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Conserved domains on  [gi|568909601|ref|XP_006529908|]
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metalloreductase STEAP3 isoform X1 [Mus musculus]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
69-242 1.43e-47

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  69 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 143
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 144 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 216
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 568909601 217 SEMARAMGFTPLDMGSLASAREVEAI 242
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 300-443 2.26e-09

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 55.35  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  300 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 379
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909601  380 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 443
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
69-242 1.43e-47

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  69 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 143
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 144 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 216
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 568909601 217 SEMARAMGFTPLDMGSLASAREVEAI 242
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
70-155 7.31e-22

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 89.98  E-value: 7.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601   70 GILGSGDFARSLATRLVGSGFS--VVVGSRNPKRTAGLFPSL---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LADQ 143
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 568909601  144 LAGKILVDVSNP 155
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 300-443 2.26e-09

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 55.35  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  300 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 379
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909601  380 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 443
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 336-427 1.58e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 39.78  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 336 WLQHRKQIGLLSFFFAMLHALYSFCLplrrSHRYDLvnlavkqvlankSRLWAeeEVWRMeIYLSLGVLALGMLSLLAVT 415
Cdd:COG2717   70 LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDL------------ALIWA--DIVKR-PYITVGFAAFLLLLPLALT 130

                         90
                 ....*....|....
gi 568909601 416 SLPSIANSL--NWK 427
Cdd:COG2717  131 STNAAIRRLgrRWK 144
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 68-129 3.87e-03

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 39.17  E-value: 3.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568909601  68 KVGILGSGDFARSLATRLVGSGF-----SVVVGSRNPKRTAgLFPSLAQVTFQ--EEAVSSPEVIFVAV 129
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVvppsrISTADDSNPARRD-VFQSLGVKTAAsnTEVVKSSDVIILAV 69
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
69-242 1.43e-47

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  69 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 143
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 144 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 216
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 568909601 217 SEMARAMGFTPLDMGSLASAREVEAI 242
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
70-155 7.31e-22

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 89.98  E-value: 7.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601   70 GILGSGDFARSLATRLVGSGFS--VVVGSRNPKRTAGLFPSL---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LADQ 143
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 568909601  144 LAGKILVDVSNP 155
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 300-443 2.26e-09

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 55.35  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  300 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 379
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909601  380 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 443
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 67-228 9.84e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 44.42  E-value: 9.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601  67 PKVGILGSGDFARSLATRLVGSGFSVV-VGSRNP---KRTAGLFPSLAQVTFqEEAVSSPEVIFVAVfreHYSSLCSLAD 142
Cdd:COG5495    4 MKIGIIGAGRVGTALAAALRAAGHEVVgVYSRSPasaERAAALLGAVPALDL-EELAAEADLVLLAV---PDDAIAEVAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 143 QLA-------GKILVDVSNPTEKEHLQHRQSNAEYLASLFPACTVVKAFNVISAWAlqagprdgnrQVLICSD-QPEAKR 214
Cdd:COG5495   80 GLAaagalrpGQLVVHTSGALGSDVLAPAARAGALTGSFHPLQTFSGPREDLERLA----------GIPFAIEgDEEALP 149

                        170
                 ....*....|....
gi 568909601 215 TISEMARAMGFTPL 228
Cdd:COG5495  150 VLEALAEALGGEPF 163
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 336-427 1.58e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 39.78  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909601 336 WLQHRKQIGLLSFFFAMLHALYSFCLplrrSHRYDLvnlavkqvlankSRLWAeeEVWRMeIYLSLGVLALGMLSLLAVT 415
Cdd:COG2717   70 LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDL------------ALIWA--DIVKR-PYITVGFAAFLLLLPLALT 130

                         90
                 ....*....|....
gi 568909601 416 SLPSIANSL--NWK 427
Cdd:COG2717  131 STNAAIRRLgrRWK 144
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 68-129 3.87e-03

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 39.17  E-value: 3.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568909601  68 KVGILGSGDFARSLATRLVGSGF-----SVVVGSRNPKRTAgLFPSLAQVTFQ--EEAVSSPEVIFVAV 129
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVvppsrISTADDSNPARRD-VFQSLGVKTAAsnTEVVKSSDVIILAV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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