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Conserved domains on  [gi|568909489|ref|XP_006529852|]
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ankyrin repeat and SOCS box protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-216 8.96e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.66  E-value: 8.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  34 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 113
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 114 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 191
Cdd:COG0666  159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                        170       180
                 ....*....|....*....|....*
gi 568909489 192 PLYISAAYHNLQCFRLLLQAGANPD 216
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 291-332 1.08e-18

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.23  E-value: 1.08e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909489 291 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-216 8.96e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.66  E-value: 8.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  34 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 113
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 114 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 191
Cdd:COG0666  159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                        170       180
                 ....*....|....*....|....*
gi 568909489 192 PLYISAAYHNLQCFRLLLQAGANPD 216
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 291-332 1.08e-18

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.23  E-value: 1.08e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909489 291 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-170 5.38e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   79 LRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEaGADPNGSRHHRsTPVYHASRVGRDDILK 158
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 568909489  159 ALIRYGADVDVN 170
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 91-270 4.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 4.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  91 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 169
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 170 nhhltpdtrppfsrrLTSLVVCPLYISAAY-HNLQCFRLLLQAGANpdfncngpVNTQEFYRG-SPgcvMDAVLRhgcEA 247
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|...
gi 568909489 248 AFVSLLVEFGANLNLVKWESLGP 270
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTP 303
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 293-330 2.55e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 2.55e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568909489  293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLL 330
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 294-332 3.08e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 3.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568909489   294 RTLLSLCRVAVRRALGKyrlhlVPSLPLPDPIKKFLLYE 332
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 35-167 8.04e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 8.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  35 DTRLHDAAYVGDLQTLRNLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGNCVDFLIRkgAEVDLVDV-------K 107
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909489 108 GQTALYVAVVNGHLESTEILLEAGADPNGSR--------------HHRSTPVYHASRVGRDDILKALIRYGADV 167
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 96-281 2.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.76  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   96 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTEILLEagadpNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDv 169
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAF- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  170 nhhltPDTRPP----------FSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANPDFNCNGpvntQEFYRGSpgcvMDA 239
Cdd:TIGR00870 109 -----RKSGPLelandqytseFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACG----DFFVKSQ----GVD 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568909489  240 VLRHG--------CEA--AFVSLLVEFGANLNLVkwESLGPEARGRRKMDPE 281
Cdd:TIGR00870 171 SFYHGesplnaaaCLGspSIVALLSEDPADILTA--DSLGNTLLHLLVMENE 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 107-135 3.39e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.39e-04
                           10        20
                   ....*....|....*....|....*....
gi 568909489   107 KGQTALYVAVVNGHLESTEILLEAGADPN 135
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-216 8.96e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.66  E-value: 8.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  34 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 113
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLE---AGADVNARDKD--GE---TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 114 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV--NHHLTpdtrppfsrrltslvvc 191
Cdd:COG0666  159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdNDGKT----------------- 221

                        170       180
                 ....*....|....*....|....*
gi 568909489 192 PLYISAAYHNLQCFRLLLQAGANPD 216
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-198 4.83e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 4.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  34 DDTRLHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALY 113
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLE---AGADVNAQDND--GN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 114 VAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHHLTPDTRPPFSRRLTSLVVCPL 193
Cdd:COG0666  192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271


                 ....*
gi 568909489 194 YISAA 198
Cdd:COG0666  272 LLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-319 1.91e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 156
Cdd:COG0666   56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 157 LKALIRYGADVDV--NHHLTpdtrppfsrrltslvvcPLYISAAYHNLQCFRLLLQAGANpdfncngpVNTQEFYRGSPg 234
Cdd:COG0666  136 VKLLLEAGADVNAqdNDGNT-----------------PLHLAAANGNLEIVKLLLEAGAD--------VNARDNDGETP- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 235 cVMDAVlRHGCEAAfVSLLVEFGANLNLVKWESLGPEARGRRKMDPEALQVFKEARSIPRTLLSLCRVAVRRALGKYRLH 314
Cdd:COG0666  190 -LHLAA-ENGHLEI-VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266


                 ....*
gi 568909489 315 LVPSL 319
Cdd:COG0666  267 IVKLL 271
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 291-332 1.08e-18

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 78.23  E-value: 1.08e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909489 291 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-170 5.38e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   79 LRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEaGADPNGSRHHRsTPVYHASRVGRDDILK 158
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 568909489  159 ALIRYGADVDVN 170
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-135 1.60e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   38 LHDAAYVGDLQTLRNLLQEESyrsriNEKSVWCCGWlpcTPLRIAATAGHGNCVDFLIRKgAEVDLVDvKGQTALYVAVV 117
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-----DANLQDKNGR---TALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAAR 70

                          90
                  ....*....|....*...
gi 568909489  118 NGHLESTEILLEAGADPN 135
Cdd:pfam12796  71 SGHLEIVKLLLEKGADIN 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-172 7.16e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.53  E-value: 7.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  38 LHDAAYVGDLQTLRNLLQeesYRSRINEKSVWccGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVV 117
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE---AGADVNARDND--GE---TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568909489 118 NGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHH 172
Cdd:COG0666  229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 293-332 9.10e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 67.14  E-value: 9.10e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03716    3 PRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-263 8.53e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.75  E-value: 8.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 156
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 157 LKALIRYGADVDVnhhltpdtrpPFSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANpdfncngpVNTQEFYRGSPgcV 236
Cdd:COG0666  103 VKLLLEAGADVNA----------RDKDGET-----PLHLAAYNGNLEIVKLLLEAGAD--------VNAQDNDGNTP--L 157

                        170       180
                 ....*....|....*....|....*..
gi 568909489 237 MDAVlRHGCEAAfVSLLVEFGANLNLV 263
Cdd:COG0666  158 HLAA-ANGNLEI-VKLLLEAGADVNAR 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 293-332 1.41e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.03  E-value: 1.41e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 91-270 4.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 4.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  91 VDFLIRKGAEVDLVDV-KGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 169
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 170 nhhltpdtrppfsrrLTSLVVCPLYISAAY-HNLQCFRLLLQAGANpdfncngpVNTQEFYRG-SPgcvMDAVLRhgcEA 247
Cdd:PHA02878 230 ---------------RDKCGNTPLHISVGYcKDYDILKLLLEHGVD--------VNAKSYILGlTA---LHSSIK---SE 280

                        170       180
                 ....*....|....*....|...
gi 568909489 248 AFVSLLVEFGANLNLVKWESLGP 270
Cdd:PHA02878 281 RKLKLLLEYGADINSLNSYKLTP 303
Ank_2 pfam12796
Ankyrin repeats (3 copies);
112-218 5.37e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 5.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  112 LYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVNHHLTpdtrppfsrrltslvvc 191
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT----------------- 63

                          90       100
                  ....*....|....*....|....*..
gi 568909489  192 PLYISAAYHNLQCFRLLLQAGANPDFN 218
Cdd:pfam12796  64 ALHYAARSGHLEIVKLLLEKGADINVK 90
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 293-330 2.55e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 2.55e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568909489  293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLL 330
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 95-220 7.32e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 59.23  E-value: 7.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  95 IRKGAEVDLVDVkgqtaLYVAVVNGHLESTEILLEAGADPN----GSRHHRSTPVYHASRVGRDDILKALIRYGADVDvn 170
Cdd:PHA02884  25 IKKKNKICIANI-----LYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDCDNDDAAKLLIRYGADVN-- 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568909489 171 hhltpdtrppfsRRLTSLVVCPLYISAAYHNLQCFRLLLQAGANPDFNCN 220
Cdd:PHA02884  98 ------------RYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTN 135
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 77-172 1.16e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.50  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEIL--LEAGADPngsrHHRSTPVYHASRVGRD 154
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDP----HAAGDLLCTAAKRNDL 635

                         90
                 ....*....|....*...
gi 568909489 155 DILKALIRYGADVDVNHH 172
Cdd:PLN03192 636 TAMKELLKQGLNVDSEDH 653
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 91-220 1.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.21  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  91 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVN 170
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568909489 171 HHltpdtrppfsrrltsLVVCPLYISAAYHNLQCFRLLLQAGANPDFNCN 220
Cdd:PHA02874 187 DN---------------NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCK 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 77-263 3.08e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 3.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVK-GQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDD 155
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 156 ILKALIRYGADVDVNhhltpdtrppfsrrlTSLVVCPLYISAAYHNLQCFRLLLQAGANPDfncngpvntqefYRGSPGC 235
Cdd:PHA02875 150 GIELLIDHKACLDIE---------------DCCGCTPLIIAMAKGDIAICKMLLDSGANID------------YFGKNGC 202

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568909489 236 VmdAVLRHGCE---AAFVSLLVEFGANLNLV 263
Cdd:PHA02875 203 V--AALCYAIEnnkIDIVRLFIKRGADCNIM 231
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-169 6.22e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 6.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  89 NCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVD 168
Cdd:PHA03100 173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252


                 .
gi 568909489 169 V 169
Cdd:PHA03100 253 T 253
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 293-332 6.43e-09

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 51.15  E-value: 6.43e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 77-245 6.52e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 6.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHA-SRVGRDD 155
Cdd:PHA02878 170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYD 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 156 ILKALIRYGADVDVNHHLtpdtrppfsRRLTslvvcPLYISaaYHNLQCFRLLLQAGANPdfncngpvNTQEFYRGSPgc 235
Cdd:PHA02878 250 ILKLLLEHGVDVNAKSYI---------LGLT-----ALHSS--IKSERKLKLLLEYGADI--------NSLNSYKLTP-- 303

                        170
                 ....*....|
gi 568909489 236 VMDAVLRHGC 245
Cdd:PHA02878 304 LSSAVKQYLC 313
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 293-332 9.66e-09

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 50.52  E-value: 9.66e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLE 42
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 293-332 1.09e-08

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 50.34  E-value: 1.09e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 83-163 1.30e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  83 ATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIR 162
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169


                 .
gi 568909489 163 Y 163
Cdd:PTZ00322 170 H 170
PHA03095 PHA03095
ankyrin-like protein; Provisional
 62-192 2.07e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.42  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  62 RINEKSVwcCGwlpCTPL----RIAATAghgNCVDFLIRKGAEVDLVDVKGQTAL--YVAVVNGHLESTEILLEAGADPN 135
Cdd:PHA03095  75 DVNAPER--CG---FTPLhlylYNATTL---DVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVN 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568909489 136 GSRHHRSTP--VYHASRVGRDDILKALIRYGAD---VDV------NHHL-TPDTRPPFSRRLTSLVVCP 192
Cdd:PHA03095 147 ALDLYGMTPlaVLLKSRNANVELLRLLIDAGADvyaVDDrfrsllHHHLqSFKPRARIVRELIRAGCDP 215
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-314 2.75e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.03  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  94 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTEI---LLEAGADPNGSRHHRSTP----VYHASRVgrdDILKALIRYGAD 166
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPlhlyLYNATTL---DVIKLLIKAGAD 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 167 VDVNHHLtpdTRPPFSRRLTSLVVCPLYIsaayhnlqcfRLLLQAGANpdfncngpVNTQEFYRGSPgcvMDAVLR-HGC 245
Cdd:PHA03095 110 VNAKDKV---GRTPLHVYLSGFNINPKVI----------RLLLRKGAD--------VNALDLYGMTP---LAVLLKsRNA 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 246 EAAFVSLLVEFGANLNLVkweslgpEARGRRKMDpEALQVFKEARSIPRTLLSL-CRVAVRRALGKYRLH 314
Cdd:PHA03095 166 NVELLRLLIDAGADVYAV-------DDRFRSLLH-HHLQSFKPRARIVRELIRAgCDPAATDMLGNTPLH 227
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 293-332 3.62e-08

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 48.82  E-value: 3.62e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 91-264 3.72e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 3.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  91 VDFLIRKGAEVDLVDVKGQTALYVAVVN--GHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDD--ILKALIRYGAD 166
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 167 VD----VNHHLT-------PDTRPpFSrrltslvvcPLYISAAYHNLQCFRLLLQAGANP-DFNCNGpvNTqefyrgspg 234
Cdd:PHA03100 169 INaknrVNYLLSygvpiniKDVYG-FT---------PLHYAVYNNNPEFVKYLLDLGANPnLVNKYG--DT--------- 227

                        170       180       190
                 ....*....|....*....|....*....|
gi 568909489 235 CVMDAVLRhgCEAAFVSLLVEFGANLNLVK 264
Cdd:PHA03100 228 PLHIAILN--NNKEIFKLLLNNGPSIKTII 255
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-270 7.42e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 7.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  25 FCDHPLEHCDDTRLHDAAYVGDLQTLRNLLQEESyrSRINEKSVwccgwLPCTPLRIAATAGHGN-CVDFLIRKGAEVDL 103
Cdd:PHA02876 264 FSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERG--ADVNAKNI-----KGETPLYLMAKNGYDTeNIRTLIMLGADVNA 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 104 VDVKGQTALYVAVVNGHLESTEI-LLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVnhhltpdtrppFS 182
Cdd:PHA02876 337 ADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA-----------LS 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 183 RRLTSLVVCPLYISAAYHNLqcfRLLLQAGANpdfncngpVNTQEFYRGSPgcvMDAVLRHGCEAAFVSLLVEFGANLNL 262
Cdd:PHA02876 406 QKIGTALHFALCGTNPYMSV---KTLIDRGAN--------VNSKNKDLSTP---LHYACKKNCKLDVIEMLLDNGADVNA 471


                 ....*...
gi 568909489 263 VKWESLGP 270
Cdd:PHA02876 472 INIQNQYP 479
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 293-331 8.12e-08

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 47.95  E-value: 8.12e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 331
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQY 41
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 293-332 8.73e-08

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 47.94  E-value: 8.73e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03721    3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 293-332 1.74e-07

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 46.94  E-value: 1.74e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03719    3 PHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 294-332 3.08e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.86  E-value: 3.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568909489   294 RTLLSLCRVAVRRALGKyrlhlVPSLPLPDPIKKFLLYE 332
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 67-253 3.40e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  67 SVWCCGWLPCTPLRIAATAGHGNC---VDFLIRKGAEVDLVDVKGQTALYVAVVNGH-LESTEILLEAGADPNGSRHHRS 142
Cdd:PHA03095  39 DVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 143 TP--VYHASRVGRDDILKALIRYGADV-DVNHHLtpdtrppfsrrLTSLVVcplYISAAYHNLQCFRLLLQAGANP---D 216
Cdd:PHA03095 119 TPlhVYLSGFNINPKVIRLLLRKGADVnALDLYG-----------MTPLAV---LLKSRNANVELLRLLIDAGADVyavD 184

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568909489 217 FNCNGPVNTQ-EFYRGSPgCVMDAVLRHGCEAAFVSLL 253
Cdd:PHA03095 185 DRFRSLLHHHlQSFKPRA-RIVRELIRAGCDPAATDML 221
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 35-167 8.04e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 8.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  35 DTRLHDAAYVGDLQTLRNLLqeESYRSRINEKsvwccGWLPCTPLRIAATAGHGNCVDFLIRkgAEVDLVDV-------K 107
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLL--KCPSCDLFQR-----GALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQ 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909489 108 GQTALYVAVVNGHLESTEILLEAGADPNGSR--------------HHRSTPVYHASRVGRDDILKALIRYGADV 167
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 73-263 1.79e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  73 WLPCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGH-----LESTEILLEAGADPNGSRHHRSTPVYH 147
Cdd:PHA03100  33 KKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489 148 AS--RVGRDDILKALIRYGADVDVnhhLTPDTRPPFsrrltslvvcPLYISAAYHNLQCFRLLLQAGANPD--------F 217
Cdd:PHA03100 113 AIskKSNSYSIVEYLLDNGANVNI---KNSDGENLL----------HLYLESNKIDLKILKLLIDKGVDINaknrvnylL 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568909489 218 NCNGPVNTQEFYRGSPgcVMDAVLRHGCEaaFVSLLVEFGANLNLV 263
Cdd:PHA03100 180 SYGVPINIKDVYGFTP--LHYAVYNNNPE--FVKYLLDLGANPNLV 221
Ank_4 pfam13637
Ankyrin repeats (many copies);
77-128 3.21e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 3.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568909489   77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL 128
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 291-331 5.78e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 42.85  E-value: 5.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568909489 291 SIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 331
Cdd:cd03729    1 STPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-105 6.70e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 6.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   19 EWLREQFCD-HPLEHCDDTRLHDAAYVGDLQTLRNLLQEESYRSRINEKsvwccgwlpcTPLRIAATAGHGNCVDFLIRK 97
Cdd:pfam12796  14 KLLLENGADaNLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR----------TALHYAARSGHLEIVKLLLEK 83


                  ....*...
gi 568909489   98 GAEVDLVD 105
Cdd:pfam12796  84 GADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-168 9.58e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.91  E-value: 9.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  38 LHDAAYVGDLQTLRNLLQEESYRSRINEKSvwccgwlPCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVV 117
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKD-------GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVM 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568909489 118 NGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVD 168
Cdd:PHA02875 145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 293-331 3.21e-05

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 40.54  E-value: 3.21e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLY 331
Cdd:cd03728    3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 287-331 9.24e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.20  E-value: 9.24e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568909489   287 KEARSIPRTLLSLCRVAVRRALgkyRLHLVPSLPLPDPIKKFLLY 331
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCT---RTDQIKTLPLPPKLKDYLSY 42
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 293-332 1.31e-04

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 39.06  E-value: 1.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLLYE 332
Cdd:cd03726    3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 293-331 2.71e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 37.96  E-value: 2.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568909489 293 PRTLLSLCRVAVRRAlgkYRLHLVPSLPLPDPIKKFLLY 331
Cdd:cd03717    3 VRSLQHLCRFVIRQC---TRRDLIDQLPLPRRLKDYLKE 38
PHA03095 PHA03095
ankyrin-like protein; Provisional
 77-162 2.79e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATagHGNC----VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVG 152
Cdd:PHA03095 224 TPLHSMAT--GSSCkrslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNN 301

                         90
                 ....*....|
gi 568909489 153 RDDILKALIR 162
Cdd:PHA03095 302 NGRAVRAALA 311
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 293-332 2.85e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.29  E-value: 2.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLH---LVPSLPLPDPIKKFLLYE 332
Cdd:cd03730    3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 126-181 2.87e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 2.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568909489 126 ILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDVnhhLTPDTRPPF 181
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL---LDKDGKTPL 152
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 96-281 2.90e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.76  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   96 RKGAE-----VDLVDVKGQTALYVAVV-NGHLESTEILLEagadpNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDv 169
Cdd:TIGR00870  35 RDLEEpkklnINCPDRLGRSALFVAAIeNENLELTELLLN-----LSCRGAVGDTLLHAISLEYVDAVEAILLHLLAAF- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  170 nhhltPDTRPP----------FSRRLTslvvcPLYISAAYHNLQCFRLLLQAGANPDFNCNGpvntQEFYRGSpgcvMDA 239
Cdd:TIGR00870 109 -----RKSGPLelandqytseFTPGIT-----ALHLAAHRQNYEIVKLLLERGASVPARACG----DFFVKSQ----GVD 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568909489  240 VLRHG--------CEA--AFVSLLVEFGANLNLVkwESLGPEARGRRKMDPE 281
Cdd:TIGR00870 171 SFYHGesplnaaaCLGspSIVALLSEDPADILTA--DSLGNTLLHLLVMENE 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 107-135 3.39e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.39e-04
                           10        20
                   ....*....|....*....|....*....
gi 568909489   107 KGQTALYVAVVNGHLESTEILLEAGADPN 135
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-135 4.05e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  36 TRLHDAAYVGDLQTLRNLLQeesYRSRINEKSvwCCGwlpCTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQ-TALYV 114
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLID---HKACLDIED--CCG---CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCY 208

                         90       100
                 ....*....|....*....|.
gi 568909489 115 AVVNGHLESTEILLEAGADPN 135
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGADCN 229
Ank_4 pfam13637
Ankyrin repeats (many copies);
110-161 4.33e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 4.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568909489  110 TALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALI 161
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 77-175 5.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI 156
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90       100
                 ....*....|....*....|.
gi 568909489 157 LKALIRYGADVDV--NHHLTP 175
Cdd:PHA02874 206 IKLLIDHGNHIMNkcKNGFTP 226
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 294-330 7.15e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.63  E-value: 7.15e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568909489 294 RTLLSLCRVAVRRalgKYRLHLVPSLPLPDPIKKFLL 330
Cdd:cd03740    4 RSLQYLCRFVIRQ---YTRIDLIQKLPLPNKMKGYLL 37
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-169 7.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 7.84e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568909489 121 LESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDILKALIRYGADVDV 169
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 58-133 8.73e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 8.73e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568909489  58 SYRSRINEKSVwcCGWlpcTPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGAD 133
Cdd:PHA03100 180 SYGVPINIKDV--YGF---TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA02946 PHA02946
ankyin-like protein; Provisional
 91-168 9.49e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.81  E-value: 9.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  91 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASrvGRDD----ILKALIRYGAD 166
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLS--GTDDevieRINLLVQYGAK 132


                 ..
gi 568909489 167 VD 168
Cdd:PHA02946 133 IN 134
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 290-331 9.64e-04

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 36.25  E-value: 9.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568909489 290 RSIPrTLLSLCRVAVRRALGKYRlhlVPSLPLPDPIKKFLLY 331
Cdd:cd03733    1 RVVS-SLQHLCRMALRRVMTTQQ---VLALPIPKKMKEFLTY 38
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 77-128 1.03e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568909489  77 TPLRIAATAGHGNCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL 128
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 107-135 2.19e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 2.19e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568909489  107 KGQTALYVAVV-NGHLESTEILLEAGADPN 135
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVN 30
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 293-332 2.61e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.58  E-value: 2.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568909489 293 PRTLLSLCRVAVRRALGKYRLHLVPS---LPLPDPIKKFLLYE 332
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGLQKLQQPSSmkkLPLPPALKRYILYK 45
Ank_4 pfam13637
Ankyrin repeats (many copies);
36-95 2.76e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 2.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489   36 TRLHDAAYVGDLQTLRNLLQeesYRSRINEksVWCCGWlpcTPLRIAATAGHGNCVDFLI 95
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLE---KGADINA--VDGNGE---TALHFAASNGNVEVLKLLL 54
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 291-330 2.88e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.20  E-value: 2.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568909489 291 SIPRTLLSLCRVAVRRALG-KYRLHLVPSLPLPDPIKKFLL 330
Cdd:cd03727    1 SAPGTLKALARYAVRRSLGvQYLPEAVKQLPLPRSVKEYLL 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 140-169 3.48e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.48e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568909489   140 HRSTPVYHASRVGRDDILKALIRYGADVDV 169
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 291-332 5.65e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 34.34  E-value: 5.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568909489 291 SIPRTLLSLCRVAVRRALGKYRLHL-VPSLPLPDPIKKFLLYE 332
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVkVKALPLPDRLKWYLLPE 43
PHA02798 PHA02798
ankyrin-like protein; Provisional
 89-172 5.94e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 38.28  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909489  89 NCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTEILL---EAGADP--NGSRHHRSTPVYHASRVGRD-DILKALIR 162
Cdd:PHA02798  90 DIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTtlLDKDGFTMLQVYLQSNHHIDiEIIKLLLE 169

                         90
                 ....*....|
gi 568909489 163 YGadVDVNHH 172
Cdd:PHA02798 170 KG--VDINTH 177
Ank_5 pfam13857
Ankyrin repeats (many copies);
94-148 7.02e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 7.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568909489   94 LIRKG-AEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHA 148
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 107-167 7.11e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 37.94  E-value: 7.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568909489 107 KGQTALYVAVVNGHLESTEILLEAGAD----PNGSRHHRST---------PVYHASRVGRDDILKALIRYGADV 167
Cdd:cd21882   72 QGQTALHIAIENRNLNLVRLLVENGADvsarATGRFFRKSPgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 76-105 7.50e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 7.50e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568909489   76 CTPLRIAAT-AGHGNCVDFLIRKGAEVDLVD 105
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 107-135 8.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 8.52e-03
                          10        20
                  ....*....|....*....|....*....
gi 568909489  107 KGQTALYVAVVNGHLESTEILLEAGADPN 135
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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