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Conserved domains on  [gi|569006435|ref|XP_006526758|]
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prostaglandin D2 receptor 2 isoform X1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
32-314 1.78e-149

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15118:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 284  Bit Score: 423.83  E-value: 1.78e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15118    1 VATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPG 191
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFALFSPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PD-RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15118  161 PDnNHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 271 AHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15118  241 AHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
 
Name Accession Description Interval E-value
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
32-314 1.78e-149

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 423.83  E-value: 1.78e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15118    1 VATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPG 191
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFALFSPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PD-RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15118  161 PDnNHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 271 AHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15118  241 AHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
84-303 9.03e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 128.57  E-value: 9.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435   84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:pfam00001  39 PFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  164 PYFVFRDTIP-RLDGRIMCYynlLLWNPGPdrdttcdYRQKALAVSKFLLAFMVPLAIIASS--HVAVSLRLHHR----- 235
Cdd:pfam00001 119 PPLLFGWTLTvPEGNVTVCF---IDFPEDL-------SKPVSYTLLISVLGFLLPLLVILVCytLIIRTLRKSASkqkss 188
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435  236 -GRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSvTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:pfam00001 189 eRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD-CELSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
43-305 2.82e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 85.84  E-value: 2.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTY--FlavgHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:PHA02638 110 ILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYneF----DQWIFGDFMCKVISASYYIGFFSNMFL 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIP-YFVFRD-----TIPRLDGRIMCYYNLLLWNpgpDR 194
Cdd:PHA02638 186 ITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPaYFIFEAsniifSAQDSNETISNYQCTLIED---NE 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLeARAHSV 274
Cdd:PHA02638 263 KNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILF-ATMYSF 341
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 275 TTLRQLASRGLPFVTSLAF----------FNSVVNPLLYVF 305
Cdd:PHA02638 342 KGFNSIISEHICGFIKLGYammlaeaislTHCCINPLIYTL 382
 
Name Accession Description Interval E-value
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
32-314 1.78e-149

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 423.83  E-value: 1.78e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15118    1 VATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPG 191
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFALFSPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PD-RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15118  161 PDnNHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 271 AHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15118  241 AHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
32-314 8.93e-102

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 302.30  E-value: 8.93e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMcyynlllWNPG 191
Cdd:cd14974   81 LNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSC-------NLTC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARA 271
Cdd:cd14974  154 VEDYDLRRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELVA 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 272 HSVTTLrqLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd14974  234 AAGLPE--VVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
33-305 2.09e-71

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 225.03  E-value: 2.09e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15116    2 LSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL-DGRIMCYYNLLLWNPG 191
Cdd:cd15116   82 NMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnNNKIICFNNFSLSGDN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 --PDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEa 269
Cdd:cd15116  162 ssPEVNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLE- 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569006435 270 rAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15116  241 -MEATRSPASVFKIGLPITSSLAFINSCLNPILYVF 275
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
33-314 3.81e-58

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 190.72  E-value: 3.81e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15117    2 LSLVIYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCYYNLLLWNPGP 192
Cdd:cd15117   82 NLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKE-NGCTHCYLNFDPWNETA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 D----RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLE 268
Cdd:cd15117  161 EdpvlWLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLE 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 569006435 269 --ARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15117  241 lvVILNQKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
33-305 1.09e-57

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 189.18  E-value: 1.09e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15119    2 VSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWnpgp 192
Cdd:cd15119   82 NMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKH---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTCdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH 272
Cdd:cd15119  158 DGDLIV-MRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIH 236
                        250       260       270
                 ....*....|....*....|....*....|...
gi 569006435 273 SVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15119  237 HSSYLHNVLRAGIPLATSLAFINSCLNPILYVL 269
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
33-309 1.68e-52

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 175.34  E-value: 1.68e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15115    2 LSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCYYNLLlwnpgp 192
Cdd:cd15115   82 NMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTD-GNHTRCGYDFL------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 drdttcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLHH-RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLeaRA 271
Cdd:cd15115  155 ----------VAITITRAVFGFLLPLLIIAACYSFIAFRMQRgRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGIL--SL 222
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 272 HSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15115  223 YGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKD 260
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
33-304 2.09e-52

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 175.67  E-value: 2.09e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15114    2 VALVLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR-LDGRIMCyynlllwnpg 191
Cdd:cd15114   82 NMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEhFPEKTVC---------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdtTCDY-----RQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSL 266
Cdd:cd15114  152 -----VVDYggstgVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGL 226
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 267 LEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYV 304
Cdd:cd15114  227 IIAASAPNSRLLANALKADPLTVSLAYINSCLNPIIYV 264
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
41-306 2.62e-49

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 167.65  E-value: 2.62e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  41 ASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:cd15120   10 TFLVGLVVNGLYLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWN--PGPDRDTTC 198
Cdd:cd15120   90 LTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYALSTnwESAEVQASR 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFS--LLEARAHSVTT 276
Cdd:cd15120  170 QWIHVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSglVLTRGRPPSLT 249
                        250       260       270
                 ....*....|....*....|....*....|
gi 569006435 277 lrqLASRGLPFVTSLafFNSVVNPLLYVFT 306
Cdd:cd15120  250 ---DITLLLTVGTTC--FNTCFTPVLYLFV 274
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
33-305 1.55e-41

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 147.24  E-value: 1.55e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTT-WVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFF 111
Cdd:cd14975    2 LGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMlLVLNLALADLAVLLTLPVWIYFLATGT-WDFGLAACKGCVYVCA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdTIPRLDGRIMCYYNlllwnpg 191
Cdd:cd14975   81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFR-HVEETVENGMCKYR------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdttcdYRQKALAVSKFLL----AFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd14975  153 --------HYSDGQLVFHLLLetvvGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 268 EA------RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14975  225 EVvseligGSKMAGTLGKVAEAGRPIAGALAFLSSSINPLLYAF 268
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
37-307 1.34e-39

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 142.05  E-value: 1.34e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVgcrMR----QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFL 112
Cdd:cd14970    6 VYSVVCVVGLTGNSLVIYVI---LRyskmKTVTNIYILNLAVADELFLLGLPFLATSYLLG-YWPFGEVMCKIVLSVDAY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCyynLLLWnPGP 192
Cdd:cd14970   82 NMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISC---NLQW-PDP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL---------HHRGRQRTGRFV-RLVAAIVVAFVLCWGPYH 262
Cdd:cd14970  158 P-----DYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLrssrnlstsGAREKRRARRKVtRLVLVVVAVFVVCWLPFH 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 569006435 263 IFSLleARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd14970  233 VFQI--VRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLD 275
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
43-305 1.82e-38

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 139.05  E-value: 1.82e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd14985   12 LVGLLGNLFVVWVFLFPRGPkRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRI-MCYYNLLLWNpgpdrdttcdy 200
Cdd:cd14985   92 TCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKtACIMLYPHEA----------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKALAVSKFLLAFMVPLAIIASS--HVAVSLRLHH----RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEArahsV 274
Cdd:cd14985  161 WHFGLSLELNILGFVLPLLIILTCyfHIARSLRKRYertgKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDF----L 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 275 TTLRQLAS--------RGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14985  237 AQLGAIRPcfwelfldLGLPIATCLAFTNSCLNPFIYVF 275
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
40-311 1.73e-37

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 136.47  E-value: 1.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMR---QTVVTTWVLHLALSDLLAAASLPFFTYFLAVgHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15122    9 LAALLGLPGNGFIIWSILWKMKargRSVTCILILNLAVADGAVLLLTPFFITFLTR-KTWPFGQAVCKAVYYLCCLSMYA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtiprldgrimcyynllLWNPGPDRDT 196
Cdd:cd15122   88 SIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRH----------------VWKDEGMNDR 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 TCDYRQKALAVSKF------LLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15122  152 ICEPCHASRGHAIFhytfetLVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVV 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 569006435 271 AHSVT-----TLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDML 311
Cdd:cd15122  232 ANLAPgevleKLGGAAKAARAGATALAFFSSSVNPLLYVFAAGDLI 277
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
43-305 3.29e-37

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 135.80  E-value: 3.29e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVG-CRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhsWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd14984   12 LLGLVGNSLVLLVLLyYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSALYTINFYSGILFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRImCYYNLllwnpgpDRDTTCDYR 201
Cdd:cd14984   90 ACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSI-CSYDY-------PEDTATTWK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 202 QkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI------FSLLEARAHSVT 275
Cdd:cd14984  162 T-LLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIvllldtLQLLGIISRSCE 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 569006435 276 TLRQLaSRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14984  241 LSKSL-DYALQVTESLAFSHCCLNPVLYAF 269
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-305 3.72e-36

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 132.95  E-value: 3.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRM-RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15191    6 LYSIIFILGFLGNSLVVCVFCHQSgPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNhRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP----RLDGRIMCYYN--LLLWN 189
Cdd:cd15191   86 ASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYieelGVNACIMAFPNekYAQWS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 PGpdrdttcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRL-----HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIF 264
Cdd:cd15191  165 AG-------------LALMKNTLGFLIPLIVIATCYFGIGRHLlktkgFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 265 SLLEARAHS--------VTTLRQLasrgLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15191  232 TFLDALARMgvinncwvITVIDKA----LPFAICLGFSNSCINPFLYCF 276
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
37-309 3.68e-35

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 130.26  E-value: 3.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVlVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNlllWNPGPDRD 195
Cdd:cd15088   86 TSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVS---LPSPDDLY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYrqkalavsKFLLAFMVPLAIIASSHVAVSLRL--------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15088  163 WFTIY--------HFILGFAVPLVVITVCYILILHRLargvapgnQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 268 EARAHSVTTLRQLasrGLPFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15088  235 NLAMNRPTLAFEV---AYFLSICLGYANSCLNPFVYILVSEN 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
84-303 9.03e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 128.57  E-value: 9.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435   84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:pfam00001  39 PFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  164 PYFVFRDTIP-RLDGRIMCYynlLLWNPGPdrdttcdYRQKALAVSKFLLAFMVPLAIIASS--HVAVSLRLHHR----- 235
Cdd:pfam00001 119 PPLLFGWTLTvPEGNVTVCF---IDFPEDL-------SKPVSYTLLISVLGFLLPLLVILVCytLIIRTLRKSASkqkss 188
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435  236 -GRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSvTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:pfam00001 189 eRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD-CELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
33-306 1.86e-33

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 125.70  E-value: 1.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTT-WVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFF 111
Cdd:cd15121    2 LGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCiLVLNLALADAAVLLTAPFFLHFLSGG-GWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYynLLLWNPG 191
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCI--PYHPSVG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLE--- 268
Cdd:cd15121  159 ---------HEAFQYLFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQvag 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 269 ARAHSVTTLRQL--ASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15121  230 ALQNQAGNASVLkaAKLARPNVTALAFLSSSVNPVLYAFA 269
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-305 4.60e-33

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 124.85  E-value: 4.60e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15192    6 VYSIIFVVGIFGNSLVVIVIYCYMKlKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIprldgrimcyyNLLLWNpgpdrD 195
Cdd:cd15192   86 ASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVF-----------FIENTN-----I 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYRQK--------ALAVSKFLLAFMVPLAIIASSHVAV-----SLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYH 262
Cdd:cd15192  150 TVCAFHYPsqnstllvGLGLMKNLLGFLIPFLIILTCYTLIgkalkKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQ 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 263 IFSLLEA--RAHSVTTLR--QLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15192  230 IFTFLDVliQLKVIQDCHiaDIVDTAMPFTICIAYFNSCLNPILYGF 276
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
32-307 9.61e-32

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 121.22  E-value: 9.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVF 110
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKrSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWnp 190
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEW-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 191 gpdrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL-----HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd14982  159 --------LASAAPIVLIALVVGFLIPLLIILVCYSLIIRALrrrskQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTR 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 569006435 266 LLEARAHSVTTL----RQLASRGLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd14982  231 ILYLLVRLSFIAdcsaRNSLYKAYRITLCLASLNSCLDPLIYYFLS 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
35-307 8.89e-31

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 118.55  E-value: 8.89e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGC--RMRQT-------------VVTTWVLhlalsdllaaaslPFFTYFLAVGHsWELG 99
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRnrRLRTVtnyfilnlavadlLVGLLVI-------------PFSLVSLLLGR-WWFG 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 100 TTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRI 179
Cdd:cd00637   68 DALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 180 MCYYNLLLWNpgpdrdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG---------------RFV 244
Cdd:cd00637  148 CCLCWPDLTL------------SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrrerKVT 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569006435 245 RLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLAsrgLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd00637  216 KTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRIL---YFLALLLAYLNSAINPIIYAFFN 275
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
36-307 8.92e-31

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 118.64  E-value: 8.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhsWELGTTFCKLHSSVFFLNM 114
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVlLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTI--PRLDgRIMCYYNLllwnpgP 192
Cdd:cd15180   83 YCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATkdPRQN-KTECVHNF------P 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTtcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ-RTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARA 271
Cdd:cd15180  156 QSDT---YWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGfQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 272 HSVTTLRQLASRG-----LPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd15180  233 DLSVLDRNCGTESrldiaLSVTSSLGYFHCCLNPLLYAFVG 273
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
33-306 9.47e-29

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 112.95  E-value: 9.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVV--GCRMrQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVF 110
Cdd:cd15094    2 ISAVLYGLICIVGLVGNGLVIYVVlrYAKM-KTVTNLYILNLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLdGRIMCYynlLLWNP 190
Cdd:cd15094   80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDS-GRYSCT---IVWPD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 191 GPDRDTtcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG-------RQRTGRFV-RLVAAIVVAFVLCWGPYH 262
Cdd:cd15094  156 SSAVNG-----QKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGpknkskeKRRSHRKVtRLVLTVISVYIICWLPYW 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 263 IFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15094  231 AFQVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFL 274
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
36-306 1.48e-27

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 109.90  E-value: 1.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGC---RMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYLLKSnkkLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCyynlLLWNPGP 192
Cdd:cd14976   85 NMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLC----LLRFPKN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSL---RLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA 269
Cdd:cd14976  161 SSVTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRflqRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 270 -----RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd14976  241 likfdDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLV 282
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-305 4.18e-27

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 109.08  E-value: 4.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVV--GCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd15190   19 LVFVLGLSGNGLVLWTVfrSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNMYAS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIpRLDG--RIMCY--YNLLLWNpgpd 193
Cdd:cd15190   99 VFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTS-DLEGtnKVICDmdYSGVVSN---- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdTTCDYRQKALAVSKFLLAFMVPLAIIASSHVA----VSLRLHHRGR---QRTGRFVRLVAAIVVAFVLCWGPYHIFSL 266
Cdd:cd15190  174 --ESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFigrtVARHFSKLRRkedKKKRRLLKIIITLVVTFALCWLPFHLVKT 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 267 LEA-----RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15190  252 LYAlmylgILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAF 295
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
35-305 1.42e-26

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 106.97  E-value: 1.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGCRMRQTVVT-TWVLHLALSDLLAAASLPFFTyfLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd15178    4 CVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTdVYLLHLAIADLLFALTLPFWA--VSVVKGWIFGTFMCKLVSLLQEAN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHrVCLMLWALAVLNTIPYFVFRDTI-PRLDGRIMCYYNLllwnpgp 192
Cdd:cd15178   82 FYSGILLLACISVDRYLAIVHATRALTQKRHLVKF-VCAGVWLLSLLLSLPALLNRDAFkPPNSGRTVCYENL------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTCDYRQkALAVSKFLLAFMVPLAIIASSH-VAVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCWGPYHIFSLLEA-- 269
Cdd:cd15178  154 GNESADKWRV-VLRILRHTLGFLLPLVVMLFCYgFTIKTLLQTRSFQKH-RAMRVIFAVVLAFLLCWLPYNVTVLIDTlm 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 270 RAHSVT---TLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15178  232 RTKLITetcELRNHVDVALYVTQILGFLHSCINPVLYAF 270
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-305 1.31e-25

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 104.47  E-value: 1.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLN 113
Cdd:cd15093    5 CIYAVVCLVGLCGNSLVIYVVlrYAKMK-TVTNIYILNLAIADELFMLGLPFLAASNALRH-WPFGSVLCRLVLSVDGIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYynlLLWnPGPD 193
Cdd:cd15093   83 MFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACN---MQW-PEPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcDYRQKALAVSKFLLAFMVPLAIIASSHV-------AVSLRLHHRGRQRTGRFV-RLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd15093  159 -----AAWSAGFIIYTFVLGFLLPLLIICLCYLlivikvkSAGLRAGWQQRKRSERKVtRMVVMVVVVFVICWLPFYVLQ 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 266 LLEARAHSVTTlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15093  234 LVNVFVQLPET--PALVGVYHFVVILSYANSCANPILYGF 271
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
37-314 1.58e-25

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 104.06  E-value: 1.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15372    6 LYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGrimcyyNLLLWNPGPDRDT 196
Cdd:cd15372   86 SVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERL------NITLCHDVLPLDE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 TCDYRQKALaVSKFLLAFMVPLAIIASSHVAVsLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEaraHSVTT 276
Cdd:cd15372  160 QDTYLFYYF-ACLAVLGFLLPLVVILFCYGSV-LHTLLRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLH---YSDPT 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 277 LRQLASRGLPFVTSLAF--FNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15372  235 LDDGGNLYIVYMVSLAIstLNSCVDPFIYYYVSEEFRDKV 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
36-305 3.82e-25

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 103.07  E-value: 3.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLN 113
Cdd:cd15970    5 FIYSVVCLVGLCGNSMVIYVIlrYAKMK-TATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGSLLCRLVLSVDAIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCyyNLLLwnPGPD 193
Cdd:cd15970   83 MFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVAC--NMQM--PEPS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 RDTTCdyrqkALAVSKFLLAFMVPLAIIASSHV-------AVSLRLHHRGRQRTGRFVRL-VAAIVVAFVLCWGPYHIFS 265
Cdd:cd15970  159 QRWLA-----VFVVYTFLMGFLLPVIAICLCYIliivkmrVVALKAGWQQRKRSERKITLmVMMVVTVFVICWMPFYVVQ 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 266 LLE--ARAHSvTTLRQLAsrglpfvTSLAFFNSVVNPLLYVF 305
Cdd:cd15970  234 LVSvfVGQHD-ATVSQLS-------VILGYANSCANPILYGF 267
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
35-303 4.69e-25

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 103.07  E-value: 4.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGC--RMRQT----------------VVTTWvlhlalsdllaaaslpfFTYFLAVGHSW 96
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRnkSMQTVtnifilnlavsdlllcLVSLP-----------------FTLIYTLTKNW 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  97 ELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRTvavAHRVCLMLWALAVLNTIPYFVFRDTI--P 173
Cdd:cd15203   67 PFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTrPRMSKRH---ALLIIALIWILSLLLSLPLAIFQELSdvP 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 RLDGRIMCYYNLLLWnpgPDrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFV--------- 244
Cdd:cd15203  144 IEILPYCGYFCTESW---PS-----SSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTlssrrrrse 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 245 --------RLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15203  216 lrrkrrtnRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVNPLLY 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
43-305 5.52e-25

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 102.72  E-value: 5.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPF-FTYFLAvgHSWELGTTFCKLHSSVFFLNMFASGF 119
Cdd:cd15091   12 VVGLVGNSLVMFVIirYTKMK-TATNIYIFNLALADALVTTTMPFqSTVYLM--NSWPFGDVLCKIVISIDYYNMFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 120 LLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLD-GRIMCYYNLllwnpgPDRDTTc 198
Cdd:cd15091   89 TLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDvDSTECSLQF------PDDDYS- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 dYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLH-------HRGRQRT-GRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15091  162 -WWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKsvrllsgSREKDRNlRRITRLVLVVVAVFVVCWTPIHIFILVEAL 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 569006435 271 AHSVTTLRQLASrgLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15091  241 GSVSHSTAAVSS--YYFCIALGYTNSSLNPILYAF 273
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
37-305 1.50e-24

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 101.47  E-value: 1.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLNM 114
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVIlrYAKMK-TATNIYILNLAIADELFMLSVPFLAASAALQH-WPFGSAMCRTVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYynlLLWnPGPDR 194
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACN---LIW-PHPAW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTtcdyrqkALAVSKFLLAFMVPLAIIASSHV-------AVSLRLHHRGRQRT-GRFVRLVAAIVVAFVLCWGPYHIFSL 266
Cdd:cd15973  160 SA-------AFVIYTFLLGFLLPVLAIGLCYIliigkmrAVALKAGWQQRRKSeKKITRMVLMVVTVFVICWMPFYVVQL 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 267 LEarahsvTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15973  233 LN------LFLPRLDATVNHASLILSYANSCANPILYGF 265
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
37-307 6.95e-24

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 99.89  E-value: 6.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVV----GCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIvkksKFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLllwnPGP 192
Cdd:cd15338   86 SQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLL----PNP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTCdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRL--------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIF 264
Cdd:cd15338  162 ETDTYW------FTLYQFFLAFALPLVVICVVYFKILQNMastvaplpQRSLRVRTKKVTRMAVAICLAFFICWAPFYIL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 265 SLLEARAHSVTTLRQLASRglpFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd15338  236 QLAHLSIDRPSLAFLYAYN---VAISMGYANSCINPFLYIMLS 275
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
32-305 2.16e-23

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 98.20  E-value: 2.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTT-WVLHLALSDLLAAASLPFFT-YFLavgHSWELGTTFCKLHSSV 109
Cdd:cd15182    1 AFLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNiFILNLAISDLLFTFTLPFWAsYHS---SGWIFGEILCKAVTSI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 110 FFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWN 189
Cdd:cd15182   78 FYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCEYSSIKWK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 PGpdrdttcDYRQkalavskFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLea 269
Cdd:cd15182  158 LG-------YYYQ-------QNLFFLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFL-- 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 270 RAHSVTTLRQL-ASRGLP----FVTSLAFFNSVVNPLLYVF 305
Cdd:cd15182  222 RSLKDLTIPICeCSKQLDyafyICRNIAFSHCCLNPVFYVF 262
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
37-305 3.35e-23

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 97.71  E-value: 3.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILF-VVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYgIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCyynlLLWNPGPDRd 195
Cdd:cd15089   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVC----MLQFPSPSW- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 ttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHH-------RGRQRT-GRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15089  160 ----YWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSvrllsgsKEKDRNlRRITRMVLVVVAAFIICWTPIHIFVIV 235
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 268 EARAhSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15089  236 WTLV-DIDRRNPLVVAALHLCIALGYANSSLNPVLYAF 272
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
44-305 4.07e-23

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 97.56  E-value: 4.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  44 LGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLS 122
Cdd:cd15380   13 FGLLGNLFVLFVFLLPRRRlTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIFLVV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 123 AISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFR--DTIPRLD-GRIMCYYNLLLWNpgpdrdttcd 199
Cdd:cd15380   93 AISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRsvKHVPDLNiSACILLFPHEAWH---------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 200 yrqKALAVSKFLLAFMVPLAIIA--SSHVAVSLRLHHR-GRQRTG-----RFVRLVAAIVVAFVLCWGPYHIFSLLE--- 268
Cdd:cd15380  163 ---FARRVELNIVGFLLPLAAIVffNFHIIASLRERTEeSRKRCGglkdtKATRLILTLVLMFLVCWTPYHFFAFLDflf 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 269 -ARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15380  240 qVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVF 277
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
36-305 4.53e-23

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 97.53  E-value: 4.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMRQTVVT-TWVLHLALSDLLAAASLPFFTYFLAVghSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTdKYRLHLSVADLLFVLTLPFWAVDAAA--NWYFGNFLCKAVHVIYTVNL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiPRLDGRIMCyynlllwnpgpDR 194
Cdd:cd15179   83 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKV-SELDDRYIC-----------DR 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTTCDYRQKALAVSKF---LLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI------FS 265
Cdd:cd15179  151 IYPEDTFELWVVAFRFqhiLVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidtFM 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 266 LLEARAHSVtTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15179  231 LLEIIKQSC-EMEQTVHKWISITEALAFFHCCLNPILYAF 269
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
87-305 4.78e-23

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 97.47  E-value: 4.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  87 TYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYF 166
Cdd:cd15161   58 VYHLSGNH-WPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 167 VFRDTIpRLDGRIMCyynLLLwnpgpdrdttcdYRQKA--LAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG--- 241
Cdd:cd15161  137 VSPQTV-EVNNTTVC---LQL------------YREKAsrGALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPlkd 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 242 RFVRLVAAIVVAFVLCWGPYHI---FSLLEARAHSVT-TLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15161  201 KAIKMIILVLTIFLICFVPYHIsryIYILSHNGAGAScSSRRGLALANRITSCLTCLNGALDPVMYFF 268
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
43-309 1.12e-22

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 96.62  E-value: 1.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15168   12 LVGLLLNSVVLYRFIFHLKPwNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNLYGSILFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFrDTIPRLDGRIMCYynlllwnpgpdrDTTCD-- 199
Cdd:cd15168   92 TCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFF-ATTGRKNNRTTCY------------DTTSPee 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 200 ---YRQKALAVSkfLLAFMVPLAIIASSHVAVSLRLHHRGRQ-----RTGRFVRLVAAIVVAFVLCWGPYHIFSL--LEA 269
Cdd:cd15168  159 lndYVIYSMVLT--GLGFLLPLLIILACYGLIVRALIRKLGEgvtsaLRRKSIRLVIIVLALFAVCFLPFHVTRTinLAA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 270 RAHSVTT---LRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15168  237 RLLSGTAscaTLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDK 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
84-310 1.66e-22

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 95.32  E-value: 1.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALA-VLNT 162
Cdd:cd14967   54 PFSAVYTLLGY-WPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSlLISL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IPYFVFRDTIPRLDGRIMCYYNLllwnpgpdrdttcdyrQKALAVSKFLLAFMVPLAIIAS--SHVAVSLRLHHRGrqrt 240
Cdd:cd14967  133 PPLVGWRDETQPSVVDCECEFTP----------------NKIYVLVSSVISFFIPLLIMIVlyARIFRVARRELKA---- 192
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 241 grfVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLasrgLPFVTSLAFFNSVVNPLLYVFTCPDM 310
Cdd:cd14967  193 ---AKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPIL----YAVFFWLGYLNSALNPIIYALFNRDF 255
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
35-305 3.80e-22

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 94.93  E-value: 3.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFL 112
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVIlrHTKMK-TATNIYIFNLALADTLVLLTLPFQGTDIFLGF-WPFGNALCKTVIAIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCyynlLLWNPGP 192
Cdd:cd15092   82 NMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVE-DEEIEC----LVEIPTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHH-------RGRQRT-GRFVRLVAAIVVAFVLCWGPYHIF 264
Cdd:cd15092  157 Q-----DYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGvrllsgsKEKDRNlRRITRLVLVVVAVFVGCWTPIQIF 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 265 SL---LEARAHSVTTLRQLAsrglpFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15092  232 VLaqgLGVQPSSETAVAILR-----FCTALGYVNSSLNPVLYAF 270
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
36-305 9.65e-22

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 93.69  E-value: 9.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVgCRMRQTVVTT--WVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVV-ARNKPMRSTTnlFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY-FVFRDTIPRLDGRIMCyynlllWNPGP 192
Cdd:cd14971   84 MHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVlALHRLRNYTPGNRTVC------SEAWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRdttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHH---------RGRQRTGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd14971  158 SR-----AHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRvavrpvlseGSRRAKRKVTRLVLVVVVLFAACWGPIHA 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 264 FSLLEARAHSVTTLRQLASRGLPFVtsLAFFNSVVNPLLYVF 305
Cdd:cd14971  233 ILLLVALGPFPLTYATYALRIWAHC--LAYSNSAVNPVLYAF 272
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
95-305 2.03e-21

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 92.87  E-value: 2.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTI-- 172
Cdd:cd15098   67 EWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVhh 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLDGRIMCYYNlllWNPGPDRdttcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLH-------HRGRQRTGRFVR 245
Cdd:cd15098  147 WTASNQTFCWEN---WPEKQQK--------PVYVVCTFVFGYLLPLLLITFCYAKVLNHLHkklknmsKKSERSKKKTAQ 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 246 LVAAIVVAFVLCWGPYHIFSLLEARAHsvTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15098  216 TVLVVVVVFGISWLPHHIIHLWVEFGD--FPLTQASFVLRITAHCLAYANSCVNPIIYAF 273
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
37-305 2.22e-21

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 92.89  E-value: 2.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15193    6 LYLIIFFTGLLGNLFVIALMSKRSTtKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIprldgrimcyynlllwnpgpdRD 195
Cdd:cd15193   86 SSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI---------------------NE 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYRQKALAVSKF-----LLAFMVPLAIIA--SSHVAVSLRLHHRGRQRTGR----FVRLVAAIVVAFVLCWGPYHIF 264
Cdd:cd15193  145 SVCVEDSSSRFFQGIslatlFLTFVLPLIVILfcYCSILVRLRRHFHGAKRTGRrrrnSLRIVFAIVTAFVLSWLPFNTL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 569006435 265 SLLEARAHSVT-----TLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15193  225 KAVRLLLELGGgvlpcHTTVAIRQGLTITACLAFVNSCVNPLIYSL 270
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
40-304 3.02e-21

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 92.52  E-value: 3.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASG 118
Cdd:cd15381    9 IIFVLGTIENAFVLIVfCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 119 FLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdtiprldgRIMCY--YNL---LLWNPGPd 193
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFR--------TVMYFpeYNItacVLDYPSE- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcdYRQKALAVSKFLLAFMVPLAIIA--SSHVAVSLRLHHRGR----QRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15381  160 ------GWHVALNILLNVVGFLIPLSIITfcSTQIIQVLRNNKMQKfkeiQTERKATVLVLAVLLMFFICWLPFHIFTFL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 268 EA----RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYV 304
Cdd:cd15381  234 DTlhklGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYV 274
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
81-305 8.14e-21

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 91.29  E-value: 8.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  81 ASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVL 160
Cdd:cd15160   51 LTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELG 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIPYFVFRDTIPRLDGRIMCYYNLLLwnpgpdrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG---R 237
Cdd:cd15160  131 THSVFLGHDELFRDEPNHTLCYEKYPM-----------EGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPsleR 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGL--PFVTSLAF--FNSVVNPLLYVF 305
Cdd:cd15160  200 EEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGLCGFEKRVftAYQISLCLtsLNCVADPILYIF 271
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
87-307 1.37e-20

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 90.49  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  87 TYFlAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyF 166
Cdd:cd15159   58 AYY-ALGFDWPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLP-L 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 167 VFRDTIPRLDGRIMC--YYNLllwnpgpdrdttcdyrQKALAVSKFLLA-----FMVPLAIIASSHVAVSLRLHHRGRQ- 238
Cdd:cd15159  136 LFMPMTKEMGGRITCmeYPNF----------------EKIKRLPLILLGacvigFGVPVGIILFCYSQITLKLCRTAKEn 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 239 -------RTGRFVRLVAAIVVAFVLCWGPYHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd15159  200 plteksgHHKKACNVILLVLLVFVVCFSPYHLniiqFMIRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFAC 279
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
37-304 2.61e-20

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 89.87  E-value: 2.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLlwnpGPDrdt 196
Cdd:cd15339   86 CSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLT----SPD--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 tcDYRQKALAVSkfLLAFMVPLAIIASSHVAV---SLRLHHRG-----------RQRTGRFVRLVAAIVVAFVLCWGPYH 262
Cdd:cd15339  159 --DVLWYTLYQT--ITTFFFPLPLILICYILIlcyTWEMYRKNkkagryntsipRQRVMRLTKMVLVLVGVFLVSAAPYH 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 569006435 263 IFSLLEARAHSVTtlrqlasrgLPFVTS------LAFFNSVVNPLLYV 304
Cdd:cd15339  235 VIQLVNLSVSQPT---------LAFYVSyylsicLSYASSSINPFLYI 273
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
36-305 3.22e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 89.42  E-value: 3.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMRQTVVT-TWVLHLALSDLLAAASLPFFTYFLAVGhsWELGTTFCKLHSSVFFLNM 114
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTILLRRRRSRRTTeNYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFrdtiprldgrimcyynLLLWNPGPDR 194
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVF----------------LEVETSTNAN 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTTCDYRQ------KALAVSKFL---LAFMVPLAIIA--SSHVAVSLRLHHRGRQRTGRfVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15181  147 RTSCSFHQygihesNWWLTSRFLyhvVGFFLPLLIMGycYATIVVTLCQSSRRLQKQKA-IRVAILVTLVFCLCWLPYNI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 264 FSLLEARAHSVT-----TLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15181  226 VIFLDTLDDLKAvvkncKLNDLLDAAITVTESLGFSHCCLNPILYAF 272
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
37-305 7.80e-20

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 88.51  E-value: 7.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15090    6 LYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGNILCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCyyNLLLWNPGPdrd 195
Cdd:cd15090   85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR-QGSIDC--TLTFSHPSW--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 ttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLH--------HRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15090  159 ----YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 234
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 268 EARAHSVTTLRQLASrgLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15090  235 KALVTIPETTFQTVS--WHFCIALGYTNSCLNPVLYAF 270
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
36-305 9.76e-20

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 88.11  E-value: 9.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGC--RMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRhrEMR-TVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNlllwnpgpd 193
Cdd:cd15095   84 VQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQTYCR--------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL--------------HHRGRQRTGRFVRLVAAIVVAFVLCWG 259
Cdd:cd15095  155 EVWPSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLwrrsvdgnnqseqlSERALRQKRKVTRMVIVVVVLFAICWL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006435 260 PYHIFSLLEA------RAHSVTTLRQLAsrglpfvTSLAFFNSVVNPLLYVF 305
Cdd:cd15095  235 PNHVLNLWQRfdpnfpETYATYALKIAA-------LCLSYANSAVNPFVYAF 279
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-306 1.04e-19

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 88.29  E-value: 1.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGC-RMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15189   12 LFGLLGNLFVLLVFLLhRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRI---MCYYNLLLWnpgpdrdttc 198
Cdd:cd15189   92 VMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNItacVLLYPHEAW---------- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 dyrQKALAVSKFLLAFMVPLAII--ASSHVAVSLRLH----HRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEArAH 272
Cdd:cd15189  162 ---HFAHIVLLNIVGFLLPLLVItfCNYNILQALRTReestRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDF-LF 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 273 SVTTLRQ-----LASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15189  238 DVGVLDEcfwehFIDIGLQLAVFLAFSNSCLNPVLYVFV 276
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
35-305 1.43e-19

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 87.58  E-value: 1.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILF-VVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhsWELGTTFCKLHSSVFFLN 113
Cdd:cd15186    4 SIFYSLVFAFGLVGNLLVVLaLTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE--WGLHNAMCKLTTAFFFIG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtipRLDGRIMCYYNLLLWNPGPd 193
Cdd:cd15186   82 FFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTK---MKENECLGDYPEVLQEIWP- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH- 272
Cdd:cd15186  158 ---------VLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLy 228
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 273 ----SVTTLRQLaSRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15186  229 dffpSCDMKKDL-RLALSVTETIAFSHCCLNPLIYAF 264
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
91-305 2.40e-19

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 87.22  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  91 AVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRD 170
Cdd:cd15194   61 VVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRE 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 171 tIPRLDGRIMCyynlllwnpgpdRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL------HHRGRQRTGRFV 244
Cdd:cd15194  141 -LKKYEEKEYC------------NEDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLchhyqkSGKHQKKLRKSI 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 245 RLVAAIVVAFVLCWGPYHIFSLLEArahsVTTLRQ--------LASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15194  208 KIVFIVVAAFVFSWMPFNLFKALAI----ASGLQVevtclpytLAQLGMEVSAPLAFANSCANPFIYYF 272
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
42-330 5.27e-19

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 85.77  E-value: 5.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  42 SLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTyFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd14973   11 SLCGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQS-LEDLLGGSLPGFALCRLLATLMFFSYTVGLSLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFrdtiprldgrimCyyNLLLWNPGPDRdttCDYR 201
Cdd:cd14973   90 AAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYF------------C--GFLFWKFNESA---CRTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 202 QKALAVskfLLAFMVPLAIIASSHVAVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVttlrqLA 281
Cdd:cd14973  153 NFLSAL---LFLLLFLVMCVSSLTLLIRVQCSSQRRPPT-RLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNY-----LF 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 282 SRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDS 330
Cdd:cd14973  224 HTFHPISDLLSCVNSSANPIIYFFVGSLRGRRLREPLRVVLQRALRDEP 272
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
36-305 5.67e-19

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 86.01  E-value: 5.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAvgHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWVlVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLL--DQWVFGNAMCKIVSGAYYIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCYYnllLWNPGPDr 194
Cdd:cd15187   83 YSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASE-DGRLQCIP---FYPGQGN- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 dttcdyRQKALAVSKF-LLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEArAHS 273
Cdd:cd15187  158 ------SWKVFTNFEVnILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDS-LHS 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 274 VTTL-----RQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15187  231 LHIIdgcqnSQRLTLALHLTETISFTHCCLNPVIYAF 267
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
36-305 5.70e-19

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 86.05  E-value: 5.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLN 113
Cdd:cd15971    5 FIYFVVCIIGLCGNTLVIYVIlrYAKMK-TVTNIYILNLAIADELFMLGLPFLAIQVALVH-WPFGKAICRVVMTVDGIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCyynLLLWnPGPD 193
Cdd:cd15971   83 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTK-HGRSSC---TIIW-PGES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG-------RQRTGRFV-RLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd15971  158 -----SAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGirvgsskRKKSEKKVtRMVSIVVAVFVFCWLPFYIFN 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 266 LLEArahSVTTLRQLASRGL-PFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15971  233 VSSV---SVSISPTPGLKGMfDFVVVLSYANSCANPILYAF 270
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
92-305 1.07e-18

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 85.19  E-value: 1.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDT 171
Cdd:cd15012   61 LIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQT 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 IPRLDGRIMCYYNLLLWNPGpdrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGR-FVRLVAAI 250
Cdd:cd15012  141 VEILVTQDGQEEEICVLDRE-------MFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRkVVRLLVAV 213
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 251 VVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15012  214 VVSFALCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAF 268
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
86-305 2.25e-18

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 84.27  E-value: 2.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYflAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhrVCLMLWALAVLNTIPY 165
Cdd:cd15390   58 FTY--LLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKI--AIAVIWLASFLLALPQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDTI----PRLDGRIMCYynlLLWNPGPDRDTTCDYrQKALavskFLLAFMVPLAIIASSHVAVSLRL--------- 232
Cdd:cd15390  134 LLYSTTEtyyyYTGSERTVCF---IAWPDGPNSLQDFVY-NIVL----FVVTYFLPLIIMAVAYTRVGVELwgsktigen 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 233 ---HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLearAHSVTTLRQLASRGLPFVTS--LAFFNSVVNPLLYVF 305
Cdd:cd15390  206 tprQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYFIL---TYLYPDINSWKYIQQIYLAIywLAMSNSMYNPIIYCW 280
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
43-305 2.82e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 85.84  E-value: 2.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTY--FlavgHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:PHA02638 110 ILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYneF----DQWIFGDFMCKVISASYYIGFFSNMFL 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIP-YFVFRD-----TIPRLDGRIMCYYNLLLWNpgpDR 194
Cdd:PHA02638 186 ITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPaYFIFEAsniifSAQDSNETISNYQCTLIED---NE 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLeARAHSV 274
Cdd:PHA02638 263 KNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILF-ATMYSF 341
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 275 TTLRQLASRGLPFVTSLAF----------FNSVVNPLLYVF 305
Cdd:PHA02638 342 KGFNSIISEHICGFIKLGYammlaeaislTHCCINPLIYTL 382
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
84-314 3.09e-18

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 83.97  E-value: 3.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15967   54 PFLVVYYLKGRKWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIPrldGRIMCYYNlllwnpgPDRDTTCDYRQKALAVSKFllAFMVPLAIIAS--SHVAVSL-RLHHRGRQRT 240
Cdd:cd15967  134 PDLFFSKTNS---NGTKCFDT-------TFNDYLESYLTYSLGWTVT--GFVIPLLIILGcyGHVVVVLcRNNNVDKGLK 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 241 GRFVRLVAAIVVAFVLCWGPYHIFSLL-------------EARAHSVTTLRQLaSRGlpfvtsLAFFNSVVNPLLYVFTC 307
Cdd:cd15967  202 QRCLKLVIILIVLFSVCYIPYHVFRNLnllsrilqkqgscTQWFRGIYIAHQV-SRG------LVCLNSALNPLVYLMGS 274

                 ....*..
gi 569006435 308 PDMLYKL 314
Cdd:cd15967  275 EDILSRI 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
36-305 3.90e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 83.50  E-value: 3.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCR--MRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFLN 113
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNqqMRSTTNILILNLAVADLLFVVFCVPFTATDYVLP-TWPFGDVWCKIVQYLVYVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfVFRDTIPRLDGRIMC--YYNLLLWNPG 191
Cdd:cd15096   84 AYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIP--VLFLHGVVSYGFSSEaySYCTFLTEVG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG----------RQRTGRFVRLVAAIVVAFVLCWGPY 261
Cdd:cd15096  162 --------TAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKspggrrsaesQRGKRRVTRLVVVVVVVFAICWLPI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 569006435 262 HIFSLLEARAH-SVTTLRQLASrglPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15096  234 HIILLLKYYGVlPETVLYVVIQ---ILSNCLAYGNSCVNPILYAF 275
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
84-305 3.94e-18

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 83.86  E-value: 3.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PF-FTYFLAVGHSWELGTTFCKlhsSVFFLNM---FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhrVCLMLWALAV 159
Cdd:cd15204   55 PFeMDYYVVRQRSWTHGDVLCA---VVNYLRTvslYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACV--VIALVWVVSL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 LNTIPYFVFRDTIP-RLDGRIMCYynlLLWNPGPDRdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG-- 236
Cdd:cd15204  130 LLAIPSAVYSKTTPyANQGKIFCG---QIWPVDQQA------YYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRvp 200
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 237 ----------RQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15204  201 gqqteqirrrLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVA 279
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
39-308 6.22e-18

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 82.88  E-value: 6.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd14991    8 ILEFVLGLPGNVVALWIFCFHSRtWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyFVFRDTIPRLDGRIMCyYNLLLWNPGPdrdtt 197
Cdd:cd14991   88 IAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLP-LLLSTLLTVNSNKSSC-HSFSSYTKPS----- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 198 cdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGR----QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHS 273
Cdd:cd14991  161 ---LSIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSlgkqARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKN 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 274 VTTLRQLASRGLPFVTSLAF--FNSVVNPLLYVFTCP 308
Cdd:cd14991  238 LGSCRCLNSVAQLFHISLAFtyLNSALDPVIYCFSSP 274
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
96-318 8.28e-18

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 83.03  E-value: 8.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiprl 175
Cdd:cd14993   66 WVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYEL---- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgrimcyYNLLLWNPGPDRDTTCD------YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG-------- 241
Cdd:cd14993  142 -------EEIISSEPGTITIYICTedwpspELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRgsanstss 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 --------RFVRLVAAIVVAFVLCWGPYHIFSL-LEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFtcpdMLY 312
Cdd:cd14993  215 rrilrskkKVARMLIVVVVLFALSWLPYYVLSIlLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCF----MSK 290

                 ....*.
gi 569006435 313 KLRRSL 318
Cdd:cd14993  291 KFRRGF 296
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
84-305 1.03e-17

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 82.50  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAvgHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHR--TVAVAHRVCLMLWALAVLN 161
Cdd:cd15172   54 PFWAVYEA--HQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLRsrTLAYSKLICAAVWLLAILI 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 162 TIPYFVFRDTIP-RLDGRIMCyynlllwnpGPDRDTTCDYRQKALAV--SKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ 238
Cdd:cd15172  132 SLPTFIFSEVYDfGLEEQYVC---------EPKYPKNSTAIMWKLLVlsLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNS 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 239 RTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA----RAHSVTTLRQLASRglPFVT-SLAFFNSVVNPLLYVF 305
Cdd:cd15172  203 QRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAinlgEQQSCSSEKAVAYA--KTITeCLAFFHCCLNPVLYAF 272
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
43-306 1.25e-17

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 82.12  E-value: 1.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15154   12 PVGLLLNAVALWVFVRYLRlHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHY-WPFGNFLCQFSGSIFQMNMYGSCLFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYF-VFRDTIPRLDGRI--MCYYNLLLWNPGpdrdttc 198
Cdd:cd15154   91 MCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAiVHSSSDCLLHGEKvyRCFESFSDNDWK------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 dyRQKALAVSKFLLAFMVPLAIIASS--HVAVSL-RLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYH----IFSLLEARA 271
Cdd:cd15154  164 --GLLPLVVLAEILGFLLPLAAVLYCscRIFVELcRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNttlaVYGLLRANL 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569006435 272 HSVTTLRQLASRGLPFVTS-LAFFNSVVNPLLYVFT 306
Cdd:cd15154  242 VEDTWNIKDTLRKVLSVTVlLASTNCALDPLVYYFS 277
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
35-306 1.34e-17

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 81.94  E-value: 1.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVV-GCRMRQTVVTTW-VLHLALSDLLAAASLPFFTYfLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVaRFRRMRSVTNVFlASLATADLLLLVFCVPLKTA-EYFSPTWSLGAFLCKAVAYLQLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGP 192
Cdd:cd15001   82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 drdttcdYRQKALAVSKFLLAFMVPLAIIASSHVavslrlhHRGRQRTgrfVRLVAAIVVAFVLCWGPYHIFSLLEA-RA 271
Cdd:cd15001  162 -------LYSRLYVVYLAIVIFFIPLIVMTFAYA-------RDTRKQV---IKMLISVVVLFAVCWGPLLIDNLLVSfDV 224
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 569006435 272 HSVTTLRQLASRGLPFvTSLAFFNSVVNPLLYVFT 306
Cdd:cd15001  225 ISTLHTQALKYMRIAF-HLLSYANSCINPIIYAFM 258
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
43-305 4.46e-17

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 80.57  E-value: 4.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTyfLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15174   12 LVGAVGNSLVVLIyTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWA--TAASSGWVFGTFLCKVVNSMYKINFYSCMLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHR--VCLMLWALAVLNTIPYFVFRDT--IPRLDGRIMCYYNLLlwnpgpdrdtt 197
Cdd:cd15174   90 TCISVDRYIAIVQATKAHNSKNKRLLYSklVCFFVWLLSTILSLPEILFSQSkeEESVTTCTMVYPSNE----------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 198 cDYRQKALAVS-KFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA-RAHSVT 275
Cdd:cd15174  159 -SNRFKVAVLAlKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTiNAYNIT 237
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 276 TLRQLASRGLPFVT----SLAFFNSVVNPLLYVF 305
Cdd:cd15174  238 ITDCATSQNLDIAGqvtqSIAFLHSCLNPFLYVF 271
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
36-303 5.76e-17

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 80.30  E-value: 5.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMRQ--TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd15925    5 LAYGLVCAIGLLGNLAVMYLLRNCARRapPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLdGRIMCyynlLLWNPGpd 193
Cdd:cd15925   85 VYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVC-GVELC----LLKFPS-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAV-----SLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFS--- 265
Cdd:cd15925  158 -----NYWLGAYHLQRVVVAFVVPLGVITTSYLLLlsflqQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTfwg 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 266 -LLEARAHS-VTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15925  233 vLVKFRAVPwNSTFYFIHTYVFPVTTCLAHSNSCLNPVLY 272
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
44-319 5.82e-17

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 80.98  E-value: 5.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  44 LGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFlAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSA 123
Cdd:PHA03087  53 FGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYY-YILFQWSFGEFACKIVSGLYYIGFYNSMNFITV 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 124 ISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFrDTIPRLDGRIMCY-------YNLLLWnpgpdrdt 196
Cdd:PHA03087 132 MSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFV-YTTKKDHETLICCmfynnktMNWKLF-------- 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 tcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRLH-HRGRQRTGRFVRLVAAIVVAFVLCWGPYHIfSLLEARAHSVT 275
Cdd:PHA03087 203 --------INFEINIIGMLIPLTILLYCYSKILITLKgINKSKKNKKAIKLVLIIVILFVIFWLPFNV-SVFVYSLHILH 273
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569006435 276 TLR--------QLASrglpFVTS-LAFFNSVVNPLLYVFTCPDMLYKLRRSLR 319
Cdd:PHA03087 274 FKSgckavkyiQYAL----HVTEiISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
44-267 1.66e-16

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 78.92  E-value: 1.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  44 LGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYflAVGHSWELGTTFCKLHSSVFFLNMFASGFLLS 122
Cdd:cd15165   13 LGLLLNLMALWVFLFKIKKwTESTIYMINLALNDLLLLLSLPFKMH--SSKKQWPLGRTLCSFLESLYFVNMYGSILIIV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 123 AISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtipRLDGRIMCYYNLL--LWNpgpdrdttcdy 200
Cdd:cd15165   91 CISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHD---KPTNNTRCFHGFSnkTWS----------- 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 201 rqKALAVSKFLLAFMVPLAI-----IASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15165  157 --KKVIVVVEEFGFLIPMAVmvfcsVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFL 226
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
44-322 2.25e-16

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 78.78  E-value: 2.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  44 LGLVENGLILFVVGCRM--RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15926   13 LGLVGNLLVLYLMKSKQgwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIpRLDGRIMCYYNLllwnpgPDRDTTCDYR 201
Cdd:cd15926   93 TAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTA-TVSNEELCLVKF------PDNRGNAQFW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 202 QKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR-----GRQRTGRFVRLVAAIVVAFVLCWGPYHIFS----LLEARA- 271
Cdd:cd15926  166 LGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKnitgsSTKRRSKVTKSVTIVVLSFFLCWLPNQALTtwgiLIKLNVv 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569006435 272 HSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFtcpdmlykLRRSLRAVL 322
Cdd:cd15926  246 HFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCL--------MRREFRKAL 288
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
37-305 2.30e-16

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 78.64  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMRQTVVTT-WVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15162    6 VYTLVFVVGLPANGMALWVLLFRTKKKAPAViYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTI--PRLDgRIMCYYNLLLWNPGPD 193
Cdd:cd15162   86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIflPALD-ITTCHDVLPEQLLVGD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRL----HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA 269
Cdd:cd15162  165 --------WFYYFLSLAIVGFLIPFILTASCYVATIRTLaaleDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHY 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569006435 270 RAHSVTTLRQLASRGLPFVtSLAFFNSVVNPLLYVF 305
Cdd:cd15162  237 SLISSSGTGHLYFAYLLAL-CLSTLNSCIDPFIYYF 271
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
96-305 2.76e-16

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 78.57  E-value: 2.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKL--HSSVFflNMFASGFLLSAISLDRCLQVVRPVWAQNHRTvaVAHRVCLMLWALAVLNTIP-YFVFRDTI 172
Cdd:cd14986   66 WVAGDVLCRIvkYLQVV--GLFASTYILVSMSLDRYQAIVKPMSSLKPRK--RARLMIVVAWVLSFLFSIPqLVIFVERE 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRlDGRIMCyynlllWNPGPDrdttcDYRQKALAVSKFLLAFMVPLAIIA------------------------------ 222
Cdd:cd14986  142 LG-DGVHQC------WSSFYT-----PWQRKVYITWLATYVFVIPLIILSycygrilrtiwirsrqktdrpiaptamscr 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 223 -SSHVAVSLRLHHRGRQRTgrfVRLVAAIVVAFVLCWGPYHIFSLLEArahsVTTLRQLASRGLPFVTSLAFFNSVVNPL 301
Cdd:cd14986  210 sVSCVSSRVSLISRAKIKT---IKMTLVIILAFILCWTPYFIVQLLDV----YAGMQQLENDAYVVSETLASLNSALNPL 282

                 ....
gi 569006435 302 LYVF 305
Cdd:cd14986  283 IYGF 286
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
39-308 3.18e-16

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 78.17  E-value: 3.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd15201    8 ILEFVLGLLGNGLALWIFCFHLKSwKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCyynlllwnpgpDRDTT 197
Cdd:cd15201   88 IFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPR-GNATQC-----------ESFNI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 198 CDYRQKALAVSK--FLLAFMVPLAIIA--SSHVAVSLRLHHRGRQ-RTGRFVRLVAAIVVAFVLCWGP-----YHIFSLL 267
Cdd:cd15201  156 CTGTDSSSNWHEamFLLEFFLPLAIILycSVRIIWQLRGRQLDRHaKIKRAVQFIMVVAIVFIICFLPsnvtrIAIWILK 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 268 EARAHSVTTLRQLAsrgLPFVTSLAF--FNSVVNPLLYVFTCP 308
Cdd:cd15201  236 HTSNEDCQYYRSVD---LAFYITISFtyFNSMLDPVVYYFSSP 275
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
84-314 3.20e-16

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 78.27  E-value: 3.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15368   54 PFQIVYHIQRNHWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALS 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTtcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRL----HHRGRQR 239
Cdd:cd15368  134 PLERTDLTYYVKELNITTCFDVLKWTMLPNIAA-----WAAFLFTLFILLFLIPFIITVYCYVLIILKLvqtsERYGREQ 208
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 240 TGRFVRLVAAIVVAFVLCWGPYHIFSLlearAHSVTTLRQLASRGLPFVTSLAF--FNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15368  209 KRRAIYLALIVLLVFITCFAPNNFILL----AHMVSRLFYGKSLYHAYKLTLSLscLNSCLDPFIYYFASKEFRKKL 281
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
40-305 3.73e-16

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 77.89  E-value: 3.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMRQTVVT-TWVLHLALSDLLAAASLPFFTyfLAVGHSWELGTTFCKLHSSVFFLNMFASG 118
Cdd:cd15177    9 VVFVLGLVGNGLVLATHTRYRRLRSMTdVYLLNLALADLLLLLTLPFAA--AETLQGWIFGNAMCKLIQGLYAINFYSGF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 119 FLLSAISLDRCLQVVRPVWAQNHR--TVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRImCYynlLLWNPGPDRDT 196
Cdd:cd15177   87 LFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSS-CR---MIFPEVVSRTV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 TcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR---AHS 273
Cdd:cd15177  163 K-----GATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTAdllATL 237
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 274 VTTLRQLASRGLPF-VTS-LAFFNSVVNPLLYVF 305
Cdd:cd15177  238 ELSCSQSKRKDIALlVTSgLAYVRCCLNPLLYAF 271
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
43-314 4.12e-16

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 77.89  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVvGCRMRQTV--VTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:cd14988   12 VVGLVENVLVIWV-NWHRWGSKnlVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVR--PVWAQNHRTVAVAhrVCLMLWALAVLNTIPYFVFRDTIPRLDGriMCYYNLLLWNpgpdrdttc 198
Cdd:cd14988   91 LTCLSVDRYLTLTSssPFWQQHQHRIRRA--LCAGIWVLSAIIPLPEVVHMQLLDGVEP--MCLFLAPFET--------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 dYRQKALAVS--KFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTT 276
Cdd:cd14988  158 -YDEWALAVSllTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHIS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 277 LRQLASRGLPF----VTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd14988  237 LHCNLVHFLYFfydvIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
36-305 4.15e-16

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 77.53  E-value: 4.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLN 113
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVlrYAKMK-TVTNIYILNLAVADELFMLGLPFLATQNAISY-WPFGSFLCRLVMTVDGVN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDgriMCYYNlllWnPGPd 193
Cdd:cd15974   83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLN---TCNIS---W-PEP- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 rdttCDYRQKALAVSKFLLAFMVPLAIIASSHV-------AVSLRLHHRGRQRTGRFV-RLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd15974  155 ----VSVWSTAFIIYTAVLGFFGPLLVICLCYLlivikvkSSGLRVGSTKRRKSERKVtRMVVIIVVVFVFCWLPFYMLN 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 266 LLEArahSVTTLRQLASRGLPF-VTSLAFFNSVVNPLLYVF 305
Cdd:cd15974  231 IVNL---IVILPEEPAFVGVYFfVVVLSYANSCANPILYGF 268
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
94-303 4.67e-16

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 77.66  E-value: 4.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPvwAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP 173
Cdd:cd15207   64 TGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKE 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 RLDGRIMCYYNLLLWNPGPdrdttcDYRQkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG------------ 241
Cdd:cd15207  142 YQFFRGQTVHICVEFWPSD------EYRK-AYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGsasreaqaavsk 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 242 ---RFVRLVAAIVVAFVLCWGPYHIFSLLEARAH-SVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15207  215 kkvRVIKMLIVVVVLFALSWLPLHTVTMLDDFGNlSPNQREVLYVYIYPIAHWLAYFNSCVNPIVY 280
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
36-303 4.93e-16

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 77.56  E-value: 4.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVgCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHS---WELGTTFCKLHSSVFFL 112
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVL-LRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSlegWVFGSFLCKAVHFFIYL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPrldgrimcYYNLLLWNPGP 192
Cdd:cd15097   84 TMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLID--------YANSTVCMPGW 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DrdttcDYRQKALAVSKFLLAFMVPLAIIASSH--------VAVSLRLHHRGRQR-TGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15097  156 E-----EARRKAMDTCTFAFGYLIPVLVVSLSYtrtikylwTAVDPLEAMSESKRaKRKVTKMIIIVTALFCLCWLPHHV 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 264 FSLLEARAHSVTTLRQLASRGLPFVtsLAFFNSVVNPLLY 303
Cdd:cd15097  231 VILCYLYGDFPFNQATYAFRLLSHC--MAYANSCLNPIVY 268
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
86-305 5.43e-16

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 77.47  E-value: 5.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd14992   56 FNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQ 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDTIPRLDGRIMCYYNLLLWNPGPDrdttcDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR---GRQRTG- 241
Cdd:cd14992  136 LYYATTEVLFSVKNQEKIFCCQIPPVDN-----KTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRkvpGFSIKEv 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 242 ---------RFVRLVAAIVVAFVLCWGPYHIFSLLEARAH----SVTTLRQLAsrglpFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14992  211 erkrlkckrRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPlimkEKHTLQVYY-----FLHWIAMSNSMYNPIIYVT 282
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
37-306 7.06e-16

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 77.13  E-value: 7.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENgLILFVV---GCRMRQTVVTTWVLHLALSDLLAAASLPFFTyfLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd15188    6 FYTLVFLLGLAGN-LLLFVVlllYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWA--MYVAWHWVFGSFLCKFVSTLYTIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNL----LLWn 189
Cdd:cd15188   83 FYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYgghhTIW- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 pgpdrdttcdyrQKALAVSKFLLAFMVPL--AIIASSHVA-VSLRLHHRGRqrtGRFVRLVAAIVVAFVLCWGPYHI--- 263
Cdd:cd15188  162 ------------KLVFQFQQNLLGFLFPLlaMVFFYSRIAcVLTRLRPPGQ---GRALRFVAALVVVFFVLWFPYNLtlf 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 264 -FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15188  227 lHSLQDLHVIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFV 270
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
84-305 8.84e-16

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 76.68  E-value: 8.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKlhSSVFFLN--MFASGFLLSAISLDRCLQVVRPVWAQN--HRTVAvahRVCLMLWALAV 159
Cdd:cd15002   56 PFRAAAYSKGS-WPLGWFVCK--TADWFGHacMAAKSFTIAVLAKACYMYVVNPTKQVTikQRRIT---AVVASIWVPAC 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 LNTIPYFVFRdTIPRLDGRIMCyynLLLWNPGPDRDttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ- 238
Cdd:cd15002  130 LLPLPQWLFR-TVKQSEGVYLC---ILCIPPLAHEF------MSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKt 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 239 -------RTGRFVRLVAAIVVAFVLCWGPYHIFSL-LEARAHSVTTLRQLASrglPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15002  200 qnlrnqiRSRKLTHMLLSVVLAFTILWLPEWVAWLwLIHIKSSGSSPPQLFN---VLAQLLAFSISSVNPIIFLL 271
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
32-305 1.36e-15

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 76.36  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  32 HVSVLLHGLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVF 110
Cdd:cd15364    1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRkNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTipRLDGRIMCYYNLllwnP 190
Cdd:cd15364   81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMREG--QTEGSHTCFETL----Q 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 191 GPDRDTTCDYrqkalavSKFLLAFMVPLAII--------ASSHVAVSLRLHHRGRQRtgrfvRLVAAIVVAFVLCWGPYH 262
Cdd:cd15364  155 MDTQVAGFYY-------ARFCIGFAIPLAILiftnyrifRSIQTSTSLTPHQKAKVK-----YLAIAVIVIFLICFAPYH 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569006435 263 IFSLLEARAHSvttLRQLASRGL------PFVTSLAF--FNSVVNPLLYVF 305
Cdd:cd15364  223 LVLLVRAIAFS---LYPNGMCGFeeriytPSVIFLCLstVNSVADPIIYVL 270
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
39-313 3.20e-15

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 75.19  E-value: 3.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd15200    8 GIEFVLGLVGNGIALFIFCFHRRPwKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiprLDGRIMCYYNLLLWNPGPDRdtt 197
Cdd:cd15200   88 IVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHV---QSNSTCLSYDHGTDPSASDR--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 198 cdyRQKALavskFLLAFMVPLAIIASSHVAVSLRLHHR---GRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSV 274
Cdd:cd15200  162 ---WHRIL----FFLEFFLPLGIILFCIFSIILTLKQRklaKQAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFKV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 275 TTLRQLASRGLPFVTSLAF--FNSVVNPLLYVFTCPDMLYK 313
Cdd:cd15200  235 SQCRSLDLCTQLFHGSLAFtyLNSALDPVLYCFSSPSFLNQ 275
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
40-330 5.93e-15

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 74.36  E-value: 5.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMRQTVVTTWVL------HLALSDLLAAASLPFFTYFLAVGHSWELGTTFcklhsSVFFLN 113
Cdd:cd15110    9 IICLLGLVGNGIVLWFLGFRIRRNPFTVYILhlaiadFTFLLCIFILSIMYIGPFNFSHSRDYVAMLIF-----IILFLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGF-LLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVL-NTIPYFVFRDTIPRLDGrimcyynlllwnpg 191
Cdd:cd15110   84 GYNTGLyLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLmTSLEYLMCIDEGFHVRN-------------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdtTCDYRQKALAVSKFLLafMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWgPYHIFSLLEARA 271
Cdd:cd15110  150 -----ECRAVLIFIGILTFLV--FTPLMLISSLILFIKVRCNSQRRHPGKLYIIIMLTVIFFLIFAM-PMRVLLLLNYLH 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 272 HSvtTLRQLasrgLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDS 330
Cdd:cd15110  222 HS--SFLFS----NPVPFLLSTVNSSINPIVYFLVGSLRRKRIKKSLKVALQRVFEDKA 274
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
89-305 6.32e-15

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 74.45  E-value: 6.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVG---HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15972   55 FLAAQnalSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDtIPRldGRIMCYYNlllWnPGPdrdttCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG--------- 236
Cdd:cd15972  135 VIFSG-VPG--GMGTCHIA---W-PEP-----AQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGrrvratstk 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 237 RQRTGRFV-RLVAAIVVAFVLCWGPYHIFSLLEArahSVTTLRQLASRGL-PFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15972  203 RRGSERKVtRMVVIVVAAFVLCWLPFYALNIVNL---VCPLPEEPSLFGLyFFVVVLSYANSCANPIIYGF 270
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
37-305 8.38e-15

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 73.75  E-value: 8.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVlIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKD-DWIFGDAMCKFLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGR----IMCYYNLLLWNpg 191
Cdd:cd15183   85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHtcsaHFPRKSLIRWK-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdttcdyRQKALAVSkfLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARA 271
Cdd:cd15183  163 ---------RFQALKLN--LLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQ 231
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 569006435 272 HSVTTLRQLASRGLPF----VTSLAFFNSVVNPLLYVF 305
Cdd:cd15183  232 DVLFTPSCEQSQQLDLalqvTEVIAYTHCCVNPVIYVF 269
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-303 1.28e-14

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 73.24  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFF--TYFLavgHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd14999    7 SLMCVVGVAGNVYTLVVMCLSMRpRASMYVYILNLALADLLYLLTIPFYvsTYFL---KKWYFGDVGCRLLFSLDFLTMH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNhRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLD----GRIMCyynLLLWNPg 191
Cdd:cd14999   84 ASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDksggSKRIC---LPTWSE- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdttcdYRQKALAVSKFLLAFMVPLAII-------ASSHVAVSLRLHHRGRQRT--GRFVRLVAAIVVAFVLCWGPYH 262
Cdd:cd14999  159 --------ESYKVYLTLLFSTSIVIPGLVIgylyirlARKYWLSQAAASNSSRKRLpkQKVLKMIFTIVLVFWACFLPFW 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 263 IFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd14999  231 IWQLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLY 271
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
35-305 2.27e-14

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 72.39  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLIL--FVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGhSWELGTTFCKLHSSVFFL 112
Cdd:cd15061    3 ISFLILAIIFTIFGNLLVIlaVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLG-YWPLGSHLCDFWISLDVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVfrdtIPRldgrimcyynlllwNPGP 192
Cdd:cd15061   82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV----GPS--------------WHGR 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTCDYRQ-KALAVSKFLLAFMVPLAIIASSHVAVSlRLHHRGRqrtgRFVRLVAAIVVAFVLCWGPYHIFSLLEARA 271
Cdd:cd15061  144 RGLGSCYYTYdKGYRIYSSMGSFFLPLLLMLFVYLRIF-RVIAKER----KTAKTLAIVVGCFIVCWLPFFIMYLIEPFC 218
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 272 HSvttlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15061  219 DC-----QFSEALSTAFTWLGYFNSVINPFIYAF 247
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
86-303 2.42e-14

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 72.59  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYflAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaqNHRTVAVAHRVCL-MLWALAVLNTIP 164
Cdd:cd16002   58 FTY--AIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPL---QPRLSATATKVVIcVIWVLAFLLAFP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 165 YFVFRDTIPrLDGRIMCYYNlllWNPGPDRDTTCDYRqkalaVSKFLLAFMVPLAIIASSHVAVSLRL------------ 232
Cdd:cd16002  133 QGYYSDTEE-MPGRVVCYVE---WPEHEERKYETVYH-----VCVTVLIYFLPLLVIGCAYTVVGITLwaseipgdssdr 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 233 HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEaRAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd16002  204 YHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQ-YFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
94-305 2.70e-14

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 72.46  E-value: 2.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQN--HRTVAVAHRVCLMLWALAVLNTIPYFVFRDT 171
Cdd:cd15087   63 QQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGV 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 IPRLDGRIMCYYNLllwnPGPDRdttcdYRQKALAVSKFLLAFMVPLAIIASSHV-------AVSLRLHHRGRQRTGRFV 244
Cdd:cd15087  143 YSNELGRKSCVLSF----PSPES-----LWFKASRIYTLVLGFAIPVSTICILYTmmlyklrNMRLNSNAKALDKAKKKV 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 245 RLVAAIVVAF-VLCWGPYHIFSLLEArahsVTTLRQ--LASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15087  214 TLMVLVVLAVcLFCWTPFHLSTVVAL----TTDLPQtpLVIGISYFITSLSYANSCLNPFLYAF 273
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
43-306 3.48e-14

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 72.12  E-value: 3.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15968   12 LLGLPLNSVVLTRCCRHTKAwTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYGSILFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDT-IPRldGRIMCyynlllWNPGPDRDTTcDY 200
Cdd:cd15968   92 TCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTgIIR--NRTVC------YDLAPPALFP-HY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKALAVSkfLLAFMVPLAIIASSHVAVSLRL-------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYH----IFSLLEA 269
Cdd:cd15968  163 VPYGMALT--VSGFLLPFSIILWCYCLVVRTLcrtlgpaEPPAQARRRKSIRTIVTVTLLFALCFLPFHitrtIYLAVRV 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 270 RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15968  241 TPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLT 277
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
84-305 3.58e-14

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 72.12  E-value: 3.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15365   54 PLWIDYLWNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNA 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIPRLDGRIMCY--YNLLLWnpgpdrdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR---GRQ 238
Cdd:cd15365  134 VILTWEDSFHESSSHTLCYdkFPLEDW-------------QARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNqatEDQ 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 239 RTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA-RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15365  201 EKKKIFKLLLLITVTFVICFTPYHVVLLIRSiVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCF 268
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
43-303 4.17e-14

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 72.10  E-value: 4.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd16001   12 VLGLPLNGTVLWLSWCRTKRwTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYGSILFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiPRLDGRIMCyYNLllwnPGPDRDTTCDYR 201
Cdd:cd16001   92 TCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYART-GSINNRTVC-YDL----TSPDNFGNYFPY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 202 QKALAVSKFLLAFMVPLA----IIASshVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSL--LEARAHSVT 275
Cdd:cd16001  166 GMVLTVTGFLIPFLIILLcyclMIKS--LIRSEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHITRTiyLFVRVYLVQ 243
                        250       260       270
                 ....*....|....*....|....*....|
gi 569006435 276 --TLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd16001  244 dcPLLQFVSLAYKIWRPLVSFNSCINPLLY 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
84-303 5.08e-14

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 71.39  E-value: 5.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWA 156
Cdd:cd15301   55 PLFTVYTALGY-WPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTtkkaavmIASAWIISLLLWP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 157 LAVLnTIPYFVFRDTIPRldGRimCYYNLLLWNPgpdrdttcdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG 236
Cdd:cd15301  134 PWIY-SWPYIEGKRTVPA--GT--CYIQFLETNP-------------YVTFGTALAAFYVPVTIMCILYWRIWRETKKRQ 195
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 237 RQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEArahsVTTLRQLASRGL-PFVTSLAFFNSVVNPLLY 303
Cdd:cd15301  196 KKQESKAAKTLSAILLAFIVTWTPYNVLVLIKA----FFPCSDTIPTELwDFSYYLCYINSTINPLCY 259
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
89-303 5.23e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 71.50  E-value: 5.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVGHS-WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaqNHRTVAVAHRVCLM-LWALAVLNTIPYF 166
Cdd:cd16003   58 FIYALHSeWYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPL---KPRLSATATKVVIGsIWILAFLLAFPQC 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 167 VFrDTIPRLDGRIMCYynlLLWNPGPDRDTTcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRL------------HH 234
Cdd:cd16003  135 LY-SKTKVMPGRTLCF---VAWPGGPDQHFT-------YHIIVIVLVYCLPLLVMGITYTIVGITLwggeipgdtsdkYH 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 235 RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPfVTSLAFFNSVVNPLLY 303
Cdd:cd16003  204 EQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQVYLA-SFWLAMSSTMYNPIIY 271
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
43-306 6.55e-14

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 71.49  E-value: 6.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLS 122
Cdd:cd15155   12 ILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 123 AISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFrDTIPRLDGRIMCYynlllwnPGPDRDTTCDYRQ 202
Cdd:cd15155   92 CISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLF-STTNVSNTSTTCF-------EGFSKSIWKTYLS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 203 KaLAVSKFLLAFMVPLA--IIASSHVAVSLR----LHHRGRQRTgRFVRLVAAIVVAFVLCWGPYH----IFSLLEARAH 272
Cdd:cd15155  164 K-ITIFIEVVGFIIPLLlnLTCSSLVLRTLRkpatLSQIGTNKE-KVLKMILVHVAIFVVCFVPYNsilfLYALVRSQAI 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 273 SVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15155  242 ANCGVERFARTMYPITLCLATLNCCFDPFVYYFT 275
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
40-306 7.49e-14

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 70.98  E-value: 7.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGF 119
Cdd:cd15371    9 IVVVLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGNMYCSIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 120 LLSAISLDRCLQVVRPVWAQN--HRTVAVAhrVCLMLWALAVLNTIPYFVFRDT--IPRLDgRIMCYYNLllwnpgpDRD 195
Cdd:cd15371   89 LLTCISINRYLAIVHPFIYRSlpKKTYAVL--ICALVWTIVFLYMLPFFILKQTyyLKELN-ITTCHDVL-------PEC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGrFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVT 275
Cdd:cd15371  159 EQNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTLNAYEHKWFW-YVKITALVLIIFTICFAPSNVILIIHHFNYYYF 237
                        250       260       270
                 ....*....|....*....|....*....|.
gi 569006435 276 TLRQLASRGLpFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15371  238 NNDNLYSIYL-IALCLGSLNSCLDPFLYFLM 267
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
43-306 8.09e-14

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 71.04  E-value: 8.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLaVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15156   12 VLGLIANCVAIYIFMCTLKvRNETTTYMINLAISDLLFVFTLPFRIFYF-VQRNWPFGDLLCKISVTLFYTNMYGSILFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLD-GRIMCYYNLllwnpgpDRDTTCDY 200
Cdd:cd15156   91 TCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNnNSETCFENF-------SSKTWKTY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKALAVSKfLLAFMVPLA--IIASSHVAVSLR---LHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI----FSLLEARA 271
Cdd:cd15156  164 LSKIVIFIE-IVGFFIPLIlnVTCSTMVLKTLRrpnTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVnlvlYSLVRTQT 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 569006435 272 HSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15156  243 FKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFT 277
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
37-305 9.22e-14

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 70.94  E-value: 9.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGL-ILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAvgHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15184    6 LYSLVFIFGFVGNMLvVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAA--NEWVFGNAMCKLLTGLYHIGFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiPRLDGRIMCyynlllwNPGPDRD 195
Cdd:cd15184   84 SGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKS-QKEGSHYTC-------SPHFPPS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYRQkALAVSKFLLAFMVPLAIIASSHVAVSLRL-HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEA----- 269
Cdd:cd15184  156 QYQFWKN-FQTLKMNILGLVLPLLVMIICYSGILKTLlRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTfqeff 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569006435 270 RAHSVTTLRQLaSRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15184  235 GLNNCSSSNRL-DQAMQVTETLGMTHCCINPVIYAF 269
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
84-305 9.94e-14

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 70.43  E-value: 9.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWA 156
Cdd:cd15049   55 NLYTVYLVMGY-WPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTpkrailmIALAWVISFVLWA 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 157 LAVLNTiPYFVFRDTIPrlDGRimCYYNLLlwnpgpdrdttcdyRQKALAVSKFLLAFMVPLAIIasshVAVSLRLHhRG 236
Cdd:cd15049  134 PAILGW-QYFVGERTVP--DGQ--CYIQFL--------------DDPAITFGTAIAAFYLPVLVM----TILYWRIY-RE 189
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 237 RQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLAsrglpFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15049  190 TARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWS-----FGYWLCYINSTINPFCYAL 253
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
94-305 1.35e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 70.16  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRpvwAQNHRTVAVAHRV-CLMLWALAVLNTIPYFVFrDTI 172
Cdd:cd15176   62 NGWVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAITK---ATSRQFTGKHCWIvCLCVWLLAILLSIPDLVF-STV 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLDGRIMCyynLLLWNPGPDRDTTCdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVV 252
Cdd:cd15176  138 RENSDRYRC---LPVFPPSLVTSAKA-----TIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVG 209
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 253 AFVLCWGPYHIFSLLEA--RAHSVTTLRQLASR---GLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15176  210 VFIVTQLPYNVVKFYRAidVIYLLITDCSMSKTldiAIQVTESIALFHSCLNPVLYVF 267
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
33-305 1.49e-13

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 70.23  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15979    2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRlRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP-RLDGRIMCYYNLLLWnP 190
Cdd:cd15979   82 VSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPvPVGDRPRGHQCRHAW-P 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 191 GPDrdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhHRGRQRTGRFVRLVAAIVVAFVLCWGPyhIFSLLEAR 270
Cdd:cd15979  161 SAQ-------VRQAWYVLLLLILFFIPGVVMIVAYGLISREL-YRGLLAKKRVIRMLVVIVAMFFLCWLP--IFSANTWR 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569006435 271 A-HSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15979  231 AfDPLSAHRALSGAPISFIHLLSYTSACVNPLVYCF 266
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
36-305 1.77e-13

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 69.80  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYflAVGHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15173    5 CMYSVMFVTGLVGNSLVIVIyIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAY--SAAHEWIFGTVMCKITNGLYTINL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQN--HRTVAVAHRVCLMLWALAVLNTIPYFVFrDTIPRLDGRImCYYNLllwnpgp 192
Cdd:cd15173   83 YSSMLILTCITVDRFIVIVQATKAHNchAKKMRWGKVVCTLVWVISLLLSLPQFIY-SEVRNLSSKI-CSMVY------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 drdtTCDYRQKALAVSKFLLAFMVPLA--IIASSHVAVSLrLHHRGRQRTgRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15173  154 ----PPDAIEVVVNIIQMTVGFFLPLLamIICYSVIIKTL-LHAKGFQKH-KSLKIIFVVVAVFILTQLPYNIMKLIRTL 227
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 569006435 271 AHSVTTLRQLASRGLpFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15173  228 HIENTDSTNFKYAIL-ITEAIAYLHACLNPILYAF 261
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
81-305 1.92e-13

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 69.79  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  81 ASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVL 160
Cdd:cd15367   51 FSLPFWLQYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELM 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIPYFVFRDTIPRLDGRIMC--YYNLLLWnpgpdrdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVsLRLHHRG-- 236
Cdd:cd15367  131 TCVFFFLHGEISKDKENHSVCfeHYPIKAW-------------EHNINYYRFYAGFLFPIFLLSFSYCRI-LRAVRKShg 196
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 237 --RQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15367  197 tqKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF 267
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
44-305 1.94e-13

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 69.83  E-value: 1.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  44 LGLVENGLILFVVGC-RMRQTVVTTWVLHLALSDLLAAASLPFFTYFlavgHSWELGTTFCKLHSSVFFLNMFASGFLLS 122
Cdd:cd15920   13 VGLLSNTLALWVFFLrQQRETSISVYMRNLALADLLLVLCLPFRVAY----QNTAGPLSFCKIVGAFFYLNMYASILFLS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 123 AISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdtiprldgrimcyynlllWNPGPDRDTTCDYRQ 202
Cdd:cd15920   89 LISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFES------------------RNEGPCDNKCFHFRS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 203 KAL--------AVSKF---LLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVA-FVLCWGPYHI----FSL 266
Cdd:cd15920  151 KGLtagginltAVVIFyilSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLAiFIVCFVPYHIvrvpYVL 230
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 267 LEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15920  231 AQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFF 269
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
38-263 1.94e-13

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 70.17  E-value: 1.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  38 HGLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15373    7 YGIVFVVGLVLNILALYVFLFRTKPwNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCYynlllwnpgpdrDT 196
Cdd:cd15373   87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDK-GGNITCH------------DT 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 197 TCD--YRQKALAVSKFL-LAFMVPLAIIASSHVAVSLRL------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15373  154 SSPelFDQFVVYSSVMLvLLFCVPFVVILVCYALMVRKLlkpsagTSTNSRSKKKSVKMIIIVLAVFILCFLPFHV 229
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
86-305 2.44e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 69.51  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaqNHRTVAVAHRVCLML---WALAVLNT 162
Cdd:cd15055   56 FSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPL---LYPTKITIRRVKICIclcWFVSALYS 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IPYFVFRDTIPRLDGRIMCYYN-LLLWNpgpdrdttcdyrqKALAVSKFLLAFMVPLAII----------ASSHVAV--S 229
Cdd:cd15055  133 SVLLYDNLNQPGLIRYNSCYGEcVVVVN-------------FIWGVVDLVLTFILPCTVMivlymrifvvARSQARAirS 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 230 LRLHHRGRQRTGRFVR---LVAA-----IVVAFVLCWGPYHIFSLLEARAHSVTTLrqlasrgLPFVTSLAFFNSVVNPL 301
Cdd:cd15055  200 HTAQVSLEGSSKKVSKkseRKAAktlgiVVGVFLLCWLPYYIVSLVDPYISTPSSV-------FDVLIWLGYFNSCLNPL 272

                 ....
gi 569006435 302 LYVF 305
Cdd:cd15055  273 IYAL 276
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
95-314 3.42e-13

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 69.40  E-value: 3.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR 174
Cdd:cd14987   65 QWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTS 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 -LDGRIMCY-----YNLLLWNPGpdrdttcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVA 248
Cdd:cd14987  145 pSNNETYCRsfypeESFKEWLIG-------------MELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIF 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 249 AIVVAFVLCWGPYHIFSLLEARA--HSVT---TLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd14987  212 SYVVVFLVCWLPYHTVVLLDILSflHLIPfscQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
43-304 4.69e-13

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 68.83  E-value: 4.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVgCR---MRQTVVTTWVLHLALSDLLAAASLPF--FTYFLAvghSWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd15927   12 LVGVLGNGTLILIF-LRnksMRNVPNIFILSLALGDLLLLLTCVPFtsTIYTLD---SWPFGEFLCKLSEFLKDTSIGVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP-RLDGR---IMCYynlllwnpgPD 193
Cdd:cd15927   88 VFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTfTLTDNqtiQICY---------PY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 RDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ-------------RTGRFV-RLVAAIVVAFVLCWG 259
Cdd:cd15927  159 PQELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNigsgqnqaaqrqiEARKKVaKTVLAFVVLFAVCWL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 260 PYHIFSL---LEARAHSVTTLRQLASRGLPFVtsLAFFNSVVNPL-LYV 304
Cdd:cd15927  239 PRHVFMLwfhFAPNGLVDYNAFWHVLKIVGFC--LSFINSCVNPVaLYL 285
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
37-306 5.64e-13

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 68.62  E-value: 5.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  37 LHGLASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMF 115
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQkSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyFVFRDTIPRLDGRIMCYYnlllwnpgPDRD 195
Cdd:cd15158   86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSP-FLMSGSHDTETNKTKCFE--------PPQS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL-----HHRGRQRTGR-FVRLVAAIVVAFVLCWGPYHI---FSL 266
Cdd:cd15158  157 NQQLTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLlkntmKARKQQSSRKkAIRMIIIVLLAFLVSFMPYHIqrtIHL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 569006435 267 LEARAHSVTTLRQLASRGLPFVT-SLAFFNSVVNPLLYVFT 306
Cdd:cd15158  237 HFLSRKDSTCEEVLYMQKSVVITlCLAAANCCFDPLLYFFS 277
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
84-306 7.15e-13

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 68.06  E-value: 7.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLN-T 162
Cdd:cd15170   55 PFKMAEAASGMIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHcS 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IPYFVfrdtiprldgrimcYYNLLLWNPGPDRDTTC--DYRQKALAV------SKFLLAFMVPLAIIASSHVAVS---LR 231
Cdd:cd15170  135 IVYIV--------------EYHIDSENTSVTNNSRCydNFTPEQLKIllpvrlELFLVLFCIPFLITCFCYINFIrilSS 200
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 232 LHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIfsllearAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15170  201 LPHISRQRKQRAIGLAVATLLNFIVCFAPYNI-------SHVVGFIQRKSPEWRMYALLLSTLNACLDPIIFYFS 268
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
96-303 9.52e-13

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 67.82  E-value: 9.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV---WAQNHRTvAVAhrVCLMLWALAVLNTIPYFVFRDTI 172
Cdd:cd15378   65 WLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFrehILQKKRS-AVA--ISLAIWVLVTLELLPILTFIGPN 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PrldgrimcyynlllwnpgPDRDTTC-DYRQ-----KALAVSKFL--LAFMVPLAIIASSHVAVSLRLHHRGRQRTG--- 241
Cdd:cd15378  142 L------------------KDNVTKCkDYASsgdatNSLIYSLFLtvTGFLIPLCVMCFFYYKIALFLKNRNRQLANats 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 242 --RFVRLVAAIVVAFVLCWGPYHIFS--LLEARAHS--VTTLRQLASRGLPFVTS-LAFFNSVVNPLLY 303
Cdd:cd15378  204 feKPLTLVILAVVIFSVLFTPYHVMRnvRIASRLDSigVSECTLIIIKSLYIVTRpIAFLNSVINPVFY 272
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
84-305 1.26e-12

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 67.55  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAvGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15185   54 PFWIHYVR-WNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAAL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTiPRLDGRIMCyynlllwNPGPDRDTTCDYRQ-KALAVSKFLLAfmVPLAIIASSHVAVSLRLHHRGRQRTGR 242
Cdd:cd15185  133 PEFIFYET-QELFEEFLC-------SPLYPEDTEDSWKRfHALRMNIFGLA--LPLLIMVICYTGIIKTLLRCPSKKKYK 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 243 FVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTS----LAFFNSVVNPLLYVF 305
Cdd:cd15185  203 AIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCERSKHLDLAMQvtevIAYTHCCINPVIYAF 269
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
43-305 1.33e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 67.48  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLIL--FVVGCRMRqTVVTTWVLHLALSDLLAAASLPFFTYflAVGHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:cd15175   12 FLGLLGNGLVIltYIYFKRLK-TMTDIYLLNLALADILFLLTLPFWAA--SAAKKWVFGEEMCKAVYCLYKMSFFSGMLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVRPVWAQNHR--TVAVAHRVCLMLWALAVLNTIPYFVFRDtIPRLDGRIMCyynlllwnpGPDRDTTC 198
Cdd:cd15175   89 LMCISIDRYFAIVQAASAHRHRsrAVFISKVSSLGVWVLAFILSIPELLYSG-VNNNDGNGTC---------SIFTNNKQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQKaLAVSKFLLAFMVPLAIIASSH-VAVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCWGPYHIFSLLE--ARAHSVT 275
Cdd:cd15175  159 TLSVK-IQISQMVLGFLVPLVVMSFCYsVIIKTLLQARNFEKN-KAIKVIIAVVVVFVVFQLPYNSVMLVStlSSFKGNT 236
                        250       260       270
                 ....*....|....*....|....*....|...
gi 569006435 276 TLRQLASR---GLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15175  237 TDCDYSKNldfALDVTYSLACFRCCLNPFLYAF 269
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
84-303 1.46e-12

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 67.74  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15134   55 PFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIprldgrimcYYNLLLWNPGPDRDTT-CDYRQK------ALAVSKFLLaFMVPLAIIASSHVAVSLRLHH-- 234
Cdd:cd15134  135 PFAIQTRIV---------YLEYPPTSGEALEESAfCAMLNEippitpVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRst 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 235 -------------RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTS-LAFFNSVVNP 300
Cdd:cd15134  205 llrrgqrsvsggrRSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLFINRILFYISGvLYYVSSTVNP 284

                 ...
gi 569006435 301 LLY 303
Cdd:cd15134  285 ILY 287
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
94-305 2.25e-12

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 66.85  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSsvfFLNMF---ASGFLLSAISLDRCLQVVRPVWAQ--NHRTVAVahrVCLMLWALAVLNTIPyfvf 168
Cdd:cd14969   64 GRWSFGDPGCVIYG---FAVTFlglVSISTLAALAFERYLVIVRPLKAFrlSKRRALI---LIAFIWLYGLFWALP---- 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 rdtiPrldgrimcyynLLLWN---PGPDRdTTCD---YRQKALAVSK----FLLAFMVPLAIIASSHVAVSLRLHH---- 234
Cdd:cd14969  134 ----P-----------LFGWSsyvPEGGG-TSCSvdwYSKDPNSLSYivslFVFCFFLPLAIIIFCYYKIYRTLRKmskr 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 235 -----------RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEArAHSVTTLRQLASrglpFVTSL-AFFNSVVNPLL 302
Cdd:cd14969  198 aarrknsaitkRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVS-FGGESTIPPLLA----TIPALfAKSSTIYNPII 272

                 ...
gi 569006435 303 YVF 305
Cdd:cd14969  273 YVF 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
94-303 2.35e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 66.99  E-value: 2.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIp 173
Cdd:cd14979   65 YPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQ- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 rldgrimcyyNLLLWNPGPDRDTT-CDYRQKA-----LAVSKFLLAFMVPLAIIASSHVAVSLRLHHR------------ 235
Cdd:cd14979  144 ----------YLNGPLPGPVPDSAvCTLVVDRstfkyVFQVSTFIFFVLPMFVISILYFRIGVKLRSMrnikkgtraqgt 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 236 -------GRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFF-NSVVNPLLY 303
Cdd:cd14979  214 rnvelslSQQARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLFDFYQYLYPISGILFYlSSAINPILY 289
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
36-267 3.39e-12

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 66.38  E-value: 3.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15202    5 VAYSFIIVFSLFGNVLVCWIIFKNQRmRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhrVCLMLWALAVLNTIPY-FVFRDTIPRLDGRIMCYYNLLLWnpgPD 193
Cdd:cd15202   85 HVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKF--IIAVIWTLALAFALPHaICSKLETFKYSEDIVRSLCLEDW---PE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 RDTTcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL-------------HHRGRQRTGRFVRLVAAIVVAFVLCWGP 260
Cdd:cd15202  160 RADL---FWKYYDLALFILQYFLPLLVISFAYARVGIKLwasnmpgdatterYFALRRKKKKVIKMLMVVVVLFALCWLP 236

                 ....*..
gi 569006435 261 YHIFSLL 267
Cdd:cd15202  237 FNIYVLL 243
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
84-303 3.49e-12

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 65.83  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVavaHRVCLML---WALAVL 160
Cdd:cd15053   55 PFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNS---KRVLLTIaivWVVSAA 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIPYfvfrdtiprldgrimcyynLLLWNPGPDRDTT-CDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhhrgrQR 239
Cdd:cd15053  132 IACPL-------------------LFGLNNVPYRDPEeCRFYNPDFIIYSSISSFYIPCIVMLLLYYRIFRAL-----RR 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 240 TGRFVRLVAAIVVAFVLCWGPYHIFSLLEarAHSVTTLRQLASRG-LPF--VTSLAFFNSVVNPLLY 303
Cdd:cd15053  188 EKKATKTLAIVLGVFLFCWLPFFTLNILN--AICPKLQNQSCHVGpALFslTTWLGYVNSFLNPIIY 252
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
92-309 3.59e-12

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 65.81  E-value: 3.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdt 171
Cdd:cd15064   62 LTGRWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGW-- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 iprldgrimcyynlllWNPGPDRDTTCDYRQK-ALAVSKFLLAFMVPLAIIasshVAVSLRLHhRGRQRTGRFVRLVAAI 250
Cdd:cd15064  140 ----------------RTPDSEDPSECLISQDiGYTIFSTFGAFYIPLLLM----LILYWKIY-RAAARERKAAKTLGII 198
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 251 VVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglpFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15064  199 LGAFIVCWLPFFLVALIVPLCSHCWIPLALKS----FFLWLGYFNSLINPLIYTFFNKD 253
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
95-305 3.68e-12

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 66.29  E-value: 3.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-----WAQNHRTVAVAhrvclmlWALAVLNTIPYFVFR 169
Cdd:cd15197   65 EWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMnfsqsGRQARVLICVA-------WILSALFSIPMLIIF 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 170 DTIPRLDGRIMCYYNLllwnpgpdrdTTCDYRQKALAVSKFLLaFMVPLAIIASSH--------------VAVSLRLHHR 235
Cdd:cd15197  138 EKTGLSNGEVQCWILW----------PEPWYWKVYMTIVAFLV-FFIPATIISICYiiivrtiwkkskiqVTINKAGLHD 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 GRQRTG-----------RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRglPFVTSLAFFNSVVNPLLYV 304
Cdd:cd15197  207 GSSRRSssrgiiprakiKTIKMTFVIVTVFIICWSPYFVFDLLDVFGLLPRSKTKIAAA--TFIQSLAPLNSAINPLIYC 284

                 .
gi 569006435 305 F 305
Cdd:cd15197  285 L 285
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
96-305 4.43e-12

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 65.88  E-value: 4.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRtvAVAHRVCLMLWALAVLNTIPYFVFRDTIPRl 175
Cdd:cd15195   66 WLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPQSFIFSVLRK- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgrimcyynlllWNPGPDRDTTCDYR-------QKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ---------- 238
Cdd:cd15195  143 ------------MPEQPGFHQCVDFGsaptkkqERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRardtpisnrr 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 239 --RTG-------RFVRLVAAIVVAFVLCWGPYHIFSLLEArahsvttLRQLASRGLPFVTSLAFF-----NSVVNPLLYV 304
Cdd:cd15195  211 rsRTNslerarmRTLRMTALIVLTFIVCWGPYYVLGLWYW-------FDKESIKNLPPALSHIMFllgylNPCLHPIIYG 283

                 .
gi 569006435 305 F 305
Cdd:cd15195  284 V 284
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
82-304 5.20e-12

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 65.87  E-value: 5.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  82 SLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRT--VAVAhrvCLMLWALA 158
Cdd:cd15375   52 SLPFLIYYYINGESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLrAFQVQKRrwAIVA---CAVVWVIS 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 159 VLNTIPYFVFRDTIPRlDGRIMCYynlllwnpgpdrD-TTCDYRQKALAVSKFL--LAFMVPLAIIASSHVAVSLRLHHR 235
Cdd:cd15375  129 LAEVSPMTFLITTKEK-NNRTICL------------DfTSSDNLNTIWWYNWILtvLGFLLPLVIVTLCYTRIIYTLAKG 195
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 236 GRQRTG---RFVRLVAAIVVAFVLCWGPYHIFSLL--EARAHSVTTLRQLASRGLPFVT-SLAFFNSVVNPLLYV 304
Cdd:cd15375  196 PHTGSAskqKARRLIILILLVFYVCFLPFHILRVVriETRLPPVSCCLKHQVHAIYIITrPLAALNTFGNLLLYV 270
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
39-303 9.57e-12

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 65.10  E-value: 9.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSD--LLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15376    8 GVEFLVAVLGNGLALWLFVTRERRPWHTGVVFSFNLAVsdLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYynlllwnpgpdrDT 196
Cdd:cd15376   88 SIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVERHNKTECL------------GT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 TCDYRQKA-LAVSKFLLAF--MVPLAIIASSHVAVS---LRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEAR 270
Cdd:cd15376  156 AVDSRLPTyLPYSLFLAVVgcGLPFLLTLASYLAIVwavLRSPGITTLEKRKVAALVAVVVALYAVSFVPYHILRNLNLY 235
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 271 AHsVTTLRQLASRGLPF---VTS-LAFFNSVVNPLLY 303
Cdd:cd15376  236 RR-LQWLKAAASLRIYFayqVTKgLVTLNMCIHPLLY 271
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
92-306 1.32e-11

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 64.43  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTvavAHRVCL--MLWALAVLNTIPYFVFR 169
Cdd:cd15153   61 IQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWKR---RYDVGIsaAVWIVVGLACLPFPLLR 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 170 DTIPRLDGRiMCYYNLLLWNPGPDRDTtcdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG-----RFV 244
Cdd:cd15153  138 SKSLSNNNR-SCFADLGMKKLNFGAAI-------AMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQStsekqKAL 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 245 RLVAAIVVAFVLCWGPYHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15153  210 RMVRMCAAVFFICFAPYHInflfYLMVSESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFM 275
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
95-303 1.99e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 64.00  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaQNHRTVAVAHRVCLMLWALAVLNTIPYFVF--RDTI 172
Cdd:cd15384   65 AWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILSPIFSIPQAVIfhVERG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLDGRIMC--YYNLllwnpgpdrdtTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG--------- 241
Cdd:cd15384  143 PFVEDFHQCvtYGFY-----------TAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGleiytrnrg 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 242 ------------RFVRLVAAIVVAFVLCWGPYHIFSLLearaHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15384  212 pnrqrlfhkakvKSLRMSAVIVTAFILCWTPYYVIMIW----FLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
43-263 2.03e-11

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 64.01  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVghSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15923   12 VLGLLLNILALWVFCWRLKKwTETNIYMTNLAVADLLLLISLPFKMHSYRR--ESAGLQKLCNFVLSLYYINMYVSIFTI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiprlDGRIMCYYNlllwnpgpdrdtTCDYR 201
Cdd:cd15923   90 TAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSS----NEKTMCFQR------------TKQTE 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 202 QKALAVSKFLLAFMVPLAIIA--SSHVAVSL--RLHHRGRQR-TGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15923  154 SLKVFLLLEIFGFLLPLIIMTfcSARVIHTLqkRLDDVGSRSeTKQCIRVIMANLIVFIVCFLPVHV 220
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
86-307 2.06e-11

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 64.01  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTY-FLAVGHS----WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVL 160
Cdd:cd15924   50 LTFpFKILSDAglgpWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIPYFVFRDTIPRLDGRIMCYYnlLLWNPGPDRDTTCDYRQKALAVSKFLLafMVPLAIIASSHVAVS-LRLHHRGRQR 239
Cdd:cd15924  130 LSLPNMILTNQQPREKNVKKCSF--LKSELGLKWHEIVNYICQVIFWIVFLL--MIVCYTAITKKVYRSyRRVFRSSSSR 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 240 TGRFVRLVAAIVVAFVLCWGPYHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd15924  206 RKKSNVKIFIIVAVFFVCFVPYHFaripYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLC 277
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
95-303 2.37e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 63.87  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSsvfFLNMFA---SGFLLSAISLDRCLQVVRPVwaqnhRTVAVAHRVCLML---WALAVLNTIP-YFV 167
Cdd:cd15382   66 AWLAGDFLCRLML---FFRAFGlylSSFVLVCISLDRYFAILKPL-----RLSDARRRGRIMLavaWVISFLCSIPqSFI 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 168 FR-DTIPRLDGRIMCyynlLLWNPGPDRDttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ-------- 238
Cdd:cd15382  138 FHvESHPCVTWFSQC----VTFNFFPSHD-----HELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEkkedvsek 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 239 -------RTGRF---------VRLVAAIVVAFVLCWGPYHIFSLLE-ARAHSVTTLRQLASRGLpFVtsLAFFNSVVNPL 301
Cdd:cd15382  209 sssvrlrRSSVGllerarsrtLKMTIVIVLVFIICWTPYFIMSLWYwFDRESASKVDPRIQKGL-FL--FAVSNSCMNPI 285

                 ..
gi 569006435 302 LY 303
Cdd:cd15382  286 VY 287
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
86-306 2.69e-11

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 63.69  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVW--AQNHRTVAVAhrvcLMLWALAV-LNT 162
Cdd:cd15391   56 FTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRsrHTKSRTKCII----ASIWAISFsLSS 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IPYFVFRDTIPRLD--GRIMCYYNlllWnPGPDrdttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL-------- 232
Cdd:cd15391  132 VQLFAGRTQRYGQYseGRVLCGES---W-PGPD------TSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLwnrtapgn 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 233 HHRGRQRTG-----RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPF-VTSLAFFNSVVNPLLYVFT 306
Cdd:cd15391  202 ADKGRDDMQikskrKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPQHTTRLIYGaCHWIAMSNSFVNPIIYLFM 281
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
43-305 2.99e-11

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 63.63  E-value: 2.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15369   12 VISLPLNILALVVFLRKMRvKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMYCSILLM 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDT--IPRLdGRIMCYYNLLLwnpgpdRDTTCD 199
Cdd:cd15369   92 TCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTiqIPDL-GITTCHDVLNE------QLLMGY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 200 YRQKALAVSkfLLAFMVPLAIIASSHVAV----SLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLlearAHSVT 275
Cdd:cd15369  165 YVYYFSIFS--CLFFFVPLIITTVCYVSIirclSSSSDVANSSKKTRALFMAVAVFCVFVICFGPTNVLLL----AHYVR 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 276 TLRQLASRGLPFVTSLAF----FNSVVNPLLYVF 305
Cdd:cd15369  239 FAYTSTNDASYFAYLLCVcvgsISCCLDPLIYYY 272
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
33-305 3.14e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 63.35  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVV--GCRMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVF 110
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLIIAVLirNKRMR-TVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP--RLDGRI--MCYynlL 186
Cdd:cd15978   81 GISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPftRINNSTgnMCR---L 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 187 LWnpgpdrdtTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhHRGRQ---RTGRFVRLVAAIVVAFVLCWGPyhI 263
Cdd:cd15978  158 LW--------PNDVTQQSWYIFLLLILFLIPGIVMMTAYGLISLEL-YRGIKflmAKKRVIRMLIVIVILFFLCWTP--I 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 569006435 264 FSLLEARAHSVTTLRQLASrGLP--FVTSLAFFNSVVNPLLYVF 305
Cdd:cd15978  227 FSANAWRAFDTRSADRLLS-GAPisFIHLLSYTSACVNPIIYCF 269
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
94-318 3.83e-11

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 63.11  E-value: 3.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI-PYFVFRDTI 172
Cdd:cd15337   65 KKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIpPFFGWGRYV 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PrlDG-RIMCYYNLLlwnpgpdrdtTCDYRQKALAVSKFLLAFMVPLAIIASSHVAV--SLRLHHR-------------- 235
Cdd:cd15337  145 P--EGfQTSCTFDYL----------SRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIirAVRNHEKemtqtaksgmgkdt 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 ----GRQRTGRFVRLVAAIVV-AFVLCWGPYHIFSLLearahSVTTLRQLASrglPFVTSL----AFFNSVVNPLLYVFT 306
Cdd:cd15337  213 ekndARKKAEIRIAKVAIILIsLFLLSWTPYAVVALL-----GQFGPAYWIT---PYVSELpvmfAKASAIYNPIIYALS 284
                        250
                 ....*....|..
gi 569006435 307 CPdmlyKLRRSL 318
Cdd:cd15337  285 HP----KFRAAL 292
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
40-306 4.75e-11

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 62.90  E-value: 4.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASG 118
Cdd:cd15921    9 LIFILGLTGNSISVYVFLSQYRsQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 119 FLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyFVFRDTIPRLDGRIMCYYnlllwnpgPDRDTTc 198
Cdd:cd15921   89 YFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSP-LLFAKSKQHDEGSTRCLE--------LAHDAV- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQKALAVSkFLLAFMVPLAIIASSHVAVSLRL----HHRGRQRTGRFVRLVAAIVV--AFVLCWGPYHIfslleARAH 272
Cdd:cd15921  159 DKLLLINYVT-LPVGFVVPFMTVIFCYIFIIKNLlkpsPALGRTRPSRRKACALIIISlgIFLVCFLPYHI-----VRTI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 273 SVTTLRQLASRG---------LPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15921  233 HLITERQIKESCgyilrvrkaAVITLCLAASNSCFDPLLYFFV 275
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
42-326 7.51e-11

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 62.08  E-value: 7.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  42 SLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLlaaaslpFFTYFLAVGHSWELGTTFCKLHSSVFFLNM-----FA 116
Cdd:cd15106   11 SLVGLTGNAVVLWLLGFRMRRNAFSVYILNLAAADF-------LFLCCHIIDSLLRLINIFHIISIPKILTNVmtfpyFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCyynlllwnpgpdrdT 196
Cdd:cd15106   84 GLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLFSGADSHWC--------------Q 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 TCDYRQKALAVSKFLLAFMVPLAIIasshvaVSLRLHHRGRQRTGRFVRlVAAIVVAFVLCWGPYHIFSLLEARAHsvTT 276
Cdd:cd15106  150 TFDFITTAWLIFLFVVLCGSSLALL------VRILCGSRKMPLTRLYVT-ILLTVLVFLLCGLPFGIQWFLLLWIH--ID 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 569006435 277 LRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVL 326
Cdd:cd15106  221 LEVLFCHVYLVSVVLSCLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRAL 270
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
35-303 7.89e-11

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 61.91  E-value: 7.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLIL--FVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFL 112
Cdd:cd17790    4 VITTGILSLVTVTGNLLVLisFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGH-WALGTVACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWALAVLnTIPYFVFRDTIPRLDgrimCYYNL 185
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTprraaimIGLAWLISFVLWAPAIL-FWQYLVGERTVLAGQ----CYIQF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 186 LlwnpgpdrdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd17790  158 L--------------SQPIITFGTAIAAFYLPVTIMIILYWRI-----YRETIKEKKAARTLSAILLAFILTWTPYNIMV 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 569006435 266 LLEARAHSVT--TLRQLAsrglpfvTSLAFFNSVVNPLLY 303
Cdd:cd17790  219 LVSTFCKDCVpkTLWELG-------YWLCYVNSTVNPMCY 251
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
99-305 9.04e-11

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 62.02  E-value: 9.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  99 GTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPrLDGR 178
Cdd:cd15206   69 GEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIP-MSRP 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 179 IMCYYNLLLwnpgPDRDTtcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhhrgRQRTGRFVRLVAAIVVAFVLCW 258
Cdd:cd15206  148 GGHKCREVW----PNEIA-----EQAWYVFLDLMLLVIPGLVMSVAYGLISWTL----LEAKKRVIRMLFVIVVEFFICW 214
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 259 GPYHIFSLLEArAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15206  215 TPLYVINTWKA-FDPPSAARYVSSTTISLIQLLAYISSCVNPITYCF 260
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
95-307 1.11e-10

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 61.79  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR 174
Cdd:cd15149   64 PWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFH 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDGRIMCYYnlLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAI---IASSHvavsLRLHHRGRQRTGRFVRLVAAIV 251
Cdd:cd15149  144 EANYTKCAR--LKSELGIQWHKASNYICVSIFWVVFLLLIIFYVAIsrkIYKSN----QKFRRNSTNMKAKSSRNIFSIL 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 252 VAFVLCWGPYHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTC 307
Cdd:cd15149  218 FVFFVCFVPYHAlripYTLSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLC 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
84-308 1.27e-10

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 61.73  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15199   54 PFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTI 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVfrdtIPRLDGRIMCYYnlllWNPGPDRDTTCDYRqkalaVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ----- 238
Cdd:cd15199  134 PTLL----ASQPKNFTECNS----FSPKDDEDFSDTWQ-----EAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDvgkqp 200
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 239 RTGRFVRLVAAIVVAFVLCWGP-------YHIFSLLEARAhsvttLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCP 308
Cdd:cd15199  201 KLQRAMALVTSVVVVFGFCFLPcflarvlMLIFQNKESCN-----ALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSP 272
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
38-306 1.67e-10

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 61.36  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  38 HGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFA 116
Cdd:cd15374    7 YGLVFVVGLPLNATALWLFIKRMRpWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 117 SGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRlDGRIMCYynlllwnpgpdrDT 196
Cdd:cd15374   87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRK-DNITLCH------------DT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 197 T-----CDYRQKALAVSKFLlaFMVPLAIIASSHVAVSLRLHHR---GRQRTG-----RFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15374  154 TrpeefDHYVHYSSAVMVLL--FGIPCLVIVVCYGLMARRLCKPrvgSSRQQGpsskkRSLKTIIMVLTVFAICFVPFHI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 569006435 264 FSLLearaHSVTTLRQLASRGLPFVT-------SLAFFNSVVNPLLYVFT 306
Cdd:cd15374  232 TRTL----YYVARLLKADCDTLNIINvtykvtrPLASANSCLDPILYFLA 277
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
95-303 2.17e-10

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 60.82  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIP-YFVFRDTIP 173
Cdd:cd15059   65 YWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPpLFGWKDEQP 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 RLDGRIMCYYNLLLWnpgpdrdttcdyrqkaLAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAAIVVA 253
Cdd:cd15059  145 WHGAEPQCELSDDPG----------------YVLFSSIGSFYIPLLIM----IIVYARIYRAAKRKERRFTLVLGVVMGA 204
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569006435 254 FVLCWGPYHIFSLLearahSVTTLRQLASRGL-PFVTSLAFFNSVVNPLLY 303
Cdd:cd15059  205 FVLCWLPFFFTYPL-----VVVCKTCGVPELLfKFFFWLGYCNSALNPVIY 250
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
96-319 2.30e-10

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 61.07  E-value: 2.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAvahRVCL---MLWALAVLNTIPYFVFRDTI 172
Cdd:cd15124   66 WLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALM---KICLkaaLIWILSMLLAIPEAVFSDLH 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLDGRImcYYNLLLWNPGPDRDttcDYRQKALAVSKFLLAFMVPLAII-------------ASSHVAVSLRLHHRGR-Q 238
Cdd:cd15124  143 PFYDKST--NKTFVSCAPYPHSN---ELHPKIHSMASFLIFYVIPLSIIsvyyyfiaknlirSAYNLPVEGNVHVRRQiE 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 239 RTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSvttlrQLASRGLPFVTS-----LAFFNSVVNPLlyvftcpdMLYK 313
Cdd:cd15124  218 SRKRLAKTVLVFVGLFAFCWLPNHIIYLYRSYHYS-----EVDTSMLHFVSSicariLAFTNSCVNPF--------ALYL 284

                 ....*.
gi 569006435 314 LRRSLR 319
Cdd:cd15124  285 LSKSFR 290
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
36-303 2.66e-10

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 60.50  E-value: 2.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15393    5 ILYGIISLVAVVGNFLVIWVVAKNRRmRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTvaVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDG-----RIMCYynlllwN 189
Cdd:cd15393   85 NVSVFTLTVIAVDRYRAVIHPLKARCSKK--SAKIIILIIWILALLVALPVALALRVEELTDKtnngvKPFCL------P 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 PGPDRDTTCDYRqkalaVSKFLLAFMVPLAII--ASSHVAVSL------------RLHHRGRQrTGRFVRLVAAIVVAFV 255
Cdd:cd15393  157 VGPSDDWWKIYN-----LYLVCVQYFVPLVIIcyAYTRIAVKIwgtkapgnaqdvRDDEILKN-KKKVIKMLIIVVALFA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 569006435 256 LCWGPYHIFSLLEARAHSVTTLRQLasrGLPFVTS--LAFFNSVVNPLLY 303
Cdd:cd15393  231 LCWLPLQTYNLLNEIKPEINKYKYI---NIIWFCShwLAMSNSCYNPFIY 277
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
91-316 3.32e-10

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 60.14  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  91 AVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFR- 169
Cdd:cd14983   61 ALSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTLVFILEt 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 170 -----DTIPRLDGRIMCYYNlllWNPgpdrdttcdyRQKALAV----SKFLLAFMVPLAIIASS-----HVAVSLRLHHR 235
Cdd:cd14983  141 sggtlDINTPVGNSSTCYEN---FTP----------EQLALLApvrlELSLVLFFLPLAITAFCyvrciRILVRSRLHER 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 GRQRTgrfVRLVAAIVVAFVLCWGPYHIfsllearAHSVTTLRQLAS--RGLPFVTSLafFNSVVNPLLYVFTCPDMLYK 313
Cdd:cd14983  208 RKRRA---VRVAVSTLLTFVVCFGPYNI-------SHVVGFVRHESVwwRKLALLTST--CNAFLDPLIFYFLSSSMERG 275

                 ...
gi 569006435 314 LRR 316
Cdd:cd14983  276 FVH 278
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
33-309 4.90e-10

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 59.52  E-value: 4.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLAsLLGLVENGLILFVVGC-RMRQTVVTTWVLHLALS-DLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVF 110
Cdd:cd15325    3 LGVILGGFI-LFGVLGNILVILSVAChRHLQTVTHYFIVNLAVAdLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI-PYFVFRDtiprldgrimcyynlllwn 189
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIgPLFGWKE------------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 PGPDRDTTCDYRQK-ALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRtgRFVRLVAAIVVAFVLCWGPYH----IF 264
Cdd:cd15325  142 PAPEDETICQITEEpGYALFSALGSFYLPLAIILVMYCRVYVVALKFSREK--KAAKTLGIVVGCFVLCWLPFFlvmpIG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 569006435 265 SLLEARAHSVTTLRqlasrglpFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15325  220 SIFPAYKPSDTVFK--------ITFWLGYFNSCINPIIYPCSSQE 256
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
42-306 6.01e-10

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 59.34  E-value: 6.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  42 SLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL 120
Cdd:cd15157   11 FVLGVVGNGLSIYVfLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMYCSIYF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 121 LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfVFRDTIPRLDGRIMCYynlllwnpgpdrDTTCDY 200
Cdd:cd15157   91 LTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSP--LLSKGTSKYNSQTKCL------------DLHPSK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKALAVSKFLLA--FMVPLAIIASSHVAV------SLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH 272
Cdd:cd15157  157 IDKLLILNYIVLVvgFILPFCTLSICYILIikallkPRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHLMQW 236
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 273 SVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15157  237 SEGQCNLRLHKAVVITLCLAAANSCLDPLLYYFA 270
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
96-319 7.01e-10

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 59.58  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15125   66 WMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIM 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMCYYNLLlwnPGPDRDttcDYRQKALAVSKFLLAFMVPLAIIA--SSHVAVSL----------RLHHRGRQRT--G 241
Cdd:cd15125  146 PDDNTTFTACI---PYPQTD---EMHPKIHSVLIFLVYFLIPLAIISiyYYHIAKTLiksahnipgeYSEHSKRQMEtrK 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 RFVRLVAAIVVAFVLCWGPYHIFSLLE---------ARAHSVTTLrqlasrglpFVTSLAFFNSVVNPLlyvftcpdMLY 312
Cdd:cd15125  220 RLAKIVLVFVGLFAFCWFPNHVLYMYRsfnyneidsSLGHMIVTL---------VARVLSFCNSCVNPF--------ALY 282

                 ....*..
gi 569006435 313 KLRRSLR 319
Cdd:cd15125  283 LLSESFR 289
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
96-303 7.71e-10

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 59.23  E-value: 7.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtiprl 175
Cdd:cd14997   67 WLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITE----- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgrimcyYNLLLWNPGpDRDTTCD-----YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL-------------HHRGR 237
Cdd:cd14997  142 -------FKEEDFNDG-TPVAVCRtpadtFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLvghpalesrradaANRHT 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 238 QRTGR-FVRLVAAIVVAFVLCWGPYHIFSLLEArahsVTTLRQLASRGLP-------FVTSLAFFNSVVNPLLY 303
Cdd:cd14997  214 LRSRRqVVYMLITVVVLFFVCLLPFRVVTLWII----FAPDEDLQALGLEgylnllvFCRVMVYLNSALNPILY 283
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
84-307 1.20e-09

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 58.55  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQV----VRPVWAQNHRTVAvahrVCLMLWALAV 159
Cdd:cd15148   54 PFRILYHVNNNQWTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKInrssRRQKFLTRKWSIV----ACGVLWAVAL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 LNTIPY-------------FVFRDtipRLDGRIMCYYNLLLwnpgpdrdttcdyrqkalaVSKFLLAFMVplaiIASSHV 226
Cdd:cd15148  130 VGFVPMivltekneestkcFQYKD---RKNAKGKAIFNFLI-------------------VAMFWLVFLL----LILSYG 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 227 AVSLRLHHRGRQR-----TGRFVRLVAA---IVVAFVLCWGPYH---IFSLLEARAHSVTTLRQLASRGLPFVTSLAFFN 295
Cdd:cd15148  184 KIAKKLLRISRDKpdfpnAAKYNRTARKsffVLFIFTVCFVPYHafrIFYITSQLQNNSCYWKEILHKTNEIMLLLSAFN 263
                        250
                 ....*....|..
gi 569006435 296 SVVNPLLYVFTC 307
Cdd:cd15148  264 SCLDPVMYFLLS 275
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
100-305 1.70e-09

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 58.30  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 100 TTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiPRLDGRI 179
Cdd:cd14989   68 AVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQA-QHTGEVH 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 180 MCYYNLllwnpgpdrdttcdyrqKALAVSKFLLAFMVPLAIIA---SSHVAVSLRLH-HRG-RQRTGRFVRLVAAIVVAF 254
Cdd:cd14989  147 FCFADV-----------------REIQWLEVTLGFIIPFSIIGlcySLIVRVLVRAQkHRRlRPRRQKALRMILVVVLVF 209
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 255 VLCWGPYHIF---SLLEARAHSVTTLRQLASRGLPF----VTSLAFFNSVVNPLLYVF 305
Cdd:cd14989  210 FICWLPENVFisiQLLQGTQEPSESYDESFRHNHPLtghiVNLAAFSNSCLNPLIYSF 267
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
96-307 1.91e-09

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 57.88  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15969   65 WNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMCYYnlLLWNPGPDRDTTCDYRQKALavskfllaFMVPLAIIASSHVAVSLRLHHRGRQ------RTGRFVRLVAA 249
Cdd:cd15969  145 DNIHDCSK--LKSPLGVKWHTAVSYINICI--------FVAVLVILIVCYISISRYIYKSSKQfissssRTRKHNQSIRV 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 250 IVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVN----PLLYVFTC 307
Cdd:cd15969  215 VVAVFFVCFLPYHLCRIPFTFSQLDKILDCTIKTILYYCKEATLFLSACNvcldPIIYFFMC 276
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
84-303 2.51e-09

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 57.29  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLML---WALAVL 160
Cdd:cd15310   55 PWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMItavWVLAFA 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIP-YFVFRDTiprldgrimcyynlllwnpgpDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhhrgrQR 239
Cdd:cd15310  135 VSCPlLFGFNTT---------------------GDPTVCSISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVVL-----LR 188
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 240 TGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRglpfVTSLAFFNSVVNPLLY 303
Cdd:cd15310  189 EKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPELYSA----TTWLGYVNSALNPVIY 248
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
45-329 3.07e-09

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 57.46  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  45 GLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLA--VGHSWELGTtfcKLHSSVFFLNMFASGFLLS 122
Cdd:cd15108   14 GMAGNGLVVWLLSCRGRRTPFCVYVLHLAVADLLFLLCMASTLSLETspLVITHDLAY---EVVRRVKYFAYTASLSLLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 123 AISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiprldgrimcyynllLWNPGPDRDTTCDyrq 202
Cdd:cd15108   91 AISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSE---------------FWHPDEWQCFKVD--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 203 kaLAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQR--TGRFVRLVAAIVVaFVLCWGPYHIFSLLEARAH---SVTTL 277
Cdd:cd15108  153 --MVFSFLIMGIFTPVMALSSLILFVRVRRSSRQWRRrpTRLYVVVLASVLV-FLACALPLGIYWFLLYWLDlpqEVKTL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006435 278 RQLASRGLPFVTSLAffnsvvNPLLYVFTCPDMLYKLRRSLRAVLESVLVED 329
Cdd:cd15108  230 FSCLSRLSSSVSSSA------NPVIYFLVGSRGSRRLREPLGAVLQRALREE 275
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
40-326 3.48e-09

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 57.22  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTyFLAVGHSWELGTTFCKLHSSVFFLNMFASGF 119
Cdd:cd15109    9 LLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFS-ILNTGGFLGTFADYIRSVSRILGLCTFLTGV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 120 -LLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIpyfvfrdtiprldgrIMCYYNLLLWNPGPdrDTTC 198
Cdd:cd15109   88 sLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTC---------------IHNYFCVFLGREAP--GAAC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQKALAVSKFLLafMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLC-------WGPYHIFslleara 271
Cdd:cd15109  151 RHMDIFLGILLFLL--FCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSsiylgidWFLFWVF------- 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 272 hsvttlrQLASRGLPFVTSLAF-FNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVL 326
Cdd:cd15109  222 -------QIPAPFPEYVTDLCIcINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRAL 270
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
103-305 3.70e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 56.86  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 103 CKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTvAVAHRVCLMLWALAVLNTIP-YFVFRDTIPRlDGRIMC 181
Cdd:cd15196   73 CRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTS-RRVHLMVAIAWVLSLLLSIPqLFIFSYQEVG-SGVYDC 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 182 YYNLllwnpgpdrdtTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSlRLHHRGRQRTgrfVRLVAAIVVAFVLCWGPY 261
Cdd:cd15196  151 WATF-----------EPPWGLRAYITWFTVAVFVVPLIILAFCYGRIC-YVVWRAKIKT---VKLTLVVVACYIVCWTPF 215
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 262 HIFSLLEARAHSvttlrqlASRGLPFVTSLAFF---NSVVNPLLYVF 305
Cdd:cd15196  216 FVVQMWAAWDPT-------APIEGPAFVIIMLLaslNSCTNPWIYLA 255
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
84-305 4.02e-09

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 56.98  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15067   54 PFSILHEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIprldgrimcyynlllwNPGPDRDTTCDY--RQKALAVSKfLLAFMVPLAIIasshVAVSLRLhHRGRQRTG 241
Cdd:cd15067  134 PAIAWWRAV----------------DPGPSPPNQCLFtdDSGYLIFSS-CVSFYIPLVVM----LFTYYRI-YRAAAKEQ 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 242 RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15067  192 KAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCV--SNPDILFPLVTWLGYINSGMNPIIYAC 253
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
84-305 4.07e-09

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 57.03  E-value: 4.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLhsSVFFL--NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLN 161
Cdd:cd15922   54 PLLIAYFSLGSHWPFGQFLCQL--KVFLLstHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQ 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 162 TIPYFVFRDTiPRLDGRIMC-------------YYNLLLWNPGpdrdttcdyrqkalavskFLLAFMVPLAIIA--SSHV 226
Cdd:cd15922  132 GLPFFFVLKT-SVIDGKTKClsihqselsllyfVWNFVLLILG------------------FLLPFGVSLTCYAllGASI 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 227 AVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH-----SVTTLRQL-ASRGLPFVTSLAffNSVVNP 300
Cdd:cd15922  193 AKMNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKlfypeSCTLLHKVeVAYYISWVLTGV--NCCLDP 270

                 ....*
gi 569006435 301 LLYVF 305
Cdd:cd15922  271 LLYCF 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
96-303 5.45e-09

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 56.47  E-value: 5.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFR-DTIPR 174
Cdd:cd15321   72 WYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKgKQKDE 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDGRIMCYYNLLLWnpgpdrdttcdyrqkaLAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAAIVVAF 254
Cdd:cd15321  152 QGGLPQCKLNEEAW----------------YILSSSIGSFFAPCLIM----ILVYLRIYLIAKNREKRFTFVLAVVIGVF 211
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 255 VLCWGPYHIFSLLEArahSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15321  212 VLCWFPFFFSYSLGA---ICPELCKVPHSLFQFFFWIGYCNSSLNPVIY 257
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
43-303 5.59e-09

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 56.75  E-value: 5.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVV-GCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15399   12 LLGVVGNSLVIYVViKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRpvwaqnHRTVAVAHRVCLML----WALAVLNTIPYFVFRDTIPRldgRIMCYYNLLL----WNPGPD 193
Cdd:cd15399   92 TVIALDRHRCIVY------HLESKISKKISFLIigltWAASALLASPLAIFREYSVI---EISPDFKIQAcsekWPNGTL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 194 RDTTcdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLRL------------HHRGRQRTgrfVRLVAAIVVAFVLCWGPY 261
Cdd:cd15399  163 NDGT------IYSVSMLLIQYVLPLAIISYAYIRIWTKLknhvspgggndhYHQRRRKT---TKMLVCVVVVFAVSWLPF 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 262 HIFSLLEARAHSVTTLRQLASRGLPFVTsLAFFNSVVNPLLY 303
Cdd:cd15399  234 HAFQLASDIDSKVLDLKEYKLIYTIFHV-IAMCSTFANPLLY 274
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
85-303 6.45e-09

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 56.13  E-value: 6.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWAL 157
Cdd:cd15297   56 LYTLYTVIGY-WPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTtkmagmmIAAAWVLSFILWAP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 158 AVLnTIPYFVFRDTIPRLDgrimCYYNLllwnpgpdrdttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSlrlhhRGR 237
Cdd:cd15297  135 AIL-FWQFIVGGRTVPEGE----CYIQF--------------FSNAAVTFGTAIAAFYLPVIIMTVLYWQIS-----RAS 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVttlrqLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15297  191 SREKKVTRTILAILLAFIITWTPYNVMVLINTFCASC-----IPNTVWTIGYWLCYINSTINPACY 251
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
96-308 7.26e-09

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 56.30  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15317   66 WYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 D---GRIMCYYNLLLwnpgpdrdttcdYRQKALAVSKFLLaFMVPLAIIASSHVAVSL---------------------R 231
Cdd:cd15317  146 EeysSEISCVGGCQL------------LFNKIWVLLDFLT-FFIPCLIMIGLYAKIFLvarrqarkiqnmedkfrsseeN 212
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 232 LHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglpfVTSLAFFNSVVNPLLYVFTCP 308
Cdd:cd15317  213 SSKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAIVFDA-----VIWLGYFNSAFNPFIYAFFYP 284
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
86-303 9.03e-09

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 55.73  E-value: 9.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15334   56 FSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRdtiprldgrimcyynlllwNPGPDRDTTCDYRQKALAVSKF--LLAFMVPLAIIASSHVAVslrlhHRGRQRTGRF 243
Cdd:cd15334  136 LFWR-------------------HQTTSREDECIIKHDHIVFTIYstFGAFYIPLALILILYYKI-----YRAATRERKA 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 244 VRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15334  192 ATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSN----FLTWLGYINSLINPLIY 247
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
96-303 9.51e-09

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 55.99  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTvAVAHRVCLML--WALAVLNTIPYFVFrdtip 173
Cdd:cd15295   66 WDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQT-ATLRIVTQMVavWVLAFLVHGPAILV----- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 rldgrimcyynlllWNPGPDRDTTCDYR----QKALAVSKFLlAFMVPLAIIASSHVAVSLRLHHRGRQRtgRFVRLVAA 249
Cdd:cd15295  140 --------------SDSWKTEDGECEPEffsnWYILAITSVL-EFLVPVILVAYFNTQIYWSLWKRLRDR--KLAKSLAI 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569006435 250 IVVAFVLCWGPYHIFSLLEARAHsvttlRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15295  203 ILGTFAICWAPYSLFTIIRAACE-----KHRGSPWYNFAFWLQWFNSFINPFLY 251
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
85-303 1.27e-08

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 55.34  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWAL 157
Cdd:cd15299   59 LFTTYIIMNR-WALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTtkragvmIGLAWVISFVLWAP 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 158 AVLnTIPYFVFRDTIPRLDgrimCYYNLLlwnpgpdrdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGR 237
Cdd:cd15299  138 AIL-FWQYFVGKRTVPPDE----CFIQFL--------------SEPIITFGTAIAAFYLPVTIMTILYWRI-----YKET 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlRQLASRGLpfvtSLAFFNSVVNPLLY 303
Cdd:cd15299  194 IKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIP-KTYWNLGY----WLCYINSTVNPVCY 254
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
43-305 1.45e-08

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 55.53  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGcRMRQTV----VTTWVLHLALSDLLAAASLPFF-TYFLAVGHsWELGTTFCKLHSSVFFLNMFAS 117
Cdd:cd15147   12 VLGLIANCYVLWVFA-RLYPSKklneIKIFMVNLTIADLLFLITLPFWiVYYHNEGN-WILPKFLCNVAGCLFFINTYCS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 118 GFLLSAISLDRCLQVVRPVWA--QNHRTVAVAhrVCLMLWALAVLNTIPYFVFRDT-IPRLDGRIM--CYynlllwnPGP 192
Cdd:cd15147   90 VAFLGVISYNRYQAVTRPIKTaqSTTRKRGII--ISVAIWVIIVASASYFLFMDSTnTVKIDSGNFtrCF-------EGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 DRDTTcdyrqKALAVSKFLLA---FMVPLAIIASSHVAVSLRLHHRGRQRTG-----RFVRLVAAIVVAFVLCWGPYHI- 263
Cdd:cd15147  161 EKDNS-----KPVLIIHFIIIglfFLVFLLILVCNLVIARTLLSQPVQGQRNagvkrRALWMVCTVLAVFVICFVPHHVv 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 264 -----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15147  236 qgpwtLAVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCF 282
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
40-303 1.54e-08

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 55.30  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFVVGCRMRQ-TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASG 118
Cdd:cd15377    9 LVFITGFLGNSVAIWMFVFHMKPwSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 119 FLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYynlllwnpgpdrDTTC 198
Cdd:cd15377   89 LFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCY------------DTTS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQKALAVSKF---LLAFMVPLAIIASSHVAVSLRLHHRGRQRTG--------RFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15377  157 DEYLRSYFIYSMcttVAMFCVPFILILGCYGLIVRALIYKDMKYTEennaplrrKSIYLVIIVLTVFAVSYLPFHVMKTL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 569006435 268 EARAH-SVTTLRQLASRGLPFVT-----SLAFFNSVVNPLLY 303
Cdd:cd15377  237 NLRARlDFQTPAMCAFNDRVYATyqvtrGLASLNSCVDPILY 278
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
33-263 1.57e-08

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 55.35  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMRQ---TVVttWVLHLALSDLLAAASLPFFTYFLavGHSWElGTTFCKLHSSV 109
Cdd:cd15164    2 IQLIIYIPILFFGLLFNVLALWVFCCKMKKwteTRV--YMINLAVADCCLLFSLPFVLYFL--KHSWP-DDELCLVLQSI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 110 FFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALavlnTIPYFVFRDTIPRLDGRImCYYNlllwn 189
Cdd:cd15164   77 YFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL----VIISVSLRLAWEEQEENF-CFGK----- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 pgpdRDTTcdyRQKALAVSkFLLAFMVPLAIIA--SSHVAVSL----RLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd15164  147 ----TSTR---PSKRTLIF-SLLGFFIPLIILSfcSIQVIRSLkkkkKTNPHEEKLIQKAIYIVSANLIVFIVCFLPLHI 218
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
95-307 1.71e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 55.17  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR 174
Cdd:cd15151   64 PWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPAT 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDGRIMCyyNLLLWNPGPDRDTTCDYRQKALAVSKFLLafMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVA- 253
Cdd:cd15151  144 PISVKKC--ASLKSPLGLKWHEVVNYICQFIFWGVFAL--MVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAv 219
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 254 FVLCWGPYHiFSLLEARAHSVTTLRQLASRGLPFVTS-----LAFFNSVVNPLLYVFTC 307
Cdd:cd15151  220 FFVCFAPFH-FVRVPYTLSQTGKITDCQLQNLLYIAKeitlwLAATNVCLDPLIYIFLC 277
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
89-306 1.77e-08

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 55.12  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhRVCLMLWALAVLNTIPYFVF 168
Cdd:cd15152   58 FYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDV-YISIAGWLVVCVGCLPFPLL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 RDTIPRldGRIMCYYNLllwnpgPDRDTTCDYRQKALAVSKfLLAFMVPLAII--ASSHVAVSLR-----LHHRGRQRTG 241
Cdd:cd15152  137 RQSQDT--NPTCCFADL------PLRNVGLTTSVIMLTIAE-LTGFVTPLLIVlyCSWKTVMSLRektpvLQDLGEKKKA 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 242 RFVRLVAAIVvaFVLCWGPYHI-FS---LLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFT 306
Cdd:cd15152  208 LKMILTCAVV--FLICFAPYHIsFPldfLVKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFT 274
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
43-264 1.77e-08

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 55.21  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRM-RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15166   12 IIGLFVNITALWVFSCTTkKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDE-WPFGDYFCRILGALTVFYPSIALWLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfvfrdtiprldgrimcyynLLLWNPGPDRD---TTC 198
Cdd:cd15166   91 AFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFP--------------------LLFLYEDPDKAsnfTTC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 DYRQ--------KALAVSKFLLAFMVPLAIIASSHVAVslrLHHRGRQRTGRF--------VRLVAAIVVAFVLCWGPYH 262
Cdd:cd15166  151 LKMLdiihlkevNVLNFTRLIFFFLIPLFIMIGCYLVI---IHNLVHGRTSKLkpkvkeksIRIIITLIVQVLVCFVPFH 227

                 ..
gi 569006435 263 IF 264
Cdd:cd15166  228 IC 229
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
98-305 1.80e-08

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 55.22  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  98 LGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTvavAHRV--CLMLWALAVLNTIP-YFVFRDTIPr 174
Cdd:cd15077   68 LGPLACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRG---THAIigCIATWVFGLAASLPpLFGWSRYIP- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 lDGrimcyynlLLWNPGPDRDTTCD-YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGR--------QRTGRFV- 244
Cdd:cd15077  144 -EG--------LQCSCGPDWYTTNNkWNNESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKqqeqsastQKAEREVt 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 245 RLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrgLPFVTSLAffNSVVNPLLYVF 305
Cdd:cd15077  215 KMVVVMVLGFLVCWLPYASFALWVVTNRGEPFDLRLAS--IPSVFSKA--STVYNPVIYVF 271
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
33-303 2.06e-08

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 54.80  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLAsLLGLVENGLILFVVGC-RMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15062    3 VGVALGAFI-LFAIGGNLLVILSVACnRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI-PYFVFRDtiprldgrimcyynlllwnP 190
Cdd:cd15062   82 LCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKE-------------------P 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 191 GPDRDTTCDY-RQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRtgRFVRLVAAIVVAFVLCWGPYHIFSLLEa 269
Cdd:cd15062  143 APADEQACGVnEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSREK--KAAKTLGIVVGAFVLCWFPFFVVLPLG- 219
                        250       260       270
                 ....*....|....*....|....*....|....
gi 569006435 270 rahSVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15062  220 ---SLFSTLKPPEPVFKVVFWLGYFNSCLNPIIY 250
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
92-303 2.21e-08

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 54.55  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDt 171
Cdd:cd15335   62 VMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRN- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 iprlDGRImcyynlllwnPGPDRdTTCDYRQKALAVSKFLLAFMVPLAIIasshVAVSLRLHHRGrQRTGRFVRLVAAIV 251
Cdd:cd15335  141 ----HHDA----------NIPSQ-CIIQHDHVIYTIYSTFGAFYIPLTLI----LILYYRIYHAA-SRERKAARILGLIL 200
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006435 252 VAFVLCWGPYHIFSLLEArahsvTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15335  201 GAFILSWLPFFIKELIVG-----LSVMTVSPEVADFLTWLGYVNSLVNPLLY 247
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
84-306 2.23e-08

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 55.00  E-value: 2.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15048   55 PFYIPYTLTGK-WPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 P------YFVFRDTIPRLDGRIMCYYNLllwnpgpdrdttcdYRQKALAVskflLAFMVPLAIIASSHVAVSLRLHHRGR 237
Cdd:cd15048  134 PaiigwdLWTGYSIVPTGDCEVEFFDHF--------------YFTFITSV----LEFFIPFISVSFFNLLIYLNIRKRSR 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 238 QRTGRFVRL----------------------------VAAIVVAFVLCWGPYHIFSLLEARAHSVTtlrqLASRGLPFVT 289
Cdd:cd15048  196 RRPLRSVPIlpasqnpsrarsqreqvklrrdrkaaksLAILVLVFLICWAPYTILTIIRSFCSGSC----VDSYLYEFTF 271
                        250
                 ....*....|....*..
gi 569006435 290 SLAFFNSVVNPLLYVFT 306
Cdd:cd15048  272 WLLWTNSAINPFLYAAC 288
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
96-305 2.37e-08

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 54.36  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAvahRVCLML---WALAVLNTIPyfvfrdti 172
Cdd:cd15060   66 WLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLK---RVLLMIvvvWALSALISVP-------- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 prldgrimcyyNLLLWNPGPD---RDTTCDY-RQKALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGRQRTGRFVRLVA 248
Cdd:cd15060  135 -----------PLIGWNDWPEnftETTPCTLtEEKGYVIYSSSGSFFIPLLIMTIVYVKI-----FIATSKERRAARTLG 198
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 249 AIVVAFVLCWGPYHIFSLLEARAHSVttlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15060  199 IIMGVFVVCWLPFFLMYVILPFCETC----SPSAKVVNFITWLGYVNSALNPVIYTI 251
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
80-308 2.44e-08

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 54.80  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  80 AASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAV 159
Cdd:cd15366   50 IATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 -LNTIPYF---VFRDTIprldGRIMCY--YNLLLWNPGpdrdttcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRLh 233
Cdd:cd15366  130 gANSAPLFhdeLFRDRY----NHTFCFekYPMEDWVAW-------------MNLYRVFVGFLFPWVLMLFSYRGILRAV- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 234 hRG-----RQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEarahSVTTLRQLASRGL------PFVTSLAF--FNSVVNP 300
Cdd:cd15366  192 -RGnvsteQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSR----SVVYLGKPCDCGFeervftAYHVSLALtsLNCVADP 266

                 ....*...
gi 569006435 301 LLYVFTCP 308
Cdd:cd15366  267 ILYCLVNE 274
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
95-319 2.51e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 54.93  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR 174
Cdd:cd15123   65 TWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSF 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDgrimcyynlllwnpgPDRDTTCD----------YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLH----------- 233
Cdd:cd15123  145 RD---------------PEKNTTFEacapypvsekILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYkstfnmpaeeh 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 234 ---HRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLearaHSVTTLRQLASRGLPFVTS-----LAFFNSVVNPLlyvf 305
Cdd:cd15123  210 shaRKQIESRKRVAKTVLVLVALFAFCWLPNHILYLY----RSFTYHTSVDSSAFHLIATifsrvLAFSNSCVNPF---- 281
                        250
                 ....*....|....
gi 569006435 306 tcpdMLYKLRRSLR 319
Cdd:cd15123  282 ----ALYWLSKSFR 291
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
84-303 3.15e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 54.07  E-value: 3.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaqNHRTVAVAHRvclmlwALAVLNTI 163
Cdd:cd15308   55 PLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPL---NYNRRQGSVR------QLLLISAT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIPRLDGrimcyynlllWNPGPDRD-TTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVslrLHHRGRQRtgR 242
Cdd:cd15308  126 WILSFAVASPVIFG----------LNNVPNRDpAVCKLEDNNYVVYSSVCSFFIPCPVMLVLYCAM---FRGLGRER--K 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 243 FVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15308  191 AMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLIS----IVTWLGYVNSALNPVIY 247
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
94-318 3.17e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 54.26  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIP 173
Cdd:cd15083   64 GRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYV 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 RLDGRIMCYYNLLlwnpgpDRDTTcdyrQKALAVSKFLLAFMVPLAIIASSHVAV---------------------SLRL 232
Cdd:cd15083  144 LEGLLTSCSFDYL------SRDDA----NRSYVICLLIFGFVLPLLIIIYCYSFIfravrrhekamkemakrfsksELSS 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 233 HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLE--ARAHSVTtlrqlasrglPFVTSL-AFF---NSVVNPLLYVFT 306
Cdd:cd15083  214 PKARRQAEVKTAKIALLLVLLFCLAWTPYAVVALIGqfGYLEVLT----------PLATAIpAAFaktSAIYNPVIYAFS 283
                        250
                 ....*....|..
gi 569006435 307 CPdmlyKLRRSL 318
Cdd:cd15083  284 HP----KFRRAL 291
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
95-267 3.38e-08

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 54.36  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLhssVFFL---NMFASGFLLSAISLDRCLQVVRPVwaqnHRTVAVAHRVCLM--LWALAVLNTIP----- 164
Cdd:cd15394   66 GWVFGRFMCYF---VFLMqpvTVYVSVFTLTAIAVDRYYVTVYPL----RRRISRRTCAYIVaaIWLLSCGLALPaaaht 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 165 YFVfrdTIPRLDGRIMCYYnlllWNpGPDRDttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR--------- 235
Cdd:cd15394  139 YYV---EFKGLDFSICEEF----WF-GQEKQ------RLAYACSTLLITYVLPLLAISLSYLRISVKLRNRvvpgsmtqs 204
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 569006435 236 ----GRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15394  205 qaewDRARRRKTFRLLVVVVVAFAICWLPLHIFNVI 240
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
84-305 3.81e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 54.26  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNH---RTVAVAHRVcLMLWALAV- 159
Cdd:cd15051   55 PFSAIYELRGE-WPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRvtpRRVAIALAA-IWVVSLAVs 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 -------LNTIPYFVFRDTIPRLdgrimCYYNlllWNPgpdrdttcdyrqkALAVSKFLLAFMVPLAI------------ 220
Cdd:cd15051  133 flpihlgWNTPDGRVQNGDTPNQ-----CRFE---LNP-------------PYVLLVAIGTFYLPLLImcgvylrifria 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 221 ------IASSHVAVSLRLHHRGR-QRTGRFVRLVAAIVVAFVLCWGPYHIFsllearahsvTTLRQLASRGLP-----FV 288
Cdd:cd15051  192 reqakrINALTPASTANSSKSAAtAREHKATVTLAAVLGAFIICWFPYFTY----------FTYRGLCGDNINetalsVV 261
                        250
                 ....*....|....*..
gi 569006435 289 TSLAFFNSVVNPLLYVF 305
Cdd:cd15051  262 LWLGYANSALNPILYAF 278
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
96-303 4.92e-08

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 53.74  E-value: 4.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtiprl 175
Cdd:cd15131   66 WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVG----- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgrimcyynlLLWNPGPDRDTTCDYRQKALAVSKFLLAFMV---------PLAIIASSHVAVSLRLHHRGRQRTG----- 241
Cdd:cd15131  141 ----------VEHENGTNPIDTNECKATEYAVRSGLLTIMVwvssvffflPVFCLTVLYSLIGRKLWRRRRENIGpnash 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 ------RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLR-QLASRGLPFVTSLAFF-NSVVNPLLY 303
Cdd:cd15131  211 rdknnrQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGSLEiALISQYCNLVSFVLFYlSAAINPILY 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
35-303 5.10e-08

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 53.90  E-value: 5.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGCRMRQTVVTTW--VLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFL 112
Cdd:cd15392    4 ILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYfiVNLALSDILMAVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 113 NMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhrVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWnpgp 192
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALL--LIAVIWIFALATALPIAITSRLFEDSNASCGQYICTESW---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 193 drdtTCDYRQKALAVSKFLLAFMVPLAIIASSHV--------------AVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCW 258
Cdd:cd15392  158 ----PSDTNRYIYSLVLMILQYFVPLAVLVFTYTrigivvwakrtpgeAENNRDQRMAESKR-KLVKMMITVVAIFALCW 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 259 GPYHIFSLLEARAHSVttlrqLASRGLPFVTS----LAFFNSVVNPLLY 303
Cdd:cd15392  233 LPLNILNLVGDHDESI-----YSWPYIPYLWLaahwLAMSHCCYNPFIY 276
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
33-305 5.41e-08

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 53.63  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVV-GCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15205    2 AFVITYVLIFVLALFGNSLVIYVVtRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVfrdtIPRLDGRIMCYYNLllwnpg 191
Cdd:cd15205   82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLF----VQQLEVKYDFLYEK------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdRDTTCDYR------QKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGR-------------------QRTGRFVRL 246
Cdd:cd15205  152 --RHVCCLERwysptqQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRvgdasvlqtihgiemskisRKKKRAVKM 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 247 VAAIVVAFVLCWGPYHI------FSLLEARAHSVTTLRQLAsrglpFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15205  230 MVTVVLLFAVCWAPFHVvhmmieYSNLENKYDGVTIKLIFA-----IVQLIGFSNSFNNPIVYAF 289
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
85-305 5.86e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 53.79  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHSWELGTTFCKLHSSVFFLNMF--ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNT 162
Cdd:cd14978   57 LLPYIADYSSSFLSYFYAYFLPYIYPLANTFqtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IPYFVFRDTIPRLDGRIMCYYNLLlwnPGPDRDTTCdYRQKALAVSKFLLAFMVPLAIIA--SSHVAVSLR--------- 231
Cdd:cd14978  137 LPRFFEYEVVECENCNNNSYYYVI---PTLLRQNET-YLLKYYFWLYAIFVVLLPFILLLilNILLIRALRkskkrrrll 212
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 232 -----LHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGlPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14978  213 rrrrrLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLG-DISNLLVVLNSAVNFIIYCL 290
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
33-317 7.27e-08

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 53.16  E-value: 7.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVgCRMRQTVVTTWVLHLAL----SDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSS 108
Cdd:cd14995    2 VATFLVLLICGVGIVGNIMVVLVV-LRTRHMRTPTNCYLVSLavadLMVLVAAGLPNEIESLLGPDSWIYGYAGCLLITY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 109 VFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRldgrimcyynlllw 188
Cdd:cd14995   81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIK-------------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 189 NPGPDRDTTCDYR-----QKALAVSKFLLAFMVPLaIIASSHVAVSLRLHHRGRQRTgrfVRLVAAIVVAFVLCWGPYHI 263
Cdd:cd14995  147 HYGDDIVVRCGYKvsrhyYLPIYLADFVLFYVIPL-LLAIVLYGLIGRILFSSRKQV---TKMLAVVVVLFALLWMPYRT 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569006435 264 FSLLearaHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFtcpdMLYKLRRS 317
Cdd:cd14995  223 LVVY----NSFASPPYLDLWFLLFCRTCIYLNSAINPILYNL----MSQKFRAA 268
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
89-303 8.23e-08

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 53.03  E-value: 8.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVF 168
Cdd:cd15130   64 FIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFT 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 RDTIPRLDGRImcYYNLLLWNPGPDRDTTcdyrqKALAVSKFLLAFMVPLAIIA------SSHVAVSLRlhhrgrqrtgR 242
Cdd:cd15130  144 MGLQNESDDGT--HPGGLVCTPIVDTATL-----KVVIQVNTFMSFLFPMLVTSilntviANKLVQALR----------R 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 243 FVRLVAAIVVAFVLCWGPYHIFSLLEARAHS---VTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15130  207 GVLVLRAVVIAFVVCWLPYHVRRLMFCYISDeqwTTFLFDFYHYFYMLTNALFYVSSAINPILY 270
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
59-267 9.07e-08

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 52.92  E-value: 9.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  59 RMRqTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwa 138
Cdd:cd16004   30 RMR-TVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAIAADRYMAIIHPF-- 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 139 qNHRTVAVAHRVCL-MLWALAVLNTIPYfVFRDTIPRLDGRIMCYYNlllWNPGPDRDTTCDYRqkaLAVskFLLAFMVP 217
Cdd:cd16004  107 -KPRLSAGSTKVVIaGIWLVALALAFPQ-CFYSTVTMDQGRTKCIVA---WPGDSGGKHQLTYH---LAV--IVLIYLLP 176
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569006435 218 LAIIASSHVAVSLRL-------------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd16004  177 LAVMFVTYSIIGITLwrsavpghqahgaYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFIL 239
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
85-305 1.62e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 51.95  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWAL 157
Cdd:cd15300   56 LYTSYILMGY-WALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTpkragimIGLAWLISFILWAP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 158 AVLnTIPYFVFRDTIPRLDGRIMCYYnlllwnpgpdrdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGR 237
Cdd:cd15300  135 PIL-CWQYFVGKRTVPERECQIQFLS------------------EPTITFGTAIAAFYIPVSVMTILYCRI-----YKET 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLrQLASRGLpfvtSLAFFNSVVNPLLYVF 305
Cdd:cd15300  191 IKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPL-TLWHLGY----WLCYVNSTVNPMCYAL 253
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
36-308 2.30e-07

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 51.80  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVgCRMRQ--TVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLN 113
Cdd:cd15379    5 LVYSVVFLLGLPLNAVVIGQI-WATRQalSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 114 MFASGFLLSAISLDRCLQVVRPVWAQNHRT-VAVAHRVCLMLWALAVLNTIPYFVFRDT-IPRldGRIMCyYNLllwnPG 191
Cdd:cd15379   84 LHGSILFLTCISVQRYLGICHPLASWHKKKgKKLTWLVCGAVWLVVIAQCLPTFVFASTgTQR--NRTVC-YDL----SP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PDRDTTCDYRQKALAVSKFLLAFMVPLAIIAS---------SHVAVSLRLHHRgRQRTGRfvrlvAAIVVAFVLCWG--P 260
Cdd:cd15379  157 PARSTAYFPYGITLTRTGFLLPFAARLACYCSmatilcrvvIAVAVVAAPGEK-RGKAAR-----MIIVVAAVFLISflP 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006435 261 YHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCP 308
Cdd:cd15379  231 FHYtktrYLQVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQS 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
95-305 2.62e-07

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 51.62  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNhrTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPr 174
Cdd:cd15208   65 TWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIPQAIVMECSR- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 lDGRIMCYYNLLlwnpgpdrdTTCDYR------QKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR---------GRQR 239
Cdd:cd15208  142 -VVPLANKTILL---------TVCDERwsdsiyQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRqipgtssvvQRKW 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 240 TGRFVRLVAA-----------------IVVAFVLCWGPYHIFSLLeaRAHSVTTLRQLASRGLPFVTS--LAFFNSVVNP 300
Cdd:cd15208  212 NKPRKSAVAAeekqlrsrrktakmlivVVIMFAICYLPVHLLNIL--RYVFGLFTVDRETIYAWFLFShwLVYANSAINP 289

                 ....*
gi 569006435 301 LLYVF 305
Cdd:cd15208  290 IIYNF 294
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
84-309 4.09e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 50.73  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAvahRVCLML---WALAVL 160
Cdd:cd15329   55 PLAIIYELSGY-WPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPK---RMALMIaivWLLSAL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTIPyfvfrdtiprldgrimcyyNLLLWNPGPDRDTTCDYRQK-ALAVSKFLLAFMVPLAIIasshVAVSLRLhHRGRQR 239
Cdd:cd15329  131 ISIP-------------------PLFGWKNKVNDPGVCQVSQDfGYQIYATFGAFYIPLIVM----LVLYYKI-YRAAKS 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 240 TGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAhSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15329  187 ERKAIKTLGIIMGAFTLCWLPFFILALLRPFL-KPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNRE 255
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
96-303 4.27e-07

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 50.71  E-value: 4.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15323   66 WYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMCYYNLLLWnpgpdrdttcdyrqkaLAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAAIVVAFV 255
Cdd:cd15323  146 DVYPQCKLNDETW----------------YILSSCIGSFFAPCLIM----ILVYIRIYRVAKAREKRFTFVLAVVMGVFV 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569006435 256 LCWGP----YHIFSLLEARAHSVTTLrqlasrgLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15323  206 VCWFPfffsYSLYGICREACEVPEPL-------FKFFFWIGYCNSSLNPVIY 250
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
84-305 4.74e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 50.95  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVavahRVCLMLWALAVLNTI 163
Cdd:cd15056   55 PFGAIELVNNR-WIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPL----RVAVMLGGCWVIPTF 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFvfrdtIPRLDGRIMCYYNLLLWNPGPDRDTTCDYR-QKALAVSKFLLAFMVPLAIIASSHVAVSL------------ 230
Cdd:cd15056  130 ISF-----LPIMQGWNHIGIEDLIAFNCASGSTSCVFMvNKPFAIICSTVAFYIPALLMVLAYYRIYVaareqahqirsl 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 231 -----RLHHRGRQRTGRFVRLVAA------IVVAFVLCWGPYHIFSLLEARAHSvttlrqlASRGLPFVTS--LAFFNSV 297
Cdd:cd15056  205 qragsSNHEADQHRNSRMRTETKAaktlgiIMGCFCVCWAPFFVTNIVDPFIGY-------RVPYLLWTAFlwLGYINSG 277

                 ....*...
gi 569006435 298 VNPLLYVF 305
Cdd:cd15056  278 LNPFLYAF 285
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
96-319 4.91e-07

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 50.88  E-value: 4.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPvwaQNHRTVAVAHRVCLML---WALAVLNTIPYFVFRDT- 171
Cdd:cd14977   66 WLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNS---MPMQTIGACLSTCVKLaviWVGSVLLAVPEAVLSTVa 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 -IPRLDGrimCYYNLLLWNPGPDRDTTcdyRQKALAVSKFLLAFMVPLAIIA--SSHVAVSLRLHHRGRQR--------T 240
Cdd:cd14977  143 rESSLDN---SSLTVCIMKPSTPFAET---YPKARSWWLFGCYFCLPLAFTAvcYLLMARTLIRAAKEYTRgtkkhmkqR 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 241 GRFVRLVAAIVVAFVLCWGPYHIFSLLeaRAHSVTTLRQLASRGLPFVT----SLAFFNSVVNPLLyvftcpdmLYKLRR 316
Cdd:cd14977  217 RQLAKTVLCLVLVFAFCWLPEHISNIL--RATLYNEVLIDTRSTLDILDligqFLSFFNSCVNPIA--------LYLLSE 286

                 ...
gi 569006435 317 SLR 319
Cdd:cd14977  287 PFR 289
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
43-303 4.98e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 50.68  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGC-RMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15327   12 LMAIVGNILVILSVACnRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfvfrdtiprldgrimcyyNLLLWN-PGPDRDTTCDY 200
Cdd:cd15327   92 CVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIG-------------------PLLGWKePPPPDESICSI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKA-LAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRtgRFVRLVAAIVVAFVLCWGPYHIF----SLLEARAHSVT 275
Cdd:cd15327  153 TEEPgYALFSSLFSFYLPLMVILVMYFRVYVVALKFSREK--KAAKTLAIVVGVFILCWFPFFFVlplgSFFPALKPSEM 230
                        250       260
                 ....*....|....*....|....*...
gi 569006435 276 TLRqlasrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15327  231 VFK--------VIFWLGYFNSCVNPIIY 250
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
36-303 7.73e-07

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 50.29  E-value: 7.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  36 LLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVAIGRTQRlQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWAL-AVLNTIPYFV--FRDTIPRldgRIMCYYnlllwNPG 191
Cdd:cd15958   85 TASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAIsALVSFLPIMMhwWRDEDDQ---ALKCYE-----DPG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrdtTCDY-RQKALAVSKFLLAFMVPLAIIASSHVAV--------------SLRLHHR----GRQRTGRFVRLVAA--- 249
Cdd:cd15958  157 -----CCDFvTNRAYAIASSIISFYIPLLIMIFVYLRVyreakkqikkidkcEGRFHNTltglGRKCKRRPSRILALreq 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 250 --------IVVAFVLCWGPYHIFSLLEARAHSVttlrqLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15958  232 kalktlgiIMGVFTLCWLPFFLVNVVNVFNREL-----VPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
42-305 8.05e-07

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 50.21  E-value: 8.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  42 SLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYflAVGHSWELGTTFCK---------LHSSVFF 111
Cdd:cd15171   11 FLVGLLDNGLVVFIlVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAH--AAWHGGSLGNPTCKvlvalssvgLHSEALF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 lnmfasGFLLSAISLDRCLQVVRPVWAQnhRTVAVAHRVCLMLWALAVLNTIPYFVFRDTiPRLDGRIMCYYNLLLWNPG 191
Cdd:cd15171   89 ------NVLLTVQASRVFFHGRLASSAR--RVAPCGIIASVLAWLTAFLVTLPEFVFYKP-QMDSQKSKCAFSRPHFLPA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 pdrDTTcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTgrFVRLVAAIVVAFVLCWGPYHIFSLLEARA 271
Cdd:cd15171  160 ---EET--FWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRD--LSKLVFAIMVVFLLMWAPYNIALFLSAFK 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 569006435 272 HSVtTLRQLAS-----RGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15171  233 EHF-SLRDCKSsyhldASVQVTKLIATTHCCVNPLLYAL 270
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
86-308 9.70e-07

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 49.86  E-value: 9.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTiPY 165
Cdd:cd15318   56 FSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYT-SV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDTI-----------PRLDGRIMCYYNLLLWNPGPDRDTTCdyrqkALAVSKFLLAFMVplAIIASSHVAVSLRLHH 234
Cdd:cd15318  135 FLYTKAVeeglaelltsvPCVGSCQLLYNKLWGWLNFPVFFIPC-----LIMIGLYVKIFIV--AKRQARAIASLLSDTN 207
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 235 RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqlasrglPFVTSL----AFFNSVVNPLLYVFTCP 308
Cdd:cd15318  208 GASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITP---------PLLFDIiiwfAYFNSACNPLIYVFSYP 276
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
86-267 1.09e-06

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 49.64  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQnhRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15389   56 FTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPH 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTtcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRL------------- 232
Cdd:cd15389  134 AIYQKLVEFEYSNERTRSRCLPSFPEPSDLF-----WKYLDLATFILQYVLPLLIIGVAYTRVAKKLwlrnaigdvtteq 208
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 569006435 233 ---HHRGRQRTgrfVRLVAAIVVAFVLCWGPYHIFSLL 267
Cdd:cd15389  209 yvaQRRKKKKT---IKMLMLVVLLFAICWLPLNCYHVL 243
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
96-305 1.12e-06

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 49.89  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15980   66 WPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPF--KQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEK 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMCYY----NLLLWN----PGPDrdttcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL--------------- 232
Cdd:cd15980  144 NYRVVLGSqnktSPVYWCredwPNQE-------MRKIYTTVLFANIYLAPLSLIVIMYARIGITLfktamphtgkhnqeq 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006435 233 HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH-SVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15980  217 RHVVSRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYANlSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGF 290
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
43-303 1.16e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 49.51  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGC-RMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15326   12 LFAIVGNILVILSVVCnRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVwaqNHRTVAVAHRVCLMLWALAVLNTipyfvfrdtiprldgrIMCYYNLLLW-NPGPDRDTTCDY 200
Cdd:cd15326   92 CAISIDRYIGVRHSL---QYPTIVTRKRAILALLGVWVLST----------------VISIGPLLGWkEPAPPDDKVCEI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 201 RQKAL-AVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRtgRFVRLVAAIVVAFVLCWGPYHIF----SLLEARAHSVT 275
Cdd:cd15326  153 TEEPFyALFSSLGSFYIPLIVILVMYCRVYIVALKFSREK--KAAKTLGIVVGMFILCWLPFFIAlplgSLFSHLKPPET 230
                        250       260
                 ....*....|....*....|....*...
gi 569006435 276 TLRqlasrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15326  231 LFK--------IIFWLGYFNSCLNPIIY 250
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
35-305 1.21e-06

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 49.41  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGCRMRQTvvTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNM 114
Cdd:cd15163    4 MVINTLIFLVGIVLNSLALYVFCFRTKTK--TTSVIYTINLVVTDLLVGLSLPTRIVMYYSAGNCLTCSFVHIFSYFVNM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 FASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTipyFVFRDTIPRLDGRIMCYYNLLlwnpgpdr 194
Cdd:cd15163   82 YCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVT---FSILTTAIKFASCCLSKLFAL-------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 dTTCDYRQKALAVSKFLLAFMVPLAiiasshvavSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSV 274
Cdd:cd15163  151 -TVFEFFLPLLIITFFTIRIMCALS---------RPGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAVAFNPDI 220
                        250       260       270
                 ....*....|....*....|....*....|.
gi 569006435 275 TTLRQLASRGLpfVTSLAFFNSVVNPLLYVF 305
Cdd:cd15163  221 PHHTSLIVYHV--TVTLSSLNSCMDPIVYCF 249
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
85-305 1.21e-06

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 49.25  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRT-------VAVAHRVCLMLWAL 157
Cdd:cd15298   56 LYTVYIIKGY-WPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTtkmaglmIAAAWVLSFVLWAP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 158 AVLnTIPYFVFRDTIPRLDgrimCYYNLLLwNPgpdrdttcdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLrlhhrGR 237
Cdd:cd15298  135 AIL-FWQFVVGKRTVPDNQ----CFIQFLS-NP-------------AVTFGTAIAAFYLPVVIMTVLYIHISL-----AS 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVttlrqLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15298  191 ARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-----IPDTVWSIGYWLCYVNSTINPACYAL 253
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
96-303 1.30e-06

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 49.44  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdTIPRL 175
Cdd:cd15981   66 WPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPSAVTL-TVTRE 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMC-----YYNLL-LWNPGPDRDTtcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHH--------------- 234
Cdd:cd15981  143 EHHFMVddynnSYPLYsCWEAWPDTEM-----RKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKssapirgsqgeeeeg 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 235 -RGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAH-SVTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15981  218 rRVSKRKIKVINMLIIVALFFTLSWLPLWTLMLLTDYGHlSEDQLNLVTVYVFPFAHWLAFFNSSVNPIIY 288
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
43-309 1.44e-06

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 49.41  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  43 LLGLVENGLILFVVGCRMRQTVVTT-WVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLL 121
Cdd:cd15370   12 VVGLPSNAMALWVFLFRTKKKHPAViYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSILFM 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 122 SAISLDRCLQVVRPVwAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLlwnpgPDRDTTCDYR 201
Cdd:cd15370   92 TCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVL-----PEQLLVGDMF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 202 QKALAVSkfLLAFMVPLAIIASSHV------AVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCWGPYHIFSLLearaHSVT 275
Cdd:cd15370  166 NYFLSLA--IGVFLFPAFLTAVAYVlmiralKSSINDESIEKKRK-RAIKLIVTVLVMYLICFTPSNLLLVV----HYFL 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 276 TLRQLASRGLPFVTS---LAFFNSVVNPLLYVFTCPD 309
Cdd:cd15370  239 LKNQGQSSVYAFYITalcLSTLNSCIDPFVYYFVSHD 275
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
96-266 2.26e-06

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 48.90  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRtvavaHRVCLML---WALAVLNTIPYFVFRDTI 172
Cdd:cd15383   67 WYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSAR-----RRNRIMLcaaWGLSALLALPQLFLFHTV 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRldgrimcyynlllwnPGPDRDTTC--------DYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG--- 241
Cdd:cd15383  142 TA---------------TPPVNFTQCathgsfpaHWQETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDsak 206
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 569006435 242 -----------------RFVRLVAAIVVAFVLCWGPYHIFSL 266
Cdd:cd15383  207 nevalrsssdnipkarmRTLKMTIVIVSSFIVCWTPYYLLGL 248
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
200-306 2.32e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 48.70  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 200 YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGR---QRTG--------RFVRLVAAIVVAFVLCWGPYHIFSLLE 268
Cdd:cd15085  159 WSNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKkieQQGGkncpeeeeRAVIMVLAMVIAFLICWLPYTVFALIV 238
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 569006435 269 ARAHSVTTLRQLASrgLPfvTSLAFFNSVVNPLLYVFT 306
Cdd:cd15085  239 VVNPELSISPLAAT--MP--TYFAKTSPVYNPIIYIFL 272
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
110-310 2.48e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.44  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 110 FFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAV-LNTIPYFVfrdtiprldgrimcyynlllW 188
Cdd:cd14972   77 LVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVlLALLPVLG--------------------W 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 189 NPGPDRDTTCDYRQKALAVSKFLL---AFMVPLAII----------ASSHVAVSLRLHHRG---RQRTGR-FVRLVAAIV 251
Cdd:cd14972  137 NCVLCDQESCSPLGPGLPKSYLVLilvFFFIALVIIvflyvrifwcLWRHANAIAARQEAAvpaQPSTSRkLAKTVVIVL 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 252 VAFVLCWGPYHIFSLLEarahsVTTLRQLASRGLPFVTS-LAFFNSVVNPLLYVFTCPDM 310
Cdd:cd14972  217 GVFLVCWLPLLILLVLD-----VLCPSVCDIQAVFYYFLvLALLNSAINPIIYAFRLKEM 271
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
92-305 2.73e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 48.44  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfvfrdt 171
Cdd:cd15330   62 VLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP------- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 iprldgrimcyyNLLLWNPGPDR---DTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGRQRTGRFVRLVA 248
Cdd:cd15330  135 ------------PMLGWRTPEDRsdpDACTISKDPGYTIYSTFGAFYIPLILMLVLYGRI-----FKAAARERKTVKTLG 197
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 249 AIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15330  198 IIMGTFILCWLPFFIVALVLPFCESTCHMPELLG---AIINWLGYSNSLLNPIIYAY 251
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
196-305 2.90e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 48.25  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 196 TTCD-------YRQKALAVSKFLLAFMVPLAIIASSHVAVSLRL----HHRGRQRTGR-----FVRLVAAIVVAFVLCWG 259
Cdd:cd15082  161 TTCEpnwysgnMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLrkvsNTQGRLGNARkperqVTRMVVVMIVAFMVCWT 240
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 260 PYHIFSLLEARAHSVTTLRQLASrgLPfvtslAFFN---SVVNPLLYVF 305
Cdd:cd15082  241 PYAAFSILVTAHPTIHLDPRLAA--IP-----AFFSktaAVYNPIIYVF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
96-303 3.24e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 48.02  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRL 175
Cdd:cd15322   66 WYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQ 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 DGRIMCYYNlllwnpgpdrdttcdyRQKALAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAAIVVAFV 255
Cdd:cd15322  146 PEGPICKIN----------------DEKWYIISSCIGSFFAPCLIM----VLVYIRIYQIAKNREKRFTFVLAVVIGVFV 205
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 569006435 256 LCWGPYhIFSLLEARAHSVTTLRQLasrgLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15322  206 ICWFPF-FFTYTLTAVCDCSVPETL----FKFFFWFGYCNSSLNPVIY 248
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
84-303 4.49e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 47.87  E-value: 4.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15928   54 PLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVfrdtiprldgrimcyynLLLWNPGPDRDTTCDYRQKALAVSKFLLA---------FMVPLAIIASSHVAVSLRLHH 234
Cdd:cd15928  134 PALV-----------------LVGVEHIQGQQTPRGFECTVVNVSSGLLSvmlwvstsfFFVPMVCLSLLYGLIGRALWD 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 235 RGRQRTG-----------RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFF-NSVVNPLL 302
Cdd:cd15928  197 RRQRSRTagasrrdnnhrQTVRMLAVIVLAFVLCWLPFHVGRVIFNHSRASTKHLHYVSQYFNLVSFVLFYlSAAINPIL 276

                 .
gi 569006435 303 Y 303
Cdd:cd15928  277 Y 277
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
105-305 4.93e-06

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 47.47  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 105 LHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLntipyfvfrdtiprldgriMCYYN 184
Cdd:cd15349   74 LREGLLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFL-------------------IGFLP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 185 LLLWNpgpdrdTTCDYRQ---------KALAVSKFLLAFMVPLAIIAS-----SHVAVSLR--LHHRGRQRTGRFVRLVA 248
Cdd:cd15349  135 LLGWN------CLCDFRScssllplysKSYILFCLVIFFIILLTIIGLyfaiyCLVRASGQrvISARSRRRSLRLLKTVL 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569006435 249 AIVVAFVLCWGPYHIFSLLEARAHSVTtlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15349  209 MILGAFMVCWGPLFILLLVDFFCSSRS---CKPLFGMEWVLALAVLNSAINPLIYSF 262
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
35-305 5.06e-06

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 47.78  E-value: 5.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  35 VLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDllaaaslpFFTYFLAVGHSWELgttFCKLHSSVFF--- 111
Cdd:cd15107    4 NFLSIIIALVGLAGNAIVLWLLGFHMHRNAFSVYILNLAGAD--------FLFLCTQIVFSLEI---VLQFHSIDIHipl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 ----LNMFA--SGF-LLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLntipyfvfrdtIPRLDGRImCyyN 184
Cdd:cd15107   73 flltVTMFAylAGLsMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLL-----------LSLLEGKG-C--G 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 185 LLLWNPGPDRDTTCDYrqkaLAVSKFLLAFMVPLAiiasSHVAVSLRLHHrGRQRT--GRFVRLVAAIVVAFVLCWGPYH 262
Cdd:cd15107  139 FLFSTYDYYWCWTLDL----ITTAWLIVLFVVLSG----SSLALLVRIFC-GSHRIpvTRLYVTIALTVLVFLIFGLPFG 209
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 569006435 263 IFSLLEARAHSVTTLRqlASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15107  210 IYWFLLKWIEEFYIVP--CCGFYEVILFLSCVNSCANPIIYFL 250
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
30-305 5.19e-06

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 47.98  E-value: 5.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  30 IDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAvgHSWELGTTFCKLHSSV 109
Cdd:PHA02834  27 VNYFVIVFYILLFIFGLIGNVLVIAVLIVKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDL--NEWIFGEFMCKLVLGV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 110 FFLNMFASGFLLSAISLDRCLQVVRPVWAQNhRTVAVAHRVCLMLWALAVLNTIPYFVFRdTIPRLDGRIMCYYNlllwn 189
Cdd:PHA02834 105 YFVGFFSNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMVLY-YVDNTDNLKQCIFN----- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 190 pgpdrdttcDYrQKALAVSKFL------LAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHI 263
Cdd:PHA02834 178 ---------DY-HENFSWSAFFnfeiniFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNI 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 569006435 264 FSLLEArAHSVTTLRQLASRGLPFVTS------LAFFNSVVNPLLYVF 305
Cdd:PHA02834 248 VLFINS-LQSVGLIDIGCYHFKKIVYSidiaelISFVHCCVNPIIYAF 294
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
95-307 7.31e-06

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 47.12  E-value: 7.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPR 174
Cdd:cd15150   64 SWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPT 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDGRIMCYynlllwnpgpdrDTTCDYRQKALAVSKFL--LAFMVPLAIIASSHVAVSLRLHH------RGRQRTGRFVRL 246
Cdd:cd15150  144 PKNVKKCS------------LLKSEFGLVWHEIVNYIcqVIFWVNFLIVIVCYTLITKELYKsykrtrGVGKVSRKKVNV 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 247 VAAIVVA-FVLCWGPYHI----FSLLEARA----HSVTTLRQLASRGLpFVTSLaffNSVVNPLLYVFTC 307
Cdd:cd15150  212 KVFIIIAvFFICFVPFHFaripYTLSQTRDvfdcTAKNTLFYVKESTL-WLTSL---NACLDPFIYFFLC 277
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
120-326 7.47e-06

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 47.05  E-value: 7.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 120 LLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDtiprldgrimcyynllLWNPGPDRDTTCd 199
Cdd:cd15105   88 MLSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYFCG----------------FLDTKYENDSVC- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 200 yrqkaLAVSKFLLAFMVPLAIIAS-SHVAVSLRLHHRGRQRtgRFVRLVAAI---VVAFVLCWGPYHIFSLLEARAHSVT 275
Cdd:cd15105  151 -----LASNFFTAAYLMFLFVVLClSSLALLARLFCGAGQM--KLTRLYVTImltVLVFLLCGLPFGIYWFLLFWIKDDF 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569006435 276 TLRQLASRGLPFVtsLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVL 326
Cdd:cd15105  224 HVLDYGLYLASVV--LTAVNSCANPIIYFFVGSFRHRLKHQTLKMVLQSAL 272
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
86-305 8.37e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 47.12  E-value: 8.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRTVAVAHRVclmLWALAVLNTIP 164
Cdd:cd15395   56 FTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLIINPRgWRPNNRHAYVGIAV---IWVLAVLTSLP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 165 YFV--------FRDTIPRLDGRIMCYYNLLLWnpgPDRDTTCDYrqkalAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG 236
Cdd:cd15395  133 FLIfqvltdepFKNVNVSLDAYKGKYVCLDQF---PSDTIRLSY-----TTCLLVLQYFGPLCFIFICYLKIYIRLKRRN 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 237 R------------QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqLASRGLPFVTS--LAFFNSVVNPLL 302
Cdd:cd15395  205 NmmdkmrdnkyrsSETKRINIMLISIVVAFAVCWLPLNIFNAVFDWNHEAIA---TCNHNLLFLIChlTAMISTCVNPIF 281

                 ...
gi 569006435 303 YVF 305
Cdd:cd15395  282 YGF 284
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
86-303 9.99e-06

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 46.59  E-value: 9.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRpvwAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15213   56 FAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQ---RQDKLNPHRAKILIAVSWVLSFCVSFPP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 fVFRDTIprldgrimcyYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLhhrgRQRTGRFVR 245
Cdd:cd15213  133 -LVGWGK----------YEFPPRAPQCVLGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTV----RSFKTRAFT 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 246 LVAAIVVAFVLCWGPYHIFSLLearahsvTTLRQLASRGLPFVTS---LAFFNSVVNPLLY 303
Cdd:cd15213  198 TILILFIGFSVCWLPYTVYSLL-------SVFSRYSSSFYVISTCllwLSYLKSAFNPVIY 251
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
98-305 1.07e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 46.78  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  98 LGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV----WAQNHRTVAvahrvCLMLWALAVLNTIP-YFVFRDTI 172
Cdd:cd15084   78 FGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMgdfrFQQRHAVSG-----CAFTWGWSLLWTSPpLFGWSSYV 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRlDGRIMCYYNlllWNPGPDRDTTcdyrqkaLAVSKFLLAFMVPLAIIASSHVAVSLRLH--------HRGRQRTGRFV 244
Cdd:cd15084  153 PE-GLRTSCGPN---WYTGGTNNNS-------YILALFVTCFALPLSTIIFSYSNLLLTLRavaaqqkeSETTQRAEKEV 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 245 -RLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrgLPfvtslAFFN---SVVNPLLYVF 305
Cdd:cd15084  222 tRMVIAMVMAFLICWLPYATFAMVVATNKDVVIQPTLAS--LP-----SYFSktaTVYNPIIYVF 279
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
103-305 1.12e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 46.73  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 103 CKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAhrvCLMLWALAVLNTIP---YFVFRDTIPrldGRI 179
Cdd:cd15387   73 CRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVY---VLFSWLLSLVFSIPqvhIFSLREVGN---GVY 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 180 MCYYNLLL-WNPgpdrdttcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG----------------- 241
Cdd:cd15387  147 DCWADFIQpWGP------------KAYITWITLSVYIIPVLILSVCYGLISFKIWQNVKLKTRretktplssaasggaal 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 --------------RFVRLVAAIVVAFVLCWGPY---HIFSLLEARAhsvttlrqlASRGLPFVTS--LAFFNSVVNPLL 302
Cdd:cd15387  215 arvssvkliskakiRTVKMTFVIVLAYIVCWTPFffvQMWSVWDPNA---------PKEASPFIIAmlLASLNSCCNPWI 285

                 ...
gi 569006435 303 YVF 305
Cdd:cd15387  286 YMF 288
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
84-305 1.81e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 46.10  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHsWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15307   55 PLGILTLVKGH-FPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFRDTIPrldgrimcyYNLLLwnpgpdrDTTCDYRQKALAVSKFLLAFMVPLAIIASSHvAVSLRLHHRGRQRTGRF 243
Cdd:cd15307  134 PLSLMYSKDH---------ASVLV-------NGTCQIPDPVYKLVGSIVCFYIPLGVMLLTY-CLTVRLLARQRSRHGRI 196
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 244 VRL-------VAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15307  197 IRLeqkatkvLGVVFFTFVILWSPFFVLNLLPTVCAECEE--RISHWVFDVVTWLGYASSMVNPIFYTI 263
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
90-303 1.92e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 45.91  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  90 LAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTipyFV-- 167
Cdd:cd15058   60 IVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVS---FVpi 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 168 ----FRDTIPRldgRIMCYYNlllwnpgpdrDTTCDYR-QKALAVSKFLLAFMVPLAIIASSHVAV-------------- 228
Cdd:cd15058  137 mnqwWRANDPE---ANDCYQD----------PTCCDFRtNMAYAIASSVVSFYIPLLIMIFVYARVfliatrqlqlidkr 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 229 SLRLH----------------HRGRQ------RTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqlasrGLP 286
Cdd:cd15058  204 RLRFQsecpapqttspegkrsSGRRPsrltvvKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPP-------GEV 276
                        250
                 ....*....|....*....
gi 569006435 287 F--VTSLAFFNSVVNPLLY 303
Cdd:cd15058  277 FllLNWLGYINSGLNPIIY 295
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
96-309 1.93e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 45.81  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNhRTvavAHRVCLML---WALAVLNTI-PYFVFRDT 171
Cdd:cd15331   66 WFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTNIDYIRR-RT---AKRILIMIavvWFVSLIISIaPLFGWKDE 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 IPRLDgrimcyynlllwnpgPDRDTTCDYRQ-KALAVSKFLLAFMVPLAIIasshVAVSLRLHhRGRQRTGRFVRLVAAI 250
Cdd:cd15331  142 DDLDR---------------VLKTGVCLISQdYGYTIFSTVGAFYVPLLLM----IIIYWKIY-QAAKRERKAARTLAII 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 251 VVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPfvtsLAFFNSVVNPLLYVFTCPD 309
Cdd:cd15331  202 TGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLW----LGYFNSLLNPIIYTIFSPD 256
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
93-303 1.96e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 45.77  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  93 GHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVF--RD 170
Cdd:cd15052   64 GGVWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLgiID 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 171 TIprldgrimcyyNLLlwnpgpdRDTTCDYRQKALAVSKFLLAFMVPLAIIAsshVAVSLRLHHRGRQRtgRFVRLVAAI 250
Cdd:cd15052  144 TT-----------NVL-------NNGTCVLFNPNFVIYGSIVAFFIPLLIMV---VTYALTIRLLSNEQ--KASKVLGIV 200
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569006435 251 VVAFVLCWGPYHIFSLLEA--RAHSVTTLRQLASrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15052  201 FAVFVICWCPFFITNILTGlcEECNCRISPWLLS----VFVWLGYVSSTINPIIY 251
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
84-305 2.28e-05

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 45.50  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLW---ALAVL 160
Cdd:cd15302   55 PFYTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWiipALLFF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 161 NTI---PYFVFRDTiPRLDGRIMCYYnllLWNPgpdrdttcdYRQKALAVSKFLLAFMVPLAIIASShvavslrlhHRGR 237
Cdd:cd15302  135 ISIfgwQYFTGQGR-SLPEGECYVQF---MTDP---------YFNMGMYIGYYWTTLIVMLILYAGI---------YRAA 192
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006435 238 QRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRqlasrglPFVTSLAFF----NSVVNPLLYVF 305
Cdd:cd15302  193 NRARKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVN-------ETLYTISYYlcymNSPINPFCYAL 257
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
33-303 2.42e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 45.56  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  33 VSVLLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFF 111
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKlRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 112 LNMFASGFLLSAISLDRCLQVVRPVwaqNHRTVAVAHRVCLMLWALAVLNtipyFVfrdtiprldgriMCYYNLLLWNPG 191
Cdd:cd15063   82 WMCTASILNLCAISLDRYLAITRPI---RYPSLMSTKRAKCLIAGVWVLS----FV------------ICFPPLVGWNDG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 192 PDRD----------TTCDY-RQKALAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTgRFVRLVAAIVVAFVLCWGP 260
Cdd:cd15063  143 KDGImdysgssslpCTCELtNGRGYVIYSALGSFYIPMLVM----LFFYFRIYRAARMET-KAAKTVAIIVGCFIFCWLP 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 569006435 261 YHIFSLLEARAHSVTTlrqlasrglPFVTSLAFF----NSVVNPLLY 303
Cdd:cd15063  218 FFTVYLVRAFCEDCIP---------PLLFSVFFWlgycNSALNPCIY 255
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
84-303 3.01e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 45.24  E-value: 3.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15357   55 PLEVYEMWSNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSI 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 P----------YFVFRDTIPrldGRIMCYYNLLLWnpgpdrdttcdYRQKALAVSKFLLaFMVPLAIIASSHVAVSLRLH 233
Cdd:cd15357  135 PntsihgiklqYFPNGTLIP---DSATCTVVKPLW-----------IYNLIIQITSLLF-YVLPMGVISVLYYLMGLKLR 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 234 ----------HRGRQRTGR--FVRLVAAIVVAFVLCWGPYHI----FSLLEARAHSVTTLRQLASrglpfVTSLAFF--N 295
Cdd:cd15357  200 gdksleademNVNIQRPSRksVTKMLFVLVLVFAICWAPFHVdrlfFSFVVEWTEPLANVFNLIH-----VVSGVFFylS 274

                 ....*...
gi 569006435 296 SVVNPLLY 303
Cdd:cd15357  275 SAVNPIIY 282
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
207-305 4.05e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 44.90  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 207 VSKFLLAFMV-----PLAIIASSHVAVSLRLHHRGRQRT---------GRFVRLVAAIVVAFVLCWGPYHIFSLLEArAH 272
Cdd:cd15081  175 VQSYMIVLMItcciiPLAIIILCYLQVWLAIRAVAQQQKesestqkaeKEVSRMVVVMIFAYCFCWGPYTFFACFAA-AN 253
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 569006435 273 SVTTLRQLASrGLPfvtslAFF---NSVVNPLLYVF 305
Cdd:cd15081  254 PGYAFHPLAA-ALP-----AYFaksATIYNPIIYVF 283
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
84-308 4.42e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 44.71  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFtyFLAVGHS-WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV----WAQNHRTVAVAHRVCL--MLWA 156
Cdd:cd15336   55 PIF--FVNSLHKrWIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLasirWVSKKRAMIIILLVWLysLAWS 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 157 LAvlntiPYFVFRDTIPrlDG-RIMCYYNLLLWNPGpdrdttcdyrQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHR 235
Cdd:cd15336  133 LP-----PLFGWSAYVP--EGlLTSCTWDYMTFTPS----------VRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRST 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 GR--QRTGRFVR-----------------LVAAIV-VAFVLCWGPYHIFSLLE--ARAHSVTTLrqlaSRGLPFVTSLAf 293
Cdd:cd15336  196 GRevQKLGSQDRkekakqyqrmknewkmaKIAFVViLLFVLSWSPYACVALIAwaGYAHLLTPY----MKSVPAVIAKA- 270
                        250
                 ....*....|....*
gi 569006435 294 fNSVVNPLLYVFTCP 308
Cdd:cd15336  271 -SAIYNPIIYAITHP 284
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
96-303 5.11e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 44.40  E-value: 5.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAV-AHRVCLMLWALAVLNTIP------YFVF 168
Cdd:cd15296   66 WKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRqAVLKMVLVWVLAFLLYGPaiisweYIAG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 RDTIPRLDGRIMCYYNlllWnpgpdrdttcdyrqkALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ--RTGRFVRL 246
Cdd:cd15296  146 GSIIPEGECYAEFFYN---W---------------YFLMTASTLEFFTPFISVTYFNLSIYLNIQKRRFRlsRDKKVAKS 207
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 247 VAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLasrglpFVTS--LAFFNSVVNPLLY 303
Cdd:cd15296  208 LAIIVCVFGLCWAPYTLLMIIRAACHGHCVPDYW------YETSfwLLWVNSAINPVLY 260
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
39-318 7.05e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 43.96  E-value: 7.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  39 GLASLLGLVENGLILfVVGCRMRQTVVTTWVLHLALSDLLAAASLpfFTY-FLAVGH---SWELGTTFCKLHSsvfFLNM 114
Cdd:cd15073    8 IVAGIISTISNGIVL-VTFVKFRELRTPTNALIINLAVTDLGVSI--IGYpFSAASDlhgSWKFGYAGCQWYA---FLNI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 115 F---ASGFLLSAISLDRCLQVVRP-----VWAQNHRTVAVAHRVCLMLWALAvlntiPYFVFRDTIPRLDGrIMCYYNll 186
Cdd:cd15073   82 FfgmASIGLLTVVAVDRYLTICRPdlgrkMTTNTYTVMILLAWTNAFFWAAM-----PLVGWASYALDPTG-ATCTIN-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 187 lWnpgpdrdTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTG-----------RFVRLVAAIVVAFV 255
Cdd:cd15073  154 -W-------RKNDSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLesvnidwtdqnDVTKMSVIMIVMFL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569006435 256 LCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFnsvvNPLLYVFTCPdmlyKLRRSL 318
Cdd:cd15073  226 VAWSPYSIVCLWASFGEPKKIPPWMAIIPPLFAKSSTFY----NPCIYVIANK----KFRRAI 280
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
84-303 7.06e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 44.13  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHS-WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRTVAVAHRVCLMlWALAVLN 161
Cdd:cd15401   53 PYPLILLAIFHNgWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLrYDKLYNMKKTCCYVCLT-WVLTLAA 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 162 TIPYFvfrdtiprldgrimcYYNLLLWNPgpdRDTTCDYRQ---KALAVSKFLLAFMVPLAIIASSHVAV---SLRLHHR 235
Cdd:cd15401  132 IVPNF---------------FVGSLQYDP---RIYSCTFAQtvsSSYTITVVVVHFIVPLSIVTFCYLRIwvlVIQVKHR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 GRQRTGRFVR--------LVAAIVVAFVLCWGPYHIFSLlearahSVTTLRQLASRGLP---FVTS--LAFFNSVVNPLL 302
Cdd:cd15401  194 VRQDSKQKLKandirnflTMFVVFVLFAVCWGPLNFIGL------AVAINPLKVAPKIPewlFVLSyfMAYFNSCLNAVI 267

                 .
gi 569006435 303 Y 303
Cdd:cd15401  268 Y 268
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
86-305 7.68e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 44.15  E-value: 7.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLntipy 165
Cdd:cd15314   56 PSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSAL----- 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVFRDTIPRLDGRIMcYYNLLLWNPGpdrdttCDYRQ-KALAVSKFLLAFMVPLAIIAS---------SHVAVSLRLHHR 235
Cdd:cd15314  131 VGFGIIFLELNIKGI-YYNHVACEGG------CLVFFsKVSSVVGSVFSFYIPAVIMLCiylkiflvaQRQARSIQSART 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 236 GRQRTGRFVRLVA----AIVV-AFVLCWGPYHIFSLLEARAHSVTTlrqlasrgLPFVTSL---AFFNSVVNPLLYVF 305
Cdd:cd15314  204 KSGASSSKMERKAtktlAIVMgVFLLCWTPFFLCNIIDPFINYSIP--------PVLIEVLnwlGYSNSTLNPFIYAF 273
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
96-305 8.04e-05

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 43.96  E-value: 8.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-W--AQNHRTVAVAhrvclMLWALAVLNTIPYFVFRDTI 172
Cdd:cd15397   66 WIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLIINPTgWkpSVSQAYLAVV-----VIWMLACFISLPFLAFHILT 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLdgrimcYYNLLLWNPGPDRDTTC----DYRQKALAVSKFLLAFM--VPLAIIASSHVAVSLRLHHRGR---QRTGRF 243
Cdd:cd15397  141 DEP------YKNLSHFFAPLADKAVCteswPSEHHKLAYTTWLLLFQycLPLLFILVCYLRIYLRLRRRKDmleRRGEYN 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569006435 244 VR---------LVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQlasRGLPFVTS--LAFFNSVVNPLLYVF 305
Cdd:cd15397  215 RRaghskrinvMLVSLVAAFALCWLPLNVFNAIADWNHEAIPHCQ---HNLIFSLChlAAMASTCVNPIIYGF 284
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
98-303 9.07e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 43.99  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  98 LGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIP----YFVFRDTIP 173
Cdd:cd15358   69 LGAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntslHGIFQLTVP 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 ---RLDGRIMC-------YYNLLLwnpgpdRDTTcdyrqkalavskfLLAFMVPLAIIASSHVAVSLRL----------- 232
Cdd:cd15358  149 crgPVPDSATCmlvkprwMYNLII------QITT-------------LLFFFLPMGTISVLYLLIGLQLkrekmllvlea 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 233 ---------HHRGRQRTGRFVRLVA----AIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFF-NSVV 298
Cdd:cd15358  210 kgskagdsyQHRRIQQEKRRRRQVTkmlfVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIISGVFFYlSSAA 289

                 ....*
gi 569006435 299 NPLLY 303
Cdd:cd15358  290 NPVLY 294
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
88-303 1.11e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 43.57  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  88 YFLAvgHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPyfv 167
Cdd:cd15050   60 YLLE--SKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIP--- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 168 frdtiprldgrIMCYYNLLLWNPGPDRDTTCD---YRQKALAVSKFLLAFMVPLAIIASSHVAVslrLHHRGRQRtgRFV 244
Cdd:cd15050  135 -----------ILGWHHFARGGERVVLEDKCEtdfHDVTWFKVLTAILNFYIPSLLMLWFYAKI---FKAVNRER--KAA 198
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 245 RLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqlaSRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15050  199 KQLGFIMAAFILCWIPYFILFMVIAFCKNCCN-----ENLHMFTIWLGYINSTLNPFIY 252
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
85-314 1.28e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 43.38  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  85 FFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPvwAQNHR-TVAVAHRVCLMLWALA-VLNT 162
Cdd:cd14980   63 YYRGRYAQYSEEWLRSPPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYP--FSNKRlSYKSAKIILILGWLFSiIFAA 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 163 IP--YFVFRDTIPRLDGRI-MCY------YNLLLWnpgpdrdttcdyrqkalaVSKFLLAFMVPLAIIASSHVAVSLRLH 233
Cdd:cd14980  141 IPilYSINQPGDNRLYGYSsICMpsnvsnPYYRGW------------------LIAYLLLTFIAWIIICILYILIFISVR 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 234 HRGRQRT-------GRFVRLVAAIVVAFVLCWGPYHIFSLlearaHSVTTLRQLASRGLPFVTSLAF-FNSVVNPLLYVF 305
Cdd:cd14980  203 KSRKSARrssskrdKRIAIRLALILITDLICWLPYYIVIF-----SGLLTSTEIDIHVLQFIAILALpLNSAINPYLYTL 277

                 ....*....
gi 569006435 306 TCPDMLYKL 314
Cdd:cd14980  278 TTPTFKRDF 286
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
103-314 1.49e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 43.22  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 103 CKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMlWALAVLNTIPYFVFRDTIPRLDGRIMCY 182
Cdd:cd15388   73 CRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPQVFIFSKVEVAPGVYECW 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 183 YNLLL-WNPgpdrdttcdyrqKALAVSKFLLAFMVPLAIIASSHV-------------------AVSLRLHHRGRQRTG- 241
Cdd:cd15388  152 ACFIEpWGL------------KAYVTWITLVVFVLPTLIITVCQVlifkeihiniylksqiivaVVKKKQLLSSRASSVa 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 -------RFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqlasRGLPFV--TSLAFFNSVVNPLLYVFTCPDMLY 312
Cdd:cd15388  220 evskamiKTVKMTLVIVLVYVLCWAPFFLVQLWSVWDPKAPT------EGATFTilMLLASLNSCTNPWIYMAFSSSVSK 293

                 ..
gi 569006435 313 KL 314
Cdd:cd15388  294 EL 295
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
95-312 1.60e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 43.31  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNT---IPYFVFRDT 171
Cdd:cd15957   65 TWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSflpIQMHWYRAT 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 IPRldgRIMCYYNlllwnpgpdrDTTCD-YRQKALAVSKFLLAFMVPLAIIASSHVAV--------------SLRLHHR- 235
Cdd:cd15957  145 HQE---AINCYAE----------ETCCDfFTNQAYAIASSIVSFYVPLVIMVFVYSRVfqeakrqlqkidksEGRFHNQn 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 236 ----------GRQRTGRF-------VRLVAAIVVAFVLCWGPYHIFSLlearahsVTTLRQLASRGLPFV--TSLAFFNS 296
Cdd:cd15957  212 idqngsggggGNRRRSKFclkehkaLKTLGIIMGTFTLCWLPFFIVNI-------VHVIQDNLIRKEVYIllNWIGYVNS 284
                        250
                 ....*....|....*.
gi 569006435 297 VVNPLLYVFTcPDMLY 312
Cdd:cd15957  285 GFNPLIYCRS-PDFRI 299
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
111-303 1.96e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 42.82  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 111 FLNMF---ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdtiPRLDGR--IMCYYNL 185
Cdd:cd15220   77 FLSVClvsASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGW---PSYGGPapIAARHCS 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 186 LLWNPGPDRdttcdyrqKALAVSKFLLAFMVPLAIIASSHVAVSLRLHhrgrqrTGRFVRLVAAIVVAFVLCWGPYHIFS 265
Cdd:cd15220  154 LHWSHSGHR--------GVFVVLFALVCFLLPLLLILVVYCGVFKVFG------GGKAALTLAAIVGQFLCCWLPYFAFH 219
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 569006435 266 LLEARAHSVTTLRQLASrglpFVTSLAFFNSVVNPLLY 303
Cdd:cd15220  220 LYSALAASPVSGGEAEE----VVTWLAYSCFAVNPFFY 253
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
92-305 2.29e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 42.49  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRcLQVVRPVWAQNHRTVAVAhrvcLMLWALAVLNTIP-YFVFRD 170
Cdd:cd15198   63 LGDRWMAGDVACRLLKLLQASARGASANLVVLLALDR-HQAIRAPLGQPLRAWKLA----ALGWLLALLLALPqAYVFRV 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 171 TIP-----RLDGRIMCYYnllLWNPGPDrdttcdYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGR--- 242
Cdd:cd15198  138 DFPddpasAWPGHTLCRG---IFAPLPR------WHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAkkp 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 243 -----------------------FVRLVAAIVVAFVLCWGPYHIFSLlearAHSVTTLRQLASRGLPFVTSLAFFNSVVN 299
Cdd:cd15198  209 wkkpskshlratapsalprakvkTLKMTLVIALLFVGCSLPYFIAEL----AAAFGSGDWEPEKVAAALGVMAVANSATN 284

                 ....*.
gi 569006435 300 PLLYVF 305
Cdd:cd15198  285 PFVFLF 290
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
221-310 2.68e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 42.36  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 221 IASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASrglpFVTSLAFFNSVVNP 300
Cdd:cd15104  194 IYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLED----YLWLLGLCNSLLNP 269
                         90
                 ....*....|
gi 569006435 301 LLYVFTCPDM 310
Cdd:cd15104  270 WIYAFWQKEV 279
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
84-303 2.87e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 42.09  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15132   54 PFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVF-----RDTIPRLDGRIMCYYNLLLWNPGpdrdttcdyrqkALAVSKFLLA--FMVPLAIIASSHVAVSLRLHH-- 234
Cdd:cd15132  134 PFLFLvgveqDNNIHPDDFSRECKHTPYAVSSG------------LLGIMIWVTTtyFFLPMLCLSFLYGFIGRKLWKsk 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 235 ---RGRQRTGR------FVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLrqLASRGLPFVTSLAFFNSV-VNPLLY 303
Cdd:cd15132  202 ndlRGPNAAARershrqTVRILAVVVLAFIICWLPFHIGRILFANTEDYRTM--MFSQYFNIVAMQLFYLSAsINPILY 278
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
84-303 3.21e-04

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 42.15  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHS-WELGTTFCKLHSSVFFLNMFASGFLLSAISLDR-CLQVVRPVWAQNHRTVAVAHRVCLmLWALAVLN 161
Cdd:cd15400   53 PYPLVLVAIFHNgWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRyCYICHSFAYDKLYSRWNTLLYVCL-IWALTVVA 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 162 TIPYFvfrdtiprldgrimcYYNLLLWNPgpdRDTTCDYRQKA---LAVSKFLLAFMVPLAIIASSHVAV---------S 229
Cdd:cd15400  132 IVPNF---------------FVGSLEYDP---RIYSCTFVQTAsssYTIAVVVIHFIVPITVVSFCYLRIwvlviqvrrK 193
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 230 LRLHHRGRQRTGRFVRLVAAIV--VAFVLCWGPYHIFSLleARAHSVTTLRQLASRGLpFVTS--LAFFNSVVNPLLY 303
Cdd:cd15400  194 VKSESKPRLKPSDFRNFLTMFVvfVIFAICWAPLNLIGL--AVAINPQEMAPKVPEWL-FVVSyfMAYFNSCLNAIIY 268
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
84-303 3.57e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 41.79  E-value: 3.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFlAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15079   54 PIFIYN-SFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPL-NGNPLTRGKALLLILFIWLYALPWAL 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PYFVFrdtiprLDGRIMCYYNLllwnpgpdrdTTC-------DYRQKALAVSKFLLAFMVPLAIIASS------HVA--- 227
Cdd:cd15079  132 LPLLF------GWGRYVPEGFL----------TSCsfdyltrDWNTRSFVATIFVFAYVIPLIIIIYCysfivkAVFahe 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 228 ------------VSLRLHHRGRQRT--GRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHsvttlRQLASrglPFVTSL-A 292
Cdd:cd15079  196 kalreqakkmnvVSLRSNADANKQSaeIRIAKVALTNVFLWFIAWTPYAVVALIGAFGN-----QSLLT---PLVSMIpA 267
                        250
                 ....*....|....
gi 569006435 293 FF---NSVVNPLLY 303
Cdd:cd15079  268 LFaktAACYNPIVY 281
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
92-305 3.64e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 41.70  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  92 VGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDT 171
Cdd:cd15333   66 VTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQA 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 iprldgrimcyynlllwnPGPDRDTTC--DYRQKALAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAA 249
Cdd:cd15333  146 ------------------KAEEEVSECvvNTDHILYTVYSTVGAFYIPTLLL----IALYGRIYVEARARERKATKTLGI 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 250 IVVAFVLCWGPYHIFSLLEARAHSVTTLRQLAsrgLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15333  204 ILGAFIVCWLPFFIISLVLPICKDACWFHLAI---FDFFTWLGYLNSLINPIIYTM 256
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
86-305 3.80e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 41.59  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSS--VFFLNmfASGFLLSAISLDRCLQVVRPVWAQNHRTVAvahRVCLML---WAL-AV 159
Cdd:cd15066   55 FNASVEITGRWMFGYFMCDVWNSldVYFST--ASILHLCCISVDRYYAIVQPLEYPSKMTKR---RVAIMLanvWISpAL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 LNTIPYFVFRDTIPRldgrimcYYNLLLWNPgpdrdTTCDYR-QKALAVSKFLLAFMVPLAIIASSHVAVSLRLHhrgrq 238
Cdd:cd15066  130 ISFLPIFLGWYTTEE-------HLQYRKTHP-----DQCEFVvNKIYALISSSVSFWIPCIVMIFTYYRIYLEAK----- 192
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569006435 239 RTGRFVRLVAAIVVAFVLCWGPYHIFsllearaHSVTTLRQLASRGLPFVTSLAF----FNSVVNPLLYVF 305
Cdd:cd15066  193 REHKAAKTLGIIMGAFILCWLPFFLW-------YVTTTLCGDACPYPPILVSILFwigyFNSTLNPLIYAY 256
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-303 4.11e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 41.75  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  98 LGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTI---PR 174
Cdd:cd15133   69 LGSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKflgSG 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 175 LDGRIMCYYNLLLW--NPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIAS--SHVAVSLRLHHRGRQRTGRFVR----- 245
Cdd:cd15133  149 VPASAQCTVRKPQAiyNMIPQHTGHLFFVLPMAVISVLYLLMALRLARERGldATGAGSKIGTRTGQLLQHPRTRaqvtk 228
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 246 LVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFF-NSVVNPLLY 303
Cdd:cd15133  229 MLFILVVVFAICWAPFHIDRLMWSFISDWTDNLHEVFQYVHIISGVFFYlSSAVNPILY 287
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
89-303 4.46e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 41.77  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVf 168
Cdd:cd15356   64 FVWFHYPWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 rdtiprldgrIMCY-YNLLLWNPGPD---RDTTCDYRQKALAV---SKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTg 241
Cdd:cd15356  143 ----------IMGQkYELETADGEPEpssRVCTVLVSRATLKVfiqVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQHS- 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 242 rfVRLVAAIVVAFVLCWGPYH----IFSLLEARAHSvTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15356  212 --VQVLRAIVIAYVICWLPYHarrlMFCYVPDDAWT-DSLYNFYHYFYMLTNTLFYVSSAVNPLLY 274
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
86-305 4.81e-04

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 41.74  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNhrtVAVAHRVCLMLWALAVLNTIP 164
Cdd:cd15396   56 FTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNPRgWKPS---ASHAYWGIVLIWLFSLMISIP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 165 YFVFR----DTIPRLDGRIMCYYNLLLWNPGPDRDTtcdyRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRG---- 236
Cdd:cd15396  133 FLIFHqltdEPFRNLSSHSDFYKDKVVCIEAWPSET----ERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNskid 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 237 RQR--------TGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVttlrqLASRGLPFVTSL----AFFNSVVNPLLYV 304
Cdd:cd15396  209 RMRenesrlseNKRINTMLISIVVTFAACWLPLNIFNVVFDWNHEV-----LMSCHHNLVFTLchlvAMVSTCINPIFYG 283

                 .
gi 569006435 305 F 305
Cdd:cd15396  284 F 284
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
234-310 6.35e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 41.30  E-value: 6.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 234 HRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLE--ARAHSVTTLRQlasrgLPFVTSLAFFNSVVNPLLYVFTCPDM 310
Cdd:cd15102  193 ASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDvaCPVKTCPILYK-----ADWFLALAVLNSALNPIIYTLRSREL 266
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
89-303 6.55e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 41.37  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  89 FLAVGHSWELGTTFCKlhsSVFFLN---MFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15355   64 FIWVHHPWAFGDAACR---GYYFLRdacTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPM 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 FVfrdtiprldgrIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKF--LLAFMVPLAIIASSHVAVSLRL----------- 232
Cdd:cd15355  141 LF-----------TMGEQNRSGTHPGGLICTPIVDTSTLKVVIQVnaFLSFLFPMLVISVLNTLIANQLtvmvnqaeqen 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 233 --HHRGRQRTG--------------RFVRLVAAIVVAFVLCWGPYHIFSLL---EARAHSVTTLRQLASRGLPFVTSLAF 293
Cdd:cd15355  210 qvCTIGGQRTVlsvsmepgrvqslrHGVLVLRAVVIAFVVCWLPYHVRRLMfcyVSDEQWTTFLYDFYHYFYMLTNVLFY 289
                        250
                 ....*....|
gi 569006435 294 FNSVVNPLLY 303
Cdd:cd15355  290 VSSAINPILY 299
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
90-262 7.39e-04

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 41.15  E-value: 7.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  90 LAVGhSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAV---------- 159
Cdd:cd15169   62 LASG-AWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLchlglvfgle 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 160 -----LNTIPYFVFRDTipRLDGRIMCyynLLLWNP---GPDRdttcdyrqkalaVSKFLLAFMVPLAIIASSHVAVSLR 231
Cdd:cd15169  141 apggwLDHSNTSLGINT--PVNGSPVC---LEAWDPasaGPAR------------FSLSLLLFFLPLAITAFCYVGCLRA 203
                        170       180       190
                 ....*....|....*....|....*....|...
gi 569006435 232 LHHRG--RQRTGRFVRLVAAIVVAFVLCWGPYH 262
Cdd:cd15169  204 LARSGltHRRKLRAAWVAGGALLTLLLCVGPYN 236
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
95-314 7.51e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 41.08  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI-PYFVFrdtip 173
Cdd:cd14981   68 EWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASlPLLGL----- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 rldGRIMCYYnlllwnPGpdrdTTC--DYRQKALAVSKFLLAFMV-------------PLAIIASSHVAVSLRLHHRGRQ 238
Cdd:cd14981  143 ---GSYVLQY------PG----TWCflDFYSKNTGDAAYAYLYSIlgllillvtllcnLLVIITLLRMRRRKKRHRRSRR 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 239 RTGRFVR-------LVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQ--LASRglpfvtsLAFFNSVVNPLLYVFTCPD 309
Cdd:cd14981  210 SARRQKRneiqmvvLLLAITVVFSVCWLPLMIRVLINATGDSEKNGKTdlLAVR-------MASWNQILDPWVYILLRKE 282

                 ....*
gi 569006435 310 MLYKL 314
Cdd:cd14981  283 VLRRL 287
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
98-305 7.61e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 40.96  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  98 LGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPV----WAQNHRTVAVahrvcLMLWALAV-LNTIPYFVFRDTI 172
Cdd:cd15076   68 FGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFgnfrFGSKHALGAV-----VATWIIGIgVSLPPFFGWSRYI 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PrlDGrimcyynlLLWNPGPDRDTT-CDYRQKALAVSKFLLAFMVPLAIIASSHVAV--SLRL------HHRGRQRTGRF 243
Cdd:cd15076  143 P--EG--------LQCSCGPDWYTVgTKYRSEYYTWFLFIFCFIVPLSIIIFSYSQLlgALRAvaaqqqESASTQKAERE 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 244 V-RLVAAIVVAFVLCWGPYHIFSL--LEARAHSVTtlrqlasrgLPFVTSLAFFNS---VVNPLLYVF 305
Cdd:cd15076  213 VsRMVVVMVGSFCLCYVPYAALAMymVNNRDHGLD---------LRLVTIPAFFSKsscVYNPIIYCF 271
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
40-305 8.53e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 40.87  E-value: 8.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  40 LASLLGLVENGLILFV-VGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASG 118
Cdd:cd14964    7 LLTCLGLLGNLLVLLSlVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 119 FLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLllwnpgpdrdttc 198
Cdd:cd14964   87 WTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLI------------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 199 dYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQ----------RTGRFVRLVAAIVVAFVLCWGPYHIFSLLe 268
Cdd:cd14964  154 -CTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAirsaaslntdKNLKATKSLLILVITFLLCWLPFSIVFIL- 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569006435 269 araHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd14964  232 ---HALVAAGQGLNLLSILANLLAVLASTLNPFIYCL 265
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
95-305 8.70e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 40.71  E-value: 8.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNhrtVAVAHRVCLML---WALAVLNTIPYFVFRDT 171
Cdd:cd15210   65 AWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPR---IYTRRGLALMIagtWIFSFGSFLPLWLGIWG 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 IPRLDGRIMcyynlllwnpgpdrdtTC----DYRQKALAVSKFLLAFMVPLAIIASSHVavslrlhhrgRQRTGRFVRLV 247
Cdd:cd15210  142 RFGLDPKVC----------------SCsilrDKKGRSPKTFLFVFGFVLPCLVIIICYA----------RREDRRLTRMM 195
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 248 AAIVVAFVLCWGPYHIFSLLEARAhSVTTLRQLASrglpfvtSLAFFNSVVNPLLYVF 305
Cdd:cd15210  196 LVIFLCFLVCYLPITLVNVFDDEV-APPVLHIIAY-------VLIWLSSCINPIIYVA 245
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
94-303 9.58e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 40.72  E-value: 9.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHS-SVFFLNMfASGFLLSAISLDRCLQVVRPvwaqNHRTVAVAHRVCLML---WALAVLNTIPYFV-F 168
Cdd:cd15074   64 HRWLFGDIGCVFYGfCGFLFGC-CSINTLTAISIYRYLKICHP----PYGPKLSRRHVCIVIvaiWLYALFWAVAPLVgW 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 169 RDTIPRLDGRIMCyynlLLWNpgpdrDTTCDYRQKALAVSKFLLAFMVPLAIIASSHV--AVSLRLHHRGRQRTG----- 241
Cdd:cd15074  139 GSYGPEPFGTSCS----IDWT-----GASASVGGMSYIISIFIFCYLLPVLIIVFSYVkiIRKVKSSRKRVAGFDsrskr 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 242 ------RFVRLVAAIVVAFVLCWGPYHIFSLLEarAHSVTTLRQLASRGLPfvTSLAFFNSVVNPLLY 303
Cdd:cd15074  210 qhkierKVTKVAVLICAGFLIAWTPYAVVSMWS--AFGSPDSVPILASILP--ALFAKSSCMYNPIIY 273
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
96-303 1.24e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 40.24  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRl 175
Cdd:cd15324   66 WYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEW- 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgriMCYYNLLLWnpgpdrdttcdyrqkaLAVSKFLLAFMVPLAIIasshVAVSLRLHHRGRQRTGRFVRLVAAIVVAFV 255
Cdd:cd15324  145 ----ECLLNDETW----------------YILSSCTVSFFAPGLIM----ILVYCKIYRVAKMREKRFTFVLAVVMGVFV 200
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 569006435 256 LCWGPYHIFSLLEARAHSVTTLRQLAsrgLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15324  201 LCWFPFFFTYSLHAVCRKRCGIPDAL---FNLFFWIGYCNSSVNPIIY 245
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
90-303 1.24e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 40.28  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  90 LAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWAL-AVLNTIPYFV- 167
Cdd:cd15959   60 ILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAIsAAISFLPIMNq 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 168 -FRDTIPRLDGRimCYynlllwnpgpDRDTTCDY-RQKALAVSKFLLAFMVPLAIIASSHV---AVSLRLHHRGRQRTGR 242
Cdd:cd15959  140 wWRDGADEEAQR--CY----------DNPRCCDFvTNMPYAIVSSTVSFYVPLLVMIFVYVrvfVVATRQVRLIRKDKVR 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 243 F------------------VRLVA-----------AIVVAFVLCWGPYHIFSLLEARAHSVttlrqLASRGLPFVTSLAF 293
Cdd:cd15959  208 FppeesppaesrpacgrrpSRLLAikehkalktlgIIMGTFTLCWLPFFVANIIKVFCRSL-----VPDPAFLFLNWLGY 282
                        250
                 ....*....|
gi 569006435 294 FNSVVNPLLY 303
Cdd:cd15959  283 ANSAFNPIIY 292
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
96-303 1.43e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 40.15  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVwaQNHRTVAVAHRVC--LMLWALAVLNTIPYFvfrdtip 173
Cdd:cd15209   66 WTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSL--QYDRLYSLRNTCCylCLTWLLTVLAVLPNF------- 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 rldgrimcYYNLLLWNPgpdRDTTCDYRQ---KALAVSKFLLAFMVPLAIIASSHVAV-SLRLHHRGRQRTGRFVRLVAA 249
Cdd:cd15209  137 --------FIGSLQYDP---RIYSCTFAQtvsTVYTITVVVIHFLLPLLIVSFCYLRIwVLVLQVRQRVKPDQRPKLKPA 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569006435 250 ----------IVVAFVLCWGPYHIFSLleARAHSVTTLRQLASRGLpFVTS--LAFFNSVVNPLLY 303
Cdd:cd15209  206 dvrnfltmfvVFVLFAVCWAPLNFIGL--AVAINPKEMAPKIPEWL-FVASyfMAYFNSCLNAIIY 268
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
116-305 1.48e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 40.01  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 116 ASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAV-LNTIPyfvfrdtiprldgrimcyynLLLWNPGPDR 194
Cdd:cd15961   82 ASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASIcLGLLP--------------------VMGWNCLADE 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 195 DTTCDYR------QKALAVS-KFLLAFMVPLAI----IASSHV-AVSLRLH-----HRGRQRTGrfVRLVAAIVVAFVLC 257
Cdd:cd15961  142 STCSVVRpltknnAAILSVSfLLMFALMLQLYIqickIVMRHAhQIALQHHflatsHYVTTRKG--VSTLAIILGTFAAC 219
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 569006435 258 WGPYHIFSLLEARAH-SVTTLRQLasrgLPfvtslAFFNSVVNPLLYVF 305
Cdd:cd15961  220 WMPFTLYSLIADYTYpSIYTYATL----LP-----ATYNSIINPVIYAF 259
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
86-308 1.51e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 40.23  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  86 FTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPY 165
Cdd:cd15316   56 FSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSV 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 166 F---VFRDTIPRLDGRIMCYynlllwnpgpdrdTTCDY-RQKALAVSKFLLAFMVPLAII-------------------- 221
Cdd:cd15316  136 FytgVNDDGLEELVNALNCV-------------GGCQIiLNQNWVLVDFLLFFIPTFAMIilygkiflvakqqarkiemt 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 222 ASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTlrqlasrglPFVTSL----AFFNSV 297
Cdd:cd15316  203 SSKAESSSESYKDRVARRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITP---------PYIYEIccwcAYYNSA 273
                        250
                 ....*....|.
gi 569006435 298 VNPLLYVFTCP 308
Cdd:cd15316  274 MNPLIYALFYP 284
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
96-308 1.99e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 39.64  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYF---VFRDTI 172
Cdd:cd15312   66 WYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVfseVNLEGI 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 PRLDGRIMCYYN-LLLWNpgpdrdttcdyrqKALAVSKFLLAFMVPLAII----------ASSHVAVslrLHHRGRQRTG 241
Cdd:cd15312  146 EDYVALVSCTGScVLIFN-------------KLWGVIASLIAFFIPGTVMigiyikiffvARKHAKV---INNRPSVTKG 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 242 RFVRLVA-----------AIVVA-FVLCWGPYHIFSLLEarahsvttlrqlasrglPF------------VTSLAFFNSV 297
Cdd:cd15312  210 DSKNKLSkkkerkaaktlSIVMGvFLLCWLPFFVATLID-----------------PFlnfstpvdlfdaLVWLGYFNST 272
                        250
                 ....*....|.
gi 569006435 298 VNPLLYVFTCP 308
Cdd:cd15312  273 CNPLIYGFFYP 283
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
93-303 2.23e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 39.55  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  93 GHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRdti 172
Cdd:cd15328   64 GRRWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFG--- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 173 prldgrimcyynlllWNPGPDRDT-TCDYRQK-ALAVSKFLLAFMVPLAIIASSHVAVslrlhHRGRQRTGRFVRLVAAI 250
Cdd:cd15328  141 ---------------WGETYSEDSeECQVSQEpSYTVFSTFGAFYLPLCVVLFVYWKI-----YKAAQKEKRAALMVGIL 200
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569006435 251 VVAFVLCWGPYHIFSLLEArahsvttlrqLASRGLPFVTS-----LAFFNSVVNPLLY 303
Cdd:cd15328  201 IGVFVLCWIPFFLTELISP----------LCSCDIPPIWKsiflwLGYSNSFFNPLIY 248
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
93-303 4.36e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 38.37  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  93 GHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQ--NHRTVAVAHRVCLMLWALAVLNTIPYFVFRD 170
Cdd:cd15304   64 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSrfNSRTKAFLKIIAVWTISVGISMPIPVFGLQD 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 171 tiprlDGRIMcyynlllwnpgpdRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVaVSLRLHHRGRQRTGRFVRLVAAI 250
Cdd:cd15304  144 -----DSKVF-------------KEGSCLLADENFVLIGSFVAFFIPLTIMVITYF-LTIKSLQQSISNEQKASKVLGIV 204
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569006435 251 VVAFVLCWGPYHIFSLLEARAHSVTTlRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15304  205 FFLFVVMWCPFFITNVMAVICKESCN-EVVIGGLLNVFVWIGYLSSAVNPLVY 256
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
95-314 4.77e-03

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  95 SWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFR-DTIP 173
Cdd:cd15167   65 PWKLKIFHCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPiKTIE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 174 RLDGrIMCYynlllwnpgpDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVR--LVAAIV 251
Cdd:cd15167  145 EKPG-VGCA----------DFKTEFGRHWHVLTNFICMAIFLNFSAIILISNFLVIRKLYRNKDSEEYRNARqaLVNILL 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 252 V--AFVLCWGPYHI----FSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKL 314
Cdd:cd15167  214 VtaGYVICFVPYHIvripYTLSQSEVITDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
96-305 7.59e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 37.72  E-value: 7.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  96 WELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQnhrTVAVAHRVCLMlWALAvlntipyfVFRDTIPrl 175
Cdd:cd15072   65 WPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHYCTRSKLQ---WSTAISLVLFV-WLFS--------AFWAAMP-- 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 176 dgrimcyynLLLW-NPGPDRDTTC---DYRQKALAVSKFLLA-----FMVPLAIIASSHvavslRLHHRGRQRTGRFVRL 246
Cdd:cd15072  131 ---------LLGWgEYDYEPLGTCctlDYSKGDRNYVSYLFTmaffnFILPLFILLTSY-----SSIEQKLKKEGHLRFN 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569006435 247 VAAIVVAFVLCWGPYHIFSLLEArahsVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVF 305
Cdd:cd15072  197 TGLPLLTLLICWGPYAILALYAA----ITDVTSISPKLRMVPALLAKTSPTINAILYAL 251
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
94-303 8.17e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 37.58  E-value: 8.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  94 HSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQ--NHRTVAVAHRVCLMLWALAVLNTIPYFVFRDt 171
Cdd:cd15305   65 YAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSrfNSRTKAMMKIAAVWTISIGISMPIPVIGLQD- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 172 iprlDGRIMcyynlllwnpgpdRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIV 251
Cdd:cd15305  144 ----DEKVF-------------VNGTCVLNDENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIV 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569006435 252 -VAFVLCWGPYHIFSLLEARAHSvTTLRQLASRGLPFVTSLAFFNSVVNPLLY 303
Cdd:cd15305  207 fFLFLIMWCPFFITNILSVLCKE-ACDQKLMEELLNVFVWVGYVSSGINPLVY 258
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
84-244 8.61e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 37.82  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435  84 PFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTI 163
Cdd:cd15005   55 PFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006435 164 PyfvfrdtiPRLDGRIMCYYnlllwnpgpDRDTTCDYRQKALAvSKFLLAFMVPLAIIASSHVAVSLRL----HHRGRQR 239
Cdd:cd15005  135 P--------PVFDVGTYTFI---------REEDQCTFEHRSYK-ANDTLGFMLVLAVVIAATHLVYLKLliflRHHRKMK 196

                 ....*
gi 569006435 240 TGRFV 244
Cdd:cd15005  197 PAQLV 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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