404
Cdd:COG4717 213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 405 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 479
Cdd:COG4717 293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 480 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 545
Cdd:COG4717 369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936834 546 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQAQ 616
Cdd:COG4717 440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLAL 499
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
195-777 |
2.05e-12 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 72.52 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 195 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSsegikkkLVEAEERRHSLENKVKRLET--- 271
Cdd:pfam01576 6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEMRARLAARKQELEEilh 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 272 -MERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 347
Cdd:pfam01576 79 eLESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQlekVTTEAKIKKLEEDILLLEDQNSKLSKERKLLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 348 ---NMMQRHEEEAHEKGKILSEQKAMINAMdskirsleqrIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 424
Cdd:pfam01576 159 eriSEFTSNLAEEEEKAKSLSKLKNKHEAM----------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 425 TQAGKLEAQNRKLEEQL-------EKISHQDHSDKSRLLELETRLREV--SLEHE--------EQKLELKRQLTELQLSL 487
Cdd:pfam01576 229 AQIAELRAQLAKKEEELqaalarlEEETAQKNNALKKIRELEAQISELqeDLESEraarnkaeKQRRDLGEELEALKTEL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 488 QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTahrdeiQRKFDALRnsctvitDLEEQLNQLTEDNAEL 567
Cdd:pfam01576 309 EDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMR------QKHTQALE-------ELTEQLEQAKRNKANL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 568 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIterEMQLtSQKQAQLSAPDLQTMEALKTTCTMLEEqvldLEALND 647
Cdd:pfam01576 376 EKAKQALESENAELQAELRTLQQAKQDSEHKRKKL---EGQL-QELQARLSESERQRAELAEKLSKLQSE----LESVSS 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 648 ELLEKERQweawRSVLGDEKSQFECRVRELQRMLDTEKQS--------RARADQRITESRQVVELAVKEHKAE--ILALQ 717
Cdd:pfam01576 448 LLNEAEGK----NIKLSKDVSSLESQLQDTQELLQEETRQklnlstrlRQLEDERNSLQEQLEEEEEAKRNVErqLSTLQ 523
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 718 QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 777
Cdd:pfam01576 524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELD 583
|
|
| C1_MgcRacGAP |
cd20821 |
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ... |
974-1028 |
2.07e-12 |
|
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410371 Cd Length: 55 Bit Score: 63.19 E-value: 2.07e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 974 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 1028
Cdd:cd20821 1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
1-624 |
3.30e-12 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 71.93 E-value: 3.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 80
Cdd:pfam02463 361 LEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIE 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 81 KLQEIKEQEYQAQVEEM-RLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKANECQHKLMKVVSHPPRGDSG 156
Cdd:pfam02463 441 LKQGKLTEEKEELEKQElKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKleeRSQKESKARSGLKVLLALIKDGV 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 157 GTALDDLHKMQGHAGLTSAKDQGKPEVGE-----------------YSKLEKINAEQQLKIQELQEKLEKAVKASTEATE 219
Cdd:pfam02463 521 GGRIISAHGRLGDLGVAVENYKVAISTAVivevsatadeveerqklVRALTELPLGARKLRLLIPKLKLPLKSIAVLEID 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 220 LLQNIRQAKERAERELEK----LHNREDSSEGIKKKLVEAE-----ERRHSLENKVKRLETMERRENRLKDDIQTKSEQI 290
Cdd:pfam02463 601 PILNLAQLDKATLEADEDdkraKVVEGILKDTELTKLKESAkakesGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQE 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 291 QQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAM 370
Cdd:pfam02463 681 LQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKE 760
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 371 INAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKISHQDH 449
Cdd:pfam02463 761 EKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEeAELLEEEQLLIEQEEKIKEEELEELAL 840
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 450 SDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAArAALESQLRQAKTELEETTAEAEEEIQAL 529
Cdd:pfam02463 841 ELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESK-EEKEKEEKKELEEESQKLNLLEEKENEI 919
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 530 TAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 609
Cdd:pfam02463 920 EERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKER 999
|
650
....*....|....*
gi 568936834 610 TSQKQAQLSAPDLQT 624
Cdd:pfam02463 1000 LEEEKKKLIRAIIEE 1014
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
325-910 |
3.77e-12 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 71.63 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 325 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 404
Cdd:PRK03918 160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 405 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 482
Cdd:PRK03918 232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 483 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 562
Cdd:PRK03918 305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 563 DNAELNNQNF-YLSKQLDEASGAN----DEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEE 637
Cdd:PRK03918 377 LKKRLTGLTPeKLEKELEELEKAKeeieEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 638 QVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEILA-- 715
Cdd:PRK03918 457 YTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLEELEkk 523
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 716 --LQQALKEQ--KLKAESLS-----DKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQknhifrl 786
Cdd:PRK03918 524 aeEYEKLKEKliKLKGEIKSlkkelEKLEELKKKLAELEKKLDELEEELA---ELLKELEELGFESVEELEER------- 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 787 TQGLQEALDRADLLKTERSDLEYQLENIQVLYShEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptq 866
Cdd:PRK03918 594 LKELEPFYNEYLELKDAEKELEREEKELKKLEE-ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELRE------ 666
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 568936834 867 vplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 910
Cdd:PRK03918 667 ---EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
22-623 |
5.96e-12 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 70.70 E-value: 5.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 22 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 99
Cdd:PRK01156 172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 100 MMNQLEEdlvsarrrSDLYESELR--ESRLAAEEFKR-KANECQHKLMKVVSHPprgdsggtALDDLHKMQGHAGLtsak 176
Cdd:PRK01156 244 LSSLEDM--------KNRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDP--------VYKNRNYINDYFKY---- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 177 dqgKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEA 255
Cdd:PRK01156 304 ---KNDIENKKQiLSNIDAE----INKYHAIIKKL--------SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSY 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 256 EErrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEK 328
Cdd:PRK01156 369 LK---SIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRN 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 329 IKVLDNQIK-----KDLADKESlENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLF 401
Cdd:PRK01156 446 MEMLNGQSVcpvcgTTLGEEKS-NHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKI 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 402 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR-LLELETrlrevsleHEEQKLELKRQL 480
Cdd:PRK01156 525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVIsLIDIET--------NRSRSNEIKKQL 596
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 481 TELQLSLQERESQLTALQAAraaLESQLRQAKTELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 560
Cdd:PRK01156 597 NDLESRLQEIEIGFPDDKSY---IDKSIREIENEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEI 672
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 561 TEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQ 623
Cdd:PRK01156 673 TSRINDIEDNLKKSRKALDDAkanrARLESTIEILRTRINELSDRINDINETLESMKKIKKAIGDLK 739
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
228-911 |
9.39e-12 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 70.48 E-value: 9.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 228 KERAERELEKLHNREDSSEGIKKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEE 302
Cdd:TIGR02169 172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 303 KHREAQVSAQHLEVHLKQKEQHYEE---KIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ----KAMI 371
Cdd:TIGR02169 252 ELEKLTEEISELEKRLEEIEQLLEElnkKIKDLGeeeqLRVKEKIGELEAEIASLERSIAEKERELEDAEERlaklEAEI 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 372 NAMDSKIRSLEQRIVElsEANKLAANSSLFtqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS- 450
Cdd:TIGR02169 332 DKLLAEIEELEREIEE--ERKRRDKLTEEY-----AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINEl 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 451 --DKSRLLELETRLREVSLEH-------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 521
Cdd:TIGR02169 405 krELDRLQEELQRLSEELADLnaaiagiEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKE 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 522 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhlrre 601
Cdd:TIGR02169 485 LSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAV----- 559
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 602 iTEREMQLTSQKQAQ----LSAPDLQTMEALKTtcTMLEEQVLDLeALNdeLLEKERQWE-AWRSVLGDE--KSQFECRV 674
Cdd:TIGR02169 560 -AKEAIELLKRRKAGratfLPLNKMRDERRDLS--ILSEDGVIGF-AVD--LVEFDPKYEpAFKYVFGDTlvVEDIEAAR 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 675 RELQ--RM--LDTE------------KQSRARADQRITESRQVVELA--VKEHKAEILALQQALKEQKLKAESLSDKLND 736
Cdd:TIGR02169 634 RLMGkyRMvtLEGElfeksgamtggsRAPRGGILFSRSEPAELQRLRerLEGLKRELSSLQSELRRIENRLDELSQELSD 713
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 737 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLT---QGLQEALD--RADLLKTERSDLEYQL 811
Cdd:TIGR02169 714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHklEEALNDLEARLSHSRI 793
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 812 ENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEA 891
Cdd:TIGR02169 794 PEIQAELS----KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEE 869
|
730 740
....*....|....*....|
gi 568936834 892 LQKTRIELRSAREEAAHRKA 911
Cdd:TIGR02169 870 LEELEAALRDLESRLGDLKK 889
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
576-910 |
1.66e-11 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 69.70 E-value: 1.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 576 KQLDEASGA----NDEIVQLRSEVDHLRR--EITEREMQLTSQK---QAQLSAPDLQTMEA-LKTTCTMLEEQVLDLEAL 645
Cdd:TIGR02168 179 RKLERTRENldrlEDILNELERQLKSLERqaEKAERYKELKAELrelELALLVLRLEELREeLEELQEELKEAEEELEEL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 646 NDELLEKERQWEAWRsvlgDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKE 722
Cdd:TIGR02168 259 TAELQELEEKLEELR----LEVSELEEEIEELQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDE 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 723 QKLKAESLSDKLNDLEKKHAMLEM---NARSLQQKLETERELKQRLLEEQ----AKLQQQMDLQKNHIFRLTQGLQEALD 795
Cdd:TIGR02168 335 LAEELAELEEKLEELKEELESLEAeleELEAELEELESRLEELEEQLETLrskvAQLELQIASLNNEIERLEARLERLED 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 796 RADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNELK 875
Cdd:TIGR02168 415 RRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDAAE 481
|
330 340 350
....*....|....*....|....*....|....*
gi 568936834 876 LALEKEKARCAELEEALQKTRIELRSAREEAAHRK 910
Cdd:TIGR02168 482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
277-780 |
1.90e-11 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 69.16 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 277 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEE 356
Cdd:PRK01156 186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 357 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 436
Cdd:PRK01156 258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQA 499
Cdd:PRK01156 331 LSV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKK 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 500 ARAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYL 574
Cdd:PRK01156 410 ELNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKI 485
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 575 SKQLDEASGANDEIVQLRSEVDHL------------------RREITEREMQLTSQKQAQLSAP---------DLQTMEA 627
Cdd:PRK01156 486 REIEIEVKDIDEKIVDLKKRKEYLeseeinksineynkiesaRADLEDIKIKINELKDKHDKYEeiknrykslKLEDLDS 565
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 628 LKTTCTMLEEQV--LDLEALNDELLEKERQWEAWRSVLG-------DEKSQFECRVRELQRMLDT--EKQSRARADQRIT 696
Cdd:PRK01156 566 KRTSWLNALAVIslIDIETNRSRSNEIKKQLNDLESRLQeieigfpDDKSYIDKSIREIENEANNlnNKYNEIQENKILI 645
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 697 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL 772
Cdd:PRK01156 646 EKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETL 725
|
....*...
gi 568936834 773 QQQMDLQK 780
Cdd:PRK01156 726 ESMKKIKK 733
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
56-790 |
2.38e-11 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 68.84 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 56 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEmrlmmNQLEEDLVSARRRSDLYESELresrlAAEEFKRK 135
Cdd:TIGR00618 215 DTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-----LKKQQLLKQLRARIEELRAQE-----AVLEETQE 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 136 ANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEkLEKAVKAST 215
Cdd:TIGR00618 285 RINRARKAAPLAAHIKA-----VTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT-LHSQEIHIR 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 216 EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQiQQMAD 295
Cdd:TIGR00618 359 DAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQ-QELQQ 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 296 KILELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNqikkdladkesLENMMQRHEEEAHEKGKILSEQKaminam 374
Cdd:TIGR00618 438 RYAELCAAAITCTAQCEKLEkIHLQESAQSLKEREQQLQT-----------KEQIHLQETRKKAVVLARLLELQ------ 500
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 375 dSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR 454
Cdd:TIGR00618 501 -EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 455 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 534
Cdd:TIGR00618 572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHAL 651
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 535 EIQRKFDALRNSCTVITDLEEQL---NQLTEDNAE-LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLT 610
Cdd:TIGR00618 652 QLTLTQERVREHALSIRVLPKELlasRQLALQKMQsEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLG 731
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 611 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsvLGDEKSQFECRVRELQRMLDTEKQSRAR 690
Cdd:TIGR00618 732 SDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ--------TGAELSHLAAEIQFFNRLREEDTHLLKT 803
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 691 ADQRITESRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 770
Cdd:TIGR00618 804 LEAEIGQEIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNG 880
|
730 740
....*....|....*....|
gi 568936834 771 KLQQQMDLQKNHIFRLTQGL 790
Cdd:TIGR00618 881 INQIKIQFDGDALIKFLHEI 900
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
233-827 |
2.97e-11 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 68.66 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 233 RELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLetMERReNRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQ 312
Cdd:pfam01576 2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQL--CEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 313 HLEVHLKQKeqhyEEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 390
Cdd:pfam01576 79 ELESRLEEE----EERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 391 AN-KLaansslftQRNMKAQEEMISELRQQKFYLETQAGKL-------EAQNRKLEEQLEKishqdhSDKSRlLELETRL 462
Cdd:pfam01576 146 QNsKL--------SKERKLLEERISEFTSNLAEEEEKAKSLsklknkhEAMISDLEERLKK------EEKGR-QELEKAK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 463 REV---SLEHEEQKLELKRQLTELQLSLQERESQLTALQaARAALESQLRQAkteleettaeAEEEIQALTAHRDEIQRK 539
Cdd:pfam01576 211 RKLegeSTDLQEQIAELQAQIAELRAQLAKKEEELQAAL-ARLEEETAQKNN----------ALKKIRELEAQISELQED 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 540 FDALRNSCTVIT----DLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITERemqlTSQKQA 615
Cdd:pfam01576 280 LESERAARNKAEkqrrDLGEELEALKTE----------LEDTLDTTAAQQELRSKREQEVTELKKALEEE----TRSHEA 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 616 QLSapdlqtmealkttcTMLEEQVLDLEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD 692
Cdd:pfam01576 346 QLQ--------------EMRQKHTQALEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLE 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 693 QritesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQA 770
Cdd:pfam01576 412 G------QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQ 483
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936834 771 KLQ-----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 827
Cdd:pfam01576 484 KLNlstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
641-911 |
4.32e-11 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 68.04 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 641 DLEALNDELLEKERQWEAwrsvLGDEKSQFEcRVRELQRMLDT-EKQSRARADQRITESRQVVELAVKEHKAEILALQQ- 718
Cdd:COG1196 187 NLERLEDILGELERQLEP----LERQAEKAE-RYRELKEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAe 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 719 ------ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 792
Cdd:COG1196 262 laeleaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 793 ALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptqvpLQYN 872
Cdd:COG1196 342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--------EALL 413
|
250 260 270
....*....|....*....|....*....|....*....
gi 568936834 873 ELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 911
Cdd:COG1196 414 ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
189-773 |
4.69e-11 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 67.76 E-value: 4.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 189 LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER---ELEKLhnREDSSEGIKKKLVEAEERRhslENK 265
Cdd:PRK02224 211 LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETleaEIEDL--RETIAETEREREELAEEVR---DLR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 266 VKRLETMERRENRLKD------DIQTKSEQIQQMADKILELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKD 339
Cdd:PRK02224 286 ERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEEL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 340 LADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 419
Cdd:PRK02224 362 REEAAELESELEEAREA-------VEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 420 kfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQA 499
Cdd:PRK02224 435 ---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIE--------EDRERVEELEAELEDLEEEVEEVEERLERAED 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 500 ARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlD 579
Cdd:PRK02224 504 LVEA-EDRIERLEERREDLE-------ELIAERRETIEEK--------------RERAEELRERAAELE----------A 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 580 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 659
Cdd:PRK02224 552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKER------IESLERIRTLLAAIADAEDEIERLREKREALAELNDER 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 660 RSVLGDEKSqfecRVRELQRMLDTEKQSRARADQRITESRQvvelavkehkaeilalqqalkeqklkaESLSDKLNDLEK 739
Cdd:PRK02224 626 RERLAEKRE----RKRELEAEFDEARIEEAREDKERAEEYL---------------------------EQVEEKLDELRE 674
|
570 580 590
....*....|....*....|....*....|....
gi 568936834 740 KHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 773
Cdd:PRK02224 675 ERDDLQAEIGAVENELEELEELRERREALENRVE 708
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
51-594 |
4.89e-11 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 67.76 E-value: 4.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 51 KRSLEQARMEVSQEDDKAL--------QLLHDIREQSRKLQEIKEQEyQAQVEEMRLMMNQLEEdlvsARRRSDLYESEL 122
Cdd:PRK02224 186 RGSLDQLKAQIEEKEEKDLherlngleSELAELDEEIERYEEQREQA-RETRDEADEVLEEHEE----RREELETLEAEI 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 123 RESRLAAEEFKRKANECQHKLMKvvshppRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvgEYSKLEKINAEQQlkiQE 202
Cdd:PRK02224 261 EDLRETIAETEREREELAEEVRD------LRERLEELEEERDDLLAEAGLDDADAEAVEA--RREELEDRDEELR---DR 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 203 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKlhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRenrlkdd 282
Cdd:PRK02224 330 LEECRVAAQAHNEEAESLREDADDLEERAEELREE---AAELESELEEAREAVEDRREEIEELEEEIEELRER------- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 283 IQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADKESLENMMQRHEE 355
Cdd:PRK02224 400 FGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHVETIEEDRERVEE 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 356 EAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELRQQKFYLETQAGK 429
Cdd:PRK02224 480 LEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELRERAAELEAEAEE 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 430 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQERESQLTALQAA 500
Cdd:PRK02224 556 KREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELNDERRERLAEKRER 635
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 501 RAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQLTEDNAELNNQNF 572
Cdd:PRK02224 636 KRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEELRERREALENRVE 708
|
570 580
....*....|....*....|..
gi 568936834 573 YLSKQLDEASGANDEIVQLRSE 594
Cdd:PRK02224 709 ALEALYDEAEELESMYGDLRAE 730
|
|
| C1_ScPKC1-like_rpt2 |
cd20823 |
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
972-1029 |
7.52e-11 |
|
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410373 Cd Length: 59 Bit Score: 58.86 E-value: 7.52e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 972 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 1029
Cdd:cd20823 1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
190-768 |
7.70e-11 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 67.05 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--RQAKERAERELEKLHNRE---DSSEGIKKKLVEAEERRHSLEN 264
Cdd:pfam05483 130 EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaRSAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAEN 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 265 -------KVKR-LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQI 336
Cdd:pfam05483 209 arlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENL 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 337 KKDLADKESLENMMqrhEEEAHEKGKILSEQKAMINAMDSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQ 409
Cdd:pfam05483 285 KELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDLQIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 410 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL------ELKRQLTEL 483
Cdd:pfam05483 362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQEL 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 484 QLSLQERES-------QLTALQAARAALESQLRQAKTELEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQ 556
Cdd:pfam05483 442 IFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLE 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 557 LNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL-----TSQKQAQLSAPDL----QTMEA 627
Cdd:pfam05483 515 LKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkckldKSEENARSIEYEVlkkeKQMKI 591
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 628 LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQ---------SRARADQRITE- 697
Cdd:pfam05483 592 LENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQkfeeiidnyQKEIEDKKISEe 671
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 698 --------SRQVVELAVK---------EHK-AEILALQQALKEQ---------------KLKAESLSDKLNDLEKKHAML 744
Cdd:pfam05483 672 klleevekAKAIADEAVKlqkeidkrcQHKiAEMVALMEKHKHQydkiieerdselglyKNKEQEQSSAKAALEIELSNI 751
|
650 660
....*....|....*....|....
gi 568936834 745 EMNARSLQQKLETERELKQRLLEE 768
Cdd:pfam05483 752 KAELLSLKKQLEIEKEEKEKLKME 775
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
437-906 |
1.32e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 66.60 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 513
Cdd:PRK02224 192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 514 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 585
Cdd:PRK02224 269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 586 DEIVQLRSEVDHLRREITEREMQLTSQKQA------QLSAPDLQtMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 659
Cdd:PRK02224 349 EDADDLEERAEELREEAAELESELEEAREAvedrreEIEELEEE-IEELRERFGDAPVDLGNAEDFLEELREERDELRER 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 660 RSVLGDEKSQFECRVRELQRMLDTEKQSRAraDQRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN---- 735
Cdd:PRK02224 428 EAELEATLRTARERVEEAEALLEAGKCPEC--GQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraed 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 736 --DLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD 806
Cdd:PRK02224 504 lvEAEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAE 583
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 807 LEYQLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCA 886
Cdd:PRK02224 584 LKERIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKR 637
|
490 500
....*....|....*....|.
gi 568936834 887 ELEEALQKTRIE-LRSAREEA 906
Cdd:PRK02224 638 ELEAEFDEARIEeAREDKERA 658
|
|
| C1 |
smart00109 |
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ... |
976-1024 |
1.81e-10 |
|
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.
Pssm-ID: 197519 Cd Length: 50 Bit Score: 57.48 E-value: 1.81e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568936834 976 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1024
Cdd:smart00109 1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
|
|
| C1 |
cd00029 |
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ... |
976-1024 |
1.87e-10 |
|
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.
Pssm-ID: 410341 Cd Length: 50 Bit Score: 57.53 E-value: 1.87e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568936834 976 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd00029 1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
72-564 |
2.59e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 65.17 E-value: 2.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 72 LHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKANECQHKLmkvvsh 149
Cdd:COG4717 70 LKELKELEEELKEAEEKE--EEYAELQEELEELEEELEELEAELEELREELEklEKLLQLLPLYQELEALEAEL------ 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 150 pprgdsggtalddlhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEllQNIRQAKE 229
Cdd:COG4717 142 --------------------AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATE--EELQDLAE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 230 RAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMER-RENRLKDDIQTKSEQIQQMADKILELEEKHRE-- 306
Cdd:COG4717 200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGvl 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 307 ---AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 383
Cdd:COG4717 280 flvLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 384 RIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKSRLLELETRL 462
Cdd:COG4717 359 LEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEEL 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 463 REVSLEHEEQKLELKRQLTELQLSLQERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKf 540
Cdd:COG4717 438 EEELEELEEELEELREELAELEAELEQLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP- 516
|
490 500
....*....|....*....|....
gi 568936834 541 dalrnsctVITDLEEQLNQLTEDN 564
Cdd:COG4717 517 --------VLERASEYFSRLTDGR 532
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
346-582 |
2.76e-10 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 65.04 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 346 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 425
Cdd:COG3206 162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 426 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 503
Cdd:COG3206 234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 504 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 582
Cdd:COG3206 303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
160-896 |
3.31e-10 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 65.55 E-value: 3.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 160 LDDLHKMQGHAGLTSAKDQ------GKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE- 232
Cdd:PTZ00121 1047 IIDEDIDGNHEGKAEAKAHvgqdegLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEd 1126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 233 -RELEKLHNREDSSEGIKKKLVEaEERRHSLENKV---KRLETMERRENRLKDDIQTKSEQIQQMADkiLELEEKHREAQ 308
Cdd:PTZ00121 1127 aRKAEEARKAEDARKAEEARKAE-DAKRVEIARKAedaRKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAE 1203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 309 VSAQHLEVHLKQKEQHYEEKIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKI--LSEQKAMINAMDSKIRSLE 382
Cdd:PTZ00121 1204 AARKAEEERKAEEARKAEDAKKAEAvkkaEEAKKDAEEAKKAEEERNNEEIRKFEEARMahFARRQAAIKAEEARKADEL 1283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 383 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QLEKISHQDHSDKSRLLE 457
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEakkaaEAAKAEAEAAADEAEAAE 1363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 458 LETRLREVSLEHE-------EQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTAEAEEEIQALT 530
Cdd:PTZ00121 1364 EKAEAAEKKKEEAkkkadaaKKKAEEKKKADEAKKKAEEDKKKADELKKAAAA-KKKADEAKKKAEEKKKADEAKKKAEE 1442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 531 AHR-DEIQRKFDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEI---VQLRSEVDHLRREITER 605
Cdd:PTZ00121 1443 AKKaDEAKKKAEEAKKAEEAKKKAEEAKKaDEAKKKAEEAKKADEAKKKAEEAKKKADEAkkaAEAKKKADEAKKAEEAK 1522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 606 EMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVL----DLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRELQRML 681
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADELKKAEELkkaeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 682 DTEKQSRARADQRITESRQVVELAVK--EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 759
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKaeEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK 1681
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 760 --ELKQRLLEEQAKLQQQmdlQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgtisqqtklid 837
Cdd:PTZ00121 1682 kaEEDEKKAAEALKKEAE---EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE----------- 1747
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 838 flQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTR 896
Cdd:PTZ00121 1748 --EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIF 1804
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
404-808 |
3.97e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 64.79 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 404 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 481
Cdd:COG4717 71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 482 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 561
Cdd:COG4717 150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 562 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQAQ 616
Cdd:COG4717 227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 617 LSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 690
Cdd:COG4717 307 LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 691 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 770
Cdd:COG4717 387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456
|
410 420 430
....*....|....*....|....*....|....*...
gi 568936834 771 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 808
Cdd:COG4717 457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
218-789 |
4.55e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 64.40 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 218 TELLQNIRQA-KERAERELEKLHNREDssegikKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADK 296
Cdd:COG4717 37 STLLAFIRAMlLERLEKEADELFKPQG------RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 297 ILELEEKHREAQVSAQHLEVHLKQKEqhyeekikvldnqikkdlaDKESLENMMQRHEEeahekgkiLSEQKAMINAMDS 376
Cdd:COG4717 111 LEELREELEKLEKLLQLLPLYQELEA-------------------LEAELAELPERLEE--------LEERLEELRELEE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 377 KIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKS 453
Cdd:COG4717 164 ELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 454 RLLELETRLREVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 533
Cdd:COG4717 244 RLKEARLLLLIAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 534 DEIQRKFDALRNSCTVITDLEEqlnqltednaelnnqnfylsKQLDEASGANDEIVQLRSEVDHLRREIteREMQLTSQK 613
Cdd:COG4717 315 ELEEEELEELLAALGLPPDLSP--------------------EELLELLDRIEELQELLREAEELEEEL--QLEELEQEI 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 614 QAQLSAPDLQTMEALKTTCTMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRAR 690
Cdd:COG4717 373 AALLAEAGVEDEEELRAALEQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEE 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 691 ADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 770
Cdd:COG4717 444 LEEELEELRE--ELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA 521
|
570 580
....*....|....*....|
gi 568936834 771 klqqqmdlqkNHIF-RLTQG 789
Cdd:COG4717 522 ----------SEYFsRLTDG 531
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
190-849 |
9.29e-10 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 63.82 E-value: 9.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKInAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE--------------LEKLHNREDSSEGIKKKLVEA 255
Cdd:COG3096 347 EKI-ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEvdslksqladyqqaLDVQQTRAIQYQQAVQALEKA 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 256 EERRH----SLENKVKRLETMERREN-------------RLKDDIQTKSEQIQQMADKIL-------------ELEEKHR 305
Cdd:COG3096 426 RALCGlpdlTPENAEDYLAAFRAKEQqateevleleqklSVADAARRQFEKAYELVCKIAgeversqawqtarELLRRYR 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 306 EAQVSAQ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 376
Cdd:COG3096 506 SQQALAQrlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQ 585
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 377 KIRSLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISH 446
Cdd:COG3096 586 QLEQLRARIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQ 665
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 447 QDHSDKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ 490
Cdd:COG3096 666 PGGAEDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfd 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 491 ESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtedn 564
Cdd:COG3096 746 DSVFDAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF---- 821
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 565 aelnnqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQAQLSA-PDLQTMEALKTTCTMLEEQVL- 640
Cdd:COG3096 822 ---------VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLkEQLQLLNKLLPQANLLADETLa 892
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 641 ----DLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVE 703
Cdd:COG3096 893 drleELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRP 968
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 704 LAVKEHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ 779
Cdd:COG3096 969 HFSYEDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQ 1048
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 780 KNHifrltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 849
Cdd:COG3096 1049 ADA---------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
355-813 |
1.38e-09 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 63.40 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 355 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 431
Cdd:COG4913 238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 432 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 507
Cdd:COG4913 316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 508 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 566
Cdd:COG4913 396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 567 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREITEREMQLTSQKQAQLSAPD---LQTMEALKTTC 632
Cdd:COG4913 476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLVYERVRTGLPDPERPRLDPdslAGKLDFKPHPF 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 633 TM-LEEQ---------VLDLEAL---------------NDELLEKERQWEAWRS-VLG----DEKSQFECRVRELQRMLD 682
Cdd:COG4913 548 RAwLEAElgrrfdyvcVDSPEELrrhpraitragqvkgNGTRHEKDDRRRIRSRyVLGfdnrAKLAALEAELAELEEELA 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 683 T--EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEqklkAESLSDKLNDLEKKHAMLemnaRSLQQKLETERE 760
Cdd:COG4913 628 EaeERLEALEAELDALQERREALQRLAEYSWDEIDVASAERE----IAELEAELERLDASSDDL----AALEEQLEELEA 699
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 568936834 761 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRAD-LLKTERSDLEYQLEN 813
Cdd:COG4913 700 ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaAEDLARLELRALLEE 753
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
10-493 |
1.49e-09 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 63.21 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 10 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 85
Cdd:pfam15921 317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 86 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLhk 165
Cdd:pfam15921 397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERQMAAIQGKNESLEKVSSL-- 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 166 mqgHAGLTSAKDQGKPEVGEYS--KLEKINAEQQLK--IQELQEKlEKAVKAS-TEATELLQNIR---QAKERAERELEK 237
Cdd:pfam15921 467 ---TAQLESTKEMLRKVVEELTakKMTLESSERTVSdlTASLQEK-ERAIEATnAEITKLRSRVDlklQELQHLKNEGDH 542
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 238 LHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQ-QMADKILELEE----------KHRE 306
Cdd:pfam15921 543 LRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEkEINDRRLELQEfkilkdkkdaKIRE 622
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 307 AQVSAQHLEVH-----------------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILseqKA 369
Cdd:pfam15921 623 LEARVSDLELEkvklvnagserlravkdIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKL---KM 699
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 370 MINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ--------------EEMISELRQQKFYLETQAGKLE---- 431
Cdd:pfam15921 700 QLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKrgqidalqskiqflEEAMTNANKEKHFLKEEKNKLSqels 779
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 432 ---AQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 493
Cdd:pfam15921 780 tvaTEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
2-609 |
1.86e-09 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 62.83 E-value: 1.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQ------------------RSLL------------EQDLATYI------- 44
Cdd:pfam15921 141 EDLRNQLQNTVHELEAAKCLKEDMLEDSNTQieqlrkmmlshegvlqeiRSILvdfeeasgkkiyEHDSMSTMhfrslgs 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 45 ----------TECSSLK-------------RSLEQARME--VSQEDDKALQLL--HDI------------REQSRKLQE- 84
Cdd:pfam15921 221 aiskilreldTEISYLKgrifpvedqlealKSESQNKIEllLQQHQDRIEQLIseHEVeitgltekassaRSQANSIQSq 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 85 ---IKEQE------YQAQVEEMRLMMNQLEEDLVSARRRSD-----------LYESELRESRLAAEEFKRKANECQHKLM 144
Cdd:pfam15921 301 leiIQEQArnqnsmYMRQLSDLESTVSQLRSELREAKRMYEdkieelekqlvLANSELTEARTERDQFSQESGNLDDQLQ 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 145 KVvshpprgdsggtaLDDLHKMQGHagLTSAKDQGK----PEVGEYSKLEKINAEQQLKIQELQ--EKLEKAVKASTEA- 217
Cdd:pfam15921 381 KL-------------LADLHKREKE--LSLEKEQNKrlwdRDTGNSITIDHLRRELDDRNMEVQrlEALLKAMKSECQGq 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 218 TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEaeerrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKI 297
Cdd:pfam15921 446 MERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVE------ELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEI 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 298 LELEEKhreAQVSAQHLEvHLKQKEQHYEEkIKVLDNQIKKDLADK--------ESLENMMQ-----------------R 352
Cdd:pfam15921 520 TKLRSR---VDLKLQELQ-HLKNEGDHLRN-VQTECEALKLQMAEKdkvieilrQQIENMTQlvgqhgrtagamqvekaQ 594
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 353 HEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAGKLE 431
Cdd:pfam15921 595 LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVKTSR 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 432 AQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQLRQ 510
Cdd:pfam15921 667 NELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVAMGM 732
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 511 AKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASGAND 586
Cdd:pfam15921 733 QKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNKMAG 790
|
730 740
....*....|....*....|...
gi 568936834 587 EIVQLRSEVDHLRREITEREMQL 609
Cdd:pfam15921 791 ELEVLRSQERRLKEKVANMEVAL 813
|
|
| ROM1 |
COG5422 |
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
1229-1480 |
2.16e-09 |
|
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];
Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 62.60 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1229 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1300
Cdd:COG5422 868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1301 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1369
Cdd:COG5422 944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1370 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1448
Cdd:COG5422 1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091
|
250 260 270
....*....|....*....|....*....|...
gi 568936834 1449 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1480
Cdd:COG5422 1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
437-906 |
4.76e-09 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 61.32 E-value: 4.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 515
Cdd:COG4717 47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 516 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------------NFYLSKQLDEASG 583
Cdd:COG4717 126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEEleelleqlslatEEELQDLAEELEE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 584 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEALNDELLEKERQWEAWRSVL 663
Cdd:COG4717 204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLV 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 664 GdeksqfecrvrelqRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKham 743
Cdd:COG4717 283 L--------------GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR--- 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 744 lemnARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI---- 814
Cdd:COG4717 346 ----IEELQELLREAEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgel 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 815 -QVLYSHEKVKMEGTISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE--- 890
Cdd:COG4717 419 eELLEALDEEELEEELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewa 493
|
490
....*....|....*.
gi 568936834 891 ALQKTRIELRSAREEA 906
Cdd:COG4717 494 ALKLALELLEEAREEY 509
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
196-815 |
5.64e-09 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 61.51 E-value: 5.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 196 QQLKIQ-------ELQEKLEKAVKASTEATELLQNIRQAKERAERE-------------------------------LEK 237
Cdd:PRK04863 346 QQEKIEryqadleELEERLEEQNEVVEEADEQQEENEARAEAAEEEvdelksqladyqqaldvqqtraiqyqqavqaLER 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 238 -----------LHNREDSSEGIKKKLVEAEERRHSLENKVkrletmerrenRLKDDIQTKSEQIQQMADKIL-------- 298
Cdd:PRK04863 426 akqlcglpdltADNAEDWLEEFQAKEQEATEELLSLEQKL-----------SVAQAAHSQFEQAYQLVRKIAgevsrsea 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 299 -----ELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKV--LDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 368
Cdd:PRK04863 495 wdvarELLRRLREQRhlaEQLQQLRMRLSELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESV 574
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 369 AMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQN 434
Cdd:PRK04863 575 SEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARK 654
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 435 RKLEEQLEKISHQDHSDKSRLLELETRLREVSLE--HEEQKLE-----------------------LKRQLTELQ----- 484
Cdd:PRK04863 655 QALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcped 734
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 485 LSLQE------RESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 552
Cdd:PRK04863 735 LYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQR 814
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 553 LEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTC 632
Cdd:PRK04863 815 LHQAFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGL 874
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 633 TMLEE-----QVLDLEALNDELLEKERQWEAWR--------------------SVLGDEKSQFEcrvrELQRMLDTEKQS 687
Cdd:PRK04863 875 SALNRllprlNLLADETLADRVEEIREQLDEAEeakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQT 950
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 688 RARADQRI---TESRQVVELAVKEHKAEILA----LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQ 752
Cdd:PRK04863 951 QRDAKQQAfalTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYD 1030
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936834 753 QKLETERELKQRL----------LEEQAKLQQQmdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 815
Cdd:PRK04863 1031 AKRQMLQELKQELqdlgvpadsgAEERARARRD---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
70-700 |
6.36e-09 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 61.08 E-value: 6.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 70 QLLHDIREQSRKLQEIKE--QEYQAQVEEMRLMmNQLEEDLVS--ARRRSDLYESELRESRLAAEEFKRKANECQHKLmk 145
Cdd:COG4913 242 EALEDAREQIELLEPIRElaERYAAARERLAEL-EYLRAALRLwfAQRRLELLEAELEELRAELARLEAELERLEARL-- 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 146 vvshpprgDSGGTALDDLHK-MQGHAGltSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQN 223
Cdd:COG4913 319 --------DALREELDELEAqIRGNGG--DRLEQLEREIER---LERELEERERRRARLEALLAALgLPLPASAEEFAAL 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 224 IRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtmeRRENRLKDDIQTKSEQIQQmadkilELEEK 303
Cdd:COG4913 386 RAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLE---RRKSNIPARLLALRDALAE------ALGLD 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 304 HREAQVSAQHLEVhlKQKEQHYEEKI-KVLDNQiKKDLADKESLENMMQRHEEEAHEKGKILSEqKAMINAMDSKIRSLE 382
Cdd:COG4913 457 EAELPFVGELIEV--RPEEERWRGAIeRVLGGF-ALTLLVPPEHYAAALRWVNRLHLRGRLVYE-RVRTGLPDPERPRLD 532
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 383 QRivelSEANKLAANSSLFTQRnmkAQEEM-----------ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSd 451
Cdd:COG4913 533 PD----SLAGKLDFKPHPFRAW---LEAELgrrfdyvcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR- 596
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 452 ksrlleletRLREVSL---EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQA 528
Cdd:COG4913 597 ---------RIRSRYVlgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREA---------------LQR 652
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 529 LTAHRDEiQRKFDALRNSctvITDLEEQLNQLTEDNAELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQ 608
Cdd:COG4913 653 LAEYSWD-EIDVASAERE---IAELEAELERLDASSDDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKE 721
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 609 LTS-QKQAQLSAPDLQTMEALKTtctmlEEQVLDLEALNDELLEKERQWEAwrsvlgdeksqfecrVRELQRMLDTEKQS 687
Cdd:COG4913 722 LEQaEEELDELQDRLEAAEDLAR-----LELRALLEERFAAALGDAVEREL---------------RENLEERIDALRAR 781
|
650
....*....|...
gi 568936834 688 RARADQRITESRQ 700
Cdd:COG4913 782 LNRAEEELERAMR 794
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
221-816 |
1.53e-08 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 59.85 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 221 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSlenkvkRLETMERRENRLKDDIQTKSEQIQQMADKiLEL 300
Cdd:pfam12128 236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIAS------RQEERQETSAELNQLLRTLDDQWKEKRDE-LNG 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 301 EEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 378
Cdd:pfam12128 309 ELSAADAAVAKdrSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQN 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 379 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEmiSELRQQkfyletqagkLEAQNRKLEEQLEKIshqdhsdKSRLLEL 458
Cdd:pfam12128 389 NRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQ----------LEAGKLEFNEEEYRL-------KSRLGEL 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 459 ETRLREVSLEHEeqkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQR 538
Cdd:pfam12128 450 KLRLNQATATPE-----LLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR 514
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 539 kfdalrnsctvitdLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIvqLRSEV----DHLRREITEREMQLTSQKQ 614
Cdd:pfam12128 515 --------------LEERQSALDE-----------LELQLFPQAGTLLHF--LRKEApdweQSIGKVISPELLHRTDLDP 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 615 AQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARA 691
Cdd:pfam12128 568 EVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFA 644
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 692 DQRITESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELK 762
Cdd:pfam12128 645 RTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVE 724
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 763 QRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 816
Cdd:pfam12128 725 GALDAQLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
186-902 |
1.89e-08 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 59.58 E-value: 1.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 186 YSKLEKINAEQQL---------KIQELQEKLEKAVKASTEATELLQNIRQAKERAER------EL-EKLHNREDSSEGIK 249
Cdd:COG3096 295 FGARRQLAEEQYRlvemareleELSARESDLEQDYQAASDHLNLVQTALRQQEKIERyqedleELtERLEEQEEVVEEAA 374
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 250 KKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM------ADKILELEEKHREAqvSAQHLEVHLKQKEQ 323
Cdd:COG3096 375 EQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAvqalekARALCGLPDLTPEN--AEDYLAAFRAKEQQ 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 324 HYEEkikVLDNQIKKDLAD--KESLENMMQRHE--------EEAHEKGKIL----SEQKAMI---NAMDSKIRSLEQRIV 386
Cdd:COG3096 453 ATEE---VLELEQKLSVADaaRRQFEKAYELVCkiageverSQAWQTARELlrryRSQQALAqrlQQLRAQLAELEQRLR 529
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 387 ELSEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR---LLELET 460
Cdd:COG3096 530 QQQNAERLLEEFCQRIGQQLDAAeelEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARapaWLAAQD 609
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 461 RLREVSlEHEEQKLELKRQLTELQLSLQERESQLTA----LQAARAALESQLRQAKTELEETTAEAEEEIQALTAH---- 532
Cdd:COG3096 610 ALERLR-EQSGEALADSQEVTAAMQQLLEREREATVerdeLAARKQALESQIERLSQPGGAEDPRLLALAERLGGVllse 688
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 533 -RDEIQRK----FDAL----RNScTVITDLE---EQLNQLT---------EDNAELNNQNFYLSKQLDEASGANDEIVQL 591
Cdd:COG3096 689 iYDDVTLEdapyFSALygpaRHA-IVVPDLSavkEQLAGLEdcpedlyliEGDPDSFDDSVFDAEELEDAVVVKLSDRQW 767
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 592 R----SEVDHLRR-------EITEREMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEALNDEllekerqwEAWR 660
Cdd:COG3096 768 RysrfPEVPLFGRaarekrlEELRAERDELAEQYAKASF-DVQKLQRLHQAFSQFVGGHLAVAFAPDP--------EAEL 838
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 661 SVLGDEKSQFEcrvRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDL 737
Cdd:COG3096 839 AALRQRRSELE---RELAQHRAQEQQLRQQLDQlkeQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAFIQQH 915
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 738 EKKHAMLEMNARSLQQKLETERELKQRLLEeqakLQQQMDLQKNHIFRLTQGLQ--EAL---DRADLLkTERSD----LE 808
Cdd:COG3096 916 GKALAQLEPLVAVLQSDPEQFEQLQADYLQ----AKEQQRRLKQQIFALSEVVQrrPHFsyeDAVGLL-GENSDlnekLR 990
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 809 YQLENIQVLYSHEKVKMEGtisQQTKLIDFLQAKMDQPAK---KKKGLFSRRKEDPALPTQVP--------LQYNELKLA 877
Cdd:COG3096 991 ARLEQAEEARREAREQLRQ---AQAQYSQYNQVLASLKSSrdaKQQTLQELEQELEELGVQADaeaeerarIRRDELHEE 1067
|
810 820
....*....|....*....|....*
gi 568936834 878 LEKEKARCAELEEALQKTRIELRSA 902
Cdd:COG3096 1068 LSQNRSRRSQLEKQLTRCEAEMDSL 1092
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
335-813 |
1.93e-08 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 59.37 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 335 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 412
Cdd:pfam05557 13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 413 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 489
Cdd:pfam05557 75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 490 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 564
Cdd:pfam05557 151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 565 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREmqltsqKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEA 644
Cdd:pfam05557 224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV------KLAQDTGLNLRSPEDLSRRIEQLQQREIVLKE 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 645 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALK 721
Cdd:pfam05557 298 ENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSP 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 722 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDR 796
Cdd:pfam05557 377 QLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELE 456
|
490
....*....|....*..
gi 568936834 797 ADLLKTERSDLEYQLEN 813
Cdd:pfam05557 457 RQRLREQKNELEMELER 473
|
|
| C1_KSR |
cd20812 |
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ... |
974-1025 |
2.11e-08 |
|
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410362 Cd Length: 48 Bit Score: 51.56 E-value: 2.11e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 974 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 1025
Cdd:cd20812 1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
437-893 |
2.51e-08 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 58.98 E-value: 2.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEQLEKISHQdhsdksrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 509
Cdd:pfam15921 76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 510 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 559
Cdd:pfam15921 149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 560 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlQTMEALKTTCTMLEE 637
Cdd:pfam15921 229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSAR--SQANSIQSQLEIIQE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 638 QVLDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKE 708
Cdd:pfam15921 307 QARNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADL 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 709 HKAEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLT 787
Cdd:pfam15921 387 HKRE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAI 453
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 788 QGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQV 867
Cdd:pfam15921 454 QGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRV 526
|
490 500
....*....|....*....|....*...
gi 568936834 868 PLQYNELK-LALEKEKARCAELE-EALQ 893
Cdd:pfam15921 527 DLKLQELQhLKNEGDHLRNVQTEcEALK 554
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
196-444 |
2.79e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.85 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 196 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLetmERR 275
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL---ERRIAALARRIRALEQELAALEAELAEL---EKE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 276 ENRLKDDIQTKSEQIQQMAdkileleekhREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKESLENMMQRHEE 355
Cdd:COG4942 92 IAELRAELEAQKEELAELL----------RALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 356 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 435
Cdd:COG4942 147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223
|
....*....
gi 568936834 436 KLEEQLEKI 444
Cdd:COG4942 224 ELEALIARL 232
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
2-810 |
3.70e-08 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 58.52 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 78
Cdd:TIGR00606 318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 79 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShppRGDSGGT 158
Cdd:TIGR00606 392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIK---ELQQLEG 468
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 159 ALDDLHKMQghAGLTSAKdqgkpevGEYSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAErELEKL 238
Cdd:TIGR00606 469 SSDRILELD--QELRKAE-------RELSKAEKNSLTETLKKEVKSLQNEKA--------DLDRKLRKLDQEME-QLNHH 530
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 239 HNREDSSEGIKKKLVEAEER------RHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQ 312
Cdd:TIGR00606 531 TTTRTQMEMLTKDKMDKDEQirkiksRHSDE--LTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKN 608
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 313 HLEVHLKQKEQH---YEEKIKvldnqikkDLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELS 389
Cdd:TIGR00606 609 HINNELESKEEQlssYEDKLF--------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLT 673
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 390 EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDHSDKsRLLELETR 461
Cdd:TIGR00606 674 DENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDLKEK-EIPELRNK 752
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 462 LREVSLEHEEQKLELKRQLTELQLSLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRD 534
Cdd:TIGR00606 753 LQKVNRDIQRLKNDIEEQETLLGTIMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQ 832
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 535 EIQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqlt 610
Cdd:TIGR00606 833 EKQHELDTVVSKIelnrKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREI-------- 904
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 611 SQKQAQLSaPDLQTMEalkttctmleeqvlDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRAR 690
Cdd:TIGR00606 905 KDAKEQDS-PLETFLE--------------KDQQEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKD 959
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 691 ADQRITESRqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERE 760
Cdd:TIGR00606 960 IENKIQDGK---DDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEE 1036
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936834 761 LKQRLLE-----------EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 810
Cdd:TIGR00606 1037 LKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
216-756 |
4.37e-08 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 58.39 E-value: 4.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 216 EATELLQNIRQAKE------RAERELEKLHNREDSSEGIkkklVEAEERRHSLENKVKRLETMERREnrlkdDIQTKSEQ 289
Cdd:COG4913 219 EEPDTFEAADALVEhfddleRAHEALEDAREQIELLEPI----RELAERYAAARERLAELEYLRAAL-----RLWFAQRR 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 290 IQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKK-DLADKESLENMMQRHEEEAHEKGKILSEQK 368
Cdd:COG4913 290 LELLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRGnGGDRLEQLEREIERLERELEERERRRARLE 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 369 AMINAMDSKIRSLEQRIVELSEANKLAANSSlftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQD 448
Cdd:COG4913 366 ALLAALGLPLPASAEEFAALRAEAAALLEAL----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 449 HSDKSRLLELETRLREvSLEHEEQKL----ELkrqlteLQLSLQERESQLTA-----------------LQAARAALES- 506
Cdd:COG4913 436 SNIPARLLALRDALAE-ALGLDEAELpfvgEL------IEVRPEEERWRGAIervlggfaltllvppehYAAALRWVNRl 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 507 QLRQAKTELEETTAEAEEEIQALTAH-----------------RDEIQRKFD--------ALRNSCTVIT---------- 551
Cdd:COG4913 509 HLRGRLVYERVRTGLPDPERPRLDPDslagkldfkphpfrawlEAELGRRFDyvcvdspeELRRHPRAITragqvkgngt 588
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 552 -------DLEEQLNQLTEDNAELNNQnfyLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQT 624
Cdd:COG4913 589 rhekddrRRIRSRYVLGFDNRAKLAA---LEAELAEL---EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID 662
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 625 MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 704
Cdd:COG4913 663 VASAEREIAELEAELERLDASSDDLAALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEA 738
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 705 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 756
Cdd:COG4913 739 AEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELE 790
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
281-511 |
6.10e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.70 E-value: 6.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 281 DDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK 360
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 361 GKILSEQKAMINAMdskIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 440
Cdd:COG4942 96 RAELEAQKEELAEL---LRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936834 441 lekishqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 511
Cdd:COG4942 173 -----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
|
|
| PH |
pfam00169 |
PH domain; PH stands for pleckstrin homology. |
1057-1176 |
6.98e-08 |
|
PH domain; PH stands for pleckstrin homology.
Pssm-ID: 459697 [Multi-domain] Cd Length: 105 Bit Score: 52.18 E-value: 6.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1057 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1136
Cdd:pfam00169 1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 568936834 1137 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1176
Cdd:pfam00169 69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
430-777 |
8.62e-08 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 56.61 E-value: 8.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 430 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 509
Cdd:pfam19220 25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 510 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 589
Cdd:pfam19220 101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 590 QLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLE-EQVLD-----LEALNDELLEK-------ERQW 656
Cdd:pfam19220 153 KALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLAElETQLDatrarLRALEGQLAAEqaereraEAQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 657 EAWRSVLGDEKSQFECRVRELQ-RMLDTEK---QSRARADQRiTESRQVVELAVKEHKAEILALQQALKEQKLKAESLSD 732
Cdd:pfam19220 233 EEAVEAHRAERASLRMKLEALTaRAAATEQllaEARNQLRDR-DEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQ 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 568936834 733 KLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 777
Cdd:pfam19220 312 QFQEMQRARAELEERAEMLTKALAAKDAALERAEERIASLSDRIA 356
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
696-907 |
8.90e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.31 E-value: 8.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 696 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 775
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 776 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 837
Cdd:COG4942 99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 838 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 907
Cdd:COG4942 175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
67-904 |
1.02e-07 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 57.36 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 67 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQ 140
Cdd:TIGR00606 186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 141 HKLMKVVShpprgdsggtaLDDlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 220
Cdd:TIGR00606 259 HNLSKIMK-----------LDN----------------------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLND 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 221 LQNIRQAKERA--------ERELEKLhNREDSSEGIKKKLVEAEERRHSLenKVKRLETMERRENRLKDDIQTKSE---- 288
Cdd:TIGR00606 306 LYHNHQRTVREkerelvdcQRELEKL-NKERRLLNQEKTELLVEQGRLQL--QADRHQEHIRARDSLIQSLATRLEldgf 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 289 ----------------QIQQMADK-------ILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLAD 342
Cdd:TIGR00606 383 ergpfserqiknfhtlVIERQEDEaktaaqlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEkkqEELKFVIKE 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 343 KESLENMMQRHEEEAHEKGKILSE-QKAMINA------------------MDSKIRSLEQRIVELSEANKLAANSSLFTQ 403
Cdd:TIGR00606 463 LQQLEGSSDRILELDQELRKAERElSKAEKNSltetlkkevkslqnekadLDRKLRKLDQEMEQLNHHTTTRTQMEMLTK 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 404 RNMKAQEEMISELRQQKFYLETQAGKLeAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRqLTEL 483
Cdd:TIGR00606 543 DKMDKDEQIRKIKSRHSDELTSLLGYF-PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES-KEEQ 620
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 484 QLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDE-------IQRKFDALRNSCTVITDL 553
Cdd:TIGR00606 621 LSSYEDKLFDVCGSQDEESDLERlkeEIEKSSKQRAMLAGATAVYSQFITQLTDEnqsccpvCQRVFQTEAELQEFISDL 700
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 554 EEQLNQLTEDNAELNNQNFYLSKQLDEASG-----------ANDEIVQLRSEVDHLRREITEREMQLTSQ-KQAQLSAPD 621
Cdd:TIGR00606 701 QSKLRLAPDKLKSTESELKKKEKRRDEMLGlapgrqsiidlKEKEIPELRNKLQKVNRDIQRLKNDIEEQeTLLGTIMPE 780
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 622 LQTMEALKTTCTMLEEQVLDLE-----------------------ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ 678
Cdd:TIGR00606 781 EESAKVCLTDVTIMERFQMELKdverkiaqqaaklqgsdldrtvqQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQ 860
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 679 RM------LDTEK--------QSRARADQRITESRQVVEL--AVKEHKAEILALQQALKEQKLKAESL-----------S 731
Cdd:TIGR00606 861 HLksktneLKSEKlqigtnlqRRQQFEEQLVELSTEVQSLirEIKDAKEQDSPLETFLEKDQQEKEELissketsnkkaQ 940
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 732 DKLNDLEKKHAMLEMNARSLQQKLE--TERELKQRlLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 809
Cdd:TIGR00606 941 DKVNDIKEKVKNIHGYMKDIENKIQdgKDDYLKQK-ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQD 1019
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 810 QL----------ENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqvplqYNELKLALE 879
Cdd:TIGR00606 1020 NLtlrkrenelkEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKG-----------YEKEIKHFK 1088
|
970 980
....*....|....*....|....*..
gi 568936834 880 KE--KARCAELEEALQKTRIELRSARE 904
Cdd:TIGR00606 1089 KElrEPQFRDAEEKYREMMIVMRTTEL 1115
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
344-926 |
1.03e-07 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 56.90 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 344 ESLENMMQRHEEEAHEKGKILSEQ--------KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMiSE 415
Cdd:TIGR00618 179 TQLALMEFAKKKSLHGKAELLTLRsqlltlctPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-LK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 416 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlt 495
Cdd:TIGR00618 258 KQQLLKQLRARIEELRAQEAVLEETQERINRARK--AAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA---- 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 496 ALQAARAALESQLRQAKTELEETTAEAEEEIQALT--AHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 573
Cdd:TIGR00618 332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSirEISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQAT 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 574 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTctMLEEQVLDLEALNDELLEKE 653
Cdd:TIGR00618 412 IDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLK--EREQQLQTKEQIHLQETRKK 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 654 RQWEAWRSVLGDEKSQFECRVREL--QRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLS 731
Cdd:TIGR00618 490 AVVLARLLELQEEPCPLCGSCIHPnpARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQ 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 732 DKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKL---QQQMDLQKN---HIFRLTQGLQEALDRADLLKT--- 802
Cdd:TIGR00618 570 QSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTalh 649
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 803 -ERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR----RKEDPALPTQVPlQYNELKLA 877
Cdd:TIGR00618 650 aLQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtllRELETHIEEYDR-EFNEIENA 726
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 568936834 878 LEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 926
Cdd:TIGR00618 727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
25-508 |
1.10e-07 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 57.04 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 25 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 104
Cdd:pfam05483 339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 105 EE-DLVSARRRSDLYESELRESrlAAEEFKRKANECQHKLMkvvshpprgdsggTALDDLHKMQGHAGLTSAKDQgkpev 183
Cdd:pfam05483 408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIFLLQ-------------AREKEIHDLEIQLTAIKTSEE----- 467
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 184 gEYSKlekinaeqqlKIQELQEKLEKAVKASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKKlveaeer 258
Cdd:pfam05483 468 -HYLK----------EVEDLKTELEKEKLKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE------- 529
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 259 rhslENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKK 338
Cdd:pfam05483 530 ----ERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKK 601
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 339 DLADKEslENMMQRHEEEAHEKGKILSEQKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELR 417
Cdd:pfam05483 602 QIENKN--KNIEELHQENKALKKKGSAENKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKIS 669
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 418 QQKFYLETQAGKLEAQNR-KLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ESQLT 495
Cdd:pfam05483 670 EEKLLEEVEKAKAIADEAvKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAAlEIELS 749
|
490
....*....|...
gi 568936834 496 ALQAARAALESQL 508
Cdd:pfam05483 750 NIKAELLSLKKQL 762
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
187-776 |
1.37e-07 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 56.77 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 187 SKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNirQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 263
Cdd:pfam12128 290 QLLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEALED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALT 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 264 NKVKRLE-TMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 341
Cdd:pfam12128 368 GKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLG 447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 342 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 421
Cdd:pfam12128 448 ELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELEL 527
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 422 YLETQAGKLEAQNRKlEEQLEKISHQDHSDKSRLL--ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERE 491
Cdd:pfam12128 528 QLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrtDLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERL 606
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 492 SQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNsctvitdLEEQLNQLTEDNAEL 567
Cdd:pfam12128 607 DKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQS-------EKDKKNKALAERKDS 679
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 568 NNQNFylsKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQAQLSAPDLQtMEALKTTCTMLEEQvldLEALND 647
Cdd:pfam12128 680 ANERL---NSLEAQLKQLDKKHQAWLE--EQKEQKREARTEKQAYWQVVEGALDAQ-LALLKAAIAARRSG---AKAELK 750
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 648 ELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKA 727
Cdd:pfam12128 751 ALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNI 819
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 568936834 728 ESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQQQM 776
Cdd:pfam12128 820 ER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENLRGLRCEM 869
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
576-822 |
1.66e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 56.46 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 576 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQ 655
Cdd:COG4913 252 ELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLE----AELEELRAELARLEAELERLEARLDALREELDE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 656 WE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQVVELAVKEHKAEILALQQALKEQKLKAESLSDKl 734
Cdd:COG4913 328 LEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AALGLPLPASAEEFAALRAEAAALLEALEEELEA- 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 735 ndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR-ADLLKTERSDLEYQLEN 813
Cdd:COG4913 403 ----------------LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAlAEALGLDEAELPFVGEL 466
|
....*....
gi 568936834 814 IQVLYSHEK 822
Cdd:COG4913 467 IEVRPEEER 475
|
|
| PH |
smart00233 |
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ... |
1057-1176 |
2.36e-07 |
|
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.
Pssm-ID: 214574 [Multi-domain] Cd Length: 102 Bit Score: 50.62 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1057 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1136
Cdd:smart00233 1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 568936834 1137 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1176
Cdd:smart00233 69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
395-620 |
2.39e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 54.77 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 395 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL 474
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 475 ELKRQLTELQ-----LSLQERESQLTALQAARAALESQ-----LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR 544
Cdd:COG4942 98 ELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 545 nscTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAP 620
Cdd:COG4942 178 ---ALLAELEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
536-777 |
3.16e-07 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 55.41 E-value: 3.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 536 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 609
Cdd:COG3206 166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 610 tSQKQAQLSAPDLQTMEALKTTctmleeqvlDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRA 689
Cdd:COG3206 243 -AALRAQLGSGPDALPELLQSP---------VIQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 690 RADQRITESRQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE-- 767
Cdd:COG3206 309 QEAQRILASLEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrl 374
|
250
....*....|
gi 568936834 768 EQAKLQQQMD 777
Cdd:COG3206 375 EEARLAEALT 384
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
3-385 |
3.33e-07 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 55.16 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 3 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY--ITECSSLKRSLEQARMEVSQEDDKALQL---LHDIRE 77
Cdd:COG4717 81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEELeerLEELRE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 78 QSRKLQEIKEQEYQAQVEEMRLM----------MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMK-- 145
Cdd:COG4717 161 LEEELEELEAELAELQEELEELLeqlslateeeLQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAaa 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 146 -----------------VVSHPPRGDSGGTALDDLHKMQ---------GHAGLTSAKDQGKPEVGEYSKLEKINAEQQLK 199
Cdd:COG4717 241 leerlkearlllliaaaLLALLGLGGSLLSLILTIAGVLflvlgllalLFLLLAREKASLGKEAEELQALPALEELEEEE 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 200 IQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHNREDSSEGIKKKLVEAEErrhSLENKVKRLEtm 272
Cdd:COG4717 321 LEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDEE---ELRAALEQAE-- 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 273 erRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQR 352
Cdd:COG4717 396 --EYQELKEELEELEEQLEELLGELEELLEALDEEE---------LEEELEELEEELEELEEELEELREELAELEAELEQ 464
|
410 420 430
....*....|....*....|....*....|...
gi 568936834 353 HEEEahekgKILSEQKAMINAMDSKIRSLEQRI 385
Cdd:COG4717 465 LEED-----GELAELLQELEELKAELRELAEEW 492
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
225-606 |
4.16e-07 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 55.35 E-value: 4.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 225 RQAKERAERELEKLHNREDSSeGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------EQIQ 291
Cdd:PRK04863 276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 292 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKIL 364
Cdd:PRK04863 352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 365 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 439
Cdd:PRK04863 424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 440 QLEKISHQDhsdkSRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 516
Cdd:PRK04863 504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 517 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 596
Cdd:PRK04863 579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658
|
410
....*....|
gi 568936834 597 HLRREITERE 606
Cdd:PRK04863 659 EEIERLSQPG 668
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
1-776 |
5.05e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 54.80 E-value: 5.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1 MEQEMTRLHRRVSEVEAVLSQKEVELKA-------SETQRSLLEQDLATYITECSSLKRSLEQARM-------------- 59
Cdd:pfam01576 220 LQEQIAELQAQIAELRAQLAKKEEELQAalarleeETAQKNNALKKIRELEAQISELQEDLESERAarnkaekqrrdlge 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 60 ---------EVSQEDDKALQLLHDIREQS----RKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR 126
Cdd:pfam01576 300 elealktelEDTLDTTAAQQELRSKREQEvtelKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAK 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 127 LAAE-EFKRKANEcqhklMKVVSHPprgdsggtalddlhKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQE 205
Cdd:pfam01576 380 QALEsENAELQAE-----LRTLQQA--------------KQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQS 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 206 KLE-----------KAVKASTEATEL------LQNIRQAKERAEREL-EKLHNREDSSEGIKKKLVEAEERRHSLENKVK 267
Cdd:pfam01576 441 ELEsvssllneaegKNIKLSKDVSSLesqlqdTQELLQEETRQKLNLsTRLRQLEDERNSLQEQLEEEEEAKRNVERQLS 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 268 RL------------------ETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ---HYE 326
Cdd:pfam01576 521 TLqaqlsdmkkkleedagtlEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQlvsNLE 600
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 327 EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK-GKILSEQKAMINAMDSKirsleqriVELSEANKLaansslftqrn 405
Cdd:pfam01576 601 KKQKKFDQMLAEEKAISARYAEERDRAEAEAREKeTRALSLARALEEALEAK--------EELERTNKQ----------- 661
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 406 MKAQ-EEMIS----------ELRQQKFYLETQAGKLEAQNRKLEEQLekishQDHSDKSRLLELETRLREVSLEH----- 469
Cdd:pfam01576 662 LRAEmEDLVSskddvgknvhELERSKRALEQQVEEMKTQLEELEDEL-----QATEDAKLRLEVNMQALKAQFERdlqar 736
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 470 ----EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDA 542
Cdd:pfam01576 737 deqgEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEE 816
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 543 LRNSCTVI-----------TDLEEQLNQLTEDNA------------------ELNNQNFYLSKQLDEASGANDEIVQLRS 593
Cdd:pfam01576 817 ARASRDEIlaqskesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGKSALQDEKRRLEARIAQLEE 896
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 594 EvdhLRREITEREMQLTSQKQAQLSAPDLQT-MEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFE 671
Cdd:pfam01576 897 E---LEEEQSNTELLNDRLRKSTLQVEQLTTeLAAERSTSQKSESARQQLERQNKELKAKLQEMEgTVKSKFKSSIAALE 973
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 672 CRVRELQRMLDTEKQSRARADQ--RITESR-QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA 748
Cdd:pfam01576 974 AKIAQLEEQLEQESRERQAANKlvRRTEKKlKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAAR 1053
|
890 900
....*....|....*....|....*...
gi 568936834 749 RSLQQKLETERELKQRLLEEQAKLQQQM 776
Cdd:pfam01576 1054 RKLQRELDDATESNESMNREVSTLKSKL 1081
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
198-347 |
5.99e-07 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 52.23 E-value: 5.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 198 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRedsSEGIKKKLVEAEERRHSLENKVKRLET--MERR 275
Cdd:COG1579 10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 276 ENR----LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 347
Cdd:COG1579 87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
185-347 |
6.16e-07 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 52.23 E-value: 6.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAeerrhsleN 264
Cdd:COG1579 18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 265 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 344
Cdd:COG1579 87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166
|
...
gi 568936834 345 SLE 347
Cdd:COG1579 167 ELA 169
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
37-812 |
7.09e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 54.41 E-value: 7.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 37 EQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQeiKEQEYQAQVEEMRLMMnqleedlvsARRRSD 116
Cdd:pfam01576 4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQ--AETELCAEAEEMRARL---------AARKQE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 117 LYE--SELrESRLAAEEfkrkanECQHKLMkvvshpprgdsggtalDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINA 194
Cdd:pfam01576 73 LEEilHEL-ESRLEEEE------ERSQQLQ----------------NEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTT 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 195 EQQLK--------IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAEERRHSLENKV 266
Cdd:pfam01576 130 EAKIKkleedillLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAM------ISDLEERLKKEEKGR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 267 KRLETMERRENRLKDDIQTK-SEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhYEEKIKVLDNQIKKDLADKES 345
Cdd:pfam01576 204 QELEKAKRKLEGESTDLQEQiAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNN-ALKKIRELEAQISELQEDLES 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 346 LENMMQRHEEEAHEKGKILSEQKAMI------NAMDSKIRS-LEQRIVEL-----SEANKLAANSSLFTQRNMKAQEEMI 413
Cdd:pfam01576 283 ERAARNKAEKQRRDLGEELEALKTELedtldtTAAQQELRSkREQEVTELkkaleEETRSHEAQLQEMRQKHTQALEELT 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 414 SELRQQKFY---LETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEH---EEQKLELKRQLTELQL-- 485
Cdd:pfam01576 363 EQLEQAKRNkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAEKLSKLQSel 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 486 -----SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEiqrkfdalRNSctvitdLEEQLNQL 560
Cdd:pfam01576 443 esvssLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDE--------RNS------LQEQLEEE 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 561 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREItEREMQLTSQKQAQLSApdlqTMEALKTTCTMLEEQVL 640
Cdd:pfam01576 509 EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRL-QRELEALTQQLEEKAA----AYDKLEKTKNRLQQELD 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 641 DL-------EALNDELLEKERQWE-------AWRSVLGDEKSQFECRVRElqrmLDTEKQSRARADQRITESRQVVELAV 706
Cdd:pfam01576 584 DLlvdldhqRQLVSNLEKKQKKFDqmlaeekAISARYAEERDRAEAEARE----KETRALSLARALEEALEAKEELERTN 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 707 KEHKAEI---------------------LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA--------RSLQQK--- 754
Cdd:pfam01576 660 KQLRAEMedlvsskddvgknvhelerskRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMqalkaqfeRDLQARdeq 739
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 755 --------------LETER--ELKQRLLEEQAKLQQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDLEYQLE 812
Cdd:pfam01576 740 geekrrqlvkqvreLEAELedERKQRAQAVAAKKKLELDLKelEAQIDAANKGREEAVKQLKKLQAQMKDLQRELE 815
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
190-849 |
8.18e-07 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 54.28 E-value: 8.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKR 268
Cdd:TIGR00606 177 EIFSATRYIKALETLRQVRQTQGQKVQEHQMeLKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKE 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 269 LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVHLKQKEQHYEEKIKvldnQIKKDLAD-KESLE 347
Cdd:TIGR00606 257 IEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKV---FQGTDEQLNDLYHNHQRTVR----EKERELVDcQRELE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 348 NMMQRHEEEAHEKGKILSEQKAM----------INAMDSKIRSLEQR-----------------------IVELSEANKL 394
Cdd:TIGR00606 330 KLNKERRLLNQEKTELLVEQGRLqlqadrhqehIRARDSLIQSLATRleldgfergpfserqiknfhtlvIERQEDEAKT 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 395 AANSSLFTQRNMKAQEEMISELRQQKFYLetqAGKLEAQNRKLEEQLEKISH------QDHSDKSRLLELETRL----RE 464
Cdd:TIGR00606 410 AAQLCADLQSKERLKQEQADEIRDEKKGL---GRTIELKKEILEKKQEELKFvikelqQLEGSSDRILELDQELrkaeRE 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 465 VSLEHE---------------EQKLELKRQLTELQLSLQERE------SQLTALQAARAALESQLRQAKTELEETTAEAE 523
Cdd:TIGR00606 487 LSKAEKnsltetlkkevkslqNEKADLDRKLRKLDQEMEQLNhhtttrTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLL 566
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 524 EEI-------QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 596
Cdd:TIGR00606 567 GYFpnkkqleDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKE 646
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 597 HLRREITEREM-------------QLTSQKQA--QLSAPDLQTMEALKTTCTMLEEQVL----DLEALNDELLEKERQWE 657
Cdd:TIGR00606 647 EIEKSSKQRAMlagatavysqfitQLTDENQSccPVCQRVFQTEAELQEFISDLQSKLRlapdKLKSTESELKKKEKRRD 726
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 658 AWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAEIL--------ALQQALKEQKL 725
Cdd:TIGR00606 727 EMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAKVCltdvtimeRFQMELKDVER 806
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 726 KAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 800
Cdd:TIGR00606 807 KIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQF 886
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 568936834 801 KTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 849
Cdd:TIGR00606 887 EEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
341-544 |
1.10e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.84 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 341 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQk 420
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 421 fyLETQAGKLEAQNRKL-----EEQLEKISHQDHSDKS------------RLLELETRLREVSLEHEEQKLELKRQLTEL 483
Cdd:COG4942 99 --LEAQKEELAELLRALyrlgrQPPLALLLSPEDFLDAvrrlqylkylapARREQAEELRADLAELAALRAELEAERAEL 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936834 484 QLSLQERESQLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHRDEIQRKFDALR 544
Cdd:COG4942 177 EALLAELEEERAALEALKAERQKLLARLE----KELAELAAELAELQQEAEELEALIARLE 233
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
193-901 |
1.21e-06 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 53.29 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 193 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 272
Cdd:pfam10174 69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 273 ERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 339
Cdd:pfam10174 143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 340 LADKESLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 418
Cdd:pfam10174 209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 419 QKFYletqagkleaqnrkleeqlekishQDHSDKsrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 498
Cdd:pfam10174 277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 499 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 571
Cdd:pfam10174 310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 572 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdLQTMEALKTTCtmleeqvldLEALNDELLE 651
Cdd:pfam10174 383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKS---LQTDSSNTDTA---------LTTLEEALSE 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 652 KERQWEAWRsvlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA 727
Cdd:pfam10174 448 KERIIERLK-----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKS 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 728 ---------ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAld 795
Cdd:pfam10174 522 leiaveqkkEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-- 591
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 796 radllKTERSDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELK 875
Cdd:pfam10174 592 -----ENEKNDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQ 654
|
730 740
....*....|....*....|....*.
gi 568936834 876 LALEkekarcaELEEALQKTRIELRS 901
Cdd:pfam10174 655 LQLE-------ELMGALEKTRQELDA 673
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
14-322 |
1.27e-06 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 53.20 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 14 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDkalqlLHDIREQSRK--LQEIKEQEYQ 91
Cdd:pfam17380 297 EQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERE-----LERIRQEERKreLERIRQEEIA 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 92 AQVEEMR-LMMNQLEEDLVSARRRSDLYESelRESRLAAEEFKRKANECQHKLMKVvshppRGDSGGTALDDLHKMQGHA 170
Cdd:pfam17380 372 MEISRMReLERLQMERQQKNERVRQELEAA--RKVKILEEERQRKIQQQKVEMEQI-----RAEQEEARQREVRRLEEER 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 171 G--LTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQniRQAKERAERELEKLHNR---EDSS 245
Cdd:pfam17380 445 AreMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILE--KELEERKQAMIEEERKRkllEKEM 522
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 246 EGIKKKLVEAEERRHSLENKVKRLETMERREnrlkddIQtksEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKE 322
Cdd:pfam17380 523 EERQKAIYEEERRREAEEERRKQQEMEERRR------IQ---EQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
352-753 |
1.63e-06 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 53.42 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 352 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 426
Cdd:COG3096 275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 427 AGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 506
Cdd:COG3096 353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 507 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 583
Cdd:COG3096 424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 584 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQAQLSAPDLQTMEALK-TTCTMLEEQVLDLEALNDELLEK 652
Cdd:COG3096 493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQlDAAEELEELLAELEAQLEELEEQ 572
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 653 ERQWEAWRSVLGDEKSQFECRVRELQrmlDTEKQSRArADQRITESRQVVELAVkEHKAEILALQQALKEQKLKAESLSD 732
Cdd:COG3096 573 AAEAVEQRSELRQQLEQLRARIKELA---ARAPAWLA-AQDALERLREQSGEAL-ADSQEVTAAMQQLLEREREATVERD 647
|
410 420
....*....|....*....|.
gi 568936834 733 KLndLEKKHAmLEMNARSLQQ 753
Cdd:COG3096 648 EL--AARKQA-LESQIERLSQ 665
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
73-929 |
1.72e-06 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 53.04 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 73 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQL---------EEDLVSARRRsdLYES-----ELRESRLAAEEF 132
Cdd:PRK04863 307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALrqqekieryQADLEELEER--LEEQnevveEADEQQEENEAR 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 133 KRKANECQHKLMKVVSHPPRgdsggtALDDLHKM-----QGHAGLTSAKDQ-GKPEVgEYSKLEKINAEQQLKIQELQEK 206
Cdd:PRK04863 385 AEAAEEEVDELKSQLADYQQ------ALDVQQTRaiqyqQAVQALERAKQLcGLPDL-TADNAEDWLEEFQAKEQEATEE 457
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 207 L----------EKAVKASTEATELLQNI----------RQAKErAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 266
Cdd:PRK04863 458 LlsleqklsvaQAAHSQFEQAYQLVRKIagevsrseawDVARE-LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE 536
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 267 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE-------------KIKVLD 333
Cdd:PRK04863 537 RLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRlaarapawlaaqdALARLR 616
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 334 NQIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMINAmdsKIRSLEQRIVELSEANklaaNSSLFTQRNMKAQ--EE 411
Cdd:PRK04863 617 EQSGEEFEDSQDVTEYMQQLLERERE----LTVERDELAA---RKQALDEEIERLSQPG----GSEDPRLNALAERfgGV 685
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 412 MISELR-----QQKFYLETQAGK---------LEAQNRKLEEQlekishQDHSDKSRLLELE-TRLREVSLEHEEQKLEL 476
Cdd:PRK04863 686 LLSEIYddvslEDAPYFSALYGParhaivvpdLSDAAEQLAGL------EDCPEDLYLIEGDpDSFDDSVFSVEELEKAV 759
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 477 KRQLTELQLslqeRESQLTALQA-ARAALESQLRQakteleettaeaeeeiqaLTAHRDEIQRKFDALRNSCTVITDLEE 555
Cdd:PRK04863 760 VVKIADRQW----RYSRFPEVPLfGRAAREKRIEQ------------------LRAEREELAERYATLSFDVQKLQRLHQ 817
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 556 QLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTCTML 635
Cdd:PRK04863 818 AFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGLSAL 877
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 636 EE-----QVLDLEALNDELLEKERQW----EAWRSVlgdekSQFECRVRELQRMLDTEKQSRARADQritesrqvVELAV 706
Cdd:PRK04863 878 NRllprlNLLADETLADRVEEIREQLdeaeEAKRFV-----QQHGNALAQLEPIVSVLQSDPEQFEQ--------LKQDY 944
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 707 KEHKAEILALQQ---ALKE--QKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDlQKN 781
Cdd:PRK04863 945 QQAQQTQRDAKQqafALTEvvQRRAHFSYEDAAEMLAKNSDLNE----KLRQRLEQAEQERTRAREQLRQAQAQLA-QYN 1019
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 782 HIFrltQGLQEALDRAdllKTERSDLEYQLENIQVLYshekvkmegtisqqtklidflqakmDQPAKKKkglfSRRKEDp 861
Cdd:PRK04863 1020 QVL---ASLKSSYDAK---RQMLQELKQELQDLGVPA-------------------------DSGAEER----ARARRD- 1063
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 862 alptqvplqynELKLALEKEKARCAELEEALQKTRIELRSA--REEAAHRKATDHPHPSTPATARQQIAM 929
Cdd:PRK04863 1064 -----------ELHARLSANRSRRNQLEKQLTFCEAEMDNLtkKLRKLERDYHEMREQVVNAKAGWCAVL 1122
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
367-639 |
1.95e-06 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 52.75 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 367 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 444
Cdd:PRK10929 43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 445 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 517
Cdd:PRK10929 115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 518 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 594
Cdd:PRK10929 194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 595 vdhLRREITE------REMQLTSQKQAQLSAPDLQTMEALKTtctmLEEQV 639
Cdd:PRK10929 266 ---INRELSQalnqqaQRMDLIASQQRQAASQTLQVRQALNT----LREQS 309
|
|
| C1_1 |
pfam00130 |
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ... |
971-1026 |
1.96e-06 |
|
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.
Pssm-ID: 395079 Cd Length: 53 Bit Score: 46.28 E-value: 1.96e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 971 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1026
Cdd:pfam00130 1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
9-418 |
1.97e-06 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 52.98 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 9 HRRVSEVEAVLSQKEVELKASETQRSLLEqDLATYITECSSLKRSLEQARMEVsQEDDKALQLLHDIREQSRKLQEIKEQ 88
Cdd:PRK01156 328 IKKLSVLQKDYNDYIKKKSRYDDLNNQIL-ELEGYEMDYNSYLKSIESLKKKI-EEYSKNIERMSAFISEILKIQEIDPD 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 89 EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR------------------LAAEEFKRKANECQHKLMKVVSHP 150
Cdd:PRK01156 406 AIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSrnmemlngqsvcpvcgttLGEEKSNHIINHYNEKKSRLEEKI 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 151 PRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAE---QQLKIQELQEKLEKAVKASTEATEL-LQNIRQ 226
Cdd:PRK01156 486 REIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADledIKIKINELKDKHDKYEEIKNRYKSLkLEDLDS 565
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 227 AKER-----AERELEKLHNREDSSEGIKKKLVEAEERRHSLE-----------NKVKRLETMERRENRLKDDIQTKSEQI 290
Cdd:PRK01156 566 KRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEigfpddksyidKSIREIENEANNLNNKYNEIQENKILI 645
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 291 QQMADKILELEE---KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDnQIKKDLADKESLENMMQRHEEEahekgkiLSEQ 367
Cdd:PRK01156 646 EKLRGKIDNYKKqiaEIDSIIPDLKEITSRINDIEDNLKKSRKALD-DAKANRARLESTIEILRTRINE-------LSDR 717
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 368 KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQ 418
Cdd:PRK01156 718 INDINETLESMKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTSLTRK 768
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
687-964 |
2.53e-06 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 51.75 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 687 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 764
Cdd:COG3883 10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 765 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 841
Cdd:COG3883 86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 842 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 921
Cdd:COG3883 141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568936834 922 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 964
Cdd:COG3883 221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
581-909 |
3.35e-06 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 52.15 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 581 ASGANDEIVQL-----RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALkttctMLEEQVLDLEALNDELLEKERQ 655
Cdd:pfam12128 204 AILEDDGVVPPksrlnRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNTLESA-----ELRLSHLHFGYKSDETLIASRQ 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 656 wEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 735
Cdd:pfam12128 279 -EERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELE 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 736 DLEKKHAMLEMNARSLQQKLETEREL-KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENI 814
Cdd:pfam12128 358 NLEERLKALTGKHQDVTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAG 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 815 QVLYSHEKVKMEGTISQQTKLIDFLQAkmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQK 894
Cdd:pfam12128 432 KLEFNEEEYRLKSRLGELKLRLNQATA------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQS 492
|
330
....*....|....*
gi 568936834 895 TRIELRSAREEAAHR 909
Cdd:pfam12128 493 ELRQARKRRDQASEA 507
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
4-510 |
3.46e-06 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 51.96 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 4 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQ 83
Cdd:PRK02224 280 EVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAE 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 84 EIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShpprgd 154
Cdd:PRK02224 360 ELREeaaeleselEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEA------ 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 155 SGGTALDDLHKMQghagltSAKDQGK-PEVG---EYSKLEKINAEQQLKIQELQEKLEKAvkasteatellqnirqakER 230
Cdd:PRK02224 434 TLRTARERVEEAE------ALLEAGKcPECGqpvEGSPHVETIEEDRERVEELEAELEDL------------------EE 489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 231 AERELEKLHNRedssegiKKKLVEAEERRHSLENKVKRLEtmERRENRlKDDIQTKSEQIQQMADKILELEEKHREAQVS 310
Cdd:PRK02224 490 EVEEVEERLER-------AEDLVEAEDRIERLEERREDLE--ELIAER-RETIEEKRERAEELRERAAELEAEAEEKREA 559
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 311 AQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENmmqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELSE 390
Cdd:PRK02224 560 AAEAE----EEAEEAREEVAELNSKLAELKERIESLER---------------IRTLLAAIADAEDEIERLREKREALAE 620
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 391 AN-----KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREv 465
Cdd:PRK02224 621 LNderreRLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELE-ELRE- 698
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 568936834 466 slEHEEqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQ 510
Cdd:PRK02224 699 --RREA--------LENRVEALEALYDEAEELESMYGDLRAELRQ 733
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
408-644 |
3.99e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.92 E-value: 3.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 408 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSL 487
Cdd:COG4942 17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALEAELAELEKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 488 QERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 567
Cdd:COG4942 93 AELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAEL 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 568 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQlsapdLQTMEALKTTCTMLEEQVLDLEA 644
Cdd:COG4942 163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAEL-----AAELAELQQEAEELEALIARLEA 234
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
3-778 |
4.44e-06 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 51.71 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 3 QEMTRLHRRVSEVEAVLS---QKEVELKA-SETQRSlleqDLATYITECSSLKRSLEqARMEvsQEDDKALQLLHDIREQ 78
Cdd:pfam01576 29 KELEKKHQQLCEEKNALQeqlQAETELCAeAEEMRA----RLAARKQELEEILHELE-SRLE--EEEERSQQLQNEKKKM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 79 SRKLQEIKEQ--EYQAQVEEMRL-------MMNQLEED-LVSARRRSDLY-ESELRESRLAaeEFKRKANECQHKLMKVV 147
Cdd:pfam01576 102 QQHIQDLEEQldEEEAARQKLQLekvtteaKIKKLEEDiLLLEDQNSKLSkERKLLEERIS--EFTSNLAEEEEKAKSLS 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 148 SHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvGEYSKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNI 224
Cdd:pfam01576 180 KLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLE-GESTDLQEQIAELQAQIAELRAQLakkEEELQAALARLEEETAQ 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 225 RQAKERAERELE-KLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenRLKDDIQTKSEQIQQMADKILELEEK 303
Cdd:pfam01576 259 KNNALKKIRELEaQISELQEDLESERAARNKAEKQRRDLGEELEALKT------ELEDTLDTTAAQQELRSKREQEVTEL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 304 HREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 383
Cdd:pfam01576 333 KKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 384 RIVEL-SEANKLAANSSLFTQRNMKAQEE------MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL 456
Cdd:pfam01576 413 QLQELqARLSESERQRAELAEKLSKLQSElesvssLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLR 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 457 ELE---TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA----- 528
Cdd:pfam01576 493 QLEderNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAydkle 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 529 ----------------------LTAHRDEIQRKFD-ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 585
Cdd:pfam01576 573 ktknrlqqelddllvdldhqrqLVSNLEKKQKKFDqMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAK 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 586 DEI----VQLRSEVDHLrreiteremqLTSQKQAQLSAPDL--------QTMEALKTTCTMLEEQvldLEALNDELLEKE 653
Cdd:pfam01576 653 EELertnKQLRAEMEDL----------VSSKDDVGKNVHELerskraleQQVEEMKTQLEELEDE---LQATEDAKLRLE 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 654 RQWEAW----------RSVLGDEK-SQFECRVRELQRMLDTEKQSRARAdqriTESRQVVELAVKEHKAEILALQQ---- 718
Cdd:pfam01576 720 VNMQALkaqferdlqaRDEQGEEKrRQLVKQVRELEAELEDERKQRAQA----VAAKKKLELDLKELEAQIDAANKgree 795
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 719 ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQRlleEQAKLQQQMDL 778
Cdd:pfam01576 796 AVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKNL---EAELLQLQEDL 849
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
1-628 |
4.96e-06 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 51.51 E-value: 4.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 77
Cdd:TIGR00618 384 LQQQKTTLTQKLQSLCKELDILQREQATIDTRtsaFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQE 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 78 QSRKLQEIKEQEYQAQVeemrlmmnqleedlvsarrrsdlyeSELRESRLAAEEFKR----KANECQHKLMKVVSHPPRG 153
Cdd:TIGR00618 464 SAQSLKEREQQLQTKEQ-------------------------IHLQETRKKAVVLARllelQEEPCPLCGSCIHPNPARQ 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 154 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER 233
Cdd:TIGR00618 519 DIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 234 ELEKLHNREDSSEGIKKKlvEAEERRHSLENKVKRLEtmerrenrlkddiqtkseqiQQMADKILELEEKHREaqvsaQH 313
Cdd:TIGR00618 599 LTEKLSEAEDMLACEQHA--LLRKLQPEQDLQDVRLH--------------------LQQCSQELALKLTALH-----AL 651
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 314 LEVHLKQKEQHYEEKIKVldnqikkdlaDKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEank 393
Cdd:TIGR00618 652 QLTLTQERVREHALSIRV----------LPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDR--- 718
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 394 laansslftqrnmkaqeemisELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQdhsdKSRLLELETRLREVSLEHEEQK 473
Cdd:TIGR00618 719 ---------------------EFNEIENASSSLGSDLAAREDALNQSLKELMHQ----ARTVLKARTEAHFNNNEEVTAA 773
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 474 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQaltAHRDEIQRKFDALRNSCTVITDL 553
Cdd:TIGR00618 774 LQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLV---QEEEQFLSRLEEKSATLGEITHQ 850
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 554 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV----------DHLRREITEREMQLTSQKQAQLSAPDLQ 623
Cdd:TIGR00618 851 LLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDAlikflheitlYANVRLANQSEGRFHGRYADSHVNARKY 930
|
....*
gi 568936834 624 TMEAL 628
Cdd:TIGR00618 931 QGLAL 935
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
277-815 |
6.25e-06 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 51.19 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 277 NRLKDDiqtKSEQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 356
Cdd:PRK02224 179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 357 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 436
Cdd:PRK02224 250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 516
Cdd:PRK02224 295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 517 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 594
Cdd:PRK02224 367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 595 VDHLRreitEREMQLTSqkqaqlsapDLQTMEalkttcTMLEEqvldlealNDELLEKERQWEAWRSVLG----DEKSQF 670
Cdd:PRK02224 421 RDELR----EREAELEA---------TLRTAR------ERVEE--------AEALLEAGKCPECGQPVEGsphvETIEED 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 671 ECRVRELQRMLDTEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEM 746
Cdd:PRK02224 474 RERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEA 551
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 747 NARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 815
Cdd:PRK02224 552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
527-756 |
6.44e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.53 E-value: 6.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 527 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITERE 606
Cdd:COG4942 16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAAL---ARRIRALEQELAALEAELAELE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 607 MQLtSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQ 686
Cdd:COG4942 90 KEI-AELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAA 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 687 SRaradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 756
Cdd:COG4942 165 LR----AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
186-620 |
7.77e-06 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 50.89 E-value: 7.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 186 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHS---- 261
Cdd:pfam05557 6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREqael 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 262 LENKVKRLETMERRENRlKDDIQTKSEQIQ------------QMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKI 329
Cdd:pfam05557 78 NRLKKKYLEALNKKLNE-KESQLADAREVIsclknelselrrQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 330 KVLDNQiKKDLADKE----SLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ-- 403
Cdd:pfam05557 156 QNLEKQ-QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEev 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 404 --------RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQDHSDKSRLLELETRLREVS 466
Cdd:pfam05557 231 edlkrkleREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSARQLE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 467 ---LEHEEQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQ 527
Cdd:pfam05557 311 karRELEQELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQ 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 528 ALTAHRDEIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREIT 603
Cdd:pfam05557 391 KMQAHNEEMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKN 465
|
490
....*....|....*..
gi 568936834 604 EREMQLTSQKQAQLSAP 620
Cdd:pfam05557 466 ELEMELERRCLQGDYDP 482
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
581-852 |
8.66e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.15 E-value: 8.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 581 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDlqtmealkttctmleeqvlDLEALNDELLEKERQweawr 660
Cdd:COG4942 15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-------------------QLAALERRIAALARR----- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 661 svlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 740
Cdd:COG4942 71 -------------IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRR 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 741 HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSH 820
Cdd:COG4942 138 LQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAA 213
|
250 260 270
....*....|....*....|....*....|..
gi 568936834 821 EKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG 852
Cdd:COG4942 214 ELAELQQEAEELEALIARLEAEAAAAAERTPA 245
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
218-563 |
8.72e-06 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 50.07 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 218 TELLQNIRQAKERAErELEKLHNRE-DSSEGIKKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSEQIQQMAD 295
Cdd:pfam19220 37 EAILRELPQAKSRLL-ELEALLAQErAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 296 KILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMD 375
Cdd:pfam19220 116 KTAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 376 SKIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishq 447
Cdd:pfam19220 195 RRLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 448 dhsdksrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQ 527
Cdd:pfam19220 264 -------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTK 332
|
330 340 350
....*....|....*....|....*....|....*.
gi 568936834 528 ALTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 563
Cdd:pfam19220 333 ALAAKD-------AALERAEERIASLSDRIAELTKR 361
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
550-781 |
9.78e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.76 E-value: 9.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 550 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREI--TEREMQLTSQKQAQLSAPdlqtMEA 627
Cdd:COG4942 22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIraLEQELAALEAELAELEKE----IAE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 628 LKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVK 707
Cdd:COG4942 95 LRAE---LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRA 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936834 708 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 781
Cdd:COG4942 168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
187-542 |
1.28e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 49.52 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 187 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEERRHSLENKV 266
Cdd:COG4372 27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 267 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESL 346
Cdd:COG4372 94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 347 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 426
Cdd:COG4372 170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 427 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 506
Cdd:COG4372 250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 568936834 507 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 542
Cdd:COG4372 330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1533-1624 |
1.32e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 50.07 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1533 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1596
Cdd:PTZ00449 527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606
|
90 100 110
....*....|....*....|....*....|
gi 568936834 1597 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1624
Cdd:PTZ00449 607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
528-906 |
1.48e-05 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 50.04 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 528 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 607
Cdd:PRK02224 188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 608 QLTSqkqaqlsapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS 687
Cdd:PRK02224 266 TIAE---------TEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 688 -----------RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 756
Cdd:PRK02224 337 aqahneeaeslREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLE 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 757 TERELKQRLLEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshE 821
Cdd:PRK02224 416 ELREERDELREREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----E 490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 822 KVKMEGTISQQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRS 901
Cdd:PRK02224 491 VEEVEERLERAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAE 562
|
....*
gi 568936834 902 AREEA 906
Cdd:PRK02224 563 AEEEA 567
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
471-742 |
1.69e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.99 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 471 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 550
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 551 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEivQLRSevdHLRREITEREMQLTSQKQAQLSAPDLQTMEALKT 630
Cdd:COG4942 73 -ALEQELAALEAELAELEKEIAELRAELEAQKEELAE--LLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 631 TctmLEEQVLDLEALNDELLEKERQWEAWRsvlgdeksqfecrvRELQRMLDTEKQSRARADQRITESRQVvelaVKEHK 710
Cdd:COG4942 147 A---RREQAEELRADLAELAALRAELEAER--------------AELEALLAELEEERAALEALKAERQKL----LARLE 205
|
250 260 270
....*....|....*....|....*....|..
gi 568936834 711 AEILALQQALKEQKLKAESLSDKLNDLEKKHA 742
Cdd:COG4942 206 KELAELAAELAELQQEAEELEALIARLEAEAA 237
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
367-570 |
1.83e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.99 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 367 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 446
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 447 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 519
Cdd:COG4942 98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 520 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 570
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
|
|
| COG5281 |
COG5281 |
Phage-related minor tail protein [Mobilome: prophages, transposons]; |
361-797 |
1.97e-05 |
|
Phage-related minor tail protein [Mobilome: prophages, transposons];
Pssm-ID: 444092 [Multi-domain] Cd Length: 603 Bit Score: 49.22 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 361 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 440
Cdd:COG5281 3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 441 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 520
Cdd:COG5281 83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 521 EAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 600
Cdd:COG5281 160 AAAAAAAAAAAAAAAAAAALAAASAA-----AAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 601 EITEREMQLTSQKQAQLSapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRM 680
Cdd:COG5281 235 AALAAASAAAQALAALAA--AAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 681 LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERE 760
Cdd:COG5281 310 AAQLAAAAAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAG 384
|
410 420 430
....*....|....*....|....*....|....*..
gi 568936834 761 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 797
Cdd:COG5281 385 AKAALAEYADSATNVAAQVAQAATSAFSGLTDALAGA 421
|
|
| C1_SpBZZ1-like |
cd20824 |
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ... |
975-1025 |
2.03e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410374 Cd Length: 53 Bit Score: 43.46 E-value: 2.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 975 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1025
Cdd:cd20824 1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
200-819 |
2.32e-05 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 49.31 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 200 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKKlVEAEERRHSLENKVKRLETMERRENRL 279
Cdd:COG5022 819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKR-FSLLKKETIYLQSAQRVELAERQLQEL 887
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 280 KDDIqtksEQIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKESLENMMQRHEEE 356
Cdd:COG5022 888 KIDV----KSISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 357 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 434
Cdd:COG5022 964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 435 RKLEE--QLEKISHQDHSDKSRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 512
Cdd:COG5022 1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 513 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 592
Cdd:COG5022 1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 593 SEVDHLRREITEREMQLTSQKQAQLSApdlqtmeALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFE 671
Cdd:COG5022 1160 FWEANLEALPSPPPFAALSEKRLYQSA-------LYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISE 1229
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 672 CRVRELQRMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----L 744
Cdd:COG5022 1230 GWVPTEYSTSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaL 1301
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 745 EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 819
Cdd:COG5022 1302 RTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
2-259 |
2.46e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.61 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 81
Cdd:COG4942 26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 82 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvvshpprgdsggtal 160
Cdd:COG4942 106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE---------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 161 ddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 240
Cdd:COG4942 162 -----------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220
|
250
....*....|....*....
gi 568936834 241 REDSSEGIKKKLVEAEERR 259
Cdd:COG4942 221 EAEELEALIARLEAEAAAA 239
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
275-791 |
2.84e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 49.19 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 275 RENRLKD---DIQTKSEQIQQMADKILELEEKHREA-QVSAQHLEVHLkqkEQHYEEKIKVLD---NQIKKDLADKESLE 347
Cdd:PRK04863 784 REKRIEQlraEREELAERYATLSFDVQKLQRLHQAFsRFIGSHLAVAF---EADPEAELRQLNrrrVELERALADHESQE 860
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 348 nmmQRHEEEAhekgKILSEQKAMINAMDSKIR-----SLEQRIVELSEANKLAANSSLFTQRNMKA-------------Q 409
Cdd:PRK04863 861 ---QQQRSQL----EQAKEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAlaqlepivsvlqsD 933
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 410 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTELQL 485
Cdd:PRK04863 934 PEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQA 1013
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 486 SLQERESQLTALQAARAALESQLRQAKTELEET-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdn 564
Cdd:PRK04863 1014 QLAQYNQVLASLKSSYDAKRQMLQELKQELQDLgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE-- 1087
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 565 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTMeALKttctmleeqvlDL 642
Cdd:PRK04863 1088 AEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNgvERRLHRRELAYLSADELRSM-SDK-----------AL 1155
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 643 EAL------NDELLEKERQWEAWRSVlgDEKSQFECRVRELQRmldtekqSRARADqrITESRQVVElavkehkaeilAL 716
Cdd:PRK04863 1156 GALrlavadNEHLRDVLRLSEDPKRP--ERKVQFYIAVYQHLR-------ERIRQD--IIRTDDPVE-----------AI 1213
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 717 QQalkeqklkaesLSDKLNDLEKkhamlEMNARslQQKLETERElkqrllEEQAKLQQQMDLQKNHIFRLTQGLQ 791
Cdd:PRK04863 1214 EQ-----------MEIELSRLTE-----ELTSR--EQKLAISSE------SVANIIRKTIQREQNRIRMLNQGLQ 1264
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
318-511 |
3.15e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.29 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 318 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSEANK 393
Cdd:COG3883 28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEErreeLGERARALYRSGGSVSYLDV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 394 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 465
Cdd:COG3883 108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568936834 466 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 511
Cdd:COG3883 174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
307-531 |
3.41e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.29 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 307 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 386
Cdd:COG3883 3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 387 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 461
Cdd:COG3883 83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 462 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 531
Cdd:COG3883 152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
203-419 |
3.58e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 48.47 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 203 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS-------------EGIKKKLVEAEERRHSLENKVKRL 269
Cdd:COG3206 166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVdlseeaklllqqlSELESQLAEARAELAEAEARLAAL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 270 ETMERRENRLKDDIQTkSEQIQQMADKILELEEkhREAQVSAQHLEVHlkqkeqhyeEKIKVLDNQIkkdladkESLENM 349
Cdd:COG3206 246 RAQLGSGPDALPELLQ-SPVIQQLRAQLAELEA--ELAELSARYTPNH---------PDVIALRAQI-------AALRAQ 306
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936834 350 MQRheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFT--QRNMKAQEEMISELRQQ 419
Cdd:COG3206 307 LQQ------EAQRILASLEAELEALQAREASLQAQLAQLeARLAELPELEAELRrlEREVEVARELYESLLQR 373
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
462-788 |
3.90e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 48.75 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 462 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 538
Cdd:PRK11281 48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 539 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQK-- 613
Cdd:PRK11281 116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLkg 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 614 ----QAQLSAPDLQTMEAlkttctmleEQVLdLEALNDEllekERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrA 689
Cdd:PRK11281 182 gkvgGKALRPSQRVLLQA---------EQAL-LNAQNDL----QRKSLEGNTQLQD--------LLQKQRDYLTARI--Q 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 690 RADQRITESRQVV---ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLL 766
Cdd:PRK11281 238 RLEHQLQLLQEAInskRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLL 295
|
330 340
....*....|....*....|....*
gi 568936834 767 EEQAKLQQ--QMDLQ-KNHIFRLTQ 788
Cdd:PRK11281 296 KATEKLNTltQQNLRvKNWLDRLTQ 320
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
510-788 |
4.44e-05 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 47.50 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 510 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANdEIV 589
Cdd:pfam15905 66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVN-ELL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 590 QLRSEVDHLRREITEREMQLT------SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrsvl 663
Cdd:pfam15905 142 KAKFSEDGTQKKMSSLSMELMklrnklEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKI------ 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 664 gDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAM 743
Cdd:pfam15905 216 -EEKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQIKDLNEKCKL 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 568936834 744 LEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 788
Cdd:pfam15905 287 LE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
373-542 |
5.06e-05 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 46.46 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 373 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 452
Cdd:COG1579 14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 453 SRLLELETRLREVS-------LEHEEQKLELKRQLTE-LQLSLQER----ESQLTALQAARAALESQLRQAKTELEETTA 520
Cdd:COG1579 73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEdEILELMERieelEEELAELEAELAELEAELEEKKAELDEELA 152
|
170 180
....*....|....*....|..
gi 568936834 521 EAEEEIQALTAHRDEIQRKFDA 542
Cdd:COG1579 153 ELEAELEELEAEREELAAKIPP 174
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
262-443 |
5.36e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.52 E-value: 5.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 262 LENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 337
Cdd:COG3883 18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 338 -----------------KDLADKESLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 400
Cdd:COG3883 98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 568936834 401 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 443
Cdd:COG3883 172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
|
|
| C1_CeDKF1-like_rpt2 |
cd20798 |
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ... |
975-1026 |
5.95e-05 |
|
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410348 Cd Length: 54 Bit Score: 42.10 E-value: 5.95e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568936834 975 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 1026
Cdd:cd20798 1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
535-844 |
6.15e-05 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 47.64 E-value: 6.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 535 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITEREMQLT 610
Cdd:COG5185 233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTKSID 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 611 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 688
Cdd:COG5185 307 IKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 689 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 768
Cdd:COG5185 387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 769 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 844
Cdd:COG5185 458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
279-688 |
6.59e-05 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 47.87 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 279 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESLEnmmqrheeEAH 358
Cdd:PRK10246 424 LRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQE 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 359 EKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrk 436
Cdd:PRK10246 488 ARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA---- 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 437 LEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQ 493
Cdd:PRK10246 556 LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQ 631
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 494 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR------KFDALRNSCTVITDLEEQLNQLTEDNAEL 567
Cdd:PRK10246 632 IIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSwqqrqnELTALQNRIQQLTPLLETLPQSDDLPHSE 711
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 568 NnqnfylSKQLDEASGANDEIVQLRSEVDHLRREITErEMQLTSQKQAQLSApdlqtmeALKTTCtmLEEQVLDLEALND 647
Cdd:PRK10246 712 E------TVALDNWRQVHEQCLSLHSQLQTLQQQDVL-EAQRLQKAQAQFDT-------ALQASV--FDDQQAFLAALLD 775
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 568936834 648 EllEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR 688
Cdd:PRK10246 776 E--ETLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHR 814
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
174-376 |
6.77e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.13 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 174 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 253
Cdd:COG3883 13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 254 EAEERR-------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQ 320
Cdd:COG3883 93 RALYRSggsvsyldvllgsESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 321 KEQHYEEK---IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 376
Cdd:COG3883 173 LEAQQAEQealLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
|
|
| PH_ROCK |
cd01242 |
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ... |
1058-1103 |
6.82e-05 |
|
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269948 Cd Length: 110 Bit Score: 43.88 E-value: 6.82e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 568936834 1058 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1103
Cdd:cd01242 2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
|
|
| C1_aPKC |
cd20794 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
977-1025 |
7.77e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410344 Cd Length: 55 Bit Score: 41.87 E-value: 7.77e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568936834 977 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1025
Cdd:cd20794 9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
|
|
| PH_MRCK |
cd01243 |
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ... |
1060-1175 |
8.37e-05 |
|
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269949 Cd Length: 135 Bit Score: 44.21 E-value: 8.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 1060 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1136
Cdd:cd01243 15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 568936834 1137 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1175
Cdd:cd01243 91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
|
|
| C1_Munc13-1 |
cd20858 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ... |
974-1024 |
8.48e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410408 Cd Length: 60 Bit Score: 42.00 E-value: 8.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 974 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20858 6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
414-900 |
8.51e-05 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 47.41 E-value: 8.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 414 SELRQQKFYLETQAGKLEAQNRKLEE---QLEKISH------QDHSDKSR-----------LLELETRLREVSLEHEEQK 473
Cdd:pfam05483 99 AELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLkleeeiQENKDLIKennatrhlcnlLKETCARSAEKTKKYEYER 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 474 LELKRQLTELQLSLqerESQLTALQAARAalesQLRQAKTELEETTAEAEEEIQALtahRDEIQRKFDALRNSCTVItdl 553
Cdd:pfam05483 179 EETRQVYMDLNNNI---EKMILAFEELRV----QAENARLEMHFKLKEDHEKIQHL---EEEYKKEINDKEKQVSLL--- 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 554 eeqLNQLTEDNAELNNQNFYLSK------QLDEASGANDE-IVQLRSEVDHLRREITEREMQLTSQKQAQLS-APDLQTm 625
Cdd:pfam05483 246 ---LIQITEKENKMKDLTFLLEEsrdkanQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQRSMSTQKAlEEDLQI- 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 626 eALKTTCTMLEEQVLDLEALNDE-------LLEKERQWEAWRSVLGDEKSQFECRVRELqRMLDTEKQSRARADQRITES 698
Cdd:pfam05483 322 -ATKTICQLTEEKEAQMEELNKAkaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKF 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 699 RQVVELAVKEHKaEILALQQALKEQKLKAESLSDKLNDLEKKHAML----EMNARSLQQKLETERELKQRLLEEQAKLQQ 774
Cdd:pfam05483 400 KNNKEVELEELK-KILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 775 QMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtklIDFLQAKMDQpakkkkglf 854
Cdd:pfam05483 479 ELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQ----IENLEEKEMN--------- 545
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 568936834 855 sRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 900
Cdd:pfam05483 546 -LRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
461-797 |
1.01e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 47.26 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 461 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 540
Cdd:PRK04863 283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 541 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI------VQLRSEVDHLRREITEREMQLTSQKQ 614
Cdd:PRK04863 355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELksqladYQQALDVQQTRAIQYQQAVQALERAK 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 615 AQLSAPDLqTMEALKTtctMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--AD 692
Cdd:PRK04863 428 QLCGLPDL-TADNAED---WLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvAR 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 693 QRITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 770
Cdd:PRK04863 500 ELLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVS 575
|
330 340
....*....|....*....|....*..
gi 568936834 771 KLQQQMDLQKNHIFRLTQGLQEALDRA 797
Cdd:PRK04863 576 EARERRMALRQQLEQLQARIQRLAARA 602
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
194-498 |
1.05e-04 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 46.34 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 194 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 272
Cdd:pfam15905 52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 273 ERRENRLKDDIQTK-SEQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKESLENMMQ 351
Cdd:pfam15905 131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 352 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 431
Cdd:pfam15905 196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936834 432 AQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 498
Cdd:pfam15905 261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
674-928 |
1.07e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 47.22 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 674 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 745
Cdd:COG4913 213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 746 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 824
Cdd:COG4913 290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 825 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 904
Cdd:COG4913 358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426
|
250 260
....*....|....*....|....
gi 568936834 905 EAAHRKATDHPHPSTPATARQQIA 928
Cdd:COG4913 427 EIASLERRKSNIPARLLALRDALA 450
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
219-557 |
1.07e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 46.81 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 219 ELLQNIRQAKERAERELEKLHnrEDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSEQIQQMADKIL 298
Cdd:pfam07888 30 ELLQNRLEECLQERAELLQAQ--EAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 299 ELEEKHREAQVS----AQHLEVHLKQKEQH------YEEKIKVLD---------------------NQIKKDLADKESLE 347
Cdd:pfam07888 98 ELEEKYKELSASseelSEEKDALLAQRAAHearireLEEDIKTLTqrvleretelermkerakkagAQRKEEEAERKQLQ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 348 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQA 427
Cdd:pfam07888 178 AKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALLEELRSLQERLNASE 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 428 GKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 501
Cdd:pfam07888 251 RKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAEL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 502 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 557
Cdd:pfam07888 328 QRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
|
|
| C1_nPKC_theta-like_rpt2 |
cd20837 |
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ... |
976-1024 |
1.21e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410387 Cd Length: 50 Bit Score: 41.27 E-value: 1.21e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 976 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20837 1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
204-498 |
1.26e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 46.66 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 204 QEKLEKAVKasteatellQNIRQAKERAERELEKlhnredssegiKKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 283
Cdd:pfam17380 290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 284 QTKSEQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHEKGK 362
Cdd:pfam17380 347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 363 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 442
Cdd:pfam17380 406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 443 KISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 498
Cdd:pfam17380 464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
692-849 |
1.27e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 45.30 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 692 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 767
Cdd:COG1579 16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 768 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 846
Cdd:COG1579 89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
|
...
gi 568936834 847 AKK 849
Cdd:COG1579 169 AAK 171
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
598-735 |
1.30e-04 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 46.11 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 598 LRREITEREMQLtSQKQAQLSapDLQTMEAL-KTTCTMLEEQVLDLEA-LNDELLEKERqWEAWRSVLGDEKSQFECRVR 675
Cdd:PRK09039 44 LSREISGKDSAL-DRLNSQIA--ELADLLSLeRQGNQDLQDSVANLRAsLSAAEAERSR-LQALLAELAGAGAAAEGRAG 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936834 676 ELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 735
Cdd:PRK09039 120 ELAQELDSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
193-865 |
1.39e-04 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 46.97 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 193 NAEQQLKIQELQEKLEKAVKAsteatelLQNIrqakeraERELEKLH--NREDSSEGIKKKLVEAEERRHSLENKV--KR 268
Cdd:TIGR01612 691 NTEDKAKLDDLKSKIDKEYDK-------IQNM-------ETATVELHlsNIENKKNELLDIIVEIKKHIHGEINKDlnKI 756
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 269 LETMERRENRLKDDIQTKS---EQIQQMADKILELEEKHREaQVSAQHL-EVHLKQ---KEQHYEEKIKVLDNQIKKDLA 341
Cdd:TIGR01612 757 LEDFKNKEKELSNKINDYAkekDELNKYKSKISEIKNHYND-QINIDNIkDEDAKQnydKSKEYIKTISIKEDEIFKIIN 835
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 342 D----KESLENMMQRHEE-EAHEKGKILSEQKA---MINAMDSKIRSLEQRIVElseaNKLAANSSLFTQRNMKAQEEM- 412
Cdd:TIGR01612 836 EmkfmKDDFLNKVDKFINfENNCKEKIDSEHEQfaeLTNKIKAEISDDKLNDYE----KKFNDSKSLINEINKSIEEEYq 911
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 413 -ISELRQQKFYLETQAGKLEA----------QNRKLEEQLEKISHQDHSDKSRLLELETRLrevslehEEQKLELKRQLT 481
Cdd:TIGR01612 912 nINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKNIDTIKESNLIEKSYKDKFDNTL-------IDKINELDKAFK 984
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 482 ELqlSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEiqaltAHRDEIQRKFDALRNSC-------TVITDLE 554
Cdd:TIGR01612 985 DA--SLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEKEK-----ATNDIEQKIEDANKNIPnieiaihTSIYNII 1057
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 555 EQLNQLTEDNAELNNQNFYLS-----------------------------KQLDEASGANDEIVQLRSEVDHLRREITEr 605
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNKEILEEaeinitnfneikeklkhynfddfgkeeniKYADEINKIKDDIKNLDQKIDHHIKALEE- 1136
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 606 emqltSQKQAQlsapdlQTMEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcrvrELQRMLDteK 685
Cdd:TIGR01612 1137 -----IKKKSE------NYIDEIKAQINDLED-VADKAISNDDPEEIEKKIENIVTKIDKKKNIYD----EIKKLLN--E 1198
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 686 QSRARADQRITESRQVVELAVKEHKAEiLALQQaLKEQKLKAE----SLSDKLNDLE--KKHAMLEMNARSLQQKLETER 759
Cdd:TIGR01612 1199 IAEIEKDKTSLEEVKGINLSYGKNLGK-LFLEK-IDEEKKKSEhmikAMEAYIEDLDeiKEKSPEIENEMGIEMDIKAEM 1276
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 760 EL--------KQRLLEEQAKLQQQMDLqKNHIFRLTQGLQEALDRADLLKT----------ERSDLEYQLENIQVLYSHE 821
Cdd:TIGR01612 1277 ETfnishdddKDHHIISKKHDENISDI-REKSLKIIEDFSEESDINDIKKElqknlldaqkHNSDINLYLNEIANIYNIL 1355
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 568936834 822 KV----KMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 865
Cdd:TIGR01612 1356 KLnkikKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLEE 1403
|
|
| C1_aPKC_iota |
cd21094 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
976-1027 |
1.41e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410447 Cd Length: 55 Bit Score: 41.14 E-value: 1.41e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568936834 976 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 1027
Cdd:cd21094 3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
49-740 |
1.50e-04 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 46.87 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 49 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 126
Cdd:COG3096 289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 127 LAAEEFKRKANECQHKLMKVVSHPPRGDSG----GTALDDLHK-----MQGHAGLTSAKDQ-GKPE-----VGEYskLEK 191
Cdd:COG3096 368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyQQALDVQQTraiqyQQAVQALEKARALcGLPDltpenAEDY--LAA 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 192 INAEQQL---KIQELQEKLEKAVKASTE---ATELLQNIRQAKERAE---------RELEKLHNREDSSEGIKKKLVEAE 256
Cdd:COG3096 446 FRAKEQQateEVLELEQKLSVADAARRQfekAYELVCKIAGEVERSQawqtarellRRYRSQQALAQRLQQLRAQLAELE 525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 257 ERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE--------- 327
Cdd:COG3096 526 QRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKElaarapawl 605
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 328 ----KIKVLDNQIKKDLADKESLENMMQ---RHEEEAHEKGKILSEQKAminAMDSKIRSLEQ-------RIVELSE--- 390
Cdd:COG3096 606 aaqdALERLREQSGEALADSQEVTAAMQqllEREREATVERDELAARKQ---ALESQIERLSQpggaedpRLLALAErlg 682
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 391 --------------------------------------ANKLAA-------------NSSLFTQRNMKAQEE-----MIS 414
Cdd:COG3096 683 gvllseiyddvtledapyfsalygparhaivvpdlsavKEQLAGledcpedlyliegDPDSFDDSVFDAEELedavvVKL 762
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 415 ELRQQKFYL------------ETQAGKLEAQNRKLEEQLEKIS------HQDHSDKSRLLEL----------ETRLREVS 466
Cdd:COG3096 763 SDRQWRYSRfpevplfgraarEKRLEELRAERDELAEQYAKASfdvqklQRLHQAFSQFVGGhlavafapdpEAELAALR 842
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 467 leheEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNS 546
Cdd:COG3096 843 ----QRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQA---NLLADETLADRLEELREELDAAQEAQAFIQQH 915
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 547 CTVITDLEEQLNQLTEDNAelnnQNFYLSKQLDEASganDEIVQLRSEVDHLrREITEREMQLTSQKQAQLSAPDLQTME 626
Cdd:COG3096 916 GKALAQLEPLVAVLQSDPE----QFEQLQADYLQAK---EQQRRLKQQIFAL-SEVVQRRPHFSYEDAVGLLGENSDLNE 987
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 627 ALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVREL----QRMLDTEKQSRARADQRITESRQVV 702
Cdd:COG3096 988 KLRARLEQAEEA---RREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLqeleQELEELGVQADAEAEERARIRRDEL 1064
|
810 820 830
....*....|....*....|....*....|....*...
gi 568936834 703 ELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 740
Cdd:COG3096 1065 HEELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
409-810 |
1.68e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 46.27 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 409 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEEQKLELKRQLTELQLSLQ 488
Cdd:pfam17380 280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIRQEER 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 489 ERESQltalqaaraalesQLRQakteleettaeaeeeiqaltahrDEIQRKFDALRnsctvitdleeqlnQLTEDNAELN 568
Cdd:pfam17380 359 KRELE-------------RIRQ-----------------------EEIAMEISRMR--------------ELERLQMERQ 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 569 NQNFYLSKQLDEASGandeiVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEalkttctmlEEQVLDLEALNDE 648
Cdd:pfam17380 389 QKNERVRQELEAARK-----VKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE---------EERAREMERVRLE 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 649 LLEKERQWEAWRsvlgdeksQFECRVRELQRMLDTEKQSRARADQritESRQVVELAVKEHKaeilalqQALKEQKLKAE 728
Cdd:pfam17380 455 EQERQQQVERLR--------QQEEERKRKKLELEKEKRDRKRAEE---QRRKILEKELEERK-------QAMIEEERKRK 516
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 729 SLSDKLNdlEKKHAMLEMNARslqQKLETERElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 808
Cdd:pfam17380 517 LLEKEME--ERQKAIYEEERR---REAEEERR-KQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
|
..
gi 568936834 809 YQ 810
Cdd:pfam17380 591 YE 592
|
|
| C1_MTMR-like |
cd20828 |
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ... |
972-1025 |
1.97e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410378 Cd Length: 57 Bit Score: 40.89 E-value: 1.97e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 972 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1025
Cdd:cd20828 2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
185-512 |
2.03e-04 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 46.10 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEERRHsLEN 264
Cdd:COG5185 254 KLEKLVEQNTD--LRLEKLGENAESSKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEE 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 265 KVKRLETMerrenrlkddIQTKSEQIQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 344
Cdd:COG5185 330 SKRETETG----------IQNLTAEIEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQ 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 345 SLENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 424
Cdd:COG5185 399 NQRGYAQEILATLEDTLKAADRQ---IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 425 tqagkLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAAL 504
Cdd:COG5185 476 -----VRSKKEDLNEELTQI-------ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILA 540
|
....*...
gi 568936834 505 ESQLRQAK 512
Cdd:COG5185 541 LENLIPAS 548
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
584-777 |
2.11e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.59 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 584 ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL 663
Cdd:COG3883 14 ADPQIQAKQKELSELQAELEAAQAEL-DALQAELE----ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 664 GDeksqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKL 734
Cdd:COG3883 89 GE-------RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 568936834 735 NDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 777
Cdd:COG3883 157 AELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
224-377 |
2.15e-04 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 45.97 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 224 IRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKIL-ELEE 302
Cdd:PRK00409 504 IEEAKKLIGEDKEKL---NELIASLEELERELEQKAEEAEALLKEAE-------KLKEELEEKKEKLQEEEDKLLeEAEK 573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 303 KHREA-------------QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQK 368
Cdd:PRK00409 574 EAQQAikeakkeadeiikELRQLQKGGYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQK 651
|
....*....
gi 568936834 369 AMINAMDSK 377
Cdd:PRK00409 652 GEVLSIPDD 660
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
44-393 |
2.26e-04 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 46.20 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 44 ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSrKLQEIKEQEYQA----QVEEMRLMMNQLEEDLVSARRRSDLYE 119
Cdd:TIGR01612 1364 IDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIESTlddkDIDECIKKIKELKNHILSEESNIDTYF 1442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 120 SELRESR----LAAEEFKRKANECQHkLMKVvshppRGDSGGTALD-DLHKMQGHagltsaKDQGKPEVGEYSKlekiNA 194
Cdd:TIGR01612 1443 KNADENNenvlLLFKNIEMADNKSQH-ILKI-----KKDNATNDHDfNINELKEH------IDKSKGCKDEADK----NA 1506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 195 EQQLKIQELQEKLEKAVKA---STEATELLQNIRQAKERAE---RELEKLHNRED-SSEGIKKKLVEAEERRHSLENKVK 267
Cdd:TIGR01612 1507 KAIEKNKELFEQYKKDVTEllnKYSALAIKNKFAKTKKDSEiiiKEIKDAHKKFIlEAEKSEQKIKEIKKEKFRIEDDAA 1586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 268 RletmERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsaqhlevhLKQKEQhYEEKIKVLD-NQIKKDLADKESL 346
Cdd:TIGR01612 1587 K----NDKSNKAAIDIQLSLENFENKFLKISDIKKKINDC----------LKETES-IEKKISSFSiDSQDTELKENGDN 1651
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936834 347 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---------------QRIVELSEANK 393
Cdd:TIGR01612 1652 LNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEidvdqhkknyeigiiEKIKEIAIANK 1713
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
185-362 |
2.33e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 45.53 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR----- 259
Cdd:COG4942 35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 260 --------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 325
Cdd:COG4942 115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 568936834 326 EEKIKVLD----------NQIKKDLADKESLENMMQRHEEEAHEKGK 362
Cdd:COG4942 195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
573-817 |
2.38e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.78 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 573 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEAlndELL 650
Cdd:COG3206 161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfRQKNGLVDLSEEAKLLLQQL-SELESQLAEARA---ELA 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 651 EKERQWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQK 724
Cdd:COG3206 237 EAEARLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEA 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 725 LKAeslsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTER 804
Cdd:COG3206 312 QRI------LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAE 381
|
250
....*....|...
gi 568936834 805 SdleYQLENIQVL 817
Cdd:COG3206 382 A---LTVGNVRVI 391
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
7-605 |
2.51e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 46.06 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 7 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 85
Cdd:COG4913 285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 86 KE--QEYQAQVEEMRLMMNQLEEDLVSARRRS----DLYESELRESRLAAEEFKRKANECQHKLMKVVSHpprgdsggta 159
Cdd:COG4913 358 ERrrARLEALLAALGLPLPASAEEFAALRAEAaallEALEEELEALEEALAEAEAALRDLRRELRELEAE---------- 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 160 LDDLHKMQG--HAGLTSAKDQ-----GKPE-----VGEYsklekinaeqqLKIQELQEKLEKAVKA--STEATELLqnIR 225
Cdd:COG4913 428 IASLERRKSniPARLLALRDAlaealGLDEaelpfVGEL-----------IEVRPEEERWRGAIERvlGGFALTLL--VP 494
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 226 QAKERAERE-LEKLHNRED-SSEGIKKKLVEAEERR---HSLENKVKRLET---------MERRENRLK-DDIQ------ 284
Cdd:COG4913 495 PEHYAAALRwVNRLHLRGRlVYERVRTGLPDPERPRldpDSLAGKLDFKPHpfrawleaeLGRRFDYVCvDSPEelrrhp 574
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 285 ---TKSEQIQQMAdkilELEEKHREAQVSAQHLevhL----KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 357
Cdd:COG4913 575 raiTRAGQVKGNG----TRHEKDDRRRIRSRYV---LgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERR 647
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 358 HEKGKILSEQKAMINAM--DSKIRSLEQRIVELSEAN-KLAAnsslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN 434
Cdd:COG4913 648 EALQRLAEYSWDEIDVAsaEREIAELEAELERLDASSdDLAA-----LEEQLEELEAELEELEEELDELKGEIGRLEKEL 722
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 435 RKLEEQLEkishqdhsdksrllELETRLREV-SLEHEEQKLELKRQLTELQLSLQERESQlTALQAARAALESQLRQAKt 513
Cdd:COG4913 723 EQAEEELD--------------ELQDRLEAAeDLARLELRALLEERFAAALGDAVERELR-ENLEERIDALRARLNRAE- 786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 514 eleettaeaeeeiQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIV 589
Cdd:COG4913 787 -------------EELERAMRAFNREWPAETADLDAdlesLPEYLALLDRLEEDGLPEYEERF--KELLNENS--IEFVA 849
|
650
....*....|....*.
gi 568936834 590 QLRSEVDHLRREITER 605
Cdd:COG4913 850 DLLSKLRRAIREIKER 865
|
|
| C1_PKD2_rpt2 |
cd20843 |
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ... |
974-1024 |
2.86e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410393 Cd Length: 79 Bit Score: 41.11 E-value: 2.86e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 974 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20843 10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
270-510 |
3.18e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.39 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 270 ETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 349
Cdd:COG3206 164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 350 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyletqa 427
Cdd:COG3206 242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-------- 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 428 gkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAARAALESQ 507
Cdd:COG3206 307 --LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREVEVAREL 366
|
...
gi 568936834 508 LRQ 510
Cdd:COG3206 367 YES 369
|
|
| Tropomyosin |
pfam00261 |
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ... |
199-357 |
3.48e-04 |
|
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.
Pssm-ID: 459736 [Multi-domain] Cd Length: 235 Bit Score: 43.86 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 199 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERE----------------------------LEKLHNREDSSEGIKK 250
Cdd:pfam00261 2 KMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEvaalnrriqlleeelerteerlaealekLEEAEKAADESERGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 251 KL----VEAEERRHSLENKVK-----------RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE 315
Cdd:pfam00261 82 VLenraLKDEEKMEILEAQLKeakeiaeeadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLE 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 568936834 316 VHLK---QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 357
Cdd:pfam00261 162 ASEEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
177-330 |
3.61e-04 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 45.15 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 177 DQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHNREDssegikkklvEA 255
Cdd:PRK12704 45 EEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEKREE----------EL 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 256 EERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM----ADKILeLEEKHREAQVSAQHLevhLKQKEQHYEEKIK 330
Cdd:PRK12704 113 EKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLtaeeAKEIL-LEKVEEEARHEAAVL---IKEIEEEAKEEAD 187
|
|
| C1_Munc13-2-like |
cd20859 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ... |
970-1024 |
4.17e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410409 Cd Length: 82 Bit Score: 40.82 E-value: 4.17e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 970 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20859 14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
481-811 |
4.53e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 44.89 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 481 TELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiqaltahRDEIQRKFDALRNSctvITDLEEQLNQL 560
Cdd:pfam07888 34 NRLEECLQERAELLQAQEAANRQREKEKERYKRD------------------REQWERQRRELESR---VAELKEELRQS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 561 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQV- 639
Cdd:pfam07888 93 REKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAe 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 640 -----LDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEIL 714
Cdd:pfam07888 173 rkqlqAKLQQTEEELRSLSKEFQELRNSLAQRDTQ----VLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 715 ALQQALKEQKLKAESLSDKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHI 783
Cdd:pfam07888 241 SLQERLNASERKVEGLGEELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRI 320
|
330 340
....*....|....*....|....*...
gi 568936834 784 FRLTQGLQEALDRADLLKTERSDLEYQL 811
Cdd:pfam07888 321 EKLSAELQRLEERLQEERMEREKLEVEL 348
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
548-776 |
4.64e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.44 E-value: 4.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 548 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSApDLQ 623
Cdd:COG3883 16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEI-EERREELGE-RAR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 624 TMEALKTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVE 703
Cdd:COG3883 94 ALYRSGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELE 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936834 704 LAVKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 776
Cdd:COG3883 168 AAKAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
202-606 |
6.14e-04 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 44.82 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 202 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLHNREDSSEGIKKK--LVEAEERRHSLE---------NKV---- 266
Cdd:PTZ00440 2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 267 -KRLETMERRENRLKDDIQTKsEQIQQMADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 339
Cdd:PTZ00440 2250 kKKLLDNKNKINNIKDKINDK-EKELINVDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 340 LADKESLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 419
Cdd:PTZ00440 2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 420 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdksrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 499
Cdd:PTZ00440 2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 500 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 574
Cdd:PTZ00440 2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530
|
410 420 430
....*....|....*....|....*....|..
gi 568936834 575 SKQLDEASGANDEIVQLRSEVDHLRREITERE 606
Cdd:PTZ00440 2531 DNSTYIINELESHVSKLNELLSYIDNEIKELE 2562
|
|
| PspC_subgroup_1 |
NF033838 |
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ... |
2-356 |
6.28e-04 |
|
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 44.62 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARMEVSQEDdkaLQLLHDIREQSR 80
Cdd:NF033838 131 KKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDVEVKKAE---LELVKEEAKEPR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 81 KLQEIKEQEyqAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShppRGDSGGTAL 160
Cdd:NF033838 202 DEEKIKQAK--AKVESKKAEATRLEK-IKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAK---RGVLGEPAT 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 161 DDlhKMQGHAgltsakDQGKPEVGEYS------KLEKINAEQQLKIQELQEKLEK----------AVKASTEATELLQNI 224
Cdd:NF033838 276 PD--KKENDA------KSSDSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkeedrrnypTNTYKTLELEIAESD 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 225 RQAKErAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKILELEEKH 304
Cdd:NF033838 348 VKVKE-AELELVKEEAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDRKKAEEEAKRKAAEEDKVKEKP 416
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 305 REAQVSAQHLEVhlkQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 356
Cdd:NF033838 417 AEQPQPAPAPQP---EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
682-841 |
6.81e-04 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 44.23 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 682 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 752
Cdd:PHA02562 202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 753 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 822
Cdd:PHA02562 282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356
|
170
....*....|....*....
gi 568936834 823 vkmEGTISQQTKLIDFLQA 841
Cdd:PHA02562 357 ---VDKAKKVKAAIEELQA 372
|
|
| C1_dGM13116p-like |
cd20831 |
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ... |
987-1024 |
6.93e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410381 Cd Length: 58 Bit Score: 39.25 E-value: 6.93e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 568936834 987 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20831 17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
50-338 |
7.28e-04 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 43.36 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 50 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 129
Cdd:COG1340 13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 130 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKmqghagltsakdqgkpevgEYSKLEK--------INAEQQL--K 199
Cdd:COG1340 81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRK-------------------EIERLEWrqqtevlsPEEEKELveK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 200 IQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLenkVKRLETMERRE 276
Cdd:COG1340 142 IKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADELHKEI 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936834 277 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKK 338
Cdd:COG1340 219 VEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK 278
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
390-904 |
8.10e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 8.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 390 EANKLAANSSLFTQRNMKAQEEMISElrQQKFYLE---TQAGKLEaQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS 466
Cdd:PTZ00121 1070 EGLKPSYKDFDFDAKEDNRADEATEE--AFGKAEEakkTETGKAE-EARKAEEAKKKAEDARKAEEARKAEDARKAEEAR 1146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 467 LEHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALE----SQLRQAKTELeettaeaeeeiQALTAHRDEIQRKFD 541
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDArKAEEARKAEDAKKAEAARKAEEvrkaEELRKAEDAR-----------KAEAARKAEEERKAE 1215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 542 ALRNSctvitdlEEqlnqltEDNAELNNQNFYLSKQLDEASGANDEivqlrsEVDHLRREITEREMQLTSQKQAQLSAPD 621
Cdd:PTZ00121 1216 EARKA-------ED------AKKAEAVKKAEEAKKDAEEAKKAEEE------RNNEEIRKFEEARMAHFARRQAAIKAEE 1276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 622 LQTMEALKTTctmlEEQVLDLEALNDEllEKERQWEAwrsvlgDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQV 701
Cdd:PTZ00121 1277 ARKADELKKA----EEKKKADEAKKAE--EKKKADEA------KKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKA 1344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 702 VELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKhAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 778
Cdd:PTZ00121 1345 AEAAKAEAEAaadEAEAAEEKAEAAEKKKEEAKKKADAAKKK-AEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEA 1423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 779 QKN-----HIFRLTQGLQEAlDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK---- 849
Cdd:PTZ00121 1424 KKKaeekkKADEAKKKAEEA-KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKadea 1502
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 850 KKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRiELRSARE 904
Cdd:PTZ00121 1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD-ELKKAEE 1556
|
|
| COG2433 |
COG2433 |
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]; |
184-278 |
8.79e-04 |
|
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 44.08 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 184 GEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellqniRQAKERAERELEKLHNREDSsegIKKKLVEAEERRHSLE 263
Cdd:COG2433 427 AEVEELEAELEEKDERIERLERELSEARSE-----------ERREIRKDREISRLDREIER---LERELEEERERIEELK 492
|
90
....*....|....*
gi 568936834 264 NKVKRLETMERRENR 278
Cdd:COG2433 493 RKLERLKELWKLEHS 507
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
248-608 |
9.75e-04 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 43.69 E-value: 9.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 248 IKKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVH-------L 318
Cdd:pfam06160 65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 319 KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 397
Cdd:pfam06160 138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 398 sslftQRNMKAQ----EEMISELRQQKFYLETQagKLEAQNRKLEEQLEKISHQdhSDKSRLLELETRLREVS------- 466
Cdd:pfam06160 206 -----KTELPDQleelKEGYREMEEEGYALEHL--NVDKEIQQLEEQLEENLAL--LENLELDEAEEALEEIEeridqly 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 467 --LEHE-EQKLELKRQLTELQLSLQERESQLTALQA--ARAALESQLrqakteleetTAEAEEEIQALTAHRDEIQRKFD 541
Cdd:pfam06160 277 dlLEKEvDAKKYVEKNLPEIEDYLEHAEEQNKELKEelERVQQSYTL----------NENELERVRGLEKQLEELEKRYD 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936834 542 ALR----NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgaNDEIVqLRSEVDHLRREITE--REMQ 608
Cdd:pfam06160 347 EIVerleEKEVAYSELQEELEEILEQLEEIEEEQEEFKESLQSLR--KDELE-AREKLDEFKLELREikRLVE 416
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
279-447 |
9.83e-04 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 43.61 E-value: 9.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 279 LKDDIQTKSEQIQQMADKIleLEEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKeslENMMQRHEEEAH 358
Cdd:PRK12704 25 RKKIAEAKIKEAEEEAKRI--LEEAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRER---RNELQKLEKRLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 359 EKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftQRNMKAQEEMISELR-QQKFYLETQAG--KLEAQNR 435
Cdd:PRK12704 93 QKEENLDRKLELLEKREEELEKKEKELEQK--------------QQELEKKEEELEELIeEQLQELERISGltAEEAKEI 158
|
170
....*....|..
gi 568936834 436 KLEEQLEKISHQ 447
Cdd:PRK12704 159 LLEKVEEEARHE 170
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
388-608 |
1.01e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 43.85 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 388 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 467
Cdd:PHA02562 165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 468 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK--------------------------TELEETTAE 521
Cdd:PHA02562 231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctqqisegpdriTKIKDKLKE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 522 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA----NDEIVQLRSEVDH 597
Cdd:PHA02562 311 LQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdnAEELAKLQDELDK 390
|
250
....*....|.
gi 568936834 598 LRREITEREMQ 608
Cdd:PHA02562 391 IVKTKSELVKE 401
|
|
| Stathmin |
pfam00836 |
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ... |
240-327 |
1.12e-03 |
|
Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.
Pssm-ID: 459956 [Multi-domain] Cd Length: 136 Bit Score: 40.79 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 240 NREDSSEGIKKKLVEAEERRHSLE-NKVKRL-ETMER-RENRLKDDIQTK--SEQIQQMADKILELEEKHREAQVSAqhL 314
Cdd:pfam00836 39 KKDSSLEEIQKKLEAAEERRKSLEaQKLKQLaEKREKeEEALQKADEENNnfSKMAEEKLKQKMEAYKENREAQIAA--L 116
|
90
....*....|...
gi 568936834 315 EVHLKQKEQHYEE 327
Cdd:pfam00836 117 KEKLKEKEKHVEE 129
|
|
| PRK05771 |
PRK05771 |
V-type ATP synthase subunit I; Validated |
190-390 |
1.31e-03 |
|
V-type ATP synthase subunit I; Validated
Pssm-ID: 235600 [Multi-domain] Cd Length: 646 Bit Score: 43.38 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLHNREDSS-EGIKKKLVEAEERRHSLENK 265
Cdd:PRK05771 38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 266 VKRLETMERRENRLKD-DIqtkseqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------- 334
Cdd:PRK05771 116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvv 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936834 335 QIKKDLADKESLenmMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 390
Cdd:PRK05771 185 VLKELSDEVEEE---LKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
|
|
| C1_MRCK |
cd20809 |
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ... |
976-1027 |
1.38e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410359 Cd Length: 53 Bit Score: 38.41 E-value: 1.38e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568936834 976 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 1027
Cdd:cd20809 1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
|
|
| C1_MRCKalpha |
cd20864 |
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ... |
976-1029 |
1.41e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410414 Cd Length: 60 Bit Score: 38.46 E-value: 1.41e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 976 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 1029
Cdd:cd20864 3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
185-792 |
1.48e-03 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 43.20 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 185 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAE 256
Cdd:pfam07111 87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSS------LTQAH 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 257 ERrhSLENKVKRLETMERRENRLKddiQTKSEQIQQMAdkileleekhrEAQVSAQHLEVHLKQKEQHYEEKIKVLDNqI 336
Cdd:pfam07111 161 EE--ALSSLTSKAEGLEKSLNSLE---TKRAGEAKQLA-----------EAQKEAELLRKQLSKTQEELEAQVTLVES-L 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 337 KKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISEL 416
Cdd:pfam07111 224 RKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRK 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 417 RQQKFYLETQAGKleaqnrkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslqereSQLTA 496
Cdd:pfam07111 290 IQPSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQ-------EQVTS 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 497 LQAARAALESQLrQAKTELEETTAEAEEEIQAltahrdEIQRKFDALRNSCTVITDLEEQL----NQLTEDNAELNNQNF 572
Cdd:pfam07111 350 QSQEQAILQRAL-QDKAAEVEVERMSAKGLQM------ELSRAQEARRRQQQQTASAEEQLkfvvNAMSSTQIWLETTMT 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 573 YLSKQLDEASGANDEIVQLRSEVdHLRREITEREMQLTSQKQAQ----LSAPDLQTMEALKTTCTMLEEQVLDLE-ALND 647
Cdd:pfam07111 423 RVEQAVARIPSLSNRLSYAVRKV-HTIKGLMARKVALAQLRQEScpppPPAPPVDADLSLELEQLREERNRLDAElQLSA 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 648 ELLEKE-----RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE 722
Cdd:pfam07111 502 HLIQQEvgrarEQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQE 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 723 QKLKAES-----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQ 791
Cdd:pfam07111 582 KVAEVETrlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQ 652
|
.
gi 568936834 792 E 792
Cdd:pfam07111 653 E 653
|
|
| C1_TNS1_v |
cd20888 |
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ... |
976-1023 |
1.58e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410438 Cd Length: 57 Bit Score: 38.31 E-value: 1.58e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568936834 976 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 1023
Cdd:cd20888 6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
482-850 |
1.58e-03 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 43.14 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 482 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 557
Cdd:pfam05622 11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 558 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQaqlsa 619
Cdd:pfam05622 69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKK----- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 620 pDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSR 688
Cdd:pfam05622 143 -KLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 689 A------RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMN 747
Cdd:pfam05622 218 EklealqKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 748 AR--------SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYS 819
Cdd:pfam05622 298 QEgsyrerltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEA 375
|
410 420 430
....*....|....*....|....*....|.
gi 568936834 820 HEKvkmegtISQQTKLIDFLQAKMDQPAKKK 850
Cdd:pfam05622 376 QSE------LQKKKEQIEELEPKQDSNLAQK 400
|
|
| C1_ScPKC1-like_rpt1 |
cd20822 |
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
971-1024 |
1.68e-03 |
|
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410372 Cd Length: 52 Bit Score: 38.04 E-value: 1.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 971 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20822 3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
182-810 |
1.82e-03 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 43.14 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 182 EVGEYSKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLHNREDSSEGIKKKLVEAEERRHS 261
Cdd:COG5022 949 EYVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSKQYGA 1010
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 262 LENKVKRLETMERRENRLKDDIQTKSEqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIkkdla 341
Cdd:COG5022 1011 LQESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR----- 1073
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 342 dkeslenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselrQQKF 421
Cdd:COG5022 1074 -----------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ---------MIKL 1125
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 422 YLETQAGKLEAQNRKLEEQLEKishqdhSDKSRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTALQAAR 501
Cdd:COG5022 1126 NLLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALYDEKS 1192
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 502 AALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA 581
Cdd:COG5022 1193 KLSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPA 1254
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 582 SGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEkerQWeawrs 661
Cdd:COG5022 1255 SMSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNALRTKASSLRWKSATEVNYNSEELD---DW----- 1326
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 662 vlgdeksqfeCRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLN 735
Cdd:COG5022 1327 ----------CREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKEN 1388
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 736 DLEKKHaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 810
Cdd:COG5022 1389 NLPKEI-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
691-827 |
2.39e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.46 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 691 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 770
Cdd:PRK12704 62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 568936834 771 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 827
Cdd:PRK12704 139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
88-323 |
2.42e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 42.70 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 88 QEYQAQVEEMRlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANecqhklmkVVSHPPRGDSGGTALDDLHKmq 167
Cdd:COG3206 159 EAYLEQNLELR--REEARKALEFLEEQLPELRKELEEAEAALEEFRQKNG--------LVDLSEEAKLLLQQLSELES-- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 168 ghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATE--LLQNIRQAKERAERELEKLHNR--ED 243
Cdd:COG3206 227 -----------------QLAEARAELAEAEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARytPN 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 244 SSegikkKLVEAEERRHSLENKVKR------------LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA 311
Cdd:COG3206 290 HP-----DVIALRAQIAALRAQLQQeaqrilasleaeLEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVAR 364
|
250
....*....|..
gi 568936834 312 QHLEVHLKQKEQ 323
Cdd:COG3206 365 ELYESLLQRLEE 376
|
|
| ClyA_Cry6Aa-like |
cd22656 |
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ... |
526-645 |
2.52e-03 |
|
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.
Pssm-ID: 439154 [Multi-domain] Cd Length: 309 Bit Score: 41.97 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 526 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 602
Cdd:cd22656 119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 568936834 603 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 645
Cdd:cd22656 196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
526-729 |
3.22e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 41.74 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 526 IQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEAsgaNDEIVQLRSEVDHLRREITER 605
Cdd:COG3883 25 LSELQAELEAAQAELDALQAE---LEELNEEYNELQAELEALQ-------AEIDKL---QAEIAEAEAEIEERREELGER 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 606 --------------EMQLTSQKQA----------QLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRS 661
Cdd:COG3883 92 aralyrsggsvsylDVLLGSESFSdfldrlsalsKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936834 662 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 729
Cdd:COG3883 172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2-251 |
3.49e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 42.36 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 2 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE---QDLATYITECSSLKRSLEQArmevsqeddkalqlLHDIREQ 78
Cdd:TIGR02169 797 QAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEkeiQELQEQRIDLKEQIKSIEKE--------------IENLNGK 862
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 79 SRKLQEikeqeyqaQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshppRGDSGGT 158
Cdd:TIGR02169 863 KEELEE--------ELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE------LKAKLEA 928
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 159 ALDDLhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQlKIQELQEKLE----KAVKASTEATELLQNIRQAKERAERE 234
Cdd:TIGR02169 929 LEEEL------SEIEDPKGEDEEIPEEELSLEDVQAELQ-RVEEEIRALEpvnmLAIQEYEEVLKRLDELKEKRAKLEEE 1001
|
250
....*....|....*..
gi 568936834 235 LEKLHNREDSSEGIKKK 251
Cdd:TIGR02169 1002 RKAILERIEEYEKKKRE 1018
|
|
| C1_PKD_rpt2 |
cd20796 |
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ... |
975-1024 |
4.09e-03 |
|
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410346 Cd Length: 54 Bit Score: 36.88 E-value: 4.09e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 975 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20796 1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
|
|
| C1_TNS2 |
cd20887 |
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ... |
975-1027 |
4.40e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410437 Cd Length: 53 Bit Score: 37.07 E-value: 4.40e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 568936834 975 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 1027
Cdd:cd20887 2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
184-310 |
4.53e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.68 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 184 GEYSKLEKINAEQQLKIQELQEKLEKavkasteATELLQNIRQAKE--RAERELEKLHNREDSSEgikKKLVEAEERRHS 261
Cdd:COG1579 52 TELEDLEKEIKRLELEIEEVEARIKK-------YEEQLGNVRNNKEyeALQKEIESLKRRISDLE---DEILELMERIEE 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 568936834 262 LENKVKRLET-MERRENRLKDDIQTKSEQIQQMADKILELEEKhREAQVS 310
Cdd:COG1579 122 LEEELAELEAeLAELEAELEEKKAELDEELAELEAELEELEAE-REELAA 170
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
590-919 |
4.54e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 41.65 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 590 QLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQ-TMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsVLGDEKS 668
Cdd:pfam17380 300 RLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQaAIYAEQERMAMERERELERIRQEERKRELER-------IRQEEIA 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 669 QFECRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNA 748
Cdd:pfam17380 372 MEISRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEA 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 749 RSLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKV 823
Cdd:pfam17380 433 RQREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEE 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 824 KMEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIEL 899
Cdd:pfam17380 504 RKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMM 578
|
330 340
....*....|....*....|
gi 568936834 900 RSAREEAAHRKATDHPHPST 919
Cdd:pfam17380 579 RQIVESEKARAEYEATTPIT 598
|
|
| Spc7 |
smart00787 |
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ... |
199-328 |
4.72e-03 |
|
Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.
Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 41.16 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 199 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIK----KKLVEA-EERRHSLENKVKRLETME 273
Cdd:smart00787 152 NLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDptelDRAKEKlKKLLQEIMIKVKKLEELE 231
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 568936834 274 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK 328
Cdd:smart00787 232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
326-508 |
4.78e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.68 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 326 EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 405
Cdd:COG1579 23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 406 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEEQKLELKRQLTELQL 485
Cdd:COG1579 88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149
|
170 180
....*....|....*....|...
gi 568936834 486 SLQERESQLTALQAARAALESQL 508
Cdd:COG1579 150 ELAELEAELEELEAEREELAAKI 172
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
707-834 |
4.94e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.30 E-value: 4.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 707 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 783
Cdd:PRK12704 32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 568936834 784 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 834
Cdd:PRK12704 103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
471-771 |
5.52e-03 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 40.66 E-value: 5.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 471 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettAEAEEEIQALTAHRDEIQRKFDALRnsctvi 550
Cdd:COG1340 1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELA-------EKRDELNAQVKELREEAQELREKRD------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 551 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIT--EREMQ---LTSQKQAQLsapdlqtM 625
Cdd:COG1340 68 -ELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIErlEWRQQtevLSPEEEKEL-------V 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 626 EALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvela 705
Cdd:COG1340 140 EKIKELEKELEK-AKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA------ 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936834 706 vKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 771
Cdd:COG1340 212 -DELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
478-909 |
5.57e-03 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 41.58 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 478 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 552
Cdd:PRK10929 2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 553 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTSQKQA---QLS 618
Cdd:PRK10929 82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLPQQQTEarrQLN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 619 APDlQTMEALKTTCTMLEE-QVLDLEAlndellekerqweawrsvlgdEKSQFECRVRELQrmldtekQSRARADQRITE 697
Cdd:PRK10929 155 EIE-RRLQTLGTPNTPLAQaQLTALQA---------------------ESAALKALVDELE-------LAQLSANNRQEL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 698 SRQVVELAVKEHkAEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrL 765
Cdd:PRK10929 206 ARLRSELAKKRS-QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-A 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 766 LEEQAklqQQMDL----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEK 822
Cdd:PRK10929 274 LNQQA---QRMDLiasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQR 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 823 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTR 896
Cdd:PRK10929 350 LRYEDLLNKQPQLRQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN 424
|
490
....*....|...
gi 568936834 897 ielrsareEAAHR 909
Cdd:PRK10929 425 --------EATHR 429
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
219-319 |
5.89e-03 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 41.22 E-value: 5.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 219 ELLQNIRQAKERAERELEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL 298
Cdd:COG0542 411 EELDELERRLEQLEIEKEAL--KKEQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGKIP 488
|
90 100
....*....|....*....|.
gi 568936834 299 ELEEKHREAQVSAQHLEVHLK 319
Cdd:COG0542 489 ELEKELAELEEELAELAPLLR 509
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
352-774 |
5.95e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.48 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 352 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 427
Cdd:PRK04863 276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 428 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQeresqltaLQAARAaleSQ 507
Cdd:PRK04863 355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALD--------VQQTRA---IQ 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 508 LRQAKteleettaeaeeeiQALtahrDEIQR--KFDALrnsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 585
Cdd:PRK04863 416 YQQAV--------------QAL----ERAKQlcGLPDL-----TADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 586 DEIVQ----LRSEVDHLRRE-----ITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVlDLEALNDELLEKERQW 656
Cdd:PRK04863 473 SQFEQayqlVRKIAGEVSRSeawdvARELLRRLREQRHLAEQLQQLRM--RLSELEQRLRQQQ-RAERLLAEFCKRLGKN 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 657 EAWRSVLGDEKSQFECRVRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLND 736
Cdd:PRK04863 550 LDDEDELEQLQEELEARLESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALAR 614
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 568936834 737 L-EKKHAMLEMNAR---SLQQKLETEREL----------KQRLLEEQAKLQQ 774
Cdd:PRK04863 615 LrEQSGEEFEDSQDvteYMQQLLERERELtverdelaarKQALDEEIERLSQ 666
|
|
| C1_Munc13 |
cd20807 |
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ... |
976-1024 |
6.31e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410357 Cd Length: 53 Bit Score: 36.30 E-value: 6.31e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568936834 976 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1024
Cdd:cd20807 1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
248-435 |
7.26e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 40.92 E-value: 7.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 248 IKKKLVEAEERRhslenkVKRLETMERRENRLKDDIqtKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE 327
Cdd:PRK12704 29 AEAKIKEAEEEA------KRILEEAKKEAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 328 kikvldnqiKKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 407
Cdd:PRK12704 101 ---------KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEE 166
|
170 180
....*....|....*....|....*...
gi 568936834 408 AQEEMISELRQqkfyLETQAgKLEAQNR 435
Cdd:PRK12704 167 ARHEAAVLIKE----IEEEA-KEEADKK 189
|
|
| Lebercilin |
pfam15619 |
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ... |
402-609 |
7.35e-03 |
|
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Pssm-ID: 464776 [Multi-domain] Cd Length: 193 Bit Score: 39.50 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 402 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 478
Cdd:pfam15619 2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 479 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 558
Cdd:pfam15619 82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 568936834 559 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 609
Cdd:pfam15619 141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
201-392 |
7.77e-03 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 41.19 E-value: 7.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 201 QELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHnredssegikKKLVEAEERRHSLENKVKRLETMERRENRL 279
Cdd:TIGR01612 532 QNIKAKLYKEIEAGLkESYELAKNWKKLIHEIKKELEEEN----------EDSIHLEKEIKDLFDKYLEIDDEIIYINKL 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 280 K-------DDIQTKSEQIQQMAD--KILELEEKHRE--AQVSAQHLEVHLKQKEQHYEeKIKVLDNQIKKDLADK--ESL 346
Cdd:TIGR01612 602 KlelkekiKNISDKNEYIKKAIDlkKIIENNNAYIDelAKISPYQVPEHLKNKDKIYS-TIKSELSKIYEDDIDAlyNEL 680
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568936834 347 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 392
Cdd:TIGR01612 681 SSIVKENAIDNTEDKAKLDDLKSKIDKEYDKIQNMETATVELHLSN 726
|
|
| CCDC73 |
pfam15818 |
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ... |
190-334 |
8.50e-03 |
|
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.
Pssm-ID: 464893 [Multi-domain] Cd Length: 1048 Bit Score: 41.08 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKIN-AEQQLKIQELQEKL----EKAVKASTEAT-----------------ELLQNIRQAKERAEREL----EKLHNRED 243
Cdd:pfam15818 213 ENINlTIKEQKFQELQERLnmelELNKKINEEIThiqeekqdiiisfqhmqQLLQQQTQANTEMEAELkalkENNQTLER 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 244 SSEGIKKKLVEAEERRHSLENKvkrletMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhlEVHLKQKEQ 323
Cdd:pfam15818 293 DNELQREKVKENEEKFLNLQNE------HEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQ------EHYNKLCNQ 360
|
170
....*....|.
gi 568936834 324 HYEEKIKVLDN 334
Cdd:pfam15818 361 KKFEEDKKFQN 371
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
51-366 |
8.54e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.62 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 51 KRSLEQARMEVSQEDDKALQLLHDIREQSRKL----QEIKEQEYQAQVEEMRLM--MNQLEEdlvsaRRRSDLYESELRE 124
Cdd:pfam02029 12 RRRAREERRRQKEEEEPSGQVTESVEPNEHNSyeedSELKPSGQGGLDEEEAFLdrTAKREE-----RRQKRLQEALERQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 125 SRL---AAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHA------------GLTSAKDQGKPEVGEYSKL 189
Cdd:pfam02029 87 KEFdptIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIrekeyqenkwstEVRQAEEEGEEEEDKSEEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 190 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR----QAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENK 265
Cdd:pfam02029 167 EEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 266 VKRLETMERRENRLKDDIQTKSEQIQQMAdkILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldnQIKKDlADKES 345
Cdd:pfam02029 247 EQKLEELRRRRQEKESEEFEKLRQKQQEA--ELELEELKKKREERRKLLEEEEQRRKQEEAER------KLREE-EEKRR 317
|
330 340
....*....|....*....|.
gi 568936834 346 LENMMQRHEEEAHEKGKILSE 366
Cdd:pfam02029 318 MKEEIERRRAEAAEKRQKLPE 338
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
225-499 |
9.99e-03 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 40.66 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 225 RQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRlETMERRENRLKDDIQTKSEQIQQmADKILELEEKH 304
Cdd:PLN02939 38 RRRGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLR-TVMELPQKSTSSDDDHNRASMQR-DEAIAAIDNEQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 305 RE-----AQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEslenmmqrheeeahekgKILSEQKAMinamDSKIR 379
Cdd:PLN02939 116 QTnskdgEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE-----------------KILTEKEAL----QGKIN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936834 380 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkLEEQLEKISHQDHSDKSRLLELE 459
Cdd:PLN02939 174 ILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----LSKELDVLKEENMLLKDDIQFLK 246
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 568936834 460 TRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 499
Cdd:PLN02939 247 AELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
|
|
| |
