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Conserved domains on  [gi|569010102|ref|XP_006528077|]
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SLIT and NTRK-like protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569010102 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010102  400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569010102 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569010102   530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569010102   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569010102 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010102  400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 8.87e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 8.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010102   86 SNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569010102 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-531 2.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 358 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 437
Cdd:cd21340    7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 438 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 494
Cdd:cd21340   82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 569010102 495 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 531
Cdd:cd21340  142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569010102   530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-191 3.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRPgaFSGLKTLKRLHLNNNKLEV---------LRE---------- 127
Cdd:cd21340   29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveglenltnLEElhienqrlpp 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010102 128 --------DTFLGL-ESLEYLQADYNYISTIEagAFSKLNKLKVLILNDNLLLSLP--SNVFR-FVLLTHLDLRGN 191
Cdd:cd21340  105 gekltfdpRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.62e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL--EVLREdtfLG-LESLEYLQ 140
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010102 141 ADYNYIS---TIEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113 219 LGYNNLSgeiPYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569010102   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 381-458 2.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569010102 381 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 458
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 1.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569010102 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-217 3.34e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrPGAFSGLKTLKRLHLNNNKLEVLrEDTFLGLESLEYLQADYNY 145
Cdd:COG4886  140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569010102 146 ISTIEAgAFSKLNKLKVLILNDNLLLSLPSnVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGgimEIQLEENP 217
Cdd:COG4886  217 LTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
400-460 5.29e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.29e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010102  400 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 8.87e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 8.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010102   86 SNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-170 2.62e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 2.62e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  111 TLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLL 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-530 6.85e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 379 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 458
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569010102 459 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
359-531 1.38e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 359 NCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEV 438
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 439 LyPSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslpDNIFGGTALTRLNLRNNHFSHLPvkgVLDQ 518
Cdd:COG4886  220 L-PEPLANLTNLETLDLSNNQLTDL-------------------------PELGNLTNLEELDLSNNQLTDLP---PLAN 270

                        170
                 ....*....|...
gi 569010102 519 LPAFIQIDLQENP 531
Cdd:COG4886  271 LTNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-531 2.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 358 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 437
Cdd:cd21340    7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 438 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 494
Cdd:cd21340   82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 569010102 495 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 531
Cdd:cd21340  142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
135-193 3.08e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.08e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  135 SLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
530-580 1.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.97  E-value: 1.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569010102   530 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 580
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-528 1.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 366 TNISDLqPKPTSP----KKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIqEGAFTNLTSLRRLYLNGNYLEVLyP 441
Cdd:COG4886  169 NQLTDL-PEELGNltnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-P 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 442 SMFdGLQSLQYLYLEYNVIKEIKPLtfdalinlqllflnnnllrslpdniFGGTALTRLNLRNNHFSHLPVKGVLDQLPA 521
Cdd:COG4886  245 ELG-NLTNLEELDLSNNQLTDLPPL-------------------------ANLTNLKTLDLSNNQLTDLKLKELELLLGL 298


                 ....*..
gi 569010102 522 FIQIDLQ 528
Cdd:COG4886  299 NSLLLLL 305
LRR_8 pfam13855
Leucine rich repeat;
424-507 4.51e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  424 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslpdnifGGTALTRLNLR 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-----------------------GLPSLRYLDLS 57


                  ....
gi 569010102  504 NNHF 507
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
67-122 6.95e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010102   67 LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-505 1.29e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 366 TNISDLQP---KPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgaFTNLTSLRRLYLNGNYLEVLYPS 442
Cdd:COG4886  192 NQITDLPEplgNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569010102 443 MfdGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNN 505
Cdd:COG4886  269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-191 3.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRPgaFSGLKTLKRLHLNNNKLEV---------LRE---------- 127
Cdd:cd21340   29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveglenltnLEElhienqrlpp 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010102 128 --------DTFLGL-ESLEYLQADYNYISTIEagAFSKLNKLKVLILNDNLLLSLP--SNVFR-FVLLTHLDLRGN 191
Cdd:cd21340  105 gekltfdpRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-260 1.64e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  63 RIYQLFLNGNLLTRLypNEFVNYSNAVTLHLGNNGLQEIRpgAFSGLKTLKRLHLNNNKLEVLRedtflGLESLEYLQ-- 140
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-----NLENLVNLKkl 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 141 -ADYNYISTIE----------------------------AGAFSKLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGN 191
Cdd:cd21340   74 yLGGNRISVVEglenltnleelhienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 192 RLKVM-PFAGVLEHIGGIMEIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340  153 QISDLeELLDLLSSWPSLRELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.62e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKL--EVLREdtfLG-LESLEYLQ 140
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010102 141 ADYNYIS---TIEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113 219 LGYNNLSgeiPYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 1.92e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569010102   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN03150 PLN03150
hypothetical protein; Provisional
 91-170 5.14e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  91 LHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLL 170
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-197 1.23e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  40 NVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTL-HLGNNGLQEIRPGAFSGLKTLKRLHLN 118
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLlSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569010102 119 NNKLEVLREDTFLGLESLEYLQADYNyistieaGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-191 1.53e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102   96 NGLQEIRPGAFSGLKTLKRLHLNNNkLEVLREDTFLG--LESLEYLqadyNYISTIEAGAFSKLNKLKVLILNDNlLLSL 173
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNcsLTSITIP----SSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 569010102  174 PSNVFRFVLLTHLDLRGN 191
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 381-458 2.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569010102 381 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 458
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-530 4.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 338 ALTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQE 417
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 418 gaFTNLTSLRRLYLNGNylevlypSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslPDNIFGGTAL 497
Cdd:COG4886   92 --LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL------------------------PEELANLTNL 138

                        170       180       190
                 ....*....|....*....|....*....|...
gi 569010102 498 TRLNLRNNHFSHLPVkgVLDQLPAFIQIDLQEN 530
Cdd:COG4886  139 KELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN 169
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-217 8.21e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102  82 FVNYSNAVTLHLGNNGLQEIRPGAFSGL---KTLKRLHLNNNKLEVLREDTFL-GL----ESLEYLQADYNYI---STIE 150
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkGLkdlpPALEKLVLGRNRLegaSCEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010102 151 -AGAFSKLNKLKVLILNDN---------LLLSLPSNvfrfVLLTHLDLRGNRLK---VMPFAGVLEHIGGIMEIQLEENP 217
Cdd:cd00116  157 lAKALRANRDLKELNLANNgigdagiraLAEGLKAN----CNLEVLDLNNNGLTdegASALAETLASLKSLEVLNLGDNN 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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