SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909491 194 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909491 194 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491  38 DDTRLHDAAYVGDLQTLRNLLQeesyrrYGADVDV--NHHLTPdtrppfsrrltslvvcpLYISAAYHNLQCFRLLLQAG 115
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLE------AGADVNAqdNDGNTP-----------------LHLAAANGNLEIVKLLLEAG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491 116 ANpdfncngpVNTQEFYRGSPgcVMDAVlRHGCEAAfVSLLVEFGANLNLVKWESLGPEARGRRKMDPEALQVFKEARSI 195
Cdd:COG0666  177 AD--------VNARDNDGETP--LHLAA-ENGHLEI-VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                        170       180
                 ....*....|....*....|....*..
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSL 222
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLL 271

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491   42 LHDAAYVGDLQTLRNLLQEesyrryGADVDVNHHltpdtrppfsRRLTslvvcPLYISAAYHNLQCFRLLLQaGANPDFN 121
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN------GADANLQDK----------NGRT-----ALHLAAKNGHLEIVKLLLE-HADVNLK 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568909491  122 CNGpvNTqefyrgspgCVMDAVlRHGCEAAfVSLLVEFGANLNL 165
Cdd:pfam12796  59 DNG--RT---------ALHYAA-RSGHLEI-VKLLLEKGADINV 89

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491   95 PLYISAAYHNLQCFRLLLQAGANPDFNCNGpvntQEFYRGSpgcvMDAVLRHG--------CEA--AFVSLLVEFGANLN 164
Cdd:TIGR00870 131 ALHLAAHRQNYEIVKLLLERGASVPARACG----DFFVKSQ----GVDSFYHGesplnaaaCLGspSIVALLSEDPADIL 202

                          90       100
                  ....*....|....*....|
gi 568909491  165 LVkwESLGPEARGRRKMDPE 184
Cdd:TIGR00870 203 TA--DSLGNTLLHLLVMENE 220

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909491 194 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLE 42

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03721    3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491  38 DDTRLHDAAYVGDLQTLRNLLQeesyrrYGADVDVnhhltpdtrpPFSRRLTslvvcPLYISAAYHNLQCFRLLLQAGAN 117
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLE------AGADVNA----------RDKDGET-----PLHLAAYNGNLEIVKLLLEAGAD 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568909491 118 pdfncngpVNTQEFYRGSPgcVMDAVlRHGCEAAfVSLLVEFGANLNLV 166
Cdd:COG0666  146 --------VNAQDNDGNTP--LHLAA-ANGNLEI-VKLLLEAGADVNAR 182

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568909491 194 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 234
Cdd:cd03729    1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 235
Cdd:cd03726    3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568909491 196 PRTLLSLCRVAVRRAlgkYRLHLVPSLPLPDPIKKFLLY 234
Cdd:cd03717    3 VRSLQHLCRFVIRQC---TRRDLIDQLPLPRRLKDYLKE 38

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568909491 197 RTLLSLCRVAVRRalgKYRLHLVPSLPLPDPIKKFLL 233
Cdd:cd03740    4 RSLQYLCRFVIRQ---YTRIDLIQKLPLPNKMKGYLL 37

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909491   42 LHDAAYVGDLQTLRNLLQEesyrryGADVDVNHHltpdtrppfsRRLTslvvcPLYISAAYHNLQCFRLLLQaGANPDFN 121
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN------GADANLQDK----------NGRT-----ALHLAAKNGHLEIVKLLLE-HADVNLK 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568909491  122 CNGpvNTqefyrgspgCVMDAVlRHGCEAAfVSLLVEFGANLNL 165
Cdd:pfam12796  59 DNG--RT---------ALHYAA-RSGHLEI-VKLLLEKGADINV 89

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568909491 196 PRTLLSLCRVAVRRALGKYRLHLVPS---LPLPDPIKKFLLYE 235
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGLQKLQQPSSmkkLPLPPALKRYILYK 45

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568909491 194 SIPRTLLSLCRVAVRRALGKYRLHL-VPSLPLPDPIKKFLLYE 235
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVkVKALPLPDRLKWYLLPE 43